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Mahadevan, Radhakrishnan,Burgard, Anthony P.,Famili, Iman,Dien, Steve Van,Schilling, Christophe H. The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.5
Increasing numbers of value added chemicals are being produced using microbial fermentation strategies. Computational modeling and simulation of microbial metabolism is rapidly becoming an enabling technology that is driving a new paradigm to accelerate the bioprocess development cycle. In particular, constraint-based modeling and the development of genome-scale models of industrial microbes are finding increasing utility across many phases of the bioprocess development workflow. Herein, we review and discuss the requirements and trends in the industrial application of this technology as we build toward integrated computational/experimental platforms for bioprocess engineering. Specifically we cover the following topics: (1) genome-scale models as genetically and biochemically consistent representations of metabolic networks; (2) the ability of these models to predict, assess, and interpret metabolic physiology and flux states of metabolism; (3) the model-guided integrative analysis of high throughput 'omics' data; (4) the reconciliation and analysis of on- and off-line fermentation data as well as flux tracing data; (5) model-aided strain design strategies and the integration of calculated biotransformation routes; and (6) control and optimization of the fermentation processes. Collectively, constraint-based modeling strategies are impacting the iterative characterization of metabolic flux states throughout the bioprocess development cycle, while also driving metabolic engineering strategies and fermentation optimization.
Surianarayanan Mahadevan,Senthilkumar Sivaprakasam,Madhuchhanda Bhattacharya 한국생물공학회 2007 Biotechnology and Bioprocess Engineering Vol.12 No.4
Biocalorimetry has proved to be a useful tool for scale up and control of bioreactors. The findings reported here are fundamental data required for scale up and control of a reactor for the treatment of saline tannery wastewater. The study deals with biokinetics of a halo-tolerant bacteria Pseudomonas aeruginosa isolated from tannery saline wastewater (soak liquor). Batch experiments were performed in a biocalorimeter and the isolated strain was grown in a glucose-limited mineral salt medium (MSM) at optimized growth conditions. Tessier model is found to fit well for the growth of P. aeruginosa in biocalorimeter. Biokinetic constants are evaluated and simulation is done to validate experimental results with theoretical values. Respirogram and heat profiles are seen to follow the biomass growth curve. Oxycalorific coefficient is validated with the theoretical values and those noticed in the published literature. There is a good correlation between experimentally determined heat yields and the theoretical values predicted by elemental and enthalpy balances. The heat yield and biomass yield values indicated the behavior of the isolated organism in a substrate-limited well defined growth media (MSM).
Surianarayanan Mahadevan,Balaji Dhandapani,Senthilkumar Sivaprakasam,Asit Baran Mandal 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.4
Biocalorimetry has proved to be an efficient tool for studying the energetics involved in several biochemical reactions. In this study, biocalorimetry was employed to simultaneously analyze biokinetics and bioenergetics involved during cultivation of a salt tolerant Pseudomonas aeruginosa for the production of alkaline protease. Batch experiments were performed in a bench scale biocalorimeter for alkaline protease production by P. aeruginosa using optimized process conditions. Tessier’s double substrate growth model was found to provide a good fit for the growth of P. aeruginosa in the biocalorimeter,and the biokinetic parameters were estimated. The heat flow profile resulting from metabolic activity of P. aeruginosa was shown to accurately depict both the kinetics of cell growth and protease production. Biokinetic and bioenergetic analysis on the growth of P. aeruginosa revealed that peptone is preferentially used as the substrate for its intracellular activities and glycerol acts as an energy source for its growth metabolism.
Rajkumar, M.,Mahadevan, K.,Kannan, S.,Baskar, S. The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.2
Non-dominated Sorting Genetic Algorithm-II (NSGA-II) is applied for solving Combined Economic Emission Dispatch (CEED) problem with valve-point loading of thermal generators. This CEED problem with valve-point loading is a nonlinear, constrained multi-objective optimization problem, with power balance and generator capacity constraints. The valve-point loading introduce ripples in the input-output characteristics of generating units and make the CEED problem as a nonsmooth optimization problem. To validate its effectiveness of NSGA-II, two benchmark test systems, IEEE 30-bus and IEEE 118-bus systems are considered. To compare the Pareto-front obtained using NSGA-II, reference Pareto-front is generated using multiple runs of Real Coded Genetic Algorithm (RCGA) with weighted sum of objectives. Comparison with other optimization techniques showed the superiority of the NSGA-II approach and confirmed its potential for solving the CEED problem. Numerical results show that NSGA-II algorithm can provide Pareto-front in a single run with good diversity and convergence. An approach based on Technique for Ordering Preferences by Similarity to Ideal Solution (TOPSIS) is applied on non-dominated solutions obtained to determine Best Compromise Solution (BCS).
Kari Bhagyalakshmi,Mahadevan Kumar,Samudrakani Arumugachamy,Amala Joseph,Thondikulam Subramanian Raveendran,Kunnummal Kurungara Vinod 한국작물학회 2008 Journal of crop science and biotechnology Vol.11 No.4
Genetic diversity of cultivated wheat is narrowing down and is increasingly becoming non-complacent in tackling new pathogenic races and adverse environmental situations. Wild relatives of wheat are rich repositories of beneficial genes that are capable of defying adverse situations. However, these wild species are not readily crossable with cultivated ones. The present study attempted to cross three wild wheat species as females with three cultivated species of varying ploidy to understand the intricate behaviour of hybrids in relation to cytology, morphology, and molecular recombination. Post-fertilization barriers caused hybrid recovery in wild species in contrast to cultivated species. Triticum monococcum did not produce hybrids in any of the crosses. Various degrees of chromosome anomalies and hybrid sterility were seen with hybrids of T. timopheevi and T. sphaerococcum. Cytoplasmic factors were suspected to add more to the abnormality. G genome from T. timopheevi could enhance more pairing between B and D of cultivated species. Precocity of certain chromosomes in laggard formation was evident, pointing towards evolutionary self balance of the genomes which prevented homeologous pairing. They are eliminated in hybrids. Molecular diversity clearly corroborated with genetic proximity of the species, which distinguished themselves by maintaining the genome homeology. Genetic diversity of cultivated wheat is narrowing down and is increasingly becoming non-complacent in tackling new pathogenic races and adverse environmental situations. Wild relatives of wheat are rich repositories of beneficial genes that are capable of defying adverse situations. However, these wild species are not readily crossable with cultivated ones. The present study attempted to cross three wild wheat species as females with three cultivated species of varying ploidy to understand the intricate behaviour of hybrids in relation to cytology, morphology, and molecular recombination. Post-fertilization barriers caused hybrid recovery in wild species in contrast to cultivated species. Triticum monococcum did not produce hybrids in any of the crosses. Various degrees of chromosome anomalies and hybrid sterility were seen with hybrids of T. timopheevi and T. sphaerococcum. Cytoplasmic factors were suspected to add more to the abnormality. G genome from T. timopheevi could enhance more pairing between B and D of cultivated species. Precocity of certain chromosomes in laggard formation was evident, pointing towards evolutionary self balance of the genomes which prevented homeologous pairing. They are eliminated in hybrids. Molecular diversity clearly corroborated with genetic proximity of the species, which distinguished themselves by maintaining the genome homeology.
Rajkumar, M.,Mahadevan, K.,Kannan, S.,Baskar, S. The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.3
This paper discusses the application of evolutionary multi-objective optimization algorithms namely Non-dominated Sorting Genetic Algorithm-II (NSGA-II) and Modified NSGA-II (MNSGA-II) for solving the Combined Economic Emission Dispatch (CEED) problem with valve-point loading. The valve-point loading introduce ripples in the input-output characteristics of generating units and make the CEED problem as a non-smooth optimization problem. IEEE 57-bus and IEEE 118-bus systems are taken to validate its effectiveness of NSGA-II and MNSGA-II. To compare the Pareto-front obtained using NSGA-II and MNSGA-II, reference Pareto-front is generated using multiple runs of Real Coded Genetic Algorithm (RCGA) with weighted sum of objectives. Furthermore, three different performance metrics such as convergence, diversity and Inverted Generational Distance (IGD) are calculated for evaluating the closeness of obtained Pareto-fronts. Numerical results reveal that MNSGA-II algorithm performs better than NSGA-II algorithm to solve the CEED problem effectively.
Strengthening Steel Members with Holes Under Tension Using Unidirectional GFRP Sheets
E. Parvathi,Mahadevan Lakshmanan,K. M. Mini 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.2
Steel structure sections are often connected using bolts and rivets, which necessitates the need for holes. These holes provide a zone of failure during loading. In the present work an attempt is made to strengthen the steel members under tensile loading with hole provision for bolts, using Glass Fiber Reinforced Polymer (GFRP) sheets. The performance of FRP wrapping is assessed by changing the angle of orientation of fi ber. The experimental investigation is conducted for one hole, two hole and staggered hole arrangement and the results are compared with fi nite element analysis. The diff erence between experiment and fi nite element modeling are within allowable limits. From the study it is found that GFRP wrapping with 0° orientation of fi ber is the most suitable in terms of ultimate strength for all the three hole confi gurations.