Baclofen 投與에 따른 精神分裂症 患者의 血淸 成長호르몬의 反應

李圭煥,白仁浩,高孝進,李正杓,咸雄,李奎恒 서울醫大 1990 精神醫學 Vol.15 No.1

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

논문 : 동북아지역(東北亞地域)에서의 다뉴경(多뉴鏡) 부장묘(副葬墓)의 전개(展開)

이청규 ( Chung Kyu Lee ) 단국사학회 2012 史學志 Vol.44 No.-

청동기는 생업도구의 수준에서 벗어나 전쟁무기와 종교의기로 제작·보급되었다. 이논문은 종교의기이자 무구(巫具)로서 제사장들이 보유했던 청동거울, 그 가운데서도 다뉴경을 중심으로 다뉴경이 부장된 무덤들의 역사문화적 의미를 고찰한다. 다뉴경은 대릉하유역부터 한반도를 거쳐 일본 구주(九州)지역에 이르는 범(汎) 십이대영 자문화권(十二臺營子文化圈)을 나타내는 유물이다. 다뉴경 부장묘는 이 문화권에 속한 고조선, 부여, 한 왜(倭)의 범주에 속하는 소국(小國)들의 수장들의 무덤으로서, 다뉴경뿐만 아니라 다른 청동기 및 토기부장품들이 부장되어 있다. 이 부장품들은 당시의 chiefdom 사회의 수장들을 중심으로 한 정치상황뿐만 아니라 범 대영자문화권 내의 기술교류를 반영한다. 다뉴경은 중국 동북지역에서 한반도와 일본열도에 걸쳐 당시 엘리트들이 제사장의 신분과 지위를 과시하는 위세품인데, 전파과정에 따라 대릉하지역의 A형 다뉴경, 요동과 길림지역의 B형 다뉴경, 한반도 서남부와 일본 구주지역의 C형 다뉴경으로 발전되어갔다. A형 다뉴경으로부터 B형 다뉴경의 등장은 연(燕)나라의 동진으로 고조선의 강역이 이동한 것에 기인한다. C형 다뉴경은 중국 동북지역에서는 발견되지 않고 한반도 서북한과 서남한 지역, 일본 구주(九州)지역에서 발견된다. 이는 다뉴경을 최고 위세품으로 채용하는 계층이 상위급 수장(首長)에서 차상급 이하의 엘리트로 내려갔음과 일본 구주 지역의 소국들이 한반도 서남부지역의 마한(馬韓)지역과 교류하고 있었음을 보여준다. The geometric-design bronze mirrors of which numbers about 80, are assumed to be as ritual tools and political symbols of priest-king during the 8th~2nd century BCE. Those are classified into three types, that are A, B, and C, and each of them is assumed to be made and used in 800~400BCE, 400~200BCE, and 200~50BCE. The distributional range of three types were changed under the historical conditions, which includes Yen(燕)`s advance toward the northeastern China and Wiman(衛滿) becoming a king of Gojoseon(古朝鮮). The first A type mirrors were distributed mainly in northeastern China, B type ones in the geographical range from northeastern China to the Korean peninsular, and C type ones from the Korean peninsular to the Japanese archipelago. The size and numbers of mirrors are reflective of the social position of the person with whom are buried in the grave, and so the graves with mirrors in each type are those of the most unfluential leaders of ``Kuk(國)``―the political and regional groups at the time. In A type mirror stage, the graves with most abundant artefacts are located in Liaoning pronince(遼寧省); the graves with most abundant artefacts in B type mirror stage are in Chung-nam(忠南) province; and the graves with C type mirrors in Cheon-nam(全南) province. Each region with those burials was the trade-center in Korea connecting China and Japan, and is assumed to be the location of the most influential ``Kuk(國)`` in old Korea.

Infliximab으로 호전된 장관 증상없이 발생한 구강-안면 크론병

정보용 ( Bo Yong Jung ),이석호 ( Suck Ho Lee ),정승규 ( Seung Kyu Chung ),이창균 ( Chang Kyun Lee1 ),이태훈 ( Tae Hoon Lee ),정일권 ( Il Kwun Chung ),김선주 ( Sun Joo Kim ),조현득 ( Hyun Deuk Cho ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6

Crohn`s disease is a chronic inflammatory bowel disease that can involve the whole gastrointestinal tract. The orofacial manifestation of Crohn`s disease, which is rare, can develop irrespective of intestinal involvement. These orofacial lesions are often misdiagnosed as simple oral ulcers. Corticosteroids are the mainstay of therapy for orofacial Crohn`s disease. However, infliximab, the chimeric monoclonal antibody to tumor necrosis factor-α, is now considered as a primary treatment because of the disease`s relatively high rate of steroid resistance. We present a case of deep oral ulcer and periorbital swelling in a 65-year-old woman. She was diagnosed with intestinal Crohn`s disease 7 years ago, which was in remission after treatment with an immunosuppressive agent (azathioprine). The patient was given the diagnosed with orofacial Crohn`s disease and successfully treated with infliximab. (Korean J Gastroenterol 2012;59:437-440)

티타늄 임플랜트의 표면 마무리 상태 및 NaOH 수용액 침적이 유사체액 중에서의 인산칼슘 석출에 미치는 영향

정회웅,최규형,이민호,배태성 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.3

The purpose of this study was to examine whether the precipitation of calcium phosphate on titanium implant are affected by surface modification. To improve the bone conductivity of the Cheil implant(Cheil Pharma & Instrument Inc), samples were divided into 3 groups. Group 1 was untreated, group 2 was immersed in 5M-NaOH solution at 60℃ for 24 hours, and group 3 was immersed in 5M-NaOH solution at 60℃ for 24 hours and heat-treated at 600℃ for 1 hour. And then, all specimens were immersed in the MEM Eagle's medium whose composition was similar to that of extracellular fluid for 30 days. After immersion, the surfaces were observed with scanning electron microscope. The results obtained were summarized as follows; 1. The surface of Branemark implant showed more regular and smooth machined surface than that of Cheil implant. 2. The precipitation of the calcium phosphate on implant surface was increased by the immersion in the NaOH solution, and more highly accelerated by heat treatment. 3. The precipitation of the calcium phosphate on titanium implant was lower than that on the polished titanium surface.

乳齒와 後續 永久齒 近遠心 幅經의 相關關係에 關한 硏究

李斗熙,鄭圭林,李起受 대한치과교정학회 1985 대한치과교정학회지 Vol.15 No.2

The primary objective of this study is to estimate of the mesiodistal crown diameters of the unerupted permanent successors derived from the mesiodistal crown diameters of the deciduous teeth in Korean population. The subjects were 54 individuals (twenty nine boys and twenty five girls) with normal occlusion aged 6 to 13 years. The mesiodistal crown diameters of the deciduous and the successional permanent teeth were measured from the longitudinal dental cast models using the sliding calipers(Mitutoyo Co.). From the study, the results are as follows; 1. Sex differences of mesiodistal crown diameters were less in the deciduous teeth, but male were more than that of female in the successional permanent teeth. 2. The mesiondistal crown diameters of the deciduous central incisors, lateral incisors, canines were smaller than that of the successional permanent teeth and the deciduous 1st molars, and 2nd molars were more larger than that of the successional permanent teeth. 3. Size differences between sum of the mesiodistal crown diameters of central incisors and lateral incisors in the decidous teeth and the successional permanent teeth were 7.20 ±1.79mm in upper, 5.38 ±1.64mm in lower and that of canine, 1st molar 2nd molar in the deciduous teeth and the successional permanent teeth were 0.56 ±1.19mm in upper, 2.22 ±1.19mm in lower. 4. In male, the correlation coefficients between the upper deciduous central incisor and the successional permanent tooth (r=0.57) and in female, the correlation coefficients between the upper deciduous 1st molar and the successional permanent tooth (r=0.67) appeared the highest. 5. The regression constants determined to estimate the mesiodistal crown diameters of the unerupted successional permanent teeth.

제주도 高山里 출토 隆起文土器

李淸圭 제주대학교 탐라문화연구소 1989 탐라문화 Vol.0 No.9

위의 한국 융기문토기의 연구성과를 종합할 때, 고산리 융기문토기는 북쪽으로 Amurr강 유역에서부터 한반도 동해안과 남해안을 따라 잇는 분포 영역의 최남단에 위치하며, 융기문토기 중 이른바 태선 융기문 형식에서도 기하학적인 융기문 형식에 들어간다. 공반되는 석기로 다른 지역과 마찬가지로 고식의 박편석기가 있고, 가장 유사한 형식의 토기가 출토한 부산 동삼동 패총 최하층의 방사성 탄소연대로 볼 때, 그 추정연대는 기원전 4000~3000년경인 바, 장래 새로운 자료가 확인되기까지 섬으로서의 제주도에 처음 사람이 살았던 것을 보여주는 증거가 되겠다.

Mitomycin이 Mouse의 肝細胞 내 Pyronin 好性顆粒에 미치는 影響

鄭鎬三,李圭植,白斗鎭 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.1

Mitomycin, one of the mitosane antibiotics, is isolated from Streptomyces caespitosus which has anticancer effect. It is well known that mitomycin inhibites DNA synthesis in mammalian cells. The major machanism accounting for the inhibitory effect of mitomycin is interference of the template activities of the DNA by cross linking to DNA double helix. The auther has investigated the effect of mitomycin on the liver of mice, observing the distribution and disaggregation of the pyroninophilic granules in the hepatic parenchymal cells. A total of 52 healthy mice of ICR strain (the weight 20g) were divided into two groups; The control and the mitomycin treated groups. All experimental animals were given food and water ad libitum. The animals of the mitomycin treated groups were administered 4mg per kg of body weight of mitomycin diluted in the water for injection by intraperitoneal injection. The animals of the MC treated groups were sacrified at intervals of 6, 12, 24 and 36 hours after administration of mitomycin Histochemical preparations were stained with the methyl green-pyronin method for the pyroninophilic granules in the hepatic parenchymal cells. A marked reduction or disappearance of the pyroninophilic granules were observed in the entire hepatic lobule at 24 hours after administration of mitomycin. Consequently, it is suggested that mitomycin causes the loss of pyroninophilic granules in the hepatic parenchymal cells of the liver in the mitomycin treated mice.

흰쥐 肝臟의 組織發生에 관한 組織化學的 및 電子顯微鏡的 硏究

鄭鎬三,李圭植,張世榮 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.1

Numerous workers have intensively studied for physological and histochemical aspects on the histogenesis and differentiation of mammalian livers focusing attention on its hematopoietic function. In early fetal life hepatic diverticulum formed caudal part of the foregut in separated into two parts by the mesodermal septum each being developed into primordia later. The author has undertaken histological and histochemical studies to persue the morphological and functional changes to occur in hepatic lobules during development and differential period. The pregnant albino rats, Wistar strain, were sacrificed every day starting from 15th to 20th day of gestation. The specimens obtained from the fetal liver were fixed with 10% formalin and stained with hematoxylin-eosin to observe the morphological development and differentiation of the liver. The activities of acid and alkaline phosphatase were observed by the Gomori's methods(1931, 1941) and ATPase activity by the Wachstein-Meisel's method(1957). And also another liver specimens fixed with 4% glutaraldehyde in 0.1M cacodylate buffer(pH 7.4) at 4℃ by the Eranko's method(1952) were examined with electron microscope to investigate phosphatase activities in the hepatic parenchymal cells. The results were as follows. 1. In the liver of the 15th day of the fetus, undifferentiated hepatic parenchymal cells were constituted and a few nucleated erythocytes were spread at the intercellular region, and at the 16th and 17th day of the fetus a number of hematocytoblast were distributed and primitive hepatic cord and hepatic sinusoid were formed. 2. In the Liver of the 18th, 19th and 20th day of the fetus, hematopoietic cells were reduced but the differentiation of he hepatic parenchymal cells, hepatic cord and hepatic sinusoid were observed. 3. The activity of the acid phosphatase increased from the 17th to 20th day of the fetus. High activity of the enzyme at the peripheral and central zone and trace activity at the lysosome and rough endoplasmic reticulum were observed. 4. Moderate activity of the alkaline phosphatase was observed in the liver of the 19th and 20th day of the fetus at the nuclear membrane of the parenchymal cell and at the villi of the bile canaliculi. 5. The activity of the adenosine triphosphatase was observed in the liver of the 18th day of the fetus, and positive activity at the plasma membrane and weak activity at the rough endoplasmic reticulum were observed at the 19th and 20th day of the fetus, respectively.

Mitomycin이 Mouse 간장의 인산염분해 효소에 미치는 영향

정호삼,신규석,이군자,이규식 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1

Mitomycin (MC), a wide spectrum antibiotic and anticancer drug, is isolated from streptomyces caespitosus. MC decomposes DNA in cancer cell by forming a complex with DNA and inhibits division of cancer cells by interfering with the biosynthesis of DNA. In the normal cell, MC cross linkes with DNA and inhibits synthesis of RNA and protein. Therefore MC causes many complication in the MC treated patient. The authers have investigated the effect of MC on the mouse liver histochemically observing the change in the activities of alkaline phosphatase and ATPaes. Male mouse, DDY strain, weighing about 20 grams was used as experimental animals. The experimental animals were divided into the control and MC treated group and given food and water unlimited. The animals treated with 4mg of MC per kilogram of body weight were sacrificed at 6, 12, 24, 36 and 48 hour after administration. The animals of control groups were administered only water for injection. The liver specimens were fixed in 10% formalin solution at 4℃ and sliced at 14㎛ thickness in a frozen cryostat. The activities of alkaline phosphatase were observed by the Gormori's method and those of ATPase were observed by the Wachstein-Meisel's method for histochemical study. The result are as follows. 1. As the time passed, the activity of alkaline phosphatase activity was decreased in the hepatic lobule. Negative reactions were showed in the central and intermediate zone of the lobule of 36 hours of MC treated group. Trace activities of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. 2. As the time goes by, the activity of adenosine triphosphatase was decreased in the hepatic lobule. Negative reactions were observed in the entire hepatic lobule of 36 hours of MC treated group. Weak activity of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. Consequently, it is suggested that MC causes decrease in activities of hepatic alkaline phosphatase and ATPase due to live damage by cross linking of DNA with the drug in the hepatocyte and destructive change of organelles of the cell.