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Preparation of Alginate/Chitosan Microcapsules and Enteric Coated Granules of Mistletoe Lectin
Lyu, Su-Yun,Kwon, Young-Ju,Joo, Hye-Jin,Park, Won-Bong The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.1
The aqueous extract of European mistletoe (Viscum album, L.) has been used in cancer therapy. The purified mistletoe lectins, main components of mistletoe, have demonstrated cytotoxic and immune-system-stimulating activities. Korean mistletoe (Viscum album L. coloratum), a subspecies of European mistletoe, has also been reported to possess anticancer and immunological activities. A galactose- and N-acetyl-D-galactosamine-specific lectin (Viscum album L. coloratum agglutinin, VCA) with Mr 60 kDa was isolated from Korean mistletoe. Mistletoe preparations have been given subcutaneously due to the low stability of lectin in the gastrointestinal (GI) tract. In the present study, we investigated the possibility of alginate/chitosan microcapsules as a tool for oral delivery of mistletoe lectin. In addition, our strategy has been to develop a system composed of stabilizing cores (granules), which contain mistletoe lectin, extract or powder, coated by a biodegradable polymer wall. Our results indicated that successful incorporation of VCA into alginate/chitosan microcapsules has been achieved and that the alginate/chitosan microcapsule protected the VCA from degradation at acidic pH values. And coating the VCA with polyacrylic polymers, Eudragit, produced outstanding results with ideal release profiles and only minimal losses of cytotoxicity after manufacturing step. The granules prepared with extract or whole plant produced the best results due to the stability in the extract or whole plant during manufacturing process.
사람 간세포의 분리 및 SV40 Large T antigen에 의한 세포의 불멸화
허원희 ( Heo Won Hui ),윤승규 ( Yun Seung Gyu ),신주엽 ( Sin Ju Yeob ),류종순 ( Lyu Jong Sun ),왕진상 ( Wang Jin Sang ),김창욱 ( Kim Chang Ug ),최종영 ( Choe Jong Yeong ),정규원 ( Jeong Gyu Won ),선희식 ( Seon Hui Sig ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 간세포는 간의 해독 작용이나 운반체 단백질의 합성 저장과 같은 중요 기능을 수행한다. 간세포를 이용한 연구에는 간의 재생(regeneration)과 분화(differentiation) 기작과 간염 바이러스(hepatitis virus) 관련 연구 등이 있다. 특히 간염 바이러스 연구는 형질전환 동물로만 이용해야 한다는 한계를 안고있기에 새로운 신약 백신이 개발되었더라도 신약에 대한 간염 바이러스의 치료 효과를 입증하기가 어려운 실정에 있다. 이