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RISS 인기검색어
- 검색키워드
- 저자 : Manisha Tiwari (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Manisha Khatri,Manisha Tiwari,Santosh K Rai,Ranjit Ranbhor,Krishna Kishore 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7
On the basis of our earlier studies, a series of N-{4-[4-(aryl) piperazin-1-yl]-phenyl}-amine derivatives containing terminal carbamoyl fragment with alkyl spacer of different lengths (15-20) were synthesized as ligands, for 5-hydroxytryptamine-1A (5-HT1A) receptor. Molecular modeling studies were undertaken to explain the influence of spacer length on ligands affinity towards 5-HT1A receptor. Compound 19 showed all the specific interactions responsible for recognition. The protonated amine of the ligand forms an ionic hydrogen bond with the negatively charged Asp116 of transmembrane3 helix (TM3), while the carbamoyl moiety interacts with Asn386 and Tyr390 of TM7. The aryl group is involved in forming a CH-π interaction with Phe362. The strong interaction of compound 19 with 5-HT1A receptor in docking studies was confirmed by radio ligand binding studies. Compound 19 showed high affinity for the receptor (Ki = 0.018 nM). In vivo pharmacological testing of compound 19 (3 mg/kg body weight) showed increased open arm entries, as well as time spent in Elevated plus Maze test. Toxicological analysis also revealed no significant biochemical or morphological alterations in the vital organs of experimental animals. Furthermore our results suggest that these compounds share some pharmacological effects with established anxiolytics and might prove to be effective compounds for the treatment of anxiety.
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Chandra Bhushan Mishra,Shikha Kumari,Manisha Tiwari 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.5
A series of 1-phenyl-3/4-[4-(aryl/heteroaryl/alkyl-piperazine1-yl)-phenyl-urea derivatives (29–42) weredesigned, synthesized and evaluated for their anticonvulsantactivity by using maximal electroshock (MES), subcutaneouspentylenetetrazole (scPTZ) seizure tests. Theacute neurotoxicity was checked by rotarod assay. Most ofthe test compounds were found effective in both seizuretests. Compound 30 (1-{4-[4-(4-chloro-phenyl)-piperazin-1-yl]-phenyl}-3-phenyl-urea) exhibited marked anticonvulsantactivity in MES as well as scPTZ tests. The phaseII anticonvulsant quantification study of compound 30indicates the ED50 value of 28.5 mg/kg against MESinduced seizures. In addition, this compound also showedconsiderable protection against pilocarpine induced statusepilepticus in rats. Seizures induced by 3-mercaptopropionicacid model and thiosemicarbazide were significantlyattenuated by compound 30, which suggested its broadspectrum of anticonvulsant activity. Interestingly, compound30 displayed better antidepressant activity thanstandard drug fluoxetine. Moreover, compound 30appeared as a non-toxic chemical entity in sub-acute toxicitystudies.
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Metagenomics Analysis of Thrombus Samples Retrieved from Mechanical Thrombectomy
Vajpeyee Atulabh,Chauhan Puneet Singh,Pandey Swapnil,Tiwari Shivam,Yadav Lokendra Bahadur,Shroti Akhilesh Kumar,Vajpeyee Manisha 대한신경중재치료의학회 2021 Neurointervention Vol.16 No.1
Purpose: The purpose of this study was to assess the microbiota in middle cerebral artery thrombi retrieved in mechanical thrombectomy arising out of symptomatic carotid plaque within 6 hours of acute ischemic stroke. Thrombi were subjected to next-generation sequencing for a bacterial signature to determine their role in atherosclerosis.Materials and Methods: We included 4 human middle cerebral artery thrombus samples (all patients were male). The median age for the patients was 51±13.6 years. Patients enrolled in the study from Pacific Medical University and Hospital underwent mechanical thrombectomy in the stroke window period. All patients underwent brain magnetic resonance angiography (MRA) and circle of Willis and neck vessel MRA along with the standard stroke workup to establish stroke etiology. Only patients with symptomatic carotid stenosis and tandem lesions with ipsilateral middle cerebral artery occlusion were included in the study. Thrombus samples were collected, stored at –80 degrees, and subjected to metagenomics analysis.Results: Of the 4 patients undergoing thrombectomy for diagnosis with ischemic stroke, all thrombi recovered for bacterial DNA in qPCR were positive. More than 27 bacteria were present in the 4 thrombus samples. The majority of bacteria were <i>Lactobacillus, Stenotrophomonas, Pseudomonas, Staphylococcus</i>, and <i>Finegoldia</i>.Conclusion: Genesis of symptomatic atherosclerotic carotid plaque leading to thromboembolism could be either due to direct mechanisms like acidification and local inflammation of plaque milieu with lactobacillus, biofilm dispersion leading to inflammation like with pseudomonas fluorescence, or enterococci or indirect mechanisms like Toll 2 like signaling by gut microbiota.
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