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RISS 인기검색어
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- 저자 : Mao Cun-Li (검색결과 2 건)
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Cheng, Huan,Lu, Meng,Mao, Li-Jun,Wang, Jun-Qi,Li, Wang,Wen, Ru-Min,Chen, Jia-Cun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Objectives: The purpose of this study was to determine the relationship between methylation status of the Dact1 gene and MTHFR a1298c polymorphic forms in transitional cell carcinoma tissues in a Chinese population. Methods: Polymorphisms of folate metabolism enzyme gene MTHFR were assessed by restrictive fragment length polymorphism (RFLP) methods and PCR-based DNA methylation analysis was used to determine the CpG island methylation status of the Dact1 gene. Associations between the methylation status of the Dact1 gene and clinical characteristics, as well as MTHFR a1298c polymorphisms, were analyzed. Results: aberrant methylation of the Dact1 gene was found in 68.3% of cancer tissues and 12.4% of normal tissues,. The methylation rate of the Dact1 gene in cancer tissues was significantly higher in patients with lymph node metastasis than in those without lymph node metastasis (46.3% vs. 17.2%, P = 0.018). No association was found between aberrant DNA methylation and selected factors including sex, age, tobacco smoking, alcohol consumption and green tea consumption. After adjusting for potential confounding variables, variant allele of MTHFR a1298c was found to be associated with methylation of the Dact1 gene. Compared with wild type CC, the odds ratio was 4.33 (95% CI: 1.06-10.59) for AC and 4.95 (95% CI: 1.18-12.74) for AA. The N stage in TNM staging and the occurrence of lymph node metastasis were associated with an MTHFR 1298 AA+AC genotype (P<0.05). Conclusion: MTHFR 1298 AC and AA genotypes might help maintain a normal methylation status of the Dact1 gene, aberrant CpG island methylation of which is closely related to the genesis and progression of transitional cell carcinoma.
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Gao Sheng-Xiang,An Ming-Jia,Mao Cun-Li,Xian Yan-Tuan,Yu Zheng-Tao 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.2
Relative to Chinese, as to Naxi Language, its corpus is very rare, its annotation is also difficult, and these factors make its Syntactic Analysis much too difficult. Aiming to the problem, in the paper, it is proposed a method for building Naxi Language Dependency Treebank based on Chinese-Naxi Language relationship alignment. Firstly, the corresponding words of Chinese-Naxi sentence pairs are aligned; then, the dependency grammar on Chinese sentences; Finally, some characteristics and rules of Naxi Language in itself being considered, the generated Chinese Dependency Tree is mapped to Naxi Sentence by using Chinese-Naxi Languages relationship alignment, as a result, Naxi Dependency Parsing Tree is generated. Experimental results show that: This approach can simplify the process of manual collection and annotation of Naxi Treebank, and save manpower and time to build the dependency treebank of Naxi Language.
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