난포기 및 황체기에 있어서 돼지 난관 협부 평활근의 neurotransmitter들의 수축효과에 대한 estradiol-17β및 progesterone의 영향

이민기,노규진,심철수,남윤정,김주현,최상용 慶尙大學校 1991 論文集 Vol.30 No.2

The effects of estradiol-17β or progesterone on the contractility of neurotransmitters on pig oviductal isthmic smooth muscle were investigated. The motility of the isolated smooth muscle was recorded by using physiological recording system. The results were summarized as follows : 1. The contractility induced by histamine or prostaglandin F2α was depressed by the pretreatment of estradiol-17β but was not by the preteatment of progesterone in follicular or luteal stage. 2. The contractility induced by acetylcholine was depressed un follicular stage but excited in luteal stage by the pretreatment of estradiol-17β or progesterone. 3. The contractility induced by norepinephrine was depressed by the pretreatment of progesterone in follicular stage but was excited by the pretreatment estradiol-17β in luteal stage.

다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.

韓ㆍ日語 疎通上의 障碍 小考

高憲,李圭昌 군산대학교 1980 論文集 Vol.1 No.-

Nowadays, not in an enforced way as in the past but in an autonomus way, we must learn and investigate as a foreign language like Chinese or English, Japanese which is in an intimate relation with us from the viewpoint of geography history, culture, politics and economics, so that our knowledge about Japan will widen to cover the rapidly changing international society. Japanese is now officially recognized as one of the secondary foreign language which should be learned in the course of study in our highschool or college.Most of the men in the age of over 40s in our country can speak Japanese on account of the Japanese enforcement upon them to learn it during their colonial rule of imperialism, especially due to the Japanese policy of the obliteration of Korean during the later period of World War II. But in more than a quater of centry since the 1945 Liberation, the eschewal of using Japanese due to their mind of Anti-Japanese makes them speak Japanese poorly or awkwadly, and moreover influnced by their Anti-Japanese.young generation in these days is liable to ignore the role of Japanese in the changed international situation. But this tendency is equal to living at ease and in idleness whether it is against Japan or not.Living at ease is the attitude of a man of narrow views who want to live by oneself disregarding others, and living in idleness means the way of life just scratching the surface of a situation which asks for long observation with an eye not seeking for immediate gain. These ways of life ore not following the first principle of strategist "Sun-Tz(孫子)" "One who knows not only the enemy but also himself wins all the war." Briefly, ill order to know about Korea and Japan, to get rid of language wall between them is the first thing to do.

알코올 의존과 후보 유전자들간의 연관성 연구

정인원,김헌,홍주봉,지경환,이규영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 알코올 대사와 중추신경계내의 알코올 작용부위와 관련한 일부 후보유전자들이 알코올 의존과 관련이 있는지를 확인하고자 하였다. 방 법 : DSM-IV로 진단된 알코올 의존 환자 128명과 정상 대조군 128명을 대상으로 후보 유전자들의 다형성을 중합효소 연쇄반응과 제한효소처리법을 이용하여 동정하였다. 여기서 분리된 대립유전자와 유전자형에 따른 빈도의 차이를 유전자별로 각각 비교하였으며, 알코올 의존에 작용하는 서로 다른 유전자들에 의한 영향력을 배제하기 위하여 logistic regression 분석을 적용하였다. 결 과 : 알코올 의존군에서는 ALDH_2 유전자의 NN(wild type)형이 정상대조군에 비하여 유의하게 많았다(chi-square test, p<0.001). logistic regression analysis를 통하여 다른 유전자들에 의한 영향을 보정한 상태에서 ALDH_2가 NN(wild type)인 경우 다른 아형에 비하여 알코올 의존에 대한 odds ratio는 130.312이며 그 신뢰구간은 (17.22, 986.43)이었다. 한편, ASA는 N-glycosylation 부위에 변이형 대립유전자를 갖고 있는 경우(AG or GG)는 wild type에 비하여 알코올 의존에 대한 위험도는 2.344배이며 그 95% 신뢰구간은 (1.128, 4.871)이었다. 결 론 : 알코올 의존과 ALDH_2 유전자간에는 밀접한 연관성이 확인되었다. 또한 다른 유전자들은 개별 연관분석에서 의미있는 연관성이 관찰되지는 않았지만 logistic regression analysis를 통하여 N-glycosylation 부위에 다형성이 있는 ASA 유전자가 알코올 의존과 관련이 있음을 시사하였다. Objectives : This study was to explore the association between alcohol dependence and five candidate genes related to the metabolism of alcohol and the enzymes of the suspected sites in CNS. Methods : The genotype and allele frequencies of five candidate genes in 128 male hospitalized patients who met DSM-IV criteria for alcohol dependence were compared with 128 age-matched healthy male control subjects using polymerase chain reaction and restriction fragment length polymorphism. A logistic regression analysis was applied in order to exclude the reciprocal interactions among five candidate genes. Results : The NN genotype frequency of the ALDH_2 gene was significantly higher in alcoholic patients than in control subjects(chi-square test, p<0.001). No difference in frequency was found in the other four genes. In a logistic regression analysis, the odds ratio for alcohol dependence in the NN genotype of the ALDH_2 gene and AG or GG genotypes of the N glycosylation site on the ASA gene were 130.312(95% confidence interval, 17.22-986.43) and 2.344(95% confidence interval. 1.128-4.871), respectively. Conclusion : The result reiterates the association of the ALDH_2 gene polyporphism and the alcohol dependence. Logistic regression analysis additionally suggested that the N-glycosylation site on the ASA gene was associated with alcohol dependence.

콩 단백질/펙틴/몬모릴로나이트 나노복합 필름의 특성 및 산소 투과도 연구

정세환,김성철,조규순,신용섭,장상희,홍기헌,이태진,신부영 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.2

In this study, Mechanical property, thermal property, watervapor, and oxygen permeability of biodegradable Soy protein/Pectin-montmorillonite nanocomposite, prepared with Na^(+)-MMT, have been studied. X-ray diffraction and TEM experiments an polymer/silicate composite samples demonstrated that the intercalation of polymer chains leads to increase in the spacing between silicate layers. In addition, it were found that the intercalated Soy protein/Pectin/montmorillonite nanocomposite were prepared. It was found that the addition of only a small of clay was enough to improve the thermal stability and mechanical property of Soy protein/Pectin/montmorillonite nanocomposite. watervapor of Soy protein/Pectin/montmorillonite nanocomposite was generally lower than that of Soy protein/Pectin. oxygen permeability of Soy protein/Pectin/montmorillonite nanocomposite was generally lower than that of Soy protein/Pectin.

Integrins α_vβ₅ and α_vβ₆ Mediate IL-4-induced Collective Migration in Human Airway Epithelial Cells

Lee, Sang-Nam,Ahn, Ji-Suk,Lee, Seong Gyu,Lee, Hyung-Suk,Choi, Augustine M. K.,Yoon, Joo-Heon American Thoracic Society 2019 American journal of respiratory cell and molecular Vol.60 No.4

디클로로벤지딘으로부터 대사물질의 합성과 분리방법에 대한 연구

Lee, Jin-Heon,Lee, Beom-Gyu Korean Society of Environmental Health 2003 한국환경보건학회지 Vol.42 No.6

3,3'-디클로로벤지딘(DCB)는 실험동물에 발암물질로 밝혀졌고, 사람에게 암을 유발시킬 수 있는 발암물질로 의심되고있다. 많은 연구자들이 사업장에서 DCB에 폭로된 근로자들을 대상으로 뇨중에 배설된 대사물질, 헤모글로빈 부가체, 그리고 암 발생율 등에 대하여 연구를 하고 있다. 이러한 연구를 하기 위해서는 표준물질로 되어 있는 DCB의 대사물질이 꼭 필요하다. 따라서 본 연구의 목적은 DCB를 이용하여 이들의 대사물질을 합성하여 표준물질로 사용코자 합니다. DCB는 벤젠. 에테르, 에탄올, 메탄올 등에 부분적으로 용해되지만, 구연산이 1 % 이하로 함유된 70% 아세트산, 피리딘, 0.1N NaOH와 톨로엔이 1:2로 섞인 혼합물, 20 mM TRIZA염으로 포화된 페놀 등에는 완전히 용해되기 때문에 본 연구에서는 DCB를 피리딘에 녹여서 사용하였다. DCB와 대사물질인 mono-acetyl-DCB 및 diacetyl-DCB는 가스크로마노그래피(GC/MS)로 분석하였고, 검출기는 NPD와 SIM를 사용하였다. DCB의 기본피크는 252 m/z이었고, mono-acetyl-DCB의 기본피크는 252와 294 m/z로 구성되어 있었으며. diacetyl-DCB의 기본피크는 252, 294, 336 m/z로 구성되어 있었다. Discetyl-DCB는 피리딘에 용해된 DCB에 염소아세틸를 충분히 적정하여 합성하였다. 이렇게 얻은 diacetyl-DCB의 순도는 98.7%이었다. 침전물위에 있는 용해물질 속에는 DCB. mono-acetyl-DCB, diacetyl-DCB가 함유되어 있었는데, 아세트산을 아세틸화를 조절하는 물질로 사용하여 DCB를 모두 아세틸화시키었고, diacetyl-DCB로부터 mono-acetyl-DCB를 분리하여 추출하였다. 추출된 mono-acetyl-DCB는 아세톤으로 세척하여 98.8%의 순도를 얻었다. 3,3-dichlorobenzidine is suspected to be cancinogenic in experimental animal and human. Several studies have investigated excretion of metabolites in urine, hemoglobin adduction and cancer incidence among workers occupationally exposed to 3,3'-dichlorobenzidine. In these researches, metabolites of 3,3'-dichlorobenzidine had a very important role, and were required as highly purity. The purpose of this study was synthesis and isolation of its metabolites from 3,3'-dichlorobenzidine. 3,3'-dichlorobenzidine was partially dissolved in benzene, ether, ethanol and methanol, and completely dissolved in 70% acetic acid on mixtures of citric acid containing less than 1% DCB, pyridine, a mixture of 0.5N NaOH and toluene(1:2), and phenol saturated with 20 mM TRIZA base. DCB, monoacetyl-DCB and diacetyl-DCB were measured by using gas chromatography/mass spectrometry(GC/MS). Detection for checking them was nitrogen phosphorous detection mode(NPD), and for identifying them was selected ion monitoring mode(SIM). The base peaks were 252 m/z in DCB, 252, and 294 m/z in monoacetyl-DCB, and 252, 294 and 336 m/z in diacetyl-DCB, respectively. Diacetyl-DCB was synthesized by titrating DCB solution of pyridine with sufficient acetyl chloride. Precipitation was diacetyl-DCB, which was purity of 98.7%. And its supernatant was composed of DCB, monoacetyl-DCB and diacetyl-DCB. By using acetic acid as controller of acetylation, monoacetyl-DCB was isolated from diacetyl-DCB . And residual pyridine was removed by using acetone. The purity of monoacetyl-DCB was 98.8%.

Poster Session 2 : Cellular signal transduction: hormones and mediators ; A cofactor of human aminoacyl-tRNA synthetase, p43, induces cell-cell adhesion via up-regulation of intercellular adhesion molecule-1: Identification of the related signal pathways

( Heon Yong Park ),( Tae Ho Kim ),( Joong Won Lee ),( Sang Gyu Park ),( Gyu Youp Kim ),( Young Gyu Ko ),( Sung Hoon Kim ) 생화학분자생물학회 2001 생화학분자생물학회 춘계학술발표논문집 Vol.2001 No.-

Temporal Classification Method for Forecasting Power Load Patterns From AMR Data

Heon Gyu Lee,Jin Ho Shin,Hong Kyu Park,Young Il Kim,Bong Jae Lee,Keun Ho Ryu 大韓遠隔探査學會 2007 大韓遠隔探査學會誌 Vol.23 No.5

We present in this paper a novel power load prediction method using temporal pattern mining from AMR (Automatic Meter Reading) data. Since the power load patterns have time-varying characteristic and very different patterns according to the hour, time, day and week and so on, it gives rise to the uninformative results if only traditional data mining is used. Also, research on data mining for analyzing electric load patterns focused on cluster analysis and classification methods. However despite the usefulness of rules that include temporal dimension and the fact that the AMR data has temporal attribute, the above methods were limited in static pattern extraction and did not consider temporal attributes. Therefore, we propose a new classification method for predicting power load patterns. The main tasks include clustering method and temporal classification method. Cluster analysis is used to create load pattern classes and the representative load profiles for each class, Next, the classification method uses representative load profiles to build a classifier able to assign different load patterns to the existing classes. The proposed classification method is the Calendar-based temporal mining and it discovers electric load patterns in multiple time granularities. Lastly, we show that the proposed method used AMR data and discovered more interest patterns.

Resection plane-dependent error in computed tomography volumetry of the right hepatic lobe in living liver donors

( Heon-ju Kwon ),( Kyoung Won Kim ),( Bohyun Kim ),( So Yeon Kim ),( Chul Seung Lee ),( Jeongjin Lee ),( Gi Won Song ),( Sung Gyu Lee ) 대한간학회 2018 Clinical and Molecular Hepatology(대한간학회지) Vol.24 No.1

Background/Aims: Computed tomography (CT) hepatic volumetry is currently accepted as the most reliable method for preoperative estimation of graft weight in living donor liver transplantation (LDLT). However, several factors can cause inaccuracies in CT volumetry compared to real graft weight. The purpose of this study was to determine the frequency and degree of resection plane-dependent error in CT volumetry of the right hepatic lobe in LDLT. Methods: Forty-six living liver donors underwent CT before donor surgery and on postoperative day 7. Prospective CT volumetry (V< SUB >P< /SUB >) was measured via the assumptive hepatectomy plane. Retrospective liver volume (V< SUB >R< /SUB >) was measured using the actual plane by comparing preoperative and postoperative CT. Compared with intraoperatively measured weight (W), errors in percentage (%) V< SUB >P< /SUB > and V< SUB >R< /SUB > were evaluated. Plane-dependent error in V< SUB >P< /SUB > was defined as the absolute difference between V< SUB >P< /SUB > and V< SUB >R< /SUB >. % plane-dependent error was defined as follows: |V< SUB >P< /SUB >-V< SUB >R< /SUB >|/W·100. Results: Mean V< SUB >P< /SUB >, V< SUB >R< /SUB >, and W were 761.9 mL, 755.0 mL, and 696.9 g. Mean and % errors in V< SUB >P< /SUB > were 73.3 mL and 10.7%. Mean error and % error in V< SUB >R< /SUB > were 64.4 mL and 9.3%. Mean plane-dependent error in V< SUB >P< /SUB > was 32.4 mL. Mean % planedependent error was 4.7%. Plane-dependent error in V< SUB >P< /SUB > exceeded 10% of W in approximately 10% of the subjects in our study. Conclusions: There was approximately 5% plane-dependent error in liver V< SUB >P< /SUB > on CT volumetry. Plane-dependent error in V< SUB >P< /SUB > exceeded 10% of W in approximately 10% of LDLT donors in our study. This error should be considered, especially when CT volumetry is performed by a less experienced operator who is not well acquainted with the donor hepatectomy plane. (Clin Mol Hepatol 2018;24:54-60)