봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

봉독약침이 류마티스 관절염 환자의 기능회복 및 삶의 질에 미치는 영향

이상훈,이현종,박상민,김수영,박재경,홍승재,양형인,이재동,최도영,김건식,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective: To evaluate the effects of bee venom acupuncture(BVA) on the rehabilitation and quality of life in rheumatoid arthritis(RA) patients Methods: Patients with RA were treated with the BVA therapy twice a week for 3 months. Tender joint counts, swollen joint counts, morning stiffness, Erythrocyte Sedimentation Rate(ESR), C-reactive protein(CRP), patient global assessment, physician global assessment, Korean health assessment questionnaire(KHAQ) were estimated and analyzed before and after BVA therapy. Results: Tender joint counts, swollen joint counts, morning stiffness showed significant decrease after BVA therapy. But, as acute inflammatory reactants, ESR showed no significant difference and CRP showed significant increase after BVA therapy. Patient global assessment physician global assessment, and KHAQ index showed significant improvement after BVA therapy. Conclusions: BVA therapy can improve rehabilitation and health-related quality of life RA patients as well as clinical symptom and signs. Further study is required in more population with large scale including acute inflammatory reaction of BVA therapy.

고시치카제오라이트에 의한 아민류의 흡착평형특성

이성식,김형준,최정균 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.1

Liquid phase adsorption equilibria of amines in aqueous solution onto high silica zeolite pellets(HSZ) experimentally determined by use of a batch bottle technique at 298K. The data for HSZ / amines system was fit to 4 isotherm equations to determine an optimum equation. The best equation for the amine adsorption isotherms onto HSZ is the Freundlich isotherm. The products k·n of the Freundlich constant increase with the boiling point T_B, molecular volume V_m and dissociation constant pK_a of amines.

직접합성을 이용한 트리스(실릴)메탄들의 합성

이창엽,오형식 木浦大學校基礎科學硏究所 1999 基礎科學硏究誌 Vol.17 No.-

본 실험에서 디클로로메틸실란과 염화수소 혼합물과의 금속규소와의 직접반응을 연구하였다. 반응기는 유동형반응조와 교반형반응조를 결합한 형태의 유동교반형 반응기를 사용하여 촉매로 구리를 사용하였고 반응온도를 240-340℃가지 20℃씩 변화시켜 반응을 실시 하였다. 본 반응은 디클로로메틸실란의 클로로실리메탄과 금속규소가 반응하여 트리스(실릴)메탄들을 주요 생성물로 얻었다. 그 외의 부생성물은 비스(클로로실릴)메탄들이 얻어졌으며, 염화수소와 금속규소가 반응하여 트리클로로실란과 테트라클로로실란도 생성되었다. Direct reaction of elemental silicon with a mixture of (dichloromethyl)silanes and hydrogen chloride has been studied in the presence of copper catalyst using a stirred bed reactor equipped with a spiral band agitator at the carefully controlled temperature between 240℃ and 340℃. Tris(silyl)methanes with byproducts of bis(chlorosilyl)methanes, derived from the reaction of silicon with chloromethylsilane formed by the decomposition of (dichloromethyl)silanes. In addition to those products, trichlorosilane and tetrachlorosilane were produced by the reaction of elemental silicon with hydrogen chloride.

입상활성탄에 의한 방향족, 지방족고리 아민류 및 아미노산의 액상흡착

이성식,김형준,유명호,박성은 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.1

Equilibrium studies for the adsorption of aromatic, alipatic cyclic amines and amino acid from aqueous solutions onto granular activated carbon have been carried out at 298K. Two and Three-parameter isotherms were tested. Among the equations tried, the two-parameter equations of Freundlich equation yield a better fit, The Langmuir equation, However gives the poorest overall fit. For three-parameter isotherm equation, the Redlich-Peterson equation gives the most satisfactory fit over the entire range of concentrations. The adsorption amounts of the aromatic amines onto GAC increase with the number of methyl group in pyridine ring.

A2024와 SM45C 마찰용접의 열전달 해석

이상윤,고준빈,명태식,김기길,강형모 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

The heat transfer mechanism initiating the friction welding is examined and a transient three dimensional heat conduction model for the welding of two dissimilar cylindrical metal bars is investigated. The cylindrical metal bars are made of materials made of A2024 and SM45C. Numerical simulations of heat flow are performed using the finite volume method. Respectively, Commercial FLUENT code is used in the heat flow simulation and maximum temperature and distribution of temperature are calculated. Temperature of friction welded joining face is compared with the temperature distribution measured by experiment and numerical simulation. The maximum temperature of friction welded joining face is lower than melting point of A2024-T6 aluminum alloy using insert metal. The temperature distribution of friction welded joining face with insert metal is more uniform than that of without insert metal

Le Fort I 골절단술을 이용한 진구성 상악골 골절의 치험 2예

이재휘,박형식,권준호 大韓顎顔面成形外科學會 1989 Maxillofacial Plastic Reconstructive Surgery Vol.11 No.1

This is a report of 2 cases on old maxilla fractures accompanied with sagittal palatal fracture and severe malocclusion. We treated them by using of classic Le Fort 1 osteotomy and modified Le Fort I osteotomy along the old fracture lines satisfactorily. The results obtained from treatment are as follows : 1. Careful examination and correct care on sagittal palatal fracture should be need during initial diagnosis and emergency care of maxilla fracture showed malocclusion. 2. Although early definite treatment of maxilla injuries is difficult due to major organ injuries associated with accident, the positive effort to induce normal occlusion is always necessary as soon as possible. 3. In the cases of malocclusion due to transverse discrepancy of maxillary dentition associated with injury as like as our cases, classic and modified Le Fort I osteotomy and rigid internal fixation were useful to correct occlusion, to ease operation and return normal functions early.

Dimethylformamide가 Mouse 肝細胞의 微細構造에 미치는 影響

이형록,정호삼,이규식 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2

Dimethylformamide (DMF) has been widely used in the synthetic textile industry as an organic solvent. However, it is known that DMF irritates to skin and mucous membranes and causes several toxic symptoms when dermal and respiratory exposure to DMF is prolonged. It is supposed that DMF provoked toxic reaction in the liver during the metabolic process of the DMF-injected experimental animal. Therefore, the authors observed changes cytoplasmic organelles of the hepatic parenchymal cells in order to demonstrate the effect of DMF on the mouse liver. Healthy male mice of ICR strain were used in this experiment and the weight of the experimental animals were around 20gm. The animals of the experimental group were administered DMF diluted in the water for injection, by intraperitoneal injection in a dose of 1.5ml per kg of body weight in a volume of 0.2ml. The animals of the control group were amdinistered only water for injection. The experimental animals were killed at intervals of 6, 12, 24 and 48 hours after administration of DMF, respectively. Liver specimens of 1mm³ size were prefixed in the 2% glutaraldehyde-2.5% paraformaldehyde phosphate buffer solution (pH 7.2) and post-fixed in the 1% osmic acid. After specimens were dehydrated and embedded in the epon 812, ultrathin sections(600-800A°thickness) were made and double stained with uranyl acetate and lead citrate. These preparations were observed with JEM 100B electron microscope. The results obtained were as follows: 1. Cisternae of rough endoplasmic reticulum were intensely dilatated and fragmented partly. 2. Smooth endoplasmic reticulum was markedly proliferated and glycogen particles were markedly decreased or depleted. 3. The atrophies of the Golgi complex were found. 4. Primary lysosomes and secondary lysosomes-residual bodies, autophagic vacuole and multivesicular bodies were increased in number. 5. Numerous lipid droplets of irregular size were produced. Consequently, it is concluded that DMF would induce the degenerative changes in cytoplasmic organelles of the hepatic parenchymal cell in the mouse.

고정층 액상흡착탑내의 합성흡착제/콜리딘계의 열역학적 흡착특성

이성식,김형준,이봉국,최정균 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.2

Adsorption Equilibria and Kinetics of collidine in a aqueous solution onto the synthetic resin adsorbent were carried out in a fixed bed absorber at 278, 288, 298 anti 308K for various concentration ranges respectively. The effective intraparticle diffusivity, D_(e), based on the concentration difference in the liquid phase, was determined by comparing experimental and theoretical uptake curves. The ratio of the effective diffusivity to moleculer diffusivity, D_(e)´/DAB were independent of the amount adsorbed and temperature for synthetic resin/collidine system. The result supported the concept that migrated of inter-microparticle gaps predominates over effective intraparticle mass transfer within synthetic porous adsorbent. Amount adsorbed q_(e) was correlated Q_(st) = 15.35 + [(-4.14) - q_(e)] and E_(a) = 6.28 + [(-1.671 q_(e)] with heat of adsorption(Q_(st)) and activation energy(E_(a)).