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Extracellular stability of nanoparticulate drug carriers
Liu, Karen C.,Yeo, Yoon 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
Nanoparticulate (NP) drug carrier systems are attractive vehicles for selective drug delivery to solid tumors. Ideally, NPs should evade clearance by the reticuloendothelial system while maintaining the ability to interact with tumor cells and facilitate cellular uptake. Great effort has been made to fulfill these design criteria, yielding various types of functionalized NPs. Another important consideration in NP design is the physical and functional stability during circulation, which, if ignored, can significantly undermine the promise of intelligently designed NP drug carriers. This commentary reviews several NP examples with stability issues and their consequences, ending in a discussion of experimental methods for reliable prediction of NP stability.
Extracellular stability of nanoparticulate drug carriers
Karen C. Liu,여윤 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
Nanoparticulate (NP) drug carrier systems areattractive vehicles for selective drug delivery to solidtumors. Ideally, NPs should evade clearance by the reticuloendothelialsystem while maintaining the ability tointeract with tumor cells and facilitate cellular uptake. Great effort has been made to fulfill these design criteria,yielding various types of functionalized NPs. Anotherimportant consideration in NP design is the physical andfunctional stability during circulation, which, if ignored,can significantly undermine the promise of intelligentlydesigned NP drug carriers. This commentary reviews severalNP examples with stability issues and their consequences,ending in a discussion of experimental methodsfor reliable prediction of NP stability.