정상 한국인에서 연령증가에 따른 혈장 Dehydroepiandrosteronesulfate ( DHEA-S ) 농도 및 DHEA - S / cortisol 비의 변화

박성우,유형준,임성희,최문기,유재명,박민숙,이권엽,박철수,김철홍,김현규,김두만,박규용 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2

Backgroud: DHEA-S is the most abundant steroid hormone in circulation, and primarily secreted from the adrenal cortex, but its physiological role is little known. One of the characteristic features of DHEA-S is progressive decrement of plasma DHEA-S level with advancing age, in contrast, plasma levels of other adrenal hormones are not chaging or littie decreasing. To grasp the trends of plasma DHEA-S level and DHEA-S/cortisol ratio by age in healthy Korean, we measured the plasma DHEA-S levels and DHEA-S/cortisol ratios in healthy Korean. Methods: Healthy Korean(men: 99, women: 102, age range: 15-97 year old)were studied. Subjects were not taking drugs(such as glucocorticoid or androgenic medication) or cigarettes known to modify the plasma level of DHEA-S and cortisol, and had no evidence of hepatic, renal disease or hyperlipidemia as determined by serum lipid, bilirubin, SGOT, SGPT, BUN, creatinine. Data were analyzed by 10-year age group for men and women: i.e, 10-19, 20-29, 30-39, 40- 49, 50-59, 60-69, 70-79, 80-89 and 90 year or more. Plasma DHEA-S levels were measured by using a commercially available RIA kit with 125I labeled-DHEA-SO4(Coat-A Count DHEA-SO4), and for the measurement of plasma cortisol levels, commercial Gamma Coat TM[125I] Cortisol Radioimmunassay Kit was used. Results:. 1) In both men and women, plasma DHEA-S level showed high interindividual variation within the same age group. 2) There were individual sex differences in plasma levels of DHEA-S, in all age groups, plasma DHEA-S levels were significantly higher values for men than for women. 3) Maximum plasma DHEA-S levels(men; 237+-3.35 ug/dL, women; 108+-17.5 ug/dL) were at third decade in both men and women. 4) Both men and women showed the continuous decline in plasma DHEA-S level with age. These age-related decline was more prominent in men than in women(men; y= -3.152 * +292.6, r2= 0.8459, P$lt;0.05, women; y= -1.417 * +143.3, r2 = 0.7278, P$lt; 0.05). 5) As an index of aging, there was no stastical difference between DHEA-S and DHEA- S/cortisol ratio. Conclusion: In healthy Korean, there were high interindividual variation of plasrna DHEA-S levels. In both men and women plasma DHEA-S level was peak at third decade, and from when it declined progressively with age. These results suggest that although the reliability of single plasma DHEA-S measurement are limited, the decline of DHEA-S with advancing age might be a specific marker of endocrinologic hormonal milieu(aging index). Also, concerning to individual adrenal secreting capacity, we measured DHEA-S/cortisol ratio. But we did not found that plasma DHEA-S/cortisol ratio is superior to the plasma DHEA-S level as an aging index. (J Kor Soc Endocrinol 12:245-254, 1997)

Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication

Yong‑Moon Lee,Man Hwan Oh,Jai‑Hyang Go,Kyudong Han,Song‑Yi Choi 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types. Conclusion: Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.

수부 주상골 요부의 전위골절에 대한 수술적 치료

조용만,이영기,강흥식,리건영,이천동,오상수 대한골절학회 1997 대한골절학회지 Vol.10 No.1

The authors surveyed the clinical study of 17cases of scaphoid fractures from March 1989 to September 1994 with minimal I year follow up at Department of Orthopedic Surgery, Lee-Rha general Hospital. The following conclusions were obtained through clinical survey. l. Of all l 7 cases, they were l3 males and 4 females; Among the 13 males, 10 cases were aged between 20 and 39 years. forming 56.8% of all. 2. All 17 cases were treated by open reduction. Unions were obtained at average l l.5 weeks in 7 cases treated with Herbert screw fixation and l 2 weeks in l 0 cases treated with K-wire fixation. 3. Two of ten K-wire treated cases resulted in delayed union, one of seven Herbert screw treated cases resulted in delayed union. 4. Unions were obtained at average 20 weeks in 3 cases of delayed union. We concluded that open reduction and K-wire fixation were recomanded for the compatible treatment method of displaced waist fracture of scaphoid.

거골 경부 골절의 치료

조용만,이영기,리건영,이천동 대한골절학회 1996 대한골절학회지 Vol.9 No.4

The talus has some important anatomic features. Approximately 60% of its surface is cartilage and The talus often has problems with circulation. Talar neck fracture have a high association with ostonecosis and osteoarthritis. Authors have analysed l6 cases of the talar neck fractures treated at Lee-Rha General Hospital from January l990 to December l995 with minimal I year follow up. The results were as follows; 1. In thr l6 cases, there were l4 males and 2 females. the age between 20 and 40 years old was 10 cases(63%). 2. The most common cause of injury was traffic accident(63%), with sudden hyperextension as its mechanism. 3. associated injuries were 4 malleolar fracutres, 3 calcaneous fractures, 3 spine fractures, 3 tiviofibular fractures and 2 femur fractures. 4. According to the Hawkins classification: 3 cases in type I, 4 cases in type I, 5 cases in type l. 4 case in type N fractures were observed. 5. The method of treatment, all 3cases of Hawkins type I fractures were treated by closed reduction and cast immobilization, 3 cases of Hawkins type l and I case of Hawtins type III fracture were treated by closed reduction and internal fixation, other 9 cases were treated by open reduction and internal fixation. 6. Excellent results were observed in 8 cases good in 5 cases, fair in 2 cases . poor in l case with the Hawkins' therapeutic criteria. 7. Complications was observed 3 avascular necrosis, 2 post-traumatic arthritis, 2 ankle stiffness and l skin necrosis. From the above results, authors believe that early anatomical reduction k internal fixation is impotent to get a satisfactory result in de treatment of talar neck fracture.

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

십이지장과 대장을 동시에 침범한 결핵 1예

이만재,박치영,곽재정,유보열,기장도,박찬국,김만우,김정용 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Tuberculosis of duodenum is so rare and is usually secondary to pulmonary or intestinal tuberculosis . It is difficult to diagnose duodenal tuberculosis in clinical and radiologic findings due to its non-specific symptoms and inconsistent lesion. The diagnosis was made on the basis of the histological study of the endoscopic biopsy and resected surgical specimen. so we report a case of tuberculosis of duodenal bulb and of ascending colon with, the brief review of the literatures.

삼천지의 곤충상

이종욱,류성만,서경인,전영태,배찬영 嶺南大學校 基礎科學 硏究所 1998 基礎科學硏究 Vol.18 No.-

We studied insect fauna in the Samchun-impoundment during the period of from September 1997 to August 1998. The total number of insect taxa are composed to 95 species in 86 genera, 39 families and 8 orders in this examination.

외부온도에 따른 폴리머 콘크리트의 강도특성 변화

이윤수,주명기,최만용 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

불포화 에스터 수지의 큰 이용분야의 하나로 건축재료가 있으나 여기서 가장 문제로 되어 있는 것이 바로 열적 특성의 개선이다. 따라서 본 연구에서는 외부온도가 폴리머 콘크리트의 강도특성에 미치는 영향을 검토하기 위하여 외부온도 20∼120℃ 범위로 하여 폴리머 콘크리트의 물리·역학적 특성을 구명하는데 목적이 있다. 본 연구에서는 불포화 폴리에스터 수지를 결합재로 하고 탄산칼슘을 충진재로, 규사를 잔골재로 치환하고, 굵은골재를 쇄석으로하는 폴리머 콘크리트를 제조하여 외부온도에 따른 강도특성을 검토한 바, 폴리머 콘크리트의 사용 적정온도는 50℃이내가 적당할 것으로 판단되며, 50℃이상에서 사용할 경우는 난연성이 우수한 탄소섬유를 사용해야 할 것이다. In this study, the polymer concrete was made to investigate its strength properties, in which unsaturated polyester resin was used as s binder, calcium carbonate as the filler and silica sand as th fine aggregate, and crushed stone as the coarse aggregate. The effects according to the external temperature on strength properties of polymer concrete were examined. Test result showed that the compressive, flexural and tensile strengths of the polymer concretes decreased with increasing external temperature. The elasticity of modulus of the polymer concretes decreased with increasing external temperature.

사회체육의 역할과 발전방향

이용우,최병익,최동만 공주대학교산업개발연구소 2000 産業開發硏究 Vol.8 No.-

Over the past 30 years, a great number of scientists have pursued the systems on the role of sport in society. As many scholars point out, sport includes most of all human activities, accordingly it is related with industry, politics, economy, art, and so on. Hence, development of social sport could improve quality of life. Several alternatives would be suggested such as (1) fostering qualified leaders, (2) providing multi-purpose facilities for efficient use, (3) even distribution of facilities between regions, (4) development of varieties in programs, (5) finding and networking human resource for the development of sport.

단감나무의 品種別 生理 및 形態的인 特性에 관한 硏究(Ⅰ) : 잎의 生理 및 形態 Physiology and Morphology of Leaves

李容門,鄭景泰,李龍載,金萬洙 東亞大學校 大學院 1995 大學院論文集 Vol.20 No.-

Experiments on the 1eaf characteristics have been carried out in sweet persimmon cultivars. The results obtained are as followings : Mikado and Daean-Dangam were the largest for leaf length, leaf width, leaf area and leaf weight in all cultivars, while Suido was the smallest for leaf width, leaf area and leaf weight. Suruga was the thickest for the leaf thickness, but Johongsi was the thinnest. The largest leaf stalk diameter was observed in Mikado and Ichimogkei-Jiro, but the smallest was Hana-Gosho. For the leaf stalk length, Kyara was the longest and Zenjimaru the shortest. For the index of leaf shape, RO-19 showed the largest as 66.5% for the south-facing leaf and 68.3% for the north-facing leaf, but Kyara and Suido showed smallest. The south-facing leaf showed large values in lcaf shape index, leaf thickness, leaf stalk diameter and leaf stalk length, but the north-facing leaf was relatively large in leaf length, leaf width, leaf area and leaf weight. For the content of chlorophyll, Hana-Gosho and RO-19 cultivars contained higher, but Yido and Bang-Gosho contained lower. In average for all cultivars, the contents of N, Ca and B were low, that of P seemed in sufficient and those of K and Mg were difficient. However, the contents of Na, Cu, Zn, Fe and Mn were moderate. The content of Al in particular, were high(81-148ppm) for all cultivars.