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Xin Che,Qiang Wang,Xingwang Duan,Min Wang,Linfeng He,Miao Cao,Shuang Liu,Guanshi Zhang,Zhimin Zhang 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.11
Microstructure evolution, phase development and mechanical property of AZ80 alloy cup with various processing temperatures(573 K, 613 K, 653 K) and rotating revolutions (N = 0, 5, 50, 100) during rotating backward extrusion (RBE)were explored. The study founded that reducing deformation temperature or increasing revolution could promote the grainrefinement and DRX proportion. And the sample deformed at the condition of 573 K and N = 100 exhibited the best grainrefinement effect (grain size was 2.5 μm, DRX ratio was up to 99.01%). The bulk eutectic phase existed at all deformationtemperatures, while the dynamic precipitation was only precipitated at temperature of 573 K and 613 K. Increasing thedeformation temperature or revolution could reduce the proportion of the second phase. And an increase in revolution or areduction of temperature would reduce the average size of second phase, due to the phase could be broken by large strainand resolved with elevated temperature. Moreover, increasing the revolution and deformation temperature could promotethe texture weakening, which would be contributed to the occurrence of new recrystallization grains with random orientationand the activation of non-basal slip system. The mechanical property of microhardness was significantly improved withrotating revolution increasing and deformation temperature decreasing. Supported by the grain refinement and dispersionstrengthening, the sample deformed at condition of 573 K and N = 100 achieved maximum hardness values of 96.3 HV.
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Application of advanced biomaterials in photothermal therapy for malignant bone tumors
Bo Chao,Jianhang Jiao,Lili Yang,Yang Wang,Weibo Jiang,Tong Yu,Linfeng Wang,He Liu,Han Zhang,Zhonghan Wang,Minfei Wu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Malignant bone tumors are characterized by severe disability rate, mortality rate, and heavy recurrence rate owing to the complex pathogenesis and insidious disease progression, which seriously affect the terminal quality of patients' lives. Photothermal therapy (PTT) has emerged as an attractive adjunctive treatment offering prominent hyperthermal therapeutic effects to enhance the effectiveness of surgical treatment and avoid recurrence. Simultaneously, various advanced biomaterials with photothermal capacity are currently created to address malignant bone tumors, performing distinctive biological functions, including nanomaterials, bioceramics (BC), polymers, and hydrogels et al. Furthermore, PTT-related combination therapeutic strategies can provide more significant curative benefits by reducing drug toxicity, improving tumor-killing efficiency, stimulating anti-cancer immunity, and improving immune sensitivity relative to monotherapy, even in complex tumor microenvironments (TME). This review summarizes the current advanced biomaterials applicable in PTT and relevant combination therapies on malignant bone tumors for the first time. The multiple choices of advanced biomaterials, treatment methods, and new prospects for future research in treating malignant bone tumors with PTT are generalized to provide guidance.
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