급성백혈병의 화학요법에서 조혈간세포 보충요법

이규보,배선근,손상균,이재태,이건수,이경혜,서장수 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

1. 목적 급성백혈병의 화학요법에 있어서 관해유도 요법시에 보다 더 강력한 항암화학요법을 시행하고 골수억제의 회복을 위하여 말초혈액에서 채취한 조혈모세포의 투여로 그 효과를 증대시키고자 시도하였다. 2. 방법 관해유도 화학요법후에 골수억제시기로부터 회복단계로서 백혈구감소증이 호전도면서 단핵세포가 증가될 때에 말초혈액에서 조혈간세포(stem cell)로 인정되고 있는 CD34+세포의 함유량이 1% 이상되는 시기를 찾아내고 그 때부터 평균 4차례의 단핵구를 분리채집을 하여 -74。C에 냉동보관하였다가 제2차 화학요법후에 해동시켜서 정맥주입하였다. 3. 결과 대상 급성백혈병환자는 6명에 23회의 조혈간세포를 함유한 단핵구 채집을 시행하였고 유효한 단핵구의 채집은 4례에서 가능하였고 2례에서는 유효한 채집이 못되었다. 채집효율은 39.0-74.5%로서 평균 49.8%였다. 채집 후에 혈액학적 변화는 혈색소의 약간 감소 (평균 1.34g/dl)와 혈소판의 감소 (평균20.25%)를 나타내었다. 해동 단핵구를 투여할시에 일과성인 불쾌감, 기침, 흉부압박감, 호흡곤란 등이 있었다. 4. 결론 자가골수이식에서 자기말초혈액조혈간세포이식으로 관심이 이행되는 현시점에 자가조혈간세포를 채집하여 수혈하는 기술이 확립되는 기초를 이루었다고 본다. 이번 대상들은 재발된 금성백혈병들에 시행하였으나, 향후에는 초발시에 제일차 관해유도 화학요법 과정에 시도해야할 것으로 생각한다. Object: Peripheral blood stem cells(PBSC) were collected after remission induction chemotherapy and reinfused after intensified chemotherapy in order to increase the chemotherapeutic efficacy. Method: Collection of mononuclear cells (MNC) was started when CD34+ cells above 1% and WBC above 1,000/ul with mononuclear cell percentage above 30%, the collection procedures were done 2-6 time in each patient of total 6 cases. The collected MNCs were stored in - 750C and reinfused after thawing in the water bath at 370C Results: Twenty three collection procedures from the 6 cases of acute leukemia had made effective MNC collection in 4 cases and mean collection efficiency was 49.8%(from 39.0% to 74.5%). Hematological changes after the procedure were mean reduction of hemoglobin 1.34g/dl and mean 20.25% of decreased platelet count. There were noticed transient symptoms of discomfort, coughing, chest tightness and dyspnea in association with the infusion of stored cells. Conclusion: The basic process for the peripheral blood stem cell transplantation (PBSCT) was accomplished with this supportive care for the consolidation chemotherapy of acute leukemia. Effective PBSCT would be warrented with more qualified process and high does chemotherapy. (Korean J Blood Transfus 6(2) : 41~47,1995)

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

한국인 환자에서 Vancomycin의 집단약동학 (Population Pharmacokinetics)에 관한 연구

유경상,배균섭,이주연,조주연,장인진,신상구,신완균 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

킬레이트수지 흡착제에 의한 제강더스트 침출수의 금속이온 흡착 및 농축에 관한 연구

이성식,이경화,최금찬,전성균 東亞大學校 大學院 1997 大學院論文集 Vol.22 No.-

The major constituents in domestic steelmaking dust are Fe, Zn, Na, Si, K, Cu, Mn and Pb and other such as Al, Mg, W, Cr, Cu, Ba, Ni, Mo and B are contended. High concentration of Al, Cu, Fe, Mn, Ni and Zn could be well leached with 2.5mol/dm?-H?SO? as leachant. However, the metals in domestic steelmaking dust are less idssolved with 3.0mol/dm?-NaOH except boron. Copper, aluminum, iron and boron in the leaching solution with 3.0mol/dm?-NaOH were concentrated by adsorption-desorption through column packed with a glucamin type chelate resin sorbents. Boron was selectively separated and concentrated by adsorption-desorption process with chelate resin from 82.9mg/dm? in the pH 8.5 of leaching solution to 945mg/dm? in elute solution.

평생건강교실 프로그램이 노년기 여성들의 건강관련체력과 혈중지질에 미치는 영향

장경태,이규성,안종철,김문희,이미화,오재근 韓國體育大學校 1998 論文集 Vol.21 No.-

The purpose of this study were to investigate the effects of participation of health program on health related physical fitness and blood lipids in olderwomen. The subjects participated in this study were 52 older who were participated physical activity program in Korean National University of Physical Education. The analysis of this study utilized one way ANOVA design. The results of the study were as follows : 1. According to taking the treatment periods(0, 6, 12), body composition, hand grip, sit and reach, sit up, and 3200m walking were no significant difference. 3. According to taking the treatment periods(0, 6, 12), TC, TG, LDL-C, HDL-C and VLDL-C were a significant difference in p<.001 levels.

강건 설계를 이용한 전자제품 신뢰성 향상방법

김경모,이지수,신호균 金烏工科大學校 1997 論文集 Vol.18 No.-

Reliability is one of the important quality factor in electronic products. As it is time-consuming to estimate mean time to failure, it has not been integrated in the process of product design. In this study, we propose a method which can optimize the product with respect to robustness design and can estimate mean time to failure of electronic products by only one experimentation. This proposed method can quarantee quality improvement by making the life time of the designed products robust to customer's environment. We explaine the detailed steps of this proposed method through a case study.

신생아에서 용질배설에 관한 연구

김경범,박재현,최병민,이현희,윤재균 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

Purpose : Determination of urinary concentration in neonate is mandatory for precise management of fluid and electrolyte requirements. Although measurement of urine specific gravity has been proposed far monitoring fluid requirements, the reliability of specific gravity does not accurately predict urine osmolalities in the neonate period. So specific gravity should be checked by measuring the osmolality. Also the urinary excretion of creatinine has been used for the assessment of hydration state. We present the result of specific gravity, urine osmolality, urine creatinine in a spot urine sample during the first week of life as a reliable reference standard. Methods : Spontaneously-voided urine sample were obtained in 40 full term neonates. Two urine samples were available with a interval of 4 to 7days (A: 1st day, B: 4 - 7days), Urine sample was tested for specific gravity with a strip test. Also urinary osmolality, urinary creatinine, urinary creatinine/osmolality ratio were measured. Results : The mean of specific gravity tested by the strip test was 1.006±0.0040 (A) , 1.005±0.0036 (B). The mean of urine osmolality and creatinine were 177.7 ± 103.0 and 30.9±21.6 (A), 145.7 ±90.3 and 26.4± 17.7 (B). The mean of excretion rate of urine creatinine/osmolality ratio was 18.2 ±8.5 (A), 19.4 ±9.1 (B). There was correlation between urine specific gravity and osmolality in neonate(r=0.833(A), 0.842(B) p<0.001). Urinary creatinine/osmolality levels of the first urine samples were closely correlated with the second samples (r=0.617, p<0.001). Conclusion : Specific gravity of urine was enough to predict the osmolality in neonate. But Specific gravity should be checked by measuring the osmolality of urine. Urine osmolality and creatinine were spread over a wider range and did not used to urinary excretion of solute in neonate. Urinary creatinine/osmolality ratio can be used to standadise the urinary excretion on solute in the first week of life.

태산반석산이 면역기능에 미치는 영향

남경수,김희진,이태균 동국대학교 생명과학연구소 1995 생명과학연구논문집 Vol.2 No.-

To invesitigate the immunoadjuvant effect of Taesanbanseok-san(TBS), TBS was pretreated to Ballb/c mice for 10 days with intraperitioneally. After 10 days, haptenic antigen (VCR-BSA, vincristine-bovine serum albumin) complexed with Freund's complete adjuvant was immunized. The results are as follows. The antibody production in Balb/c mouse immunized with VCR-BSA was markably increased in the pretreated group of TBS compared with saline treated(control) group. The number of macrophage in Balb/c mouse immunized with VCR-BSA was considerably increased about 2.3 times in the pretreated group of TBS compared with control group. The lysozyme activity of macrophage in Balb/c mouse that was immunized with VCR-BSA was increased gradually in the pretreated groups of TBS compared with control group. In the TBS pretreated group, B cell proliferation was increased with a dose dependent manner. At the concentration of twenty microliter/well of TBS, B cell proliferation activity was most highest. On the other hand, in the T proliferation, TBS pretreated group had less considerable activity than B cell proliferation. These results may suggest that TBS will have immunoadjuvant effects on the cells which concerned with immuno mechanism.

화상으로 인한 소구증 환자의 치험례

지재휴,이병준,김영균,김수관,황경곤,여환호,박인순 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Deep burns of the face & lips often lead to scarring and contraction of the circum-oral tissues with a marked reduction in the size of the oral aperture. Such burns most commonly caused by electrical contact, for example, children sucking electric plugs, or as a result of chemical burns and the exposture to flame. Once having burns, burned tissue may contract and reduce considerably the size and mobility of the mouth ; therefore bring up the resultant functional disturbance, verbal difficulty, even disgestive difficulty, and poor appearance, which fall into difficulty in social acceptability, caused by burns. In our department, 2 patients who were complain of functional limitations and esthetic problem owing to scar contracture, were visited, and we treated this microstomia with scar excision, graft and flap technique, and postoperative intensive physical therapy. We obtained relatively favorable results, thus report this cases with literature review.

총수담관결찰이 백서 신세뇨관의 S-100 면역반응에 미치는 영향

金天浩,李永浩,朴景蘭,申台均,金源式 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

For the study on the changes of S-100 reactivity at the renal tubular epithelium of rats(SpragueDawley, b.w. 250± 20gm. male), the common bile duct ligation was performed under ether anesthesia. At 1st, 3rd, 5th and 7th day after operation, the S-100 immunoreactivity were compared with control rats. The results were as followings; 1. In the control rat, S-100 positive reactions were observed at the collectiong tubule, Henle's loop, distal tubule(partly) and renal papilla. 2. In common bile duct ligated rats, S-100 positive reactions were observed at the proximal convoluted tubule in the rats 1 day after operation, and at the collecting tubule and proximal convoluted tubule in the 3 days after operation.