Design of geocell reinforcement for supporting embankments on soft ground

Latha, G. Madhavi Techno-Press 2011 Geomechanics & engineering Vol.3 No.2

The methods of design available for geocell-supported embankments are very few. Two of the earlier methods are considered in this paper and a third method is proposed and compared with them. In the first method called slip line method, plastic bearing failure of the soil was assumed and the additional resistance due to geocell layer is calculated using a non-symmetric slip line field in the soft foundation soil. In the second method based on slope stability analysis, general-purpose slope stability program was used to design the geocell mattress of required strength for embankment. In the third method proposed in this paper, geocell reinforcement is designed based on the plane strain finite element analysis of embankments. The geocell layer is modelled as an equivalent composite layer with modified strength and stiffness values. The strength and dimensions of geocell layer is estimated for the required bearing capacity or permissible deformations. These three design methods are compared through a design example. It is observed that the design method based on finite element simulations is most comprehensive because it addresses the issue of permissible deformations and also gives complete stress, deformation and strain behaviour of the embankment under given loading conditions.

Stability analysis of a rock slope in Himalayas

Latha, Gali Madhavi,Garaga, Arunakumari Techno-Press 2010 Geomechanics & engineering Vol.2 No.2

Slope stability analysis of the right abutment of a railway bridge proposed at about 350 m above the ground level, crossing a river and connecting two huge hillocks in the Himalayas, India is presented in this paper. The site is located in a highly active seismic zone. The rock slopes are intensely jointed and the joint spacing and orientation are varying at different locations. Static slope stability of the rock slope is studied using equivalent continuum approach through the most commonly used commercial numerical tools like FLAC and SLOPE/W of GEOSTUDIO. The factor of safety for the slope under static conditions was 1.88 and it was reduced by 46% with the application of earthquake loads in pseudo-static analysis. The results obtained from the slope stability analyses confirmed the global stability of the slope. However, it is very likely that there could be possibility of wedge failures at some of the pier locations. This paper also presents the results from kinematics of right abutment slope for the wedge failure analysis based on stereographic projections. Based on the kinematics, it is recommended to flatten the slope from 50o to 43o to avoid wedge failures at all pier locations.

Amazon product recommendation system based on a modified convolutional neural network

Yarasu Madhavi Latha,B. Srinivasa Rao 한국전자통신연구원 2024 ETRI Journal Vol.46 No.4

In e-commerce platforms, sentiment analysis on an enormous number of user reviews efficiently enhances user satisfaction. In this article, an automated product recommendation system is developed based on machine and deep-learning models. In the initial step, the text data are acquired from the Amazon Product Reviews dataset, which includes 60,000 customer reviews with 14,806 neutral reviews, 19,567 negative reviews, and 25,627 positive reviews. Further, the text data denoising is carried out using techniques such as stop word removal, stemming, segregation, lemmatization, and tokenization. Removing stop-words (duplicate and inconsistent text) and other denoising techniques improves the classification performance and decreases the training time of the model. Next, vectorization is accomplished utilizing the term frequency-inverse document frequency technique, which converts denoised text to numerical vectors for faster code execution. The obtained feature vectors are given to the modified convolutional neural network model for sentiment analysis on e-commerce platforms. The empirical result shows that the proposed model obtained a mean accuracy of 97.40% on the APR dataset.

Taming of large diameter triaxial setup

Nair, Asha M.,Madhavi Latha, G. Techno-Press 2012 Geomechanics & engineering Vol.4 No.4

Triaxial tests are essential to estimate the shear strength properties of the soil or rock. Normally triaxial tests are carried out on samples of 38 mm diameter and 76 mm height. Granular materials, predominantly used in base/sub-base construction of pavements or in railways have size range of 60-75 mm. Determination of shear strength parameters of those materials can be made possible only through triaxial tests on large diameter samples. This paper describes a large diameter cyclic triaxial testing facility set up in the Geotechnical Engineering lab of Indian Institute of Science. This setup consists of 100 kN capacity dynamic loading frame, which facilitates testing of samples of up to 300 mm diameter and 600 mm height. The loading ram can be actuated up to a maximum frequency of 10 Hz, with maximum amplitude of 100 mm. The setup is capable of carrying out static as well as dynamic triaxial tests under isotropic, anisotropic conditions with a maximum confining pressure of 1 MPa. Working with this setup is a difficult task because of the size of the sample. In this paper, a detailed discussion on the various problems encountered during the initial testing using the equipment, the ideas and solutions adopted to solve them are presented. Pilot experiments on granular sub-base material of 53 mm down size are also presented.

Role of Human papilloma virus Infection and Altered Methylation of Specific Genes in Esophageal Cancer

Mohiuddin, Mohammed Khaliq,Chava, Srinivas,Upendrum, Pavani,Latha, Madhavi,Zubeda, Syeda,Kumar, Ajith,Ahuja, Yog Raj,Hasan, Qurratulain,Mohan, Vasavi Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Background: Evaluation of Human papilloma virus (HPV) and its association with promoter methylation of candidate genes, p53 and Aurora A in esophageal cancer. Materials and Methods: One hundred forty-one esophageal tissue samples from different pathologies were evaluated for HPV infection by PCR, while the promoter methylation status of p53 and Aurora A was assessed by methylation-specific restriction based PCR assay. Statistical analyses were performed with MedCalc and MDR software. Results: Based on endoscopy and histopathology, samples were categorized: cancers (n=56), precancers (n=7), esophagitis (n=19) and normals (n=59). HPV infection was found to be less common in cancers (19.6%), whereas its prevalence was relatively high in precancers (71.4%), esophagitis (57.8%) and normals (45.7%). p53 promoter methylation did not show any significant difference between cancer and normal tissues, whereas Aurora A promoter methylation demonstrated significant association with disease (p=0.00016, OR:5.6452, 95%CI:2.18 to 14.6) when compared to normals. Aurora A methylation and HPV infection was found in a higher percentages of precancer (66.6%), esophagitis (54.5%) and normal (45.2%) when compared to cancers (14.2%). Conclusions: Aurora A promoter methylation is significantly associated with esophageal cancer, but the effect of HPV infection on this epigenetic alteration is not significant. However MDR analysis showed that the hypostatic effect of HPV was nullified when the cases had Aurora methylation and tobacco exposure. Further HPV sub-typing may give an insight into its reduced prevalence in esophageal cancer verses normal tissue. However, with the present data it is difficult to assign any significant role to HPV in the etiopathology of esophageal cancer.

HER-2/neu Status: A Neglected Marker of Prognostication and Management of Breast Cancer Patients in India

Zubeda, Syeda,Kaipa, Prabhakar Rao,Shaik, Noor Ahmad,Mohiuddin, Mohammed Khaliq,Vaidya, Sireesha,Pavani, Boddana,Srinivasulu, Mukta,Latha, Manolla Madhavi,Hasan, Qurratulain Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Background: Categorizing breast tumors based on the ER, PR and HER/Neu 2 receptor status is necessary in order to predict outcome and assist in management of breast cancer. Herfe we assessed this question in South Indian patients. Materials and Methods: A total of 619 formalin fixed paraffin embedded breast tumor tissues were collected from pathology archives after receipt of ethical clearance. With the help of primary and secondary conjugated antibodies, expression status of ER, PR and HER2/neu was determined. All the experimental data were assessed for correlations with histopathological features of tumors and clinical presentation of the subjects. Results: In the present study, the ages ranged from 20-87 years with a mean of $50.0{\pm}12.q$ years, and majority of the tumors (84%) were of infiltrating duct cell carcinoma type. Assessment of ER, PR and Her-2/neu expression showed that 46% were triple negative. Interestingly, an inverse relation between ER, PR and HER-2/neu was apparent in 41.2% (p<0.0001) of the tumors, of which 24.5% (p<0.0001) were ER and PR co-negative but HER-2 positive. Conclusions: ER and PR positive tumors are less common (i.e<30%) compared to HER-2/neu positive tumors (i.e>50%) in Indian breast cancer patients, underlining the need for effective diagnostic screening and specific therapeutic managements in order to improve the survival rate of patients in low resource countries such as India.