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Liwen Gao,Yan Lin,Shuhui Yang 대한수학회 2024 대한수학회지 Vol.61 No.2
In this paper, the weighted $L^{p}$ boundedness of multilinear commutators and multilinear iterated commutators generated by the multilinear singular integral operators with generalized kernels and BMO functions is established, where the weight is multiple weight. Our results are generalizations of the corresponding results for multilinear singular integral operators with standard kernels and Dini kernels under certain conditions.
Yang Qianqian,Yan Ding,Zou Chaoying,Xue Qian,Lin Shuhui,Huang Qingtian,Li Xiaofen,Tang Daolin,Chen Xin,Liu Jinbao 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Triple-negative breast cancer (TNBC) is a heterogeneous malignancy in women. It is associated with poor prognosis, aggressive malignant behavior, and limited treatment options. In the ubiquitin‒proteasome system (UPS), deubiquitinases (DUBs) are potential therapeutic targets for various tumors. In this study, by performing unbiased siRNA screening, we identified STAMBP, a JAMM metalloprotease in the DUB family, as a driver of human TNBC tumor growth. Functionally, the knockdown of STAMBP inhibited the proliferation, migration, and invasion of multiple TNBC cell lines. Immunoprecipitation–mass spectrometry combined with functional and morphological analysis verified the interaction between STAMBP and the actin-binding protein RAI14. Mechanistically, STAMBP stabilized the RAI14 protein by suppressing the K48-linked ubiquitination of RAI14 and thus prevented its proteasomal degradation. Therefore, knocking down STAMBP resulted in the reduction in RAI14 protein levels and suppression of tumor growth in vitro and in vivo. Importantly, high levels of STAMBP were correlated with poor prognosis in TNBC patients. In summary, we reveal a previously unrecognized DUB pathway that promotes TNBC progression and provides a rationale for potential therapeutic interventions for the treatment of TNBC.
Significant Underestimation of Gaseous Methanesulfonic Acid (MSA) over Southern Ocean
Yan, Jinpei,Jung, Jinyoung,Zhang, Miming,Xu, Suqing,Lin, Qi,Zhao, Shuhui,Chen, Liqi American Chemical Society 2019 Environmental science & technology Vol.53 No.22
<P>Methanesulfonic acid (MSA), derived from the oxidation of dimethylsulfide (DMS), has a significant impact on biogenic sulfur cycle and climate. Gaseous MSA (MSA<SUB>g</SUB>) has been often ignored in previous studies due to its quick conversion to particulate MSA (MSA<SUB>p</SUB>) and low concentrations. MSA<SUB>g</SUB>, MSA<SUB>p</SUB>, and nss-SO<SUB>4</SUB><SUP>2-</SUP> were observed simultaneously for the first time with high-time-resolution (1 h) in the Southern Ocean (SO). The mean MSA<SUB>g</SUB> level reached up to 3.3 ± 1.6 pptv, ranging from ∼24.5 pptv in the SO, contributing to 31% ± 3% to the total MSA (MSA<SUB>T</SUB>). A reduction of the MSA to nss-SO<SUB>4</SUB><SUP>2-</SUP> ratios by about 30% was obtained when MSA<SUB>g</SUB> was not accounted for in the calculation, indicating that MSA<SUB>g</SUB> was very important in the assessment of the biogenic sulfur contributions in the atmosphere. Mass ratios of MSA to nss-SO<SUB>4</SUB><SUP>2-</SUP> increased first and then decreased with the temperature from −10 to 5 °C, with a maximum value at the temperature of −3 °C. Positive correlations between MSA<SUB>g</SUB> to MSA<SUB>T</SUB> ratios and temperature were presented, when the temperature was higher than 5 °C. This study highlights the importance of MSA<SUB>g</SUB> for understanding the atmospheric DMS oxidation mechanism and extends the knowledge of MSA formation in the marine atmosphere.</P> [FIG OMISSION]</BR>