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- 검색키워드
- 저자 : Ma Jeong-Rim (검색결과 12 건)
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Ma Yuanqiang,Jeong su Park,Wang Feng,Hwan Ma,Gyu rim Lee,Yeo jin Lee,Yoon-seok Roh 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Psoriasis, a chronic inflammation-mediated skin disease, affects 2-3% of the total populations in the world. It is characterized by keratinocytes hyperproliferation and immune cell infiltration. The JAK/STAT3 and JAK/STAT1 signaling pathways triggered by IL-6 and IFN- γ from dendritic cell and T lymphocytes, play important roles in psoriasis. Thus, blockade of JAK/STAT signaling will be potential strategy in psoriasis. CMX, an extract of Centipeda minima enriched in Brevilin A, Arnicolide D, Arnicolide C, and Microhelenin C which have already been reported in anti-inflammation, anti-cancer, antiallergy, and suppression of proliferation. We established chronic inflammatory and cell proliferating models in macrophages and keratinocytes with LPS (250ng/mL), rh-IL-6 (10ng/mL), or rh-IFN-γ (10ng/mL) to evaluate the effect of CMX. CCK-8 was used for cell proliferation assay, and the protein and RNA were collected and analyzed by western blot and RT-qPCR. We found that CMX inhibited pro-inflammatory cytokines production by inhibiting LPS-induced JAK1/2 and STAT1/3 phosphorylation in macrophages. Moreover, CMX down-regulated chemokines and cell proliferation in HaCaT cell induced by rh-IL-6 and rh-IFN-γ, respectively. Consistently, we demonstrated that reduction of chemokines expression and hyperproliferation was medicated by the regulation of IFN-γ-activated JAK/STAT1 and IL-6-activated JAK/STAT3 signaling. In conclusion, CMX inhibited JAK/STAT-mediated inflammatory responses and cell proliferation in macrophages and keratinocytes, consequently CMX may improve psoriasis development as an important therapeutic approach.
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Ma, Seung Hyun,Park, Bo-Young,Yang, Jae Jeong,Jung, En-Joo,Yeo, Yohwan,Whang, Yungi,Chang, Soung-Hoon,Shin, Hai-Rim,Kang, Daehee,Yoo, Keun-Young,Park, Sue Kyung The Korean Society for Preventive Medicine 2012 예방의학회지 Vol.45 No.6
Objectives: Diabetes and obesity each increases mortality, but recent papers have shown that lean Asian persons were at greater risk for mortality than were obese persons. The objective of this study is to determine whether an interaction exists between body mass index (BMI) and diabetes, which can modify the risk of death by cardiovascular disease (CVD). Methods: Subjects who were over 20 years of age, and who had information regarding BMI, past history of diabetes, and fasting blood glucose levels (n=16 048), were selected from the Korea Multi-center Cancer Cohort study participants. By 2008, a total of 1290 participants had died; 251 and 155 had died of CVD and stroke, respectively. The hazard for deaths was calculated with hazard ratio (HR) and 95% confidence interval (95% CI) by Cox proportional hazard model. Results: Compared with the normal population, patients with diabetes were at higher risk for CVD and stroke deaths (HR, 1.84; 95% CI, 1.33 to 2.56; HR, 1.82; 95% CI, 1.20 to 2.76; respectively). Relative to subjects with no diabetes and normal BMI (21 to 22.9 $kg/m^2$), lean subjects with diabetes (BMI <21 $kg/m^2$) had a greater risk for CVD and stroke deaths (HR, 2.83; 95% CI, 1.57 to 5.09; HR, 3.27; 95% CI, 1.58 to 6.76; respectively), while obese subjects with diabetes (BMI ${\geq}25kg/m^2$) had no increased death risk (p-interaction <0.05). This pattern was consistent in sub-populations with no incidence of hypertension. Conclusions: This study suggests that diabetes in lean people is more critical to CVD deaths than it is in obese people.
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Soo-Jeong Kwon,Tea-Ho Kim,Hye-Rim Kim,Y. Yasui,K. Matsui,Kyung-Ho Ma,Keun-Yook Chung,Hong-Sig Kim,Young-Ho Yun,Chul-Ho Park,Sun-Hee Woo 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
Common buckwheat has the sporophytic self-incompatibility mechanism and that’s why it has the ability to cross pollinate between two plants with different styles (thepin type and thrum type). The S supergene is thought to govern self-incompatibility, flower morphology and pollen size in buckwheat. Already, we have produced self-compatible buckwheat lines by an interspecific hybridization between Fagopyrum esculentum and F. homotropicum by embryo culture. The pollen size of F1 plants produced by a cross between a pin type plant and the self-compatible plant was similar to that of the self-compatible lines and segregated together with flower morphology without exception. The pollen tubes of the self-compatible plants were compatible with styles of the pin plants but incompatible with the styles of thrum plants. But, the pollen tubes of thrum flowers were compatible with the styles of self-compatible plants. Also, the pollen tubes of pin flowers were incompatible with the styles of self-compatible plants. Already, from these results, we have reported a tentative genotype for heterostyle and homostyle flower types. Homomorphism was controlled by a single allele Sh, while the pin/thrum-complex gene was governed by a single genetic locus S, with two alleles, S and s, which control Ss (thrum-type) as well as the ss (pin-type), respectively. Corresponding represents the case of a single locus S with three alleles, Sh, S and s, and the phenotypes, homomorphic, pin and thrum. It can be characterized by relationship of dominance, S>Sh>s. Using the two self-fertile lines, one is considered as the long-homostyle flowers and the other is considered as the short homostyle flowers. If the short-homostyle trait had arisen by recombination in the S supergene, its genotype would be considered to be GIs ip a/GIs ip a. The pollen tubes of the short-homostylous plant should be compatible with the styles of thrum plants. Also, the pollen tubes of short-homostylous plants should be incompatible with the style of long-homostylous plants, and the reciprocal cross also should be incompatible, because the genotype of long homostyle is gis Ip PA/gis Ip PA. Furthermore, the flower morphology of F1plants produced by the cross between cross and short homostyle flowers should be thrum or short homostyle and only short-homostylous plants should be produced by the cross between pin and short homostyle flowers. However, the compatibility or incompatibility of short homostyle flower was not clarified. So, we need to clarify the compatibility or incompatibility of the style of short homostyle flowers for the next step.
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IL6ST regulates liver tumorigenesis via the regulation of mitophagy
Hwan Ma,Jeong-Su Park,Feng Wang,Yeo-Jin Lee,Gyu-Rim Lee,Ekihiro Seki,Hwan-Soo Yoo,Yoon-Seok Roh 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Hepatocellular carcinoma (HCC) is the sixth most commonly occurring cancer in the world and the third largest cause of cancer mortality. There is increasing evidence that the inflammatory process is inherently associated with many different cancer types, including HCC. Cytokines are released in response to a diverse range of cellular stresses, including carcinogen-induced injury, infection, and inflammation. A number of cytokines that are produced in the tumor microenvironment have an important role in cancer pathogenesis. Among them, there are IL-6 family cytokines that share the common receptor subunit IL6ST. IL6ST regulates cell survival, growth, and proliferation through the regulation of JAK-Stat3 and PI3K-mTORC1. Both downstream pathways have been linked with autophagy and mitochondrial function. Moreover, mitophagy contributes to metabolic dysfunction syndrome and chronic liver diseases such as NAFLD, NASH, and HCC. However, the mechanism of how IL6ST modulates hepatocyte mitophagy and HCC development remains unclear. IL6ST activated Stat3 and mTORC1 signaling in HCC, as evidenced by the controls phosphorylation of Stat3 (Tyr705), P70S6K(T389), EIF4E(S209), and RPS6(S235). Interestingly, IL6ST prevents mitochondrial stress and improves cell viability by inhibition of Stat3 and mTORC1-ULK1 mediated mitophagy and apoptosis. In genetically engineered mouse models of HCC (TAK1ΔHep), hepatocyte-specific deletion of IL6ST suppressed the multiplicity and maximum size of naturally occurring cancer. In conclusion, IL6ST governs parallel activation of carcinogenic STAT3 along with mTORC1 in the pathogenesis of HCC by regulation of mitophagy-dependent apoptosis and cancer cell survival.
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Shin, Kyung Rim,Kang, Younhee,Kim, Mi Young,Jung, Dukyoo,Kim, Jeong Soo,Hong, Chong Min,Yun, Eun Suk,Ma, Rye Won Blackwell Publishing Asia 2010 NURSING AND HEALTH SCIENCES Vol.12 No.4
<P><B>Abstract</B></P><P>This study determined the predictors of the fear of falling (FOF) in 213 South Korean community‐dwelling elderly. The Fall Efficacy Scale, Pittsburgh Sleep Quality Index, Korean Geriatric Depression Screening Scale, and Barthel Index were used to measure the FOF, sleep quality, depression, and activities of daily living, respectively. In addition, information regarding the participants' demographic details and the number of types of medication was collected. The data were analyzed by using hierarchical regression. The general regression model, with the FOF as a dependent variable, was statistically significant. The FOF variance was partially explained. Depression and activities of daily living significantly influenced the FOF. Thus, the results indicate that the FOF in community‐dwelling elderly Koreans is affected by depression and activities of daily living. Therefore, an older adult with recognized signs of depression must be provided with more appropriate care and the allocation of specific interventional strategies in order to maintain activities of daily living should be developed to manage the FOF.</P>
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Spectal Characteristics of Dry-Vegetation Cover Types Observed by Hyperspectral Data
Kyu Sung Lee,Sun Hwa Kim,Jeong Rim Ma,Min Jung Kook,Jung II Shin,Yang Dam Eo,Yong Woong Lee 大韓遠隔探査學會 2006 大韓遠隔探査學會誌 Vol.22 No.3
Because of the phenological variation of vegetation growth in temperate region, it is often difficult to accurately assess the surface conditions of agricultural croplands, grasslands, and disturbed forests by multi-spectral remote sensor data. In particular, the spectral similarity between soil and dry vegetation has been a primary problem to correctly appraise the surface conditions during the non-growing seasons in temperature region. This study analyzes the spectral characteristics of the mixture of dry vegetation and soil. The reflectance spectra were obtained from laboratory spectroradiometer measurement (GER-2600) and from EO-1 Hyperion image data. The reflectance spectra of several samples having different level of dry vegetation fractions show similar pattern from both lab measurement and hyperspectral image. Red-edge near 700nm and shortwave IR near 2,200nm are more sensitive to the fraction of dry vegetation. The use of hyperspectral data would allow us for better separation between bare soils and other surfaces covered by dry vegetation during the leaf-off season.
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Spectal Characteristics of Dry-Vegetation Cover Types Observed by Hyperspectral Data
Lee Kyu-Sung,Kim Sun-Hwa,Ma Jeong-Rim,Kook Min-Jung,Shin Jung-Il,Eo Yang-Dam,Lee Yong-Woong The Korean Society of Remote Sensing 2006 大韓遠隔探査學會誌 Vol.22 No.3
Because of the phenological variation of vegetation growth in temperate region, it is often difficult to accurately assess the surface conditions of agricultural croplands, grasslands, and disturbed forests by multi-spectral remote sensor data. In particular, the spectral similarity between soil and dry vegetation has been a primary problem to correctly appraise the surface conditions during the non-growing seasons in temperature region. This study analyzes the spectral characteristics of the mixture of dry vegetation and soil. The reflectance spectra were obtained from laboratory spectroradiometer measurement (GER-2600) and from EO-1 Hyperion image data. The reflectance spectra of several samples having different level of dry vegetation fractions show similar pattern from both lab measurement and hyperspectral image. Red-edge near 700nm and shortwave IR near 2,200nm are more sensitive to the fraction of dry vegetation. The use of hyperspectral data would allow us for better separation between bare soils and other surfaces covered by dry vegetation during the leaf-off season.
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Intake of Soy Products and Other Foods and Gastric Cancer Risk: A Prospective Study
Ko, Kwang-Pil,Park, Sue K.,Yang, Jae Jeong,Ma, Seung Hyun,Gwack, Jin,Shin, Aesun,Kim, YeonJu,Kang, Daehee,Chang, Soung-Hoon,Shin, Hai-Rim,Yoo, Keun-Young Japan Epidemiological Association 2013 Journal of epidemiology Vol.23 No.5
<P><B>Background</B></P><P>Gastric cancer, the most common cancer in the world, is affected by some foods or food groups. We examined the relationship between dietary intake and stomach cancer risk in the Korean Multi-Center Cancer Cohort (KMCC).</P><P><B>Methods</B></P><P>The KMCC included 19 688 Korean men and women who were enrolled from 1993 to 2004. Of those subjects, 9724 completed a brief 14-food frequency questionnaire at baseline. Through record linkage with the Korean Central Cancer Registry and National Death Certificate databases, we documented 166 gastric cancer cases as of December 31, 2008. Cox proportional hazard models were used to estimate relative risks (RRs) and 95% CIs.</P><P><B>Results</B></P><P>Frequent intake of soybean/tofu was significantly associated with reduced risk of gastric cancer, after adjustment for age, sex, cigarette smoking, body mass index, alcohol consumption, and area of residence (<I>P</I> for trend = 0.036). We found a significant inverse association between soybean/tofu intake and gastric cancer risk among women (RR = 0.41, 95% CI: 0.22–0.78). Men with a high soybean/tofu intake had a lower risk of gastric cancer, but the reduction was not statistically significant (RR = 0.77, 95% CI: 0.52–1.13). There was no interaction between soybean/tofu intake and cigarette smoking in relation to gastric cancer risk (<I>P</I> for interaction = 0.268).</P><P><B>Conclusions</B></P><P>Frequent soybean/tofu intake was associated with lower risk of gastric cancer.</P>
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