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MANJUNATHA, N.,SUMITHRA, R.,VANISHREE, R.K. The Korean Society for Computational and Applied M 2022 Journal of applied mathematics & informatics Vol.40 No.1-2
The problem of Benard double diffusive Marangoni convection is investigated in a horizontally infinite composite layer system consisting of a two component fluid layer above a porous layer saturated with the same fluid, using Darcy-Brinkman model with constant heat sources/sink in both the layers. The lower boundary of the porous region is rigid and upper boundary of the fluid region is free with Marangoni effects. The system of ordinary differential equations obtained after normal mode analysis is solved in closed form for the eigenvalue, thermal Marangoni number for two types of thermal boundary combinations, Type (I) Adiabatic-Adiabatic and Type (II) Adiabatic -Isothermal. The corresponding two thermal Marangoni numbers are obtained and the essence of the different parameters on non-Darcy-Benard double diffusive Marangoni convection are investigated in detail.
Exploration of Heat Stress-Responsive Markers in Understanding Trait Associations in Wheat
Manjunatha P. B.,Nivedita Sinha,Hari Krishna,Divya Chauhan,Pawan Kumar,Ranjeet R. Kumar,Neelu Jain,P. K. Singh,G. P. Singh 한국식물학회 2021 Journal of Plant Biology Vol.64 No.2
Heat stress (HS) is detrimental to wheat production and productivity globally. To combat HS, several genetic, molecular, and genomic approaches have been employed in the past. Analyzing the physiochemical mechanisms and the important regulatory genes involved is the key to develop HS tolerant plants. In the present work, a total of 243 novel simple sequence repeat (SSR) markers developed from stress-associated genes identified through RNA-seq were used for understanding marker–trait associations. 37 SSRs were found to be clearly polymorphic and among these, 28 SSR loci were significantly associated with component traits of HS tolerance. The polymorphic SSRs were validated for diversity analysis on a subset of 85 genotypes. The genotypes were grouped into four clusters representing diverse and similar alleles imparting HS tolerance in Indian and exotic genotypes. Additionally, 28 genes selected for the expression analysis confirmed that 15 genes were induced under HS in the thermotolerant WH1021 and Raj3765 and repressed in thermosusceptible HD2009 cultivar. Hence, the information on traits associated with candidate genes and the SSR markers overlying on the gene will enhance our understanding of thermotolerance mechanism operating in wheat and will help the breeders in the precise development of heat-tolerant genotypes through marker-assisted selection (MAS).
Manjunatha M. Revanappa,Atul P. Sattur,Venkatesh G. Naikmasur,Arpita Rai Thakur 대한구강악안면방사선학회 2013 Imaging Science in Dentistry Vol.43 No.1
Non-Hodgkin’s lymphoma (NHL) constitutes a group of malignancies those arises from cellular components of lymphoid or extranodal tissues. The head and neck is the most common area for the presentation of these lymphoproliferative disorders. Primary involvement of salivary glands is uncommon. This report described a case of a 73-year-old female patient who presented with involvement of both nodal and extranodal sites, with predominant involvement of salivary glands. The tumor staging worked up along with imaging, histopathological, and immunohistochemical findings were discussed. Computed tomographic images showed the involvement of Waldeyer’s ring, larynx, orbit, and spleen. This report described imaging and prognostic tumor markers in diagnosing, treatment planning, and prognosis.
Muttigi, Manjunatha S.,Kim, Byoung Ju,Choi, Bogyu,Yoshie, Arai,Kumar, Hemant,Han, Inbo,Park, Hansoo,Lee, Soo‐,Hong Wiley (John WileySons) 2018 Journal of tissue engineering and regenerative med Vol.12 No.3
<P>Matrilin-3 is an essential extracellular matrix component present only in cartilaginous tissues. Matrilin-3 exerts chondroprotective effects by regulating an anti-inflammatory function and extracellular matrix components. We hypothesized that the codelivery of matrilin-3 with infrapatellar adipose-tissue-derived mesenchymal stem cells (Ad-MSCs) may enhance articular cartilage regeneration. Matrilin-3 treatment of Ad-MSCs in serum-free media induced collagen II and aggrecan expression, and matrilin-3 in chondrogenic media also enhanced in vitro chondrogenic differentiation. Next, the in vivo effect of matrilin-3 codelivery with Ad-MSCs on cartilage regeneration was assessed in an osteochondral defect model in Sprague Dawley rats: Ad-MSCs and hyaluronic acid were implanted at the defect site with or without matrilin-3 (140, 280, and 700ng). Safranin O staining revealed that matrilin-3 (140 and 280ng) treatment significantly improved cartilage regeneration and glycosaminoglycan accumulation. In the animals treated with 140-ng matrilin-3, in particular, the defect site exhibited complete integration with surrounding tissue and a smooth glistening surface. The International Cartilage Repair Society macroscopic and O'Driscoll microscopic scores for regenerated cartilage were furthermore shown to be considerably higher for this group (matrilin-3; 140ng) compared with the other groups. Furthermore, the defects treated with 140-ng matrilin-3 revealed significant hyaline-like cartilage regeneration in the osteochondral defect model; in contrast, the defects treated with 700-ng matrilin-3 exhibited drastically reduced cartilage regeneration with mixed hyaline-fibrocartilage morphology. Codelivery of matrilin-3 with Ad-MSCs significantly influenced articular cartilage regeneration, supporting the potential use of this tissue-specific protein for a cartilage-targeted stem cell therapy.</P>
Matrilin-3 Role in Cartilage Development and Osteoarthritis
Muttigi, Manjunatha S.,Han, Inbo,Park, Hun-Kuk,Park, Hansoo,Lee, Soo-Hong MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.4
<P>The extracellular matrix (ECM) of cartilage performs essential functions in differentiation and chondroprogenitor cell maintenance during development and regeneration. Here, we discuss the vital role of matrilin-3, an ECM protein involved in cartilage development and potential osteoarthritis pathomechanisms. As an adaptor protein, matrilin-3 binds to collagen IX to form a filamentous network around cells. Matrilin-3 is an essential component during cartilage development and ossification. In addition, it interacts directly or indirectly with transforming growth factor β (TGF-β), and bone morphogenetic protein 2 (BMP2) eventually regulates chondrocyte proliferation and hypertrophic differentiation. Interestingly, matrilin-3 increases interleukin receptor antagonists (IL-Ra) in chondrocytes, suggesting its role in the suppression of IL-1β-mediated inflammatory action. Matrilin-3 downregulates the expression of matrix-degrading enzymes, such as a disintegrin metalloproteinase with thrombospondin motifs 4 (ADAMTS4) and ADAMTS5, matrix metalloproteinase 13 (MMP13), and collagen X, a hypertrophy marker during development and inflammatory conditions. Matrilin-3 essentially enhances collagen II and aggrecan expression, which are required to maintain the tensile strength and elasticity of cartilage, respectively. Interestingly, despite these attributes, matrilin-3 induces osteoarthritis-associated markers in chondrocytes in a concentration-dependent manner. Existing data provide insights into the critical role of matrilin-3 in inflammation, matrix degradation, and matrix formation in cartilage development and osteoarthritis.</P>