직교이방성 CFRP적층판의 초음파 탐사에 관한 연구

임광희,양인영,나승우 朝鮮大學校 機械技術硏究所 1999 機械技術硏究 Vol.2 No.2

This work ethibits how susceptive the shear ultrasonic waves are to a little misoriented plies according to the angle variation of shear ultrasoic waves 0˚, 45˚ and 90˚. Also, it is shown that shear waves, particularly the transmission mode with the transmitter and receiver perpendicular to each other, have high sensitivity for detecting anomalies in fiber orientation and ply layup sequence that may occur in the manufacturing of composite laminates. Experimental results are agreed with modeling solutions which were based on decomposition of shear wave polarization vector as it propagates through the composite laminates. This wave appeared considerably to be sensitive to CFRP composites to the thickness direction along in-plane fibers .

조도 감지기를 이용한 절전형 간판 자동 전원 제어기

라승탁(Ra, Seung-Tak),임송환(Lim, Song-Hwan),이승호(Lee, Seung-Ho) 한국전기전자학회 2016 전기전자학회논문지 Vol.20 No.2

본 논문에서는 조도 감지기를 이용하여 사용자가 설정한 조도량에 따라 점등되는 방식의 절전형 간판 자동 전원 제어기를 제안한다. 조도량 설정 방식은 사용자의 편리성을 감안하여 조도량 단위별 구간 분류 알고리즘을 통해 설정 과정이 누구나 쉽게 조작이 가능한 가변저항 방식을 제안한다. 자동 점등의 기준이 되는 조도량의 데이터는 조도 감지기가 측정한 조도량을 무선 통신을 통해 간판 자동 전원 제어기에 보내어 간판의 점등을 제어하게 된다. 본 논문에서 제안된 조도 감지기를 이용한 절전형 간판 자동 전원 제어기의 성능을 평가하기 위하여 공인 시험기관에서 외부의 빛이 모두 차단된 상태에서 시험한 결과, 각 구간별로 오차율이 ±3%이하로 측정되어 우수한 성능을 나타내었다. In this paper, we propose energy-efficient automatic power controller which can power on and off the signboard at the specified light intensity using the Illuminance Detector. By using segmented section Classification algorithm, light intensity setup system propose variable resistor method which makes users more easy to control. Automatic light on-off system set a standard by measured illuminance data. Measured light-intensity through the Illuminance Detector are communicated with the signboard power controller with wireless communication, and it controls lighting system. In this paper, we evaluated the Energy-Efficient Automatic Power Controller of The Signboard using illuminance detector. Experimental results in lightless environment shows that the error rate is less than 3% by Accredited Testing Laboratories.

Cordycepin Induces Apoptosis through DR3 Pathway in Human Colon Cancer HT-29

Seung Yuan Lee,Sa Ra Park,Da Hye Kim,Tirishna debnath,Abul hasnat,Pervin mehnaz,Heung Mook Shin,Beong Ou Lim 한국식품영양과학회 2012 한국식품영양과학회 학술대회발표집 Vol.2012 No.10

Anti-inflammatory effects of PT-7 and Ilantide peptides on cultured keratinocytes and fibroblasts exposed to particulate matter 10

( Seung-yeon Lee ),( Bo-ra Lim ),( Chil-hwan Oh ),( Jeong-hee Kim ),( Kun Park ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Recent research has indicated that Particulate matter (PM) induced inflammatory response in the skin. And it has been reported that Ilantide, interleukin-1 receptor antagonist, and palmitoyl tetrapeptide-7(PT-7) have anti-inflammatory effects. Objectives: We asked whether PM10 can stimulate the human skin keratinocytes and fibroblast to induction of inflammation and by what mechanism play the changes. Also, we asked whether Ilantide and PT-7 can suppress PM10-induced inflammation. Methods: Human skin keratinocytes, HaCaT, and human skin fibroblasts, HS68, were used. The MTT assay was used to measure the cell viability when PM10 was treated and when Ilantide or PT-7 were added to the PM10-treated cells. Western blot was used to measure the protein expression of inflammatory cytokines induced by PM10, Ilantide, and PT-7. Results: We found that PM10 decrease the cell viability of HaCaT and HS68, and induce various inflammatory cytokines from these cells. Also, we found that Ilantide and PT-7 induce the various expression rate of different inflammatory cytokines in these cells. Although Ilantide didn’t change cell viability, PT-7 increased cell viability in both HaCaT and HS68. Conclusion: These data demonstrate that PM10 decreases cell viability by inducing the increase of inflammatory cytokines in these cells and PT-7 can reduce inflammatory response induced by PM10. Therefore, it is expected that a method using this new peptide can be devised to reduce skin damage caused by PM10.

The Safety and Efficacy of CKD-497 in Patients with Acute Upper Respiratory Tract Infection and Bronchitis Symptoms: A Multicenter, Double-blind, Double-dummy, Randomized Controlled Phase 2 Study

( Seung Won Ra ),( Sun Young Kim ),( Yun Young Lim ),( Shin Jung Park ),( Chin Kook Rhee ),( Deog Kyeom Kim ),( Yong Bum Park ),( Chang Youl Lee ),( Hyoung Kyu Yoon ),( Jeong-woong Park ),( Kwang Ha Y 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Botanical medicines used as expectorants and antitussives have proven to be effective while also having excellent safety margins. We aimed at evaluating the efficacy and safety of a new botanical drug, CKD-497, in patients with acute upper respiratory tract infections and bronchitis. Methods In this phase 2 study, 225 patients were enrolled and randomly assigned to one of four treatment groups: placebo (n=55), Synatura® (n=49), CKD-497 200mg (n=68), or CKD-497 300mg (n=53). The study drugs were administered three times daily over the course of 7 days. Primary endpoint was the change in the bronchitis severity score (BSS) from baseline to day 7. Secondary endpoint was evaluated based on clinical response rates on days 4 and 7. A safety analysis was also performed. The Kruskal-Wallis test for intergroup differences and a Chi-square test were applied. Results Between baseline and day 7, the mean BSS scores decreased significantly in each group (P<0.001): 4.04±1.85, 4.31±1.47, 4.09±1.48, and 4.28±1.69. However, neither the CKD-497 nor Synatura® group showed any significant effect on the difference in BSS change (P=0.75). The rate of clinical response was higher in the CKD-497 300mg group as compared to the placebo only on day 4 (18% vs. 36%; P<0.05) and those having more severe bronchitis (phlegm score≥3) showed a significant reduction of total BSS in the Synatura® and CKD-497 groups (P=0.042). No significant adverse events were observed in either of the CKD-497 groups. Conclusion CKD-497 and even the positive control drug had no significant effect on BSS change in this phase 2 clinical trial. However, CKD- 497 300mg had a mild but significant clinical improvement in early bronchitis patients with more severe phlegm. Considering both efficacy and safety, a future study using 300mg of CKD-497 with a shorter-term endpoint is warranted in patients with more severe bronchitis symptoms.

중심부 유방암에서 중심 종양절제술의 의의

임라주(Ra Joo Lim),이경상(Kyung Sang Lee),이숙현(Suok Hyun Lee),윤찬석(Chan Seok Yoon),고승상(Seung Sang Ko),허민희(Min Hee Hur),이해경(Hae Kyung Lee),홍성란(Sung Ran Hong),이지현(Ji Hyun Lee),강성수(Sung Soo Kang) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.4

Purpose: This study was conducted to evaluate the outcome of central lumpectomy for breast conservation including nipple-areolar resection and postoperative radiation therapy in patients with central breast cancers. Methods: 19 patients with central breast cancers, aged 39 to 72 years, operated on from May 2004 to March 2010 were identified. Recurrence, survival, and cosmesis were analyzed. Treatment was undertaken as complete excision of the nipple-areolar complex (NAC), followed by external radiation to the whole breast and tumor bed. The mean follow-up period was 37.9 (1 to 71) months. Results: At pathology, 13 had invasive ductal carcinoma; 5 had ductal carcinoma in situ. 1 had neuroendocrine cancer. Only 1 had atypical ductal hyperplasia at resection margin; the remaining 18 were free margins. The mean tumor size was 1.6 ㎝ (range, 0.8∼4 ㎝) and the distance from the nipple was 0∼1 ㎝. 37.5% had positive axillary nodes. Adjuvant chemotherapy was given for 12 patients, followed by radiation therapy. All 15 patients, who were hormone receptor positive, were given tamoxifen or aromatase inhibitors. With a mean follow up of 37.9 months, all 19 patients are alive and free of disease. Cosmetic results ranged from good to excellent in 18 (94.7%) patients, as judged by both the patients and the surgeons. Conclusion: Although this study needs further evaluation and long-term follow up, subareolar or central breast cancers can be successfully treated with breast conserving therapy using nipple-areolar resection and postoperative radiation therapy, along with acceptable cosmesis.

누리과정에 기초한 자유선택활동의 사회관계영역 활동 내용 분석

임승렬(Lim, Seung-Ryoul),정미라(Joung, Mi-Ra),김연미(Kim, Yeon-Mi) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.3

본 연구의 목적은 유아교육 현장에서 누리과정에 기초한 자유선택활동의 사회관계 영역 운영 실태를 밝히기 위한 것으로, 유치원 및 어린이집 교사들의 일일계획안을 분석하였다. 연구 결과 첫째, 유치원 및 어린이집 교사들이 계획한 자유선택활동 중 사회관계영역 내용을 포함하는 활동이 15% 내외 수준으로 낮게 편성되었고, 생활주제별 편성 정도의 차이는 크게 나타났다. 자유선택활동의 흥미 영역 내에서 계획된 사회관계영역 관련 내용은 기관 유형에 따른 차이는 보이지 않았으며 누리과정에서 제시한 사회관계영역 관련 내용 범주가 골고루 편성되지 않았다. 또한 유치원 및 어린이집 교사들의 사회관계영역 내용 편성은 흥미 영역에 따라 편차가 있었다. 둘째, 유치원 및 어린이집 교사들은 자유선택활동의 사회관계영역 관련 활동 내용을 약 60% 이상 평가하지 않는 것으로 나타났다. 계획된 사회관계영역 활동의 평가 내용을 분석한 결과 유치원 및 어린이집 교사들은 ‘교수내용’ 또는 ‘유아 태도’를 주로 평가하였으며, ‘교육목표’, ‘교수방법’, ‘유아흥미’, ‘유아발달’ 등에 관한 평가는 대부분 이루어 지지 않았다. 따라서 누리과정 사회관계영역의 효율적인 운영을 위해서는 누리과정의 내용과 운영 방법에 대한 교사의 충분한 이해가 선행되어야 할 것이며, 사회관계영역의 효율적 운영을 위한 교사의 재교육 등 교사 지원이 절실히 요구된다. The purpose of this study was to examine how social relationship activities in free choice activity time based on Nuri curriculum, were conducted. To achieve this, daily lessons plans of teachers in kindergartens and daycare centers were analyzed. As a result of the study, it was found that, within the planned free-choice activities, the portion of activities regarding social relationship area were quite low, as the portion was only about 15%. In addition there was a gap in the degree of composition of activity in accordance with each daily life based theme. Among kindergartens and daycare centers, there was no apparent difference in contents of social relationship area planned for the area of interest in free choice activity. Furthermore, categories of social relationship area set out by Nuri curriculum, were not evenly composed by all kindergarten teachers and day care center teachers. Moreover, there was a big difference in contents of social relationship area according to areas of interest in all teachers from both kindergartens and day care centers. Also it was found that 60% of teachers in kindergartens and daycare centers, did not evaluate the content of free-choice activities in social relationship area. Upon analyzing the evaluation of planned social relationship area activities, it was found that most kindergarten and day care center teachers did not conduct evaluation on teacher or children’s interest or attitudes, using categories that should have been included in the plan during their evaluation, such as education objective, teaching methodology, child development factors. Therefore, for an effective implementation of social relationship area within the Nuri curriculum, teachers should fully understand the content and operational methods of the Nuri curriculum. Also it is imperative to provide sufficient teacher support such as teacher training regarding the efficient management of social relationship area.

폐기능검사 해석에 정상하한치 변화와 새 해석흐름도가 미치는 영향

나승원 ( Seung Won Ra ),오지선 ( Ji Seon Oh ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),고윤석 ( Youn Suck Koh ),이상도 ( Sang Do Lee ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),김원동 ( Won D 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.2

연구 배경: 폐기능검사를 해석하는데 정상하한치(lower limits of normal) 선정과 해석흐름도 합의가 필수적이다. COPD 국제지침은 FEV1/FVC 정상하한치로 0.7을 사용하여 폐쇄성장애를 진단한다. 한편, 미국흉부학회(ATS)와 유럽호흡기학회(ERS) 공동으로 새 해석흐름도를 제시하였다. `FEV1/FVC 정상하한치 0.7`의 정확성과 새 해석흐름도가 실제 폐기능검사 해석에 어떤 영향을 미치는지 알아 보고자 하였다. 방법: 서울 아산병원의 호흡기검사실에서 2005년 7월 1일부터 11월 30일까지 5개월간 폐활량측정법을 시행한 7362명을 대상으로 하여 `FEV1/FVC 정상하한치 0.7`의 정확성을 평가하였고 새로운 ATS/ERS 해석흐름도에 따르면 폐용적검사가 추가로 필요한 경우가 얼마나 증가하는지 평가하였다. 상기 기간 내에 같은 날 폐용적검사를 시행한 1611명을 대상으로 과거 해석흐름도와 비교하여 새로운 ATS/ERS 해석흐름도를 적용하게 되면 폐쇄성장애로 진단되는 경우가 얼마나 증가하는지 알아보았다. 결과: 1) `FEV1/FVC < 0.7`에 의한 폐쇄성장애 진단은 연령이 증가할수록 민감도는 증가하였으나 특이도는 감소하였고 양성예측도는 감소하였으나 음성예측도는 증가하였다. 2) 새 ATS/ERS 해석흐름도를 적용할 경우 34.5% (2540명/7362명)의 환자가 추가로 폐용적검사가 필요하였다. 3) 새 ATS/ERS 해석흐름도를 적용할 경우, 과거에 제한성질환으로 진단되었던 환자 중 30%(205명/681명)가 폐쇄성질환으로 진단되었고 이는 전체 환자의 13%(205명/1611명)에 해당하였다. 결론: 폐쇄성질환 진단기준으로 `FEV1/FVC < 0.7`을 사용하였을 때 연령에 따라서 민감도와 특이도가 변한다. 또한, 새로운 ATS/ERS 해석흐름도를 실제 환자를 진료하는데 적용하면 폐용적검사를 시행해야 하는 경우가 증가하게 되고 폐쇄성장애로 진단되는 경우가 더 증가하게 된다. Background: To interpret lung function tests, it is necessary to determine the lower limits of normal (LLN) and to derive a consensus on the interpretative algorithm. `0.7 of LLN for the FEV1/FVC` was suggested by the COPD International Guideline (GOLD) for defining obstructive disease. A consensus on a new interpretative algorithm was recently achieved by ATS/ERS in 2005. We evaluated the accuracy of `0.7 of LLN for the FEV1/FVC` for diagnosing obstructive diseases, and we also determined the effect of the new algorithm on diagnosing ventilatory defects. Methods: We obtained the age, gender, height, weight, FEV1, FVC, and FEV1/FVC from 7362 subjects who underwent spirometry in 2005 at the Asan Medical Center, Korea. For diagnosing obstructive diseases, the accuracy of `0.7 of LLN for the FEV1/FVC` was evaluated in reference to the 5(th) percentile of the LLN. By applying the new algorithm, we determined how many more subjects should have lung volumes testing performed. Evaluation of 1611 patients who had lung volumes testing performed as well as spirometry during the period showed how many more subjects were diagnosed with obstructive diseases according to the new algorithm. Results: 1) The sensitivity of `0.7 of LLN for the FEV1/FVC` for diagnosing obstructive diseases increased according to age, but the specificity was decreased according to age; the positive predictive value decreased, but the negative predictive value increased. 2) By applying the new algorithm, 34.5% (2540/7362) more subjects should have lung volumes testing performed. 3) By applying the new algorithm, 13% (205/1611) more subjects were diagnosed with obstructive diseases; these subjects corresponded to 30% (205/681) of the subjects who had been diagnosed with restrictive diseases by the old interpretative algorithm. Conclusion: The sensitivity and specificity of `0.7 of LLN for the FEV1/FVC` for diagnosing obstructive diseases changes according to age. By applying the new interpretative algorithm, it was shown that more subjects should have lung volumes testing performed, and there was a higher probability of being diagnosed with obstructive diseases (Tuberc Respir Dis 2006; 61: 129-136)

누리과정의 효율적 운영을 위한 교육계획안의 평가 내용 분석

임승렬(Lim, Seung-Ryoul),정미라(Joung, Mi-Ra),김연미(Kim, Yeon-Mi) 한국어린이미디어학회 2016 어린이미디어연구 Vol.15 No.2

본 연구의 목적은 유치원과 어린이집 교사들이 작성한 교육계획안의 자유선택활동, 대․소집단활동, 실외활동 평가 내용 분석을 통해 교사의 평가에 대한 인식과 어려움, 작성 현황을 파악해 보고, 이를 통해 평가가 유아의 학습과 성장에 기여할 수 있는 방안을 모색하는데 있다. 연구 참여자들이 작성한 평가 내용을 살펴본 결과, 첫째, ‘교육목표 달성 여부’관련 평가는 거의 이루어지지 않았다. 둘째, ‘교육내용’관련 평가는 자유선택활동영역에서 가장 많이 이루어졌으며, ‘추가된 교육내용’에 관한 평가는 이루어지지 않았다. 셋째, ‘교수․학습 방법의 적합 여부’와 관련된 평가는 유치원 교사들 경우 대․소집단활동에서만 이루어졌고, 어린이집 교사들은 각 활동 모두에서 이루어졌다. 넷째, ‘운영 환경 구성’관련 평가는 총 평가 내용의 10% 미만으로 이루어졌으며, ‘운영 환경 구성’평가의 필요성에 대한 인식 수준이 낮게 나타났다. 다섯째, ‘유아 평가’는 자유선택활동에서 가장 낮게 나타났다. 또한 유아평가(유아의 발달, 흥미, 태도) 중 유아의 발달에 관한 평가가 가장 적었다. 그 외 ‘교사 감정’관련 평가는 거의 나타나지 않았다. 누리과정의 목적을 달성하기 위해 교사는 평가의 목적을 구체적으로 이해하고, 평가 결과를 다음 차시 교육계획에 적용하는 순환 구조의 중요성을 인식할 수 있어야 할 것이다. 이를 위해 구체적 지침을 통한 평가가 실시 될 수 있도록 교사의 재교육 등 교사 지원이 절실히 요구된다. The purpose of this study is to explore the assessment content of free-choice activities, large/small group activities, and outdoor activities of lesson plans written by kindergarten and daycare center teachers, and to find out methods on how writing lesson plans can contribute to the learning and development of children. Upon analyzing assessment contents of lesson plans, first, kindergarten teachers did not assess the achievement of learning objectives, and daycare center teachers conducted such assessment, meaning no assessment had been conducted rarely. Second, regarding assessment of education content, kindergarten teachers showed higher assessment rate than daycare center teachers. Third, in regards to the assessment of appropriateness of teaching and learning methods, assessment was conducted in large/small group activities for kindergarten teachers, while assessment was conducted in activities for all categories while for daycare center teachers. Fourth, regarding the management of teaching-learning environment composition analysis, daycare center teachers conducted approximately four times more assessments than kindergarten teachers. Fifth, in terms of assessment of children, kindergarten teachers showed higher assessment rate than daycare center teachers, and both teachers conducted the least amount of assessment during free-choice activities. Also assessment on development of children was also conducted the least. Moreover, assessment was conducted on the emotional status of teachers. Teachers of early childhood education are required to understand the details of the purpose of assessment, and teacher support such as reeducation of teachers, are desperately needed, so that assessment through detailed instructions can be conducted.

묵 형성 전분의 특성에 관한 연구

안승요,권미라,김성란,임경숙 한국농화학회 1992 Applied Biological Chemistry (Appl Biol Chem) Vol.35 No.2

Some physicochemical properties and molecular structure of cow pea, mung bean and acorn starches(mook-forming starches) and red bean, wheat and sweat potato starches(mook-unforming starches) were investigated. Amylose contents of cow pea, mung bean and acorn starch were higher than the others. Cow pea starch was similiar to mung bean starch in gelatinization characteristics by Brabender amylogram but cold viscosity of red bean starch and peak viscosity of sweet potato starch were especially high. Whereas viscosity of wheat starch was low in whole temperature range. Amylose molecules of larger molecular size(above 5×10^5 molecular weight) of three mook-forming starches were more than shoes of red bean and wheat starch. Chain distribution ratios(DP 35∼55 to DP 10∼20) of cow pea, mung bean and acorn amylopectin were higher than thoes of red bean, sweet potato and wheat amylopectin.