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Cytotoxic Constituents of Psoralea corylifolia
Mar, Woongchon,Je, Kang-Hun,Seo, Eun-Kyoung 梨花女子大學校 藥學硏究所 2001 藥學硏究論文集 Vol.- No.10
A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L.(Leguminosae) with the IC_50 values of 0.3 and 0.4㎍/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541(lung) and HepG2 (liver hepatoma) cancer cell lines.
A DNA Strand-Nicking Principle of a Higher Plant, Caesalpinia sappan
Mar, Woongchon,Lee, Hyun-Tai,Je, Kang-Hoon,Choi, Hye-Young,Seo, Eun-Kyoung 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.
A DNA Strand-Nicking Principle of a Higher Plant, Caesalpinia sappan
Mar, Woongchon,Lee, Hyun-Tai,Je, Kang-Hoon,Choi, Hye-Young,Seo, Eun-Kyoung The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.2
To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.
DNA Strand-Nicking Principles of Mucuna birdwoodiana
Han, Ah-Reunm,Mar, Woongchon,Seo, Eun-Kyoung 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
During our research program to find DNA strand-scission agents from higher plants, the MeOH extracts of the stems of Mucuna birdwoodiana Tutcher. (Leguminosae) exhibited the most potent activity with an IC_(50) value of 4.9 ㎍/㎖. Thus, detailed laboratory investigation was performed, and led to the isolation of known compounds, (±)-catechin (1) and (-)-epicatechin (2) as active principles. Compounds 1 and 2 showed significant activity of DNA strand-scission with IC_(50) values of 10.8 and 7.5 ㎍/㎖, respectively (positive control, bleomycin: IC_(50) 3.3 ㎍/㎖).
제강훈,한아름,이현태,Woongchon Mar,서은경 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.1
A sesquiterpene lactone, 1-O-acetyl-4R,6S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an iNOS inhibitory constituent for the first time with an IC50 value of 22.1 mM which is more potent than the positive control, L-N6-(1-iminoethyl)lysine (IC50 = 33.7 mM). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.
남궁우,제강훈,Young-Jun Shin,강삼식,Woongchon Mar 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.6
Eight furoquinoline alkaloids were purified from two plants belonging to the Rutaceae family. Kokusaginine, skimmianine, evolitrine, and confusameline were purified from Melicope confusa, and haplopine, robustine, dictamine, and γ-fagarine from Dictamnus albus. In this study, the eight furoquinoline alkaloids were examined for inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro. DNA encoding the catalytic domain of human PDE5A was amplified from the mRNA of T24 cells by RT-PCR and was fused to GST in an expression vector. GST-tagged PDE5A was then purified by glutathione affinity chromatography and used in inhibition assays. Of the eight alkaloids, γ-fagarine was the most potent inhibitor of PDE5A, and its single methoxy group at the C-8 position was shown to be critical for inhibitory activity. These results clearly illustrate the relationship between PDE5A inhibition and the methoxy group position in furoquinoline alkaloids.