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A One-Step Synthesis and Antimicrobial Activities of New Substituted Dihydro-1,3,4-Thiadiazoles
Mahran, Asma M.,Hassan, Nasser A. The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.1
In this study, 2-N-arylimino-2,3-dihydro-1,3,4-thiadiazoles derivatives (6a-h) were synthetized. The mechanism of the studied reactions was discussed. The chemical structures of the compounds were elucidated by their IR, $^1H-NMR,\;^{13}C-NMR$, and Mass spectral data and elemental analyses. The compounds were tested for antimicrobial activity using diffusion agar technique.
A One-Step Synthesis and Antimicrobial Activities of New Substituted Dihydro-1,3,4-Thiadiazoles
Asma M. Mahran,Nasser A. Hassan 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.1
In this study, 2-N-arylimino-2,3-dihydro-1,3,4-thiadiazoles derivatives (6a-h) were synthetized. The mechanism of the studied reactions was discussed. The chemical structures of the compounds were elucidated by their IR, 1H-NMR, 13C-NMR, and Mass spectral data and elemental analyses. The compounds were tested for antimicrobial activity using diffusion agar technique.
( Mohammad Kamal Abdelnasser ),( Mohamed Eslam Elsherif ),( Hatem Bakr ),( Mohamed Mahran ),( Moustafa H. M. Othman ),( Yaser Khalifa ) 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.1
Purpose: Outcomes following total knee arthroplasty (TKA), whether clinical, radiological or survival analysis, have been well-studied. Still, there are some concerns about patient satisfaction with the outcome of the surgery and factors that might contribute to a suboptimal result. This study aims to determine if there is correlation between primary TKA malalignment and early patient-reported outcome measures (PROMs). Materials and methods: Sixty patients, who had primary TKA and a minimum of 2 years of follow up, were recruited for a detailed clinical and radiological examination. Knee alignment was measured in the coronal, sagittal and axial planes. Normal and the outlier measurements of the patients’ knees were defined and the clinical results (PROMs) compared to see if there was a statistically significant difference. Results: Correlation between postoperative limb malalignment in the coronal and the sagittal planes and PROMs was not significant. Conversely, there was significant negative correlation between all types of malrotation and PROMs. Conclusions: Although malalignment has been linked to inferior outcome and implant survival, our results showed that coronal and sagittal limb malalignment has no significant effect on early PROMs. However, all types of component rotational malalignment significantly worsen early PROMs.
Enas Nashaat Amin,Abdel-Alim M. Abdel-Alim,Samia G. Abdel-Moty,Abdel-Naser A. El-Shorbagi,Mahran Sh. Abdel-Rahman 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.1
4,5-dihydro-3(2H)pyridazinones such as CI-914, CI-930 and pimobendan along with tetrahydropyridopyridazine (endralazine) and perhydropyridazinodiazepine (cilazopril) have been used as potent positive inotropes, antihypertensives as well as platelet aggregation inhibitors. Accordingly, the present work involves the synthesis of 24 target compounds; 4,5-dihydro-3(2H)pyridazinones in addition to seven reported intermediates. The chemical structures of the new compounds were assigned by microanalysis, IR, 1H-NMR spectral analysis and some representatives by mass spectrometry. The positive inotropic effect of the final compounds and the intermediates 12a-12d as well as the reported intermediate compound 10 was determined in-vitro on isolated rabbit heart in comparison to digoxin. Data obtained revealed that twelve of the test compounds exhibited higher effective response than digoxin, nine compounds elicited comparable effects to digoxin and eight compounds were less active than digoxin. In addition, four compounds approved marked significant hypotensive effect better than that of the previously reported compound 10. Moreover, two compounds induced complete platelet aggregation inhibition. The last two compounds were also subjected to determination of their LD50 and they showed no signs of toxicity up to the dose level 300 mg/kg (i.p.), while the reported oral LD50 of digoxin is 17.78 mg/kg. Correlation of cardiotonic and hypotensive activities with structures of compounds was tried and pharmacophore models were computed to get useful insight onto the essential structural features required for inhibiting phosphodiesterase-III in the heart muscles and blood vessels.
Osama A. El Shabrawy,Seham Abd El Sattar El Batran,Mohamed Refat H. Mahran,Nabila M. Ibrahim 한국생약학회 2011 Natural Product Sciences Vol.17 No.4
Synthetic coumarin and furocoumarin derivatives were evaluated for anticoagulant activity and the effect on liver and kidney function. It was found that all of the compounds under investigation proved to be neither toxic nor lethal up to 500 mg/100 g body weight as a single dose for 24 hrs. All tested compounds showed a significant increase in prothrombin time (PT) in the acute model but failed to show a significant action in the chronic model. Furthermore, all tested compounds revealed a significant increase in activated partial thromboplastin time (APTT) as compared to control value in both acute and chronic model. Also, all tested compounds did not cause any significant changes on liver and kidney functions in rats.