http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Makoto Hosono 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.3
Radionuclide therapy (RNT) stands on the delivery of radiation to tumors or non-tumor target organs using radiopharmaceuticals that are designed to have specific affinity to targets. RNT is recently called molecular radiotherapy (MRT) by some advocators in order to emphasize its characteristics as radiotherapy and the relevance of dosimetry-guided optimization of treatment. Moreover, RNT requires relevant radiation protection standards because it employs unsealed radionuclides and gives therapeutic radiation doses in humans. On the basis of these radiation protection standards, the development and use of radiopharmaceuticals for combined application through diagnostics and therapeutics lead to theranostic approaches that will enhance the efficacy and safety of treatment by implementing dosimetry-based individualization.
Nakao, Makoto,Hosono, Satoyo,Ito, Hidemi,Oze, Isao,Watanabe, Miki,Mizuno, Nobumasa,Yatabe, Yasushi,Yamao, Kenji,Niimi, Akio,Tajima, Kazuo,Tanaka, Hideo,Matsuo, Keitaro Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Background: Cigarette smoking is a well-established risk factor of pancreatic cancer (PC). Although an association between nicotine dependence phenotype, namely time to first cigarette (TTFC) after waking, and the risk of several smoking-related cancers has been reported, an association between TTFC and PC risk has not been reported. We assessed the impact of smoking behavior, particularly TTFC, on PC risk in a Japanese population. Materials and Methods: We conducted a case-control study using 341 PC and 1,705 non-cancer patients who visited Aichi Cancer Center in Nagoya, Japan. Exposure to risk factors, including smoking behavior, was assessed from the results of a self-administered questionnaire. The impact of smoking on PC risk was assessed with multivariate logistic regression analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Cigarettes per day (CPD) and/or smoking duration were significantly associated with PC risk, consistent with previous studies. For TTFC and PC risk, we found only a suggestive association: compared with a TTFC of more than 60 minutes, ORs were 1.15 (95%CI, 0.65-2.04) for a TTFC of 30-60 minutes and 1.35 (95%CI, 0.85-2.15) for that of 0-30 minutes (p trend=0.139). After adjustment for CPD or smoking duration, no association was observed between TTFC and PC. Conclusions: In this study, we found no statistically significant association between TTFC and PC risk. Further studies concerning TTFC and PC risk are warranted.
노화에 따른 아스팔트의 물리화학적 변화와 혼합물 성능에 미치는 영향 연구
이백운,황의윤,Hiroki Hosono,Makoto Hiramatsu 한국도로학회 2020 한국도로학회논문집 Vol.22 No.2
PURPOSES : Asphalt pavements are damaged by various causes, such as cracks, potholes due to climate, and traffic environment. Asphalt aging has a significant effect on cracks, which may also form potholes. The purposes of this study are to estimate the change in asphalt binder and mixture performance and to correlate the physicochemical changes of the asphalt binder and mixture performance with aging. METHODS : The aging process of the asphalt was determined in the laboratory, based on the methods used in previous studies. In terms of consistency (stiffness), crack-resistance performance, moisture susceptibility, SK investigated the binder part, and Shoreki investigated the mixture part depending on the aging time. RESULTS : The consistency (stiffness) and brittleness of both the asphalt binder and mixture tended to increase with aging. In particular, the crack-resistance performance of the asphalt binder (G*sinδ, ductility, and ΔTc) and mixture (flexural fatigue test and Cantabro test) deteriorated because of asphalt aging. Furthermore, the aging mechanisms (oxidation and polymerization) were identified based on the chemical structure analysis. CONCLUSIONS : It is confirmed that the aging affected the chemical composition change and the physical properties of the asphalt. Asphalt pavements are significantly affected by the aging characteristics of the binder. It is concluded that the crack-resistance performance of the mixture decreases with aging due to these physical and chemical changes.