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Genetic characterization of porcine circovirus-2 field isolates from PMWS pigs
Young S. Lyoo,YoungS.Lyoo 대한수의학회 2002 Journal of Veterinary Science Vol.3 No.1
PMWS is a new emerging disease in swine herdsworldwide. Field isolates of PCV-2, a putative majorcausative agent of PMWS, were isolated and geneticalycharacterized. Viral genome of two field isolates(PC201DJ and PC201SS) from pigs showing typicalPMWS was equenced. The nucleotide sequence homologywith other PCV-2 isolates was ranging from 95% to99% in complete viral genomic sequence. The highlywas identical to that of other PCV-2 isolates. Todetermine the genetic heterogeneity of PCV-2 isolates,t h e p h y l o g e n e t i c t r e e b a s e d o n t h e c o m p l e t e g e n o m eof PCV-2 isolates were constructed. Two PCV-2 fieldisolates were closely related to Canadian isolates ofPCV-2. PCV-2 isolated from field may have an originof North America nd is posibly originated fromimportation of breding stocks. The result indicatesthat although the genome of PCV-2 is relatively stablein general, minor genetic variations exist amongPCV-2 isolates from the diferent geographic locations.important implication for genetic characteristics ofPCV-2 infection. Thre major imunorelevant epitopesof capsid protein showed variations in amino acidsequences. Also, the variance of amino acid sequencein antigenic epitope xisted betwen two KoreanPCV-2 isolates.
Lyoo,In Kyoon 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.5
연구목적 : 본 연구는 성인 境界線 人格障碍환자와, 환자와 心理的, 經濟的으로 밀접한 관계를 가지고 있는 부모와의 家族環境에 대한 認識의 차이를 알기 위함이다. 연구방법 : Structural Clinical Interview for DSM-Ⅲ-R과 Revised Diagnostic Interview for Personality Disorders를 사용하여 연구대상 집단으로 경계전 인격장애를 가진 주요 우울증 환자(N=24)와 이 집단의 정신과적 비교집단으로 경계선 인격장애를 가지지 않는 주요우울증 환자(N=21)를 선택하였다. 각 집단의 환자와 그 부모에게 Family Environment Scale을 시행한 후, 같은 집단 내에서 환자와 부모사이의 차이 그리고 부모간의 차이를 분석하였고, 두 집단의 구성원 사이의 가족환경에 대한 평가의 차이를 분석하였다. 연구결과 : 경계선 인격장애 환자집단은 결합력(Cohesion), 갈등(Conflict), 독립성(Independence)의 소척도에서 그들의 부모보다 부정적으로 가족환경을 인식했다. 환자의 父 와 母는 가족환경 인식에서 통계적으로 유의한 차이를 보이지 않았다. 경계선 인격장애를 가지지 않는 대조군에서는 환자와 그 부모사이 혹은 부모 서로 간에 Family Environment Scale의 어느 소척도에서도 통계적으로 유의한 차이가 없었다. 결 론 : 본 연구는 경계선 인격장애 환자와 그 부모사이의 가족환경에 대한 인식의 차이점을 구체적으로 파악하였다. 臨床的 측면에서는 이 차이점에 대한 치료적 접근의 필요성을 제기하였으며, 硏究적 측면에서는 지금까지 경계선 인격장애 환자의 시각과 회상에 주로 의존하여 환자의 가족환경, 가족관계 및 부모의 성격특성을 기술하고 정의하여 온 것에 대해서 재고가 필요함을 제시하였다.
Lyoo, Eun-kyoung,Choi, Do-young,Lee, Jae-dong 대한침구학회 2003 대한침구의학회지 Vol.20 No.2
연구 배경 및 목적 : 봉독은 항염증 등의 효과를 가지고 있다고 알려져 있지만 세포 증식과 관련된 봉독의 효과에 대한 고찰을 위해 본 硏究에서는 蜂毒 藥鍼 刺戟이 아세트산 誘發 痛覺 過敏症을 가진 쥐의 齒狀回에서의 細胞 增植과 COX2 發現에 미치는 影響에 대해 알아보고자 하였다. 실험방법 : 대조군, 아세트산 처치군, 아세트산 0.1㎎/㎏ 봉독 처치군, 아세트산 1㎎/㎏ 봉독처치군(n=5 in each group)의 네 군으로 나누고 해당 군에 일벌 蜂毒(Sigma Chemical Co., St. Louis, MO, USA)을 양측 족삼리 경혈(ST36)에 주입시키고 30분 후 아세트산(100% acetic acid 1% 용액의 0.5㎖)을 복강내로 주입하여 복부 긴장 회수를 세었으며, BrdU 양성, COX 2 양성 세포수를 면역 화학 조직법을 수행하여 세어 보았다. 결과 : 아세트산 처치군에서는 대조군에 비해 5 bromo 2' deoxyuridine 양성 세포의 수는 減少되며, 齒狀回에서의 COX2의 發現은 增强되는 것으로 보여졌다. 蜂毒 注入은 아세트산 誘發 腹部 緊張 횟수와 齒狀回에서의 COX2 發現을 抑制하여, 齒狀回에서의 細胞 增植을 增加시켰다. 결론 : 이번 結果에서 보면, 齒狀回에서의 COX2의 發現은 細胞 增植 抑制와 關聯되며 蜂毒은 COX2 發現 抑制를 통해 齒狀回에서의 새로운 細胞 形成을 增加시킨다는 것을 알 수 있다.
Virulence of a novel reassortant canine H3N2 influenza virus in ferret, dog and mouse models
Lyoo, K. S.,Na, W.,Yeom, M.,Jeong, D. G.,Kim, C. U.,Kim, J. K.,Song, D. Springer Science + Business Media 2016 Archives of virology Vol.161 No.7
<P>An outbreak of a canine influenza virus (CIV) H3N2 reassortant derived from pandemic (pdm) H1N1 and CIV H3N2 in companion animals has underscored the urgent need to monitor CIV infections for potential zoonotic transmission of influenza viruses to humans. In this study, we assessed the virulence of a novel CIV H3N2 reassortant, VC378, which was obtained from a dog that was coinfected with pdm H1N1 and CIV H3N2, in ferrets, dogs, and mice. Significantly enhanced virulence of VC378 was demonstrated in mice, although the transmissibility and pathogenicity of VC378 were similar to those of classical H3N2 in ferrets and dogs. This is notable because mice inoculated with an equivalent dose of classical CIV H3N2 showed no clinical signs and no lethality. We found that the PA and NS gene segments of VC378 were introduced from pdmH1N1, and these genes included the amino acid substitutions PA-P224S and NS-I123V, which were previously found to be associated with increased virulence in mice. Thus, we speculate that the natural reassortment between pdm H1N1 and CIV H3N2 can confer virulence and that continuous surveillance is needed to monitor the evolution of CIV in companion animals.</P>
Lyoo, Young S.,Kim, Jin-hyun,Park, Choi-kyu The Korean Society of Veterinary Science 1999 大韓獸醫學會誌 Vol.39 No.2
New emerging post weaning multisystemic wasting syndrome (PMWS) threatening swine industry worldwide and investigation of the etiological agent is underway. The porcine circovirus (PCV) consistently identified from PMWS pigs and research result indicate that there is strong relationship between PCV and PMWS. Fauns with PMWS submitted pigs suffered from various PMWS typical signs and necropsy finding showed lymph node anomalies. The PCV DNA was amplified from inguinal lymph node collected from pigs with PMWS. PCV specific primers were successfully amplified PCV DNAs and were able to differentiate PCV type I and II. We have identified noble PCV virus with genetic variation. The virus showed insertion of the nucleic acid at the 5' of the genome but did not have PCR product with primer set corresponding to PCV type II virus.
Lyoo, Kwang Soo,Hong, Sung Woo,Song, Myeong Jun,Hur, Wonhee,Choi, Jung Eun,Piao, Lian-Shu,Jang, Jeong Won,Bae, Si Hyun,Choi, Jong Young,Park, Jung Wha,Choi, Sang Wook,Yoon, Seung Kew S. Karger 2011 Intervirology Vol.54 No.6
<P>The aim of this study was to determine the prevalence of hepatitis B virus (HBV) subgenotypes, the spectrum of mutations in the precore/core region through phylogenetic analysis, and the relevance of viral characteristics in disease progression in Korean patients.</P>
Lyoo, Won Seok,Yeum, Jeong Hyun,Kwon, Oh Wook,Shin, Dong Soo,Han, Sung Soo,Kim, Byoung Chul,Jeon, Han Yong,Noh, Seok Kyun Wiley Subscription Services, Inc., A Wiley Company 2006 Journal of applied polymer science Vol.102 No.4
<P>To identify the effect of blend ratios of syndiotacticity-rich poly(vinyl alcohol) (s-PVA)/atactic PVA (a-PVA) having similar number-average degrees of polymerization (P<SUB>n</SUB>)s of 4000 and degrees of saponification (DS)s of 99.9% on the rheological properties of s-PVA/a-PVA/water solutions, water-soluble s-PVA and a-PVA with different syndiotactic diad contents of 58.5 and 54.0%, respectively, were prepared by bulk copolymerization of vinyl pivalate and vinyl acetate (VAc) and solution polymerization of VAc, followed by saponifying the corresponding copoly(vinyl pivalate/vinyl acetate) and poly(vinyl acetate). The blend ratios played a significant role in rheological behavior. Over the frequency range of 10<SUP>−1</SUP>–10<SUP>2</SUP> rad/s, s-PVA/a-PVA blend solutions with larger s-PVA content show more shear thinning at similar (P<SUB>n</SUB>)s and (DS)s of polymer, suggesting that PVA molecules are more readily oriented as s-PVA content increases. Yield stress is higher for s-PVA/a-PVA blend solutions with larger s-PVA content at similar (P<SUB>n</SUB>)s and (DS)s of polymer. This indicates that more domains with internal order are produced at larger s-PVA content in s-PVA/a-PVA blend solutions. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 3934–3939, 2006</P>