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Lee, Sang Hoon,Yeo, Yoomi,Kim, Tae-Hyung,Lee, Hong Lyeol,Lee, Jin Hwa,Park, Yong Bum,Park, Jong Sun,Kim, Yee Hyung,Song, Jin Woo,Jhun, Byung Woo,Kim, Hyun Jung,Park, Jinkyeong,Uh, Soo-Taek,Kim, Young The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia, which presents with a progressive worsening dyspnea, and thus a poor outcome. The members of the Korean Academy of Tuberculosis and Respiratory Diseases as well as the participating members of the Korea Interstitial Lung Disease Study Group drafted this clinical practice guideline for IPF management. This guideline includes a wide range of topics, including the epidemiology, pathogenesis, risk factors, clinical features, diagnosis, treatment, prognosis, and acute exacerbation of IPF in Korea. Additionally, we suggested the PICO for the use of pirfenidone and nintendanib and for lung transplantation for the treatment of patients with IPF through a systemic literature review using experts' help in conducting a meta-analysis. We recommend this guideline to physicians, other health care professionals, and government personnel in Korea, to facilitate the treatment of patients with IPF.
The Effect of Germination Temperature on Malt Quality of Malting Barely ‘Hopum’
Song-Yee Lee,Eun-Ju Song,Young-Eun Song,Hyun-Ah Han,Tae-Hee Kim,So-Hee Shin,So-Ra Choi 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The purpose of this study was to investigate malt characteristics according to the germination temperatures of tow-row variety ‘Hopum’. Hopum has been widely cultivated in Korea for beer-making. In this study, hopum material with germination rate of 97% was used and was malted at five temperatures, 10, 16, 18, 20, 25℃. The higher the germination temperature, the lower the malt yield, and EBC (European Brewery Convention) color index of the wort was darker. There was no significant differences in sugar content, pH and Kolbach index of malt germinated at a germination temperature of over the 16℃. Both α-amylase and β-amylase was induced in malts germinated at all temperatures. β-glucan remaining excessively in the malt makes it difficult to filter the wort during brewing, lowers the filtration rate, and causes problems such as haze and sediment formation in beer. In this experiment, the contents of β-glucan was lower as the germination temperature was higher. We intend to expand the diversity of beer brewing using domestic barley varieties by providing information on quality malt with different germination temperatures.
Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance
Song, Kwon-Ho,Kim, Jae-Hoon,Lee, Young-Ho,Bae, Hyun Cheol,Lee, Hyo-Jung,Woo, Seon Rang,Oh, Se Jin,Lee, Kyung-Mi,Yee, Cassian,Kim, Bo Wook American Society for Clinical Investigation 2018 The Journal of clinical investigation Vol.128 No.9
<P>The host immune system plays a pivotal role in the emergence of tumor cells that are refractory to multiple clinical interventions including immunotherapy, chemotherapy, and radiotherapy. Here, we examined the molecular mechanisms by which the immune system triggers cross-resistance to these interventions. By examining the biological changes in murine and tumor cells subjected to sequential rounds of in vitro or in vivo immune selection via cognate cytotoxic T lymphocytes, we found that multimodality resistance arises through a core metabolic reprogramming pathway instigated by epigenetic loss of the ATP synthase subunit ATP5H, which leads to ROS accumulation and HIF-1 alpha stabilization under normoxia. Furthermore, this pathway confers to tumor cells a stem-like and invasive phenotype. In vivo delivery of antioxidants reverses these phenotypic changes and resensitizes tumor cells to therapy. ATP5H loss in the tumor is strongly linked to failure of therapy, disease progression, and poor survival in patients with cancer. Collectively, our results reveal a mechanism underlying immune-driven multimodality resistance to cancer therapy and demonstrate that rational targeting of mitochondrial metabolic reprogramming in tumor cells may overcome this resistance. We believe these results hold important implications for the clinical management of cancer.</P>
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity
Lee, Eun-Young,Lee, Hyun-Cheol,Kim, Hyun-Kwan,Jang, Song Yee,Park, Seong-Jun,Kim, Yong-Hoon,Kim, Jong Hwan,Hwang, Jungwon,Kim, Jae-Hoon,Kim, Tae-Hwan,Arif, Abul,Kim, Seon-Young,Choi, Young-Ki,Lee, Che NATURE AMERICA INC 2016 NATURE IMMUNOLOGY Vol.17 No.11
<P>The mammalian cytoplasmic multi-tRNA synthetase complex (MSC) is a depot system that regulates non-translational cellular functions. Here we found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following viral infection and exhibited potent antiviral activity. Infection-specific phosphorylation of EPRS at Ser990 induced its dissociation from the MSC, after which it was guided to the antiviral signaling pathway, where it interacted with PCBP2, a negative regulator of mitochondrial antiviral signaling protein (MAVS) that is critical for antiviral immunity. This interaction blocked PCBP2-mediated ubiquitination of MAVS and ultimately suppressed viral replication. EPRS-haploid (Eprs(+/-)) mice showed enhanced viremia and inflammation and delayed viral clearance. This stimulus-inducible activation of MAVS by EPRS suggests an unexpected role for the MSC as a regulator of immune responses to viral infection.</P>