A superior dye adsorbent towards the hydrogen evolution reaction combining active sites and phase-engineering of (1T/2H) MoS₂/α-MoO₃ hybrid heterostructured nanoflowers

Manikandan, Arumugam,Ilango, P. Robert,Chen, Chia-Wei,Wang, Yi-Chung,Shih, Yu-Chuan,Lee, Ling,Wang, Zhiming M.,Ko, Hyunhyub,Chueh, Yu-Lun The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.31

<P>Here, we demonstrate the successful synthesis of (1T/2H) MoS2/α-MoO3 heterostructured nanoflowers at a low temperature of 200 °C by a one-step hydrothermal method. By tuning the reaction time under the influence of thiourea and hydrazine hydrate, we established a complete phase-engineered MoS2 with 1T and 2H phases on the surface of α-MoO3. Active sites associated with the phase-engineered (1T/2H) MoS2/α-MoO3 hybrid nanoflowers enable them to exhibit dual roles as a superior dye adsorbent and an electrocatalyst towards the hydrogen evolution reaction. The 2H-rich (1T/2H) MoS2/α-MoO3 hybrid heterostructured nanoflowers prepared at 16 h achieved a high surface area of 37.97 m<SUP>2</SUP> g<SUP>−1</SUP>, and 97% of the RhB dye with an initial concentration of 47.9 mg L<SUP>−1</SUP> was removed within 10 min through the adsorption process, which is the highest known removal efficiency reported in the literature. As a hydrogen evolution reaction (HER) electrocatalyst in acidic solution, the 1T-rich (1T/2H) MoS2/α-MoO3 hybrid heterostructured nanoflowers prepared at 12 h exhibited a highly efficient catalytic activity by achieving a low overpotential of 232 mV at a current density of 10 mA cm<SUP>−2</SUP>, which is comparable to those of previously reported HER catalysts based on MoS2. Moreover, this sample reached a low Tafel slope of 81 mV dec<SUP>−1</SUP> and was stable when operated for more than 1000 cycles.</P>

Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material.

Deering-Rice, Cassandra E,Johansen, Mark E,Roberts, Jessica K,Thomas, Karen C,Romero, Erin G,Lee, Jeewoo,Yost, Garold S,Veranth, John M,Reilly, Christopher A American Society for Pharmacology and Experimental 2012 Molecular pharmacology Vol.81 No.3

<P>Environmental particulate matter (PM) pollutants adversely affect human health, but the molecular basis is poorly understood. The ion channel transient receptor potential vanilloid-1 (TRPV1) has been implicated as a sensor for environmental PM and a mediator of adverse events in the respiratory tract. The objectives of this study were to determine whether TRPV1 can distinguish chemically and physically unique PM that represents important sources of air pollution; to elucidate the molecular basis of TRPV1 activation by PM; and to ascertain the contributions of TRPV1 to human lung cell and mouse lung tissue responses exposed to an insoluble PM agonist, coal fly ash (CFA1). The major findings of this study are that TRPV1 is activated by some, but not all of the prototype PM materials evaluated, with rank-ordered responses of CFA1 > diesel exhaust PM > crystalline silica; TRP melastatin-8 is also robustly activated by CFA1, whereas other TRP channels expressed by airway sensory neurons and lung epithelial cells that may also be activated by CFA1, including TRPs ankyrin 1 (A1), canonical 4α (C4α), M2, V2, V3, and V4, were either slightly (TRPA1) or not activated by CFA1; activation of TRPV1 by CFA1 occurs via cell surface interactions between the solid components of CFA1 and specific amino acid residues of TRPV1 that are localized in the putative pore-loop region; and activation of TRPV1 by CFA1 is not exclusive in mouse lungs but represents a pathway by which CFA1 affects the expression of selected genes in lung epithelial cells and airway tissue.</P>

Treatment of residual stress in failure assessment procedure

Lee, Hyeong-Yeon,Biglari, Farid R.,Wimpory, Robert,Nikbin, Kamran M. Pergamon Press 2006 Engineering fracture mechanics Vol.73 No.13

<P><B>Abstract</B></P><P>The effect of residual stress on component failure has been investigated using the distributions from current failure assessment procedures, and a residual stress profile simple to apply with less conservatism has been proposed for the weld geometries of T-plate and tubular T-joint. The stress intensity factors (SIFs) in the two weld geometries under various types of loads have been calculated using the Green’s function method. The Green’s functions were determined not only for the T-plate but also for the tubular T-joint with the built-in ends. The use of a linear (bending) stress profile, derived from an analysis of measured residual stress distributions in T-plate and tubular T-joints, has been examined. The profile was validated with experimentally measured residual stress distributions in two materials, a high strength and medium strength ferritic steel and two geometries, a T-plate joint and a tubular T-joint for crack lengths up to half the plate or pipe thickness. Whereas the recommended residual stress distributions are geometry and material specific, it is shown that a simplified linear bending profile provides a possible guideline, applicable to a range of materials and geometries, where detailed information on weld procedures or residual stress profiles are unavailable.</P>

Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

Lee, Sunho,Kim, Changhoon,Ann, Jihyae,Thorat, Shivaji A.,Kim, Eunhye,Park, Jongmi,Choi, Sun,Blumberg, Peter M.,Frank-Foltyn, Robert,Bahrenberg, Gregor,Stockhausen, Hannelore,Christoph, Thomas,Lee, Jee Pergamon Press 2017 Bioorganic & medicinal chemistry letters Vol.27 No.18

<P><B>Abstract</B></P> <P>A series of 1-substituted 3-(<I>t</I>-butyl/trifluoromethyl)pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides were investigated for <I>h</I>TRPV1 antagonism. The structure activity relationship indicated that the 3-chlorophenyl group at the 1-position of pyrazole was the optimized hydrophobic group for antagonistic potency and the activity was stereospecific to the <I>S</I>-configuration, providing exceptionally potent antagonists <B>13<I>S</I> </B> and <B>16<I>S</I> </B> with <I>K<SUB>i(CAP)</SUB> </I> =0.1nM. Particularly significant, <B>13<I>S</I> </B> exhibited antagonism selective for capsaicin and NADA and not for low pH or elevated temperature. Both compounds also proved to be very potent antagonists for <I>r</I>TRPV1, blocking <I>in vivo</I> the hypothermic action of capsaicin, consistent with their <I>in vitro</I> mechanism. The docking study of compounds <B>13<I>S</I> </B> and <B>16<I>S</I> </B> in our <I>h</I>TRPV1 homology model indicated that the binding modes differed somewhat, with that of <B>13<I>S</I> </B> more closely resembling that of <B>GRT12360</B>.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Widespread persistence of expanded East Antarctic glaciers in the southwest Ross Sea during the last deglaciation

Lee, Jae Il,McKay, Robert M.,Golledge, Nicholas R.,Yoon, Ho Il,Yoo, Kyu-Cheul,Kim, Hyoung Jun,Hong, Jong Kuk Geological Society of America 2017 Geology Vol.45 No.5

<P>It has been suggested that the grounding line of the Last Glacial Maximum (LGM) ice sheet in the Ross Sea, Antarctica, receded in an approximately north-to-south pattern during the Holocene. An implication of this hypothesis is that geological evidence from the southwestern Ross Sea has been used widely to interpret retreat histories of the West Antarctic Ice Sheet (WAIS) across the wider Ross Sea embayment. Accurately constraining the timing and pattern of marine-based ice sheet retreat in this embayment is critical to understanding the drivers that may have triggered this event, and its contribution to rapid sea-level rise events. Here, we present new multibeam swath bathymetry data that identifies well-preserved glacial features indicating that thick (>700 m) marine-based ice derived from the East Antarctic Ice Sheet coastal outlet glaciers dominated the ice sheet input into the southwestern Ross Sea during the last phases of glaciation. Subglacial geomorphic features indicate that ice derived from present outlet glacier valleys in South Victoria Land flowed southeastward. This is more consistent with flowlines from model-based interpretations of an earlier retreat of the WAIS in the central Ross Sea than with previous land-based geological reconstructions. This implies that coastal records of deglaciation along the Transantarctic Mountains front record only the final phases of glacial retreat in the Ross Sea. Therefore, chronological data from the central embayment are required to accurately constrain the timing of large-scale glacial retreat in the Ross Sea and to identify the mechanisms that drove it.</P>

Critique of Japan as an East-West Literary Hybrid in Yoko Tawada’s Kafka Kaikoku

Lee M. Roberts 한국외국어교육학회 2017 Foreign languages education Vol.24 No.2

Yoko Tawada’s drama Kafka Kaikoku (2013) depicts Japan’s encounter with Western culture from the Meiji era on as the catalyst for a metamorphosis much like Gregor Samsa’s in the work of the same name by Franz Kafka. Ironically, the victim of this East-West clash turns out to be Izumi Kyōka (1873- 1939), a man who was anything but an enthusiastic adopter of European literary style. Interweaving elements also from Kafka’s Ein Landarzt (A Country Doctor, 1919), Tawada’s play suggests further that Izumi’s fate was set, since he—and, by extension, all Japanese—could not resist roles the West had prepared for him. Ultimately, this article explains, Kafka Kaikoku offers a critical view of modernization as a force that made Japanese into beings with a hybrid literary consciousness who lacked both much of their own native particularity and also their very humanity.

Global relationships of total alkalinity with salinity and temperature in surface waters of the world's oceans

Lee, Kitack,Tong, Lan T.,Millero, Frank J.,Sabine, Christopher L.,Dickson, Andrew G.,Goyet, Catherine,Park, Geun-Ha,Wanninkhof, Rik,Feely, Richard A.,Key, Robert M. American Geophysical Union 2006 Geophysical research letters Vol.33 No.19

Several Regions in the Major Histocompatibility Complex Confer Risk for Anti-CCP-Antibody Positive Rheumatoid Arthritis, Independent of the DRB1 Locus

Lee, Hye-Soon,Lee, Annette T.,Criswell, Lindsey A.,Seldin, Michael F.,Amos, Christopher I.,Carulli, John P.,Navarrete, Cristina,Remmers, Elaine F.,Kastner, Daniel L.,Plenge, Robert M.,Li, Wentian,Greg Springer (Biomed Central Ltd.) 2008 Molecular Medicine Vol.14 No.5

<P>Recent evidence suggests that additional risk loci for RA are present in the major histocompatibility complex (MHC), independent of the class II HLA-DRB1 locus. We have now tested a total of 1,769 SNPs across 7.5Mb of the MHC located from 6p22.2 (26.03 Mb) to 6p21.32 (33.59 Mb) derived from the Illumina 550K Beadchip (Illumina, San Diego, CA, USA). For an initial analysis in the whole dataset (869 RA CCP + cases, 1,193 controls), the strongest association signal was observed in markers near the HLA-DRB1 locus, with additional evidence for association extending out into the Class I HLA region. To avoid confounding that may arise due to linkage disequilibrium with DRB1 alleles, we analyzed a subset of the data by matching cases and controls by DRB1 genotype (both alleles matched 1:1), yielding a set of 372 cases with 372 controls. This analysis revealed the presence of at least two regions of association with RA in the Class I region, independent of DRB1 genotype. SNP alleles found on the conserved A1-B8-DR3 (8.1) haplotype show the strongest evidence of positive association (P ~ 0.00005) clustered in the region around the HLA-C locus. In addition, we identified risk alleles that are not present on the 8.1 haplotype, with maximal association signals (P ~ 0.001-0.0027) located near the ZNF311 locus. This latter association is enriched in DRB1*0404 individuals. Finally, several additional association signals were found in the extreme centromeric portion of the MHC, in regions containing the DOB1, TAP2, DPB1, and COL11A2 genes. These data emphasize that further analysis of the MHC is likely to reveal genetic risk factors for rheumatoid arthritis that are independent of the DRB1 shared epitope alleles.</P>

Craniopharyngiomas : Radiological Differentiation of Two Types

Lee, In Ho,Zan, Elcin,Bell, W. Robert,Burger, Peter C.,Sung, Heejong,Yousem, David M. The Korean Neurosurgical Society 2016 Journal of Korean neurosurgical society Vol.59 No.5

Objective : To determine imaging features that may separate adamantinomatous and papillary variants of craniopharyngiomas given that tumors with adamantinomatous signature features are associated with higher recurrence rates, morbidity, and mortality. We specifically reviewed calcification on CT, T1 bright signal intensity, and cystic change on T2 weighted images for differentiating these two types. Methods : We retrospectively reviewed the MRI and CT studies in 38 consecutive patients with pathologically proven craniopharyngiomas between January 2004 and February 2014 for the presence of calcification on CT scans, bright signal intensity on T1 weighted images, and cystic change on T2 weighted images. Results : Of the 38 craniopharyngiomas, 30 were adamantinomatous type and 8 were papillary type. On CT scans, calcification was present in 25 of 38 tumors. All calcified tumors were adamantinomatous type. Twenty four of 38 tumors had bright signal intensity on T1 weighted images. Of these 24 tumors, 22 (91.7%) were adamantinomatous and 2 were papillary type. Cystic change on T2 weighted images was noted in 37 of 38 tumors; only 1 tumor with papillary type did not show cystic change. Conclusion : T1 bright signal intensity and calcification on CT scans uniformly favor the adamantinomatous type over papillary type of craniopharyngioma in children. However, these findings are more variable in adults where calcification and T1 bright signal intensity occur in 70.6% and 58.8% respectively of adult adamantinomatous types of craniopharyngiomas.

Critique of Japan as an East-West Literary Hybrid in Yoko Tawada’s Kafka Kaikoku

Lee M. Roberts 서울대학교 외국어교육연구소 2017 외국어교육연구 Vol.20 No.-

Yoko Tawada’s drama Kafka Kaikoku (2013) depicts Japan’s encounter with Western culture from the Meiji era on as the catalyst for a metamorphosis much like Gregor Samsa’s in the work of the same name by Franz Kafka. Ironically, the victim of this East-West clash turns out to be Izumi Kyōka (1873-1939), a man who was anything but an enthusiastic adopter of European literary style. Interweaving elements also from Kafka’s Ein Landarzt (A Country Doctor, 1919), Tawada’s play suggests further that Izumi’s fate was set, since he—and, by extension, all Japanese—could not resist roles the West had prepared for him. Ultimately, this article explains, Kafka Kaikoku offers a critical view of modernization as a force that made Japanese into beings with a hybrid literary consciousness who lacked both much of their own native particularity and also their very humanity.