The novel herbal cocktail MA128 suppresses tumor growth and the metastatic potential of highly malignant tumor cells

KIM, AEYUNG,IM, MINJU,YIM, NAM-HIU,HWANG, YOUN-HWAN,YANG, HYE JIN,MA, JIN YEUL Spandidos Publications 2015 ONCOLOGY REPORTS Vol.34 No.2

<P>MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inhibiting tyrosinase activity via the p38 MAPK and protein kinase A signaling pathways in B16F10 cells. In the present study, we examined whether oral administration of MA128 suppressed the in vivo tumor growth of HT1080 cells in athymic nude mice. The results showed that the daily oral administration of 75 and 150 mg/kg MA128 suppressed the tumorigenic growth of HT1080 cells efficiently. Since metastasis is a major cause of cancer-associated mortality and the greatest challenge during cancer treatment, we investigated the effect of non-toxic concentrations of MA128 on the metastatic potential of HT1080 cells. MA128 inhibited anchorage-independent colony formation, migration and invasion. Matrix metalloproteinase-9 (MMP-9) activity under resting and PMA-stimulated conditions was decreased in a dose-dependent manner by MA128 in HT1080 cells. In addition, the daily oral administration of MA128 at doses of 75 and 150 mg/kg efficiently blocked the lung metastasis of B16F10 cells that had been injected into the tail veins of C57BL/6 mice. In particular, none of the mice treated with MA128 exhibited systemic toxicity, such as body weight loss or liver and kidney dysfunction. MA128 also inhibited tumor-induced angiogenesis. Taken together, the results suggest that MA128 is a potential therapeutic agent and a safe herbal medicine for controlling malignant and metastatic cancer.</P>

Anti-melanogenic activity of the novel herbal medicine, MA128, through inhibition of tyrosinase activity mediated by the p38 mitogen-activated protein kinases and protein kinase signaling pathway in B16F10 cells

Kim, Aeyung,Ma, Jin Yeul Medknow PublicationsMedia Pvt Ltd 2014 Pharmacognosy magazine Vol.10 No.39

<P><B>Background:</B></P><P>Recently, our research group developed MA128, a novel herbal medicine, and demonstrated that MA128 is effective for the treatment of asthma and atopic dermatitis (AD). In particular, postinflammatory hyper-pigmentation in AD mice was improved with MA128 treatment. Thus, in this study, we determined the effect of MA128 on melanogenesis and its underlying mechanism in murine B16F10 melanoma cells.</P><P><B>Materials and Methods:</B></P><P>After treatment with MA128 at 100 and 250 μg/mL and/or alpha-melanocyte stimulating hormone (α-MSH) (1 μM), cellular melanin content and tyrosinase activity in B16F10 cells were measured. Using western blotting, expression levels of tyrosinase, tyrosinase-related protein-1 (TRP-1), TRP-2, microphthalmia-associated transcription factor (MITF), and activation of c-AMP-dependent protein kinase (PKA), c-AMP-related element binding protein (CREB) and mitogen-activated protein kinases (MAPKs) were examined.</P><P><B>Results:</B></P><P>MA128 significantly inhibited melanin synthesis and tyrosinase activity in a resting state as well as α-MSH-stimulating condition, and significantly decreased the expression of tyrosinase, TRP-1, TRP-2 and MITF. In addition, phosphorylation of PKA and CREB by α-MSH stimulation was efficiently blocked by MA128 pretreatment. Moreover, MA128 as an herbal mixture showed synergistic anti-melanogenic effects compared with each single constituent herb.</P><P><B>Conclusion:</B></P><P>MA128 showed anti-melanogenic activity through inhibition of tyrosinase activity mediated by p38 MAPK and PKA signaling pathways in B16F10 cells. These results suggest that MA128 may be useful as an herbal medicine for controlling hyper-pigmentation and as a skin-whitening agent.</P>

Oral Administration of Novel Oriental Medicine, KIOM-C, Protect against Influenza Virus

Jin Yeul Ma, Eun Ha Kim, Jun Han Lee, Min-Suk Song, Yun Hee Baek, Young Ki Choi 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

The influenza virus is an important respiratory risk affecting humans, and effective treatments are needed. Some oriental medicines are currently applied for treatment of common colds as well as influenza infection. Previous studies have reported that the therapeutic properties of MA-128 are effective for treatment of psoriasis antiasthmatic and atopic dermatitis. In this study, we investigated the therapeutic properties of the novel herbal medicine, MA-128, for treatment of influenza virus infection by oral administration. MA-128 is an active natural biological compound from herbal-marine origin. The results showed that oral administration of MA-128 in mice could confer a survival benefit against Type A influenza virus infection. Daily oral administration of MA- 128 resulted in delayed death in infected mice for three days against mouse adapted H3N2 (A/Philippines/2/82). However, it protected more than 60% of mice from lethal infection of 2009 pandemic H1N1 (A/Korea/CJ01/2009) influenza virus. In addition, lung viral titers were significantly reduced at seven days post infection (~100 times) compared with mock-treated mice and viruses were cleared at 9 dpi only in the MA-128 treated groups. This study demonstrated the potential of the novel herbal medicine, MA-128, as an herbal remedy against influenza A viruses.

A comparative study to measure the sagittal condylar inclination using mechanical articulator, virtual articulator and jaw tracking device

Liya Ma,Fei Liu,Jiansong Mei,Jiarui Chao,Zhenyu Wang,Jiefei Shen 대한치과보철학회 2023 The Journal of Advanced Prosthodontics Vol.15 No.1

Purpose. To compare the sagittal condylar inclination (SCI) in dentate individuals measured by the different methods with mechanical articulator (MA), virtual articulator (VA), and a jaw tracking device (JTD) system. Materials and methods. A total of 22 healthy dentate participants were enrolled in this study. For MA workflow, the SCI was obtained by a semi-adjustable articulator with protrusive interocclusal records. The SCI was also set on a VA by aligning intraoral scan (IOS) with cone beam computed tomography (CBCT) and facial scan (FS), respectively. These virtual workflows were conducted in a dental design software, namely VAIOS-CBCT and VAIOS-FS. Meanwhile, a JTD system was also utilized to perform the measurement. Intraclass correlation was used to assess the repeatability within workflows. The bilateral SCI values were compared by Wilcoxon matched-pairs signed rank test for each workflow, and Kruskal-Wallis test and post hoc p-value Bonferroni correction were used to compare the differences among four workflows. The agreement of VAIOS-CBCT, VAIOS-FS, and JTD compared with MA was evaluated by Bland-Altman analysis. Results. Intraclass correlation of the SCI revealed a high degree of repeatability for each workflow. There were no significant differences between the left and right sides (P > .05), except for VAIOS-CBCT (P = .028). Significant differences were not found between MA and VAIOS-FS (P > .05). Bland-Altman plots indicated VAIOS-CBCT, VAIOS-FS, and JTD were considered to substitute MA with high 95% limits of agreement. Conclusion. The workflow of VAIOS-FS provided an alternative approach to measure the SCI compared with MA.

Late Ordovician provenance and depositional setting in the southwestern Ordos Block, China: constraints from zircon U-Pb geochronology

Fu Yang,Gang Chen,Yu Kang,Dongmin Ma,Qilin Chen,Tian Tao,Fu Deliang 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.2

The U-Pb ages of single zircon grains contained in the sandstone samples were analyzed by the LA-ICP-MS method, the sediment provenances and geological significance were discussed. The LA-ICP-MS zircon U-Pb dating from the sandstones, tuffaceous sandstones and volcanic tuffs of the Pingliang and Zhaolaoyu Formations along the southwestern Ordos Block are used to limit the maximum depositional age and material sources. The results show that: (1) The youngest ages of zircon dating in the three samples are 445 Ma, 444 Ma and 443 Ma, respectively, suggesting that the studied Formations were deposited in the Late Ordovician. (2) The detrital zircon U-Pb age analysis of the sandstones sample from the Pinliang Formation clustered in the 445–477 Ma, 588–1548 Ma and 1612–2496 Ma with the corresponding youngest peak age of 454.5 ± 3.3 Ma. (3) The distribution of zircon U-Pb age in sandstone samples showing that the sedimentary rocks detritus was mainly sourced from the North Qinling-Qilian terranes and the NCC, and has double provenance supply in the north and south. The material source of the tuffaceous sandstones and volcanic tuffs mainly comes from the volcanic and magmatic activity related to the North Qilian-North Qinling Island Arcs.

Design and research of high misalignment tolerant magnetic couplers for dynamic wireless charging systems

Zhenjie Li,Xuezhi Yang,Jun Ma,Mingfei Ban,Yiqi Liu 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.3

This paper proposes a main-auxiliary cooperative receiving coil (MA-coil) with a lower space occupation rate and a simple control based on the time-sharing working principle, which can effectively improve the anti-misalignment capability of a dynamic wireless charging (DWC) system. First, the structure and circuit topology of the MA-coil are designed. The two auxiliary coils (A-coil) are connected in reverse series and symmetrically placed on both sides of the main coil (M-coil). Second, the output performance of the MA-coil in the y-direction is calculated based on the time-sharing working principle. The A-coil works by itself and enhances the output power when side shift occurs. Third, the most suitable ratio of coil width w M and w A is determined. The anti-misalignment performance and the effective side shift range are compared through simulation between the MA-coil in this case and the square coil. Finally, an experimental prototype is built to verify the feasibility of the proposed structure, and experimental results obtained from the prototype are basically consistent with the theoretical analysis. The anti-misalignment capability of the MA-coil is more than 20% higher than that of the square coil.

Sodium Alginate-Assisted Synthesis of PdAg Bimetallic Nanoparticles and their Enhanced Activity for Electrooxidation of Ethanol

Yanru Yin,Changna Wen,Ning Ma,Baoyan Wang,Lianying Zhang,Hongliang Li,Peizhi Guo 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.9

Palladium and palladium-silver bimetallic nanocrystals have been synthesized hydrothermally by using environmental-friendly sodium alginate as the stabilizer and reducing agent. The pure palladium nanoparticles were spherical-like possibly due to the principle of the lowest surface energy, however, the formation of bimetallic palladium-silver nanoparticles was much more complicated, which was thinner and more irregular nanostructures than pure palladium nanoparticles. Electrochemical measurements showed that the electrocatalytic activity toward ethanol oxidation was increased first with the increase of silver content in bimetallic nanoparticles, from pure palladium of around 1070 mA/mg, to PdAg-20 of 1160 mA/mg and to PdAg-10 of 1750 mA/mg, and declined greatly at a high content of silver, approximately 279 mA/mg. Electrochemical stability test showed that PdAg-10 and PdAg-5 were the best and worst among four palladium-based samples, respectively. Based on the experimental data, the formation mechanism of pure palladium and palladium-silver bimetallic nanoparticles and the structure-property relationship of these samples have been discussed.

Space-Time Quantization and Motion-Aligned Reconstruction for Block-Based Compressive Video Sensing

( Ran Li ),( Hongbing Liu ),( Wei He ),( Xingpo Ma ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.1

The Compressive Video Sensing (CVS) is a useful technology for wireless systems requiring simple encoders but handling more complex decoders, and its rate-distortion performance is highly affected by the quantization of measurements and reconstruction of video frame, which motivates us to presents the Space-Time Quantization (ST-Q) and Motion-Aligned Reconstruction (MA-R) in this paper to both improve the performance of CVS system. The ST-Q removes the space-time redundancy in the measurement vector to reduce the amount of bits required to encode the video frame, and it also guarantees a low quantization error due to the fact that the high frequency of small values close to zero in the predictive residuals limits the intensity of quantizing noise. The MA-R constructs the Multi-Hypothesis (MH) matrix by selecting the temporal neighbors along the motion trajectory of current to-be-reconstructed block to improve the accuracy of prediction, and besides it reduces the computational complexity of motion estimation by the extraction of static area and 3-D Recursive Search (3DRS). Extensive experiments validate that the significant improvements is achieved by ST-Q in the rate-distortion as compared with the existing quantization methods, and the MA-R improves both the objective and the subjective quality of the reconstructed video frame. Combined with ST-Q and MA-R, the CVS system obtains a significant rate-distortion performance gain when compared with the existing CS-based video codecs.

서어에서의 COMP 범주 분석

마상영 한국서어서문학회 1998 스페인어문학 Vol.13 No.1

En esta tesis hemos propuesto nuestras opiniones sobre las estructuras de las oraciones compueatas que todavi′a tienen sin solucio′n muchas caracteri′sticas sinta′ctico-sema′nticas. Las grama′ticas tradicional y funcional distinguen entre las oraciones nominales, las relatives y las interrogativas segu′n las funciones que desempen~an en la oracio′n materna. En la grama′tica generativa se ha detallado el ana′lisis de la categori′a COMP con los cambios de contenido, pero todavi′a no ha aparecido una solucio′n complete. En esta situacio′n, hemos optado la idea de la categrori′a COMP de Chomsky(1986) que consideramos relativamente ma′s refinada. La conjuncio′n que introduce la oracio′n nominal ocupa la posicio′n nuclear de COMP, mientras los relativos y los interrogativos se trasladan a la posicio′n Espec de COMP dejando sue huellas respectivas en su posicio′n originaria. Pero, la oracio′n relative de funcio′n adjetiva se caracteriza par [-C, -θ] y no requiere la inversion Verbo-Sujeto durante la relativizacio′n, mientras que la oracio′n interrogativa de funcio′n nominal tiene los rasgos [+C, +θ] y exige la inversio′n Verbo-Sujeto durante el proceso de interrogacio′n. Asi′ tales diferencias son relevantes coma se ve: a. Oracio′n nominal : SCOMP ⇒ [+C,+θ] Quiero [sc[c$quot;[c que] [SF te vayas]]]. b. Oracio′n relativa : SCOMP ⇒ [-C,-θ] Esa es la chica [sc a que] [c[cθ] [SF queri′a visitar]]]. c. Oracio′n interrogativa : SCOMP ⇒ [+C, +θ] No se′ [sc cua′l pluma [c$quot;[c Φ] [SF pro prefieres]]]. Para solucionar estos problemas, Emonds(1976) nos ha propuesto que $quot;que$quot;(that en ingle′s) es un tipo de preosicio′n oracional. Pero como hemos viato en esta tesis, su solucio′n no es perfecta y tambie′n provoca problemas teo′ricos. De acuerdo con J. M. Brucart (en prensa), hemos comprobado la validez del ana′lisis de la categori′a COMP de Chomsky(1986) criticando los problemas pendientes de las propuestas de varios lingu¨i′stas : Mari′a Luisa Rivero(1980), Susan Plann(1982), M. Sun~er(1986, 1991). Tambie′n hemos analizado las relaciones entre la misma categori′a y los rasgos sema′nticos del verbo principal, y sus caraceri′sticas sinta′ctico-sema′nticas en el discurso indirecto. Lo que se ha argumentado en esta tesis nos muestra que le conviene ma′s al espan~ol el ana′lisis de COMP de Chomsky(1986) que los otros parame′trioos. El contraejemplo aparente de la secuencia $lt;que+S-qu$gt; no deteriora las suposiaones universales sino que las apoya, lo que hemos comprobado mediante el ana′lisis discursivo en que se seleocionan a la vez dos categori′as COMP. Sin embargo, todavi′a no vemos soluaonadas las diferencias sinta′ctico-sema′nticas de los componentes de la categori′a COMP. En unas propuestas anteriores la parti′cula QUE se divide en dos categori′as(relativo y conjuncio′n) en Rivero(1981) y en otras se considera so′1o como la u′nica categori′a : complementante (o mejor dicho, conjuncio′n). Pero siguiendo a esta u′ltima opinio′n, nos quedan la cuestio′n de que la preposicio′n, en el caso de las construcciones relativas EN QUE, DE QUE, aparece sin complemento, lo que viola la generalidad de la preposicio′n : La preposicio′n requiere la presencia obligatoria de su complemento, y la de que en el caso de EN EL QUE, DEL QUE, ..., no aparece el nu′cleo nominal del SN asi′ que ocurre la violacip′n del principio X'. A pesar de estas diferencias claras, haste ahora se ha tratado de analizar la categori′a COMP con el mismo criterio sinta′ctico, lo que consideramos problema′tico y deberi′amos esforzarnos a crear otras propuestas nuevas ma′s detalladas y de gran credibilidad.

-mente형 부사의 통사적 특징

마상영 ( Ma Sang Yeong ) 한국스페인어문학회 2003 스페인어문학 Vol.0 No.28

Es bien conocido que el adverbio es una categori´a muy complicada que modifica a varios sintagmas diferentes. Esta categori´a puede ocupar casi godas las posiciones adjuntas y hasta puede aparecer en las posiciones de otras categori´as. Adema´s, puede ejercer casi todas las funciones. Mediante este trabajo, hemos tratado de aclarar algunas caracteri´sticassinta´cticas de algunos adverbios de -mente en espan~ol. El adverbio nos muestra unas complejidades tan profundas que los lingu¨istas todavi´a no han podido aclarar sus caracteri´sticas sinta´ctico-sema´nticas. La mayori´a de trabajos acerca del adverbio se basan en la clasificacio´n de la misma categori´a segu´n los rasgos sema´nticos y muy pocos lingu¨istas la han analizado sinta´cticamente. Bajo esta circunstancia, hemos tratado de aclarar, a trave´s de esta tesis, que los adverbios de -mente nos muestran casi las mismas caracteri´sticas sinta´cticas que los adverbios normales. Pero, a diferencia de e´stos, los adverbios de -mente no aparecen en las posiciones de nu´cleo nominal salvo en la complementaria de la perposicio´n de. Parece que tampoco pueden ocupar la posicio´n sujetiva de la oracio´n copulativa u oracio´n reducida y la posicio´n complementaria de la oracio´n reducida. Sabemos bien que hay tantos adverbios de -mente que no hemos tratado aqui´, pero hemos logrado verificar las posiciones y funciones ma´s relevantes de los adverbios de -mente. Y hemos aclarado que los adverbios de -mente pueden ocupar la posicio´n Espec de otrascategori´as. Deseo que esta tesis sirva para otros estudios ma´s profundos acerca de los adverbios de -mente en espan~ol.