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RISS 인기검색어
- 검색키워드
- 저자 : Maki Steven (검색결과 2 건)
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Modeling of air cushion vehicle's flexible seals under steady state conditions
Zalek, Steven F.,Karr, Dale G.,Jabbarizadeh, Sara,Maki, Kevin J. Techno-Press 2011 Ocean systems engineering Vol.1 No.1
The purpose of this paper is to demonstrate the efficacy of modeling a surface effect ship's air-cushion flexible seal utilizing a two-dimensional beam under steady state conditions. This effort is the initial phase of developing a more complex three-dimensional model of the air-seal-water fluid-structure interaction. The beam model incorporates the seal flexural rigidity and mass with large deformations while assuming linear elastic material response. The hydrodynamic pressure is derived utilizing the OpenFOAM computational fluid dynamic (CFD) solver for a given set of steady-state flow condition. The pressure distribution derived by the CFD solver is compared with the pressure required to deform the seal beam model. The air pressure, flow conditions and seal geometry are obtained from experimental analysis. The experimental data was derived from large-scale experimental tests utilizing a test apparatus of a canonical surface effect ship's flexible seal in a towing tank over a variety of test conditions.
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Treuheit Nicholas A.,Crawford Nicholas F.,Maki Steven,Payne Jason,Allen Jeff 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.4
Purpose Biosimilars can effectively reduce the cost of healthcare by providing a new source of competition for original drugs. A cornerstone of biosimilar development is assembling a comprehensive package of analytical data that demonstrates physicochemical biosimilarity to justify a shorter regimen of clinical trials. The purpose of the present work was to present part of a biosimilarity data package comparing Pfenex pegfilgrastim to its reference, Amgen’s Neulasta™ and to highlight a deuterium exchange experiment that can be used as part of the analytical tool box to demonstrate biosimilarity. Methods We used circular dichroism (CD), fluorescence, biolayer interferometry (BLI), and hydrogen–deuterium exchange (HDX) mass spectrometry experiments to analyze structural similarity between Pfenex pegfilgrastim and its reference, Amgen’s Neulasta™. In particular, we incorporated a novel HDX experiment comparing binding to the receptor by Pfenex pegfilgrastim or Neulasta™. Results The characterization experiments showed a high degree of similarity between the molecules, from secondary structure (CD/fluorescence), binding (BLI), and deuterium uptake in free and bound forms (HDX). Notably, the receptor-binding experiment found seven peptides that were similarly protected upon binding to both pegfilgrastim molecules. Conclusion These select experiments are a subset of the required characterization to demonstrate similarity, but they represent a progression of structural analysis that is enhanced and strengthened by a novel HDX experiment. This method improves our understanding of this interaction and gives us another analytical tool for demonstrating biosimilarity that should be adaptable for use with other biosimilar products in the future.
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