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Recent advances in surface-enhanced Raman scattering detection technology for microfluidic chips
Chen, Lingxin,Choo, Jaebum WILEY-VCH Verlag 2008 Electrophoresis Vol.29 No.9
<P>Microfluidic chip devices and their application to sensitive chemical and biological analyses have attracted significant attention over the past decade. The miniaturization of reaction systems offers practical advantages over conventional benchtop systems. In this case, however, a highly sensitive on-chip detection method is important for the monitoring of chemical reactions as well as for the detection of analytes inside the channel because the detection volume in a micrometer-size channel is extremely small. Recently, a surface-enhanced Raman scattering (SERS) technique is being regarded as a potential candidate for the highly sensitive detection of analytes in a microfluidic chip. This review provides a general survey and an in-depth look at recent developments in SERS techniques for the biological/environmental analysis of minute analytes in a microfluidic chip.</P>
Lingxin Li,Han Li,Yanju Long,Shan Wang,Yu Chen,Sifeng Zhang,Lulu Wang,Lijun Luo,Fengzhi Jiang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.1
In the present work, a direct Z-scheme AgI/BiOBr heterojunction displaying improved photocatalytic activity was designed by a chemical bath deposition method. The obtained photocatalysts were systematically characterized through XRD, SEM, XPS, BET and UV-Vis diffuse reflectance spectroscopy. The synthesized AgI/BiOBr photocatalyst displayed superior photocatalytic performance in the case of 17α-ethinylestradiol (EE2), where 97.0% compound has been removed within 9 min of irradiation. The rate constant using AgI/BiOBr photo-catalyst was 16.0 and 138.7 times more than that of pure AgI and BiOBr, respectively. Furthermore, the photocatalytic mechanism was investigated. The results of this study indicated that AgI/BiOBr was a stable and efficient photocatalyst, with promising practical applications.
Liang Chen,Li Han,Yang Jian,Wang Guolin,Zhang Lingxin 한국자동차공학회 2023 International journal of automotive technology Vol.24 No.2
Tire contour design theory has always been studied because of its significant effect on tire performance. Based on the new non-natural equilibrium contour theory, the influence of belt pressure share ratio on the carcass contour is studied. The type of 385 / 65R22.5 all-steel radial tire was chosen as the research object and the finite element analysis technique was adopted to calculate the belt pressure share ratio. The results show that with the increase of the belt pressure share ratio, the clamping effect of belt layer on the carcass is strengthened, the curvature of tire crown in carcass contour increases and the crown curve tends to be rounded. The influence of belt pressure share ratio on wear, footprint, rolling resistance and grip performance was also explored with the finite element technology. It turned out that with the increase of the belt pressure share ratio, the tire wear increased, rolling resistance reduced, grip performance enhanced.
Mengchi Ju,Lingxin Meng,Jingmei Xu,Xuan Chen,Junjian Yu,Zhe Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
The sulfonated poly(arylene ether ketone sulfone) containing –NH2 groups (Am-SPAEKS) and UiO-66-NH2 were respectively used as organic matrix and fillers. Am-S-U hybrid membranes were preparedby chemically anchoring UiO-66-NH2 onto the polymer main chain of Am-SPAEKS by Hinsberg reaction. The UiO-66-NH2 and Am-S-U hybrid membranes were characterized by 1H NMR, FT-IR, PXRD and SEM. The proton conductivities of Am-S-U hybrid membranes (0.072 0.088 S cm1 at 30 C and 0.125 0.168S cm1 at 80 C) were much higher than Am-SPAEKS (0.058 S cm1 at 30 C and 0.090 S cm1 at 80 C). The membranes showed good dimensional stability (swelling ratios < 9.49% at 100 C). Moreover, Am-SU-6% hybrid membrane showed relatively high peak power density (290.97 mW cm2). The results displaythat Am-S-U hybrid membranes have potential as proton exchange membranes.
Naked-eye sensitive ELISA-like assay based on gold-enhanced peroxidase-like immunogold activity
Wang, Shasha,Chen, Zhaopeng,Choo, Jaebum,Chen, Lingxin Springer 2016 Analytical and Bioanalytical Chemistry Vol.408 No.4
<P>A naked-eye sensitive ELISA-like assay was developed based on gold-enhanced peroxidase-like activity of gold nanoparticles (AuNPs). Using human IgG (H-IgG) as an analytical model, goat anti-human IgG antibody (anti-IgG) adsorbed on microtiter plate and AuNPs-labeled anti-IgG acted as capture antibody and detection antibody, respectively. Because the surfaces of AuNPs were blocked by protein molecules, the peroxidase-like activity of AuNPs was almost inhibited, evaluated by the catalytic oxidation of peroxidase enzyme substrate 3,3',5,5'-tetramethylbenzidine (TMB), which could produce a bright blue color in the presence of H2O2. Fortunately, the catalytic ability of AuNPs was dramatically increased by the deposition of gold due to the formation of a new gold shell on immunogold. Under optimal reaction conditions, the colorimetric immunoassay presented a good linear relationship in the range of 0.7-100 ng/mL and the limit of detection (LOD) of 0.3 ng/mL calculated by 3 sigma/S for UV-vis detection, and obtained LOD of 5 ng/mL for naked-eye detection. The obtained results were competitive with conventional sandwich ELISA with the LOD of 1.6 ng/mL. Furthermore, this developed colorimetric immunoassay was successfully applied to diluted human serum and fetal bovine serum samples, and predicted a broad prospect for the use of peroxidase-like activity involving nanomaterials in bioassay and diagnostics.</P>
Rapid DNA Hybridization Analysis Using a PDMS Microfluidic Sensor and a Molecular Beacon
KIM, Sungyong,CHEN, Lingxin,LEE, Sangyeop,SEONG, Gi Hun,CHOO, Jaebum,LEE, Eun Kyu,OH, Chil-Hwan,LEE, Sanghoon Japan Society for Analytical Chemistry 2007 Analytical sciences Vol.23 No.4
<P>A rapid DNA analysis has been developed based on a fluorescence intensity change of a molecular beacon in a PDMS microfluidic channel. Recently, we reported a new analytical method of DNA hybridization involving a PDMS microfluidic sensor using fluorescence energy transfer (FRET). However, there are some limitations in its application to real DNA samples because the target DNA must be labelled with a suitable fluorescent dye. To resolve this problem, we have developed a new DNA microfluidic sensor using a molecular beacon. By monitoring the change in the restored fluorescence intensity along the channel length, it is possible to rapidly detect any hybridization of the molecular beacon to the target DNA. In this case, the target DNA does not need to be labelled. Our experimental results demonstrate that this microfluidic sensor using a molecular beacon is a promising diagnostic tool for rapid DNA hybridization analysis.</P>
Optical Nanoprobes for Ultrasensitive Immunoassay
Fu, Xiuli,Chen, Lingxin,Choo, Jaebum American Chemical Society 2017 ANALYTICAL CHEMISTRY - Vol.89 No.1
<P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2017/ancham.2017.89.issue-1/acs.analchem.6b02251/production/images/medium/ac-2016-022517_0010.gif'></P>
SERS imaging of HER2-overexpressed MCF7 cells using antibody-conjugated gold nanorods
Park, Hyejin,Lee, Sangyeop,Chen, Lingxin,Lee, Eun Kyu,Shin, Soon Young,Lee, Young Han,Son, Sang Wook,Oh, Chil Hwan,Song, Joon Myong,Kang, Seong Ho,Choo, Jaebum Royal Society of Chemistry 2009 Physical chemistry chemical physics Vol.11 No.34
<P>Antibody-conjugated gold nanorods (GNRs) have been used for the targeting and imaging of specific cancer markers expressed on the surface membrane of cancer cells. GNRs with various aspect ratios were fabricated, and their surface-enhanced Raman scattering enhancement effects were evaluated. To attach the GNRs selectively onto the targets in cancer cells, specific antibodies were immobilized on the surface of GNRs using the layer-by-layer deposition method. First, Raman reporter molecules, mercaptopyridine, were attached to the surface of GNRs, and their surface charge was modified using poly(sodium 4-styrene-sulfonate) to make the surface charge negative. Then, anti-rabbit IgGs were immobilized onto the surface of the GNRs by electrostatic interactions. HER2 markers, expressed on the cell surface, were treated with anti-HER2 primary antibodies. Finally, the functionalized nanoprobes, conjugated with secondary antibodies, were attached to the markers on cancer cells by antibody–antibody interactions. In the present study, MCF7 cells overexpressing breast cancer marker HER2 were used as the optical imaging targets. Our experimental results demonstrate the potential feasibility of antibody-conjugated GNRs for the highly sensitive targeting and imaging of biomarkers expressed on the surface membrane of cancer cells.</P> <P>Graphic Abstract</P><P>We report the application of antibody-conjugated gold nanorods for the targeting and imaging of biomarkers expressed on cancer cells. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b904592a'> </P>