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RISS 인기검색어
- 검색키워드
- 저자 : Lindawati S. Kusdhany (검색결과 2 건)
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Lindawati S. Kusdhany,Elza I. Auerkari,Dwi A. Suryandari,Tribudi W. Rahardjo,Eef Hogervoorst,Christopher Talbot 대한예방치과학회 2011 International Journal of Clinical Preventive Denti Vol.7 No.1
Objective: Osteoporosis is a disease of bone metabolism, characterized by reduced density of e.g. the jawbone, with decreasing stability of the denture. Polymorphism in the estrogen receptor β gene (ER-β) has been linked with susceptibility to osteoporosis in ageing persons. The present study aimed to evaluate the association between the ER-β gene polymorphism and osteoporosis in Indonesian postmenopausal women. Methods: The research was a cross-sectional study of 288 subjects that were 47-75 years old. Bone density was determined by an ultrasonic technique and the subjects were divided on this basis into normal, osteopenia and osteoporosis groups. Peripheral blood samples were used for DNA isolation, and the ER-β polymorphism status of the subjects was evaluated using the PCR-RFLP technique with Alu1 restriction enzyme for cutting. Chi-square testing was used to evaluate the relation between the polymorphism status and the observed bone density. Results: The results showed that the status of ER-β polymorphism is significantly associated with osteoporosis in Indonesian postmenopausal women. In particular, a high fraction (68%) of subjects with osteoporosis were of the AA genotype, while osteoporosis was less common (32%) in the Aa genotype and apparently rare in the aa genotype that was in case uncommon. Conclusion: The majority of subjects with osteoporosis were of the AA genotype in terms of ER-β polymorphisms in Indonesian postmenopausal women. As the majority of all subjects were of AA genotype, the results support the view that expression of ER-β would increase the risk to osteoporosis and fracture in ageing women.
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Muslita Indrasari,Lindawati S. Kusdhany,Henni Koesmaningati 대한예방치과학회 2012 International Journal of Clinical Preventive Denti Vol.8 No.3
Introduction: Estrogen hormone deficiency in postmenopausal women results in a reduction of bone density. In this condition, estrogen hormone level decreases and bone density is less than normal, known as osteopenia and osteoporosis. Decreasing bone density becomes a risk factor of alveolar bone resorption in edentulous ridge. Objective: The aim of this study was to provide a description of alveolar bone resorption level in normal, osteopenia and osteoporosis postmenopausal women. This study provided information about bone density and postmenopausal condition in order to lower the failure of denture treatment. Methods: Data was collected cross sectionally on June 2009, in East Bekasi, West Java, Indonesia, on 312 postmenopausal women age 41∼82 years old. Bone density was measured by Ultrasound Densitometer. Alveolar bone height in edentulous ridge was measured by mouth mirror size 3 on buccal side of the edentulous ridge. Results: The result of this study showed that the resorption level of edentulous alveolar bone in women with normal bone density was lower than those of women with osteopenia and osteoporosis. Conclusion: Postmenopausal osteoporosis women had higher level of alveolar bone resorption compared to normal density and osteopenia.
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