정신과 외래환자의 약물치료 반응과 심박동 변이의 변화 양상

이상규,이홍석,김인주,김형태,김도훈,손봉기 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : The purpose of this study was to investigate the change of heart rate variability after antidepressant treatment in depressed or anxious patients. We tried to find the usefulness of heart rate variability as a predictive marker of response to pharmacological treatments in the psychiatric field. Methods : Forty-seven patients with major depression, anxiety disorder, and somatoform disorder were treated over 4 weeks with antidepressants and were then classified as responders or nonresponders according to Hamilton depression scales or CGI scores. The HRV variables were measured and compared among the responders/nonresponders and the matched normal control. Results : The responders group exhibited low heart rate, low PSI, high SDNN, RMSSD, HRV index, NN50, pNN50, LNTP, LNLF, and LNHF compared with the nonresponders after 4 weeks antidepressant treatment. However, no significant differencein HRV vanables was observed between the responders group after treatment and the nonnal control group and the responsegroup after treatment. Conclusion : These results indicate that HRV variables would are normalized after successful antidepressant treatment and it that HRV has some possible uses as a predicting marker of antidepressant response.

치과용 금합금에 대한 금속 프라이머 처리와 열순환 처리가 교정용 브라켓의 전단결합강도에 미치는 영향

이영기,차정열,유형석,황충주 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.5

치과용 금합금에 교정용 브라켓 접착 시 금속 프라이머와 열순환 처리가 전단결합강도에 미치는 영향을 알아보기 위하여 80개의 치과용 금합금 시편을 샌드블라스팅만 처리한 군과 3종류의 금속 프라이머(Alloy Primer, Metaltite, V-Primer)처리를 시행한 군으로 분류하고, 이를 열순환 처리 시행 여부에 따라 모두 8개 군으로 분류하였다. 만능물성 시험기를 사용하여 브라켓의 전단결합강도를 측정하고, modified ARI (Adhesive Remnant Index) scores를 통해 브라켓 접착면의 파절 양상을 평가하였다. 열순환 처리 미시행 시에는 금속 프라이머의 적용 시 샌드블라스팅만 단독으로 처리한 경우에 비하여 통계적으로 유의성 있는 전단결합강도의 증가가 있었다 (p < 0.05). 열순환 처리를 시행한군에는 금속 프라이머의 처리에 의한 전단결합강도의 변화는 유의한 차이가 없었다 (p > 0.05). 금속 프라이머를 적용한 경우 열순환 처리 미시행 시에는 파절 양상이 브라켓과 접착제 계면에서의 파절 발생 빈도가 높았으나, 열순환 처리 시행 시에는 각 군 간 파절 양상에 유의한 차이가 없었다. 이상의 결과로 금속 프라이머의 적용이 치과용 금합금에 대한 교정용 브라켓 접착 시 초기 접착 강도에서는 유의성 있는 결합력의 증가를 보이나, 열순환 처리 시행 후에는 결합 강도에서는 유의한 차이가 없는 것으로 나타나 금속 프라이머에 의한 결합력 증가가 감소하는 것으로 생각한다. Objective: The aim of this study was to evaluate the effect of metal primers and thermocycling on shear bond strength between the orthodontic bracket and gold alloy. Methods: For this study, 80 specimens made of dental gold alloy were divided into 8 groups based on the combination of metal primers (none, Alloy primer, Metaltite, V-primer) and thermocycling (with and without thermocycling). Shear bond strength testing was performed with a universal testing machine. Bond failure sites were classified by a modified ARI (Adhesive Remnant Index) score. Results: All metal primer treated groups showed a significantly higher shear bond strength than the only sandblasting treated group without thermocycling (p < 0.05). There were no significant differences on shear bond strength in the groups with thermocycling (p > 0.05). Bond failure sites of the metal primer treated group without thermocycling occurred at gold alloy/adhesive interface, whereas there were no differences on bonding failure sites in the groups with thermocycling. Conclusions: These findings suggest that using metal primer on gold alloy enhances the initial bracket bond strength. But, this effect was not shown with thermocycling.

계용묵 소설 연구

이주형 한국어문학회 2005 語文學 Vol.0 No.87

Kye Yongmook wrote 45 short stories from 1924 to 1950. His fiction writing training started with the reception of aestheticism, technicalism and nihilism through the literary journal The Creation. He clung to technicalism and nihilism to the end, while seeking after aestheticism, and realism from time to time. He viewed the lives of all the people of his days as tragic, and tried to depict those who fell into tragic plights in all his works. The whole period of his creative life can be divided into three: first, from late 1920s to early 1930s, second, from late 1930s to early 1940s and third, after the National Liberation. In the first period, he pursued literary realism in his stories, where he depicted the farmers who fell into tragic situations because of the barrier of class distinctions. In the second period, his works were oriented towards aestheticism, portraying diverse people who fell into tragic plights because of various obstacles including diseases. In the third period, he came back to realism, and described the national tragedy caused by the contradictions after the Liberation. But there is no character who gets out of the tragic situation in his stories, as he/she does not analyse its causes, nor try to find a way out, nor fight actively to escape from it. It resulted from the facts that Kye Yongmook, the writer, couldn't recognize the reality of his days deeply, and lacked in the unique insight of life. Consequently, Kye Yongmook stopped writing fiction at the early age of 46 in spite of good health without leaving many good works, for he didn't have an eye for the national realities and lives of the people, and couldn't develop new sources for literary creation. Thanks to the two of his works, “Adada, the Idiot” and “Counting Stars”, which can be evaluated as well written, he has been regarded as a writer who should be recorded in the modern fiction history of Korea, though he cannot belong to the main writers' group.

근육긴장으로 발생된 Tic 환자에 대한 Laser침 치험 1 예

이주형,김용석 경희대학교 2000 慶熙醫學 Vol.16 No.3-4

Cone beam형 전산화단층촬영법을 이용한 하악과두의 골변화에 관한 연구

이지운,김형섭,송주섭,김경아,고광준 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.3

Purpose : To assess bone changes of mandibular condyle using cone beam computed tomography (CBCT) in temporomandibular disorder (TMD) Patients. Materials and Methods : 314 temporomandibular joints (TMJs) images of 163 TMD patients were examined at the Department of Oral and Maxillofacial Radiology, Chonbuk National University. The images were obtained by PSR9000N (Asahi Roentgen Co., Japan) and reconstructed by using Asahivision software (Asahi Roentgen Co.,Japan). The CBCT images were examined three times with four weeks interval by three radiologists. Bone changes of mandibular condyle such as flattening, sclerosis, erosion and osteophyte formation were observed in sagittal, axial, coronal and 3 dimensional images of the mandibular condyle. The statistical analysis was performed using SPSS 12.0. Intra-and interobserver agreement were performed by 3 radiologists without the knowledge of clinical information. Results : Osteophyte (2.9%) was found more frequently on anterior surface of the mandibular condyle. Erosion (31.8%) was found more frequently on anterior and medial surfaces of the mandibular condyle. The intraobserver agreement was good to excellent(k=0.78-0.84), but interobserver agreement was fair(k=0.45). Conclusion : CBCT can provide high qualified images of bone changes of the TMJ with axial, coronal and 3 dimensional images.

사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

다이옥신으로 유발된 생쥐의 조혈모세포 증식장애에서 Oligonucleotide-Microarray를 이용한 유전자표식자의 발굴

이은주,정인혜,김형래 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1

To develop the biomarkers for the immune dysfunction induced by dioxin, 2, 3, 7, 8-TCDD was administered C57BL/6N mice 0.1㎍ TCDD/㎏ body weight. Colony forming assay showed that the proliferation potential of hemotopoieti progenitor cells in bone marrow was reduced 35-55% more by earlier exposure. The microarray experiments were duplicated, and the candidates were restricted for the genes expressed greater than 121-fold. Resulting candidates were 55 genes. The expression patterns of the whole genes were analyzed by self-organizing maps (SOM). From these results, we selected the stage-specific genes : one genes (SOM c21 : nadh dehydrogenase subunit 5 gene) for gestational 13.5day, 13 genes (c0 : sialophorin ; spn gene, etc) for postnatal 3 week. The above genes are proposed to be a potential use of biomarker for dioxin exposure in the case of immume dysfunctions. 내분비교란물질로 가장 잘 알려진 다이옥신에 의한 면역장애는 면역기관이 성숙된 후에 나타나므로 다이옥신의 노출에 의한 것인지 인과관계의 평가가 매우 어렵다. Dioxin ( 2, 3, 7, 8-TCDD)에 의한 면역기능의 저하 및 그 재표 유전자를 발굴하기 위해, C57BL/6 생쥐에서 임신 및 발생 성장 시기별로 dioxin을 노출하였다. 면역지표로서 골수 혈액줄기세포의 집락 형성이 현저하게(35~55%) 감소하였다. 말초혈액에서 유전자 발현의 변화를 생쥐용 고밀도(11K) oligonucleotide microarray로 측정하였고, 각 시기별로 대변이 가능한 유전자는 Selforganization maps (SOM) clustering으로 분석하였다. Biomarker로서 유용성을 위해 2회 반복하여 공통된 유전자를 선택하였고, 이 중 유전자 발현의 변동 폭이 2 이상 되는 유전자를 선택한 결과 55개를 고를 수 있었다. 시기별 대변이 가능한 SOM과 그 결과가 서로 일치하는 유전자는 임신 1305일에서 SOM c21인 1개(nadh dehydrogenase subunit 5), 생후 3주에서 c0 유전자 10개와 c16 유전자 3개(c0 : sialophorin ; spn 외 9개, c16 : ribosomal protein 113a ; rp113a 외 2개)를 발굴할 수 있었다. 다이옥신에 의한 면역 장애 및 노출 영향을 평가하는 biomarker로 사용할 수 있음을 알았다.

日本의 人文·社會科學 硏究動向 調査

李注衡,朴仁熙,韓點洙,金文基,朴晋泰 慶北大學校 1983 論文集 Vol.36 No.-

In January 1983, the writer visited a few universites in Japan to survey the recent trend of studies in cultural and social Sciences. At that time what I researched is as follows; In Japan, many a learned society has been organized and the research activities were very lively. Mass publication of scientific periodicals and prompt translation of foreign writings showed the maturity of scientific atmosphere. It true that their study of literature has been performed on the basis of positivism since 1930'. But now Structuralism which consider's literary works as one organic unity of parts became the main basis of literary studies. And, Learned Society of Educational Law has been organized in Japan. In consequence, the level of researches in educational law could be remarkably high. So, it is necessary for us to study the law of education. For, to make it better, we must know not only the universal principles of education but also specific ones derived from the peculiar characteristics of Korean education. At the same time, in Japan, Department of the Law of Industrial Administration was established in 14 universities including Japan University. And with the help of it, companies could improve the efficiency in dealing with judicial affairs related with industrial administration. So, to be a winner in the international trade competition, it is also required for us to study the judicial affairs of industrial administration.

STS 304 강의 저주기 및 고주기 피로에 있어 초기 마르텐사이트의 영향

이현승,신형주,김송희 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

Zero to tension fatigue tests and strain controlled fatigue tests were carried out to find how initial strain induced martensite, α' affects low and high cycle fatigue behavior and fatigue crack growth mechanisms. Microscopic study and phase analysis were carried out with TEM, SEM, EDAX, Optical Microscope, Ferriscope, and X-ray diffractometry. The amount of Initial α' was controlled from 0% to 33% by controlling the temperatures for cold working and heat treatment. Lower contents of initial α' showed higher fatigue resistance in low cycle fatigue but lower fatigue resistance in high cycle fatigue because it is ascribed to the more transformation of α' martensite during low cycle fatigue and higher ductility. In high cycle fatigue, fatigue life is attributed to the strength and phase transformation of austenite into α' during fatigue was negligible. γ boundary, γ/twin boundary, and γ/α' boundary were found to be the preferred site of fatigue crack initiation.

공침범으로 제조한 마그네시아 부분안정화 지르코니아 소결체의 특성에 미치는 열처리 효과

이재원,오응주,정윤중,이형복 明知大學校 産業技術硏究所 1989 産業技術硏究所論文集 Vol.8 No.-

The powder of ZrO₂-MgO systems prepared by co-precipitation method using ZrOCl₂· 8H₂O and MgCl₂· 6H₂O as the sintering materials. They are sintered and than heat treated to know that effects of agoing time and temperature on mechanical and electrical properties. The powder ZrO₂-MgO systems have∼30nm crystal size and tetragonal phase. The mechanical properties of these partially stabilized ZrO₂- MgO specimens are shown the best value when they are aged at 1,100℃ for 1 hr and at 1,450℃ for 10 hrs, but these are better than those, and while the specimens of 9.5 mole% in these thermal conditions. Electrical conductivities are measured as a function of temperature in the range of 500℃ to 1,000℃. The temperature dependence of electrical doncutivities is shown the activation energies by the heat reat conditions; no heat treating, heat treating at 1,100℃ for 1 hr, and heat treating at 1,450℃ for 10 hrs, and their values are 21.5㎉/㏖, 34.3㎉/㏖, and 43.5㎉/㏖, respectively.