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Hiroshi Mitoma,Mario manto,Marios Hadjivassiliou 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
Since the first description of immune-mediated cerebellar ataxias (IMCAs) by Charcot in 1868, several milestones have been reached in our understanding of this group of neurological disorders. IMCAs have diverse etiologies, such as gluten ataxia, postinfectious cerebellitis, paraneoplastic cerebellar degeneration, opsoclonus myoclonus syndrome, anti-GAD ataxia, and primary autoimmune cerebellar ataxia. The cerebellum, a vulnerable autoimmune target of the nervous system, has remarkable capacities (collectively known as the cerebellar reserve, closely linked to plasticity) to compensate and restore function following various pathological insults. Therefore, good prognosis is expected when immune-mediated therapeutic interventions are delivered during early stages when the cerebellar reserve can be preserved. However, some types of IMCAs show poor responses to immunotherapies, even if such therapies are introduced at an early stage. Thus, further research is needed to enhance our understanding of the autoimmune mechanisms underlying IMCAs, as such research could potentially lead to the development of more effective immunotherapies. We underscore the need to pursue the identification of robust biomarkers.
Suppression of Action Tremor by Sensory Electrical Stimulation in Patients with Essential Tremor
Heo, J.-H.,Kwon, Y.,Jeon, H.-M.,Kwon, D.-Y.,Lee, C.-N.,Park, K.-W.,Manto, M.,Kim, J.-W.,Eom, G.-M. World Scientific 2016 JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY Vol.16 No.8
<P>Essential tremor (ET) is the most common movement disorder that includes postural tremor and action tremor. This study investigates whether sensory electrical stimulation (SES) is effective on the action tremor in patients with ET. One task in the clinical testing of action tremor, 'Archimedes spiral drawing', was performed in 18 patients for three sessions, which were named as pre-stimulation (PRE), stimulation on (ON), and 5 min after stimulation (POST). SES (sub-motor threshold) was applied on the muscles of the elbow and wrist only at ON session. Three-dimensional (3D) angular velocities were measured on three segments (index finger, hand, and forearm) from which movements of metacarpophalangeal (MP) and wrist joints were derived. Average tremor intensity in each session was represented by root mean square of the vector sum of 3D angular velocities. Tremor intensities in ON session were smaller than in PRE session in one segment (finger) and two joints (MP and wrist) (p < 0.05). Tremor intensities in POST session were even smaller than in ON session in all segments and one joint (wrist) (p < 0.05). The results indicate that SES suppresses action tremor and the effect continues and even improves 5 min after the termination of stimulation. The findings of this study may contribute to the improvement of the quality of life in patients with ET.</P>
Sensory electrical stimulation for suppression of postural tremor in patients with essential tremor.
Heo, Jae-Hoon,Kim, Ji-Won,Kwon, Yuri,Lee, Sang-Ki,Eom, Gwang-Moon,Kwon, Do-Young,Lee, Chan-Nyeong,Park, Kun-Woo,Manto, Mario Pergamon Press 2015 Bio-medical materials and engineering Vol.26 No.1
<P>Essential tremor is an involuntary trembling of body limbs in people without tremor-related disease. In previous study, suppression of tremor by sensory electrical stimulation was confirmed on the index finger. This study investigates the effect of sensory stimulation on multiple segments and joints of the upper limb. It denotes the observation regarding the effect's continuity after halting the stimulation. 18 patients with essential tremor (8 men and 10 women) participated in this study. The task, 'arms stretched forward', was performed and sensory electrical stimulation was applied on four muscles of the upper limb (Flexor Carpi Radialis, Extensor Carpi Radialis, Biceps Brachii, and Triceps Brachii) for 15 seconds. Three 3-D gyro sensors were used to measure the angular velocities of segments (finger, hand, and forearm) and joints (metacarpophalangeal and wrist joints) for three phases of pre-stimulation (Pre), during-stimulation (On), and 5 minute post-stimulation (P5). Three characteristic variables of root-mean-squared angular velocity, peak power, and peak power frequency were derived from the vector sum of the sensor signals. At On phase, RMS velocity was reduced from Pre in all segments and joints while peak power was reduced from Pre in all segments and joints except for forearm segment. Sensory stimulation showed no effect on peak power frequency. All variables at P5 were similar to those at On at all segments and joints. The decrease of peak power of the index finger was noted by 90% during stimulation from that of On phase, which was maintained even after 5 min. The results indicate that sensory stimulation may be an effective clinical method to treat the essential tremor.</P>
본태성 진전 환자의 진전특성에 대한 수행과제 및 부위의 영향
허재훈,김지원,권유리,엄광문,권도영,이찬녕,박건우,Heo, J.H.,Kim, J.W.,Kwon, Y.R.,Eom, Gwang-Moon,Kwon, D.Y.,Lee, C.N.,Park, K.W.,Manto, M. 대한의용생체공학회 2016 의공학회지 Vol.37 No.1
Essential tremor is a neurological disorder with a tremor of the arms and hands. It is well known that essential tremor is characterized by the postural tremor and the action tremor. There has been no report on the quantitative difference in the characteristics of two tremor types. The purpose of this study was to investigate the possible difference in tremor characteristics of postural and action tremors. Seventeen patients with essential tremor ($68.9{\pm}7.9years$, 7 men, 10 women) participated in this study. Patients performed the tasks of postural maintenance (arms outstretched) and daily actions (spiral drawing). Three-axes (pitch, roll and yaw) gyro sensors were attached on index finger, back of hand and forearm, from which the segment and the joint angular velocities were calculated. Outcome measure was the tremor amplitude defined as the root-mean-square mean of the vector-sum angular velocity at segments and joints. Two-way ANOVA showed that task and joint had main factor on the tremor amplitude (p < 0.05). Post-hoc analysis revealed that tremor amplitude at the metacarpo-phalangeal joint was not affected by task (p > 0.05). However, tremor amplitude at the wrist joint differed among the tasks (p < 0.05), and it was greater in the action tasks than in postural task. Tremor was greater at finger segments than at hand and forearm and it increased in action tasks. The results of this study would be helpful for the understanding and task-specific treatments of the essential tremor.
본태성 진전 환자의 검지에서의 자세성 진전에 대한 감각자극 효과
이상기,김지원,권유리,이영재,이정환,엄광문,권도영,이찬녕,서유미,김미경,박건우,정호춘,Lee, S.K.,Kim, J.W.,Kwon, Y.R.,Lee, Y.J.,Lee, J.H.,Eom, G.M.,Kwon, D.Y.,Lee, C.N.,Seo, Y.M.,Kim, M.K.,Park, K.W.,Jeong, H.C.,Manto, M. 대한의용생체공학회 2013 의공학회지 Vol.34 No.3
The essential tremor is an involuntary oscillatory movement of body parts. Conventional treatments of essential tremor have little effects in some patients and also leads to significant side effects. Alternative to these treatments, sensory stimulation may have beneficial effects on the essential tremor. The purpose of this study was to analyze an effect of sensory stimulation on essential tremor. Ten patients with essential tremor ($67.4{\pm}8.82$ yrs, 5 men and 5 women) participated in this study. Three-axis gyro sensors were attached on index finger, hand and forearm of patients. Task of 'arms outstretched forward' was performed with and without sensory stimulation. Vectorsum of three dimensional angular velocities (pitch, roll, yaw) was calculated. Outcome measures included root-meansquare (RMS) mean of the vector-sum amplitude, total power, peak power and peak frequency. RMS amplitude, total power and peak power were reduced by sensory stimulation (p < 0.05). Peak frequency was not affected by sensory stimulation. The results indicate that the sensory stimulation is useful to suppress the essential tremor.