니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

복강경담낭절제술에서 수술전 간담도신티그라피와 경구담낭조영술의 의의

문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),원경숙(Kyoung Sook Won),류진숙(Jin Sook Ryu),한동복(Dong Bok Han),박철민(Cheol Min Park),이문규(Moon Gyu Lee),박광민(Kwang Min Park),이승규(Sung Gyu Lee) 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.1

N/A 131I-6β-iodomethyl-19-norcholesterol(NP-59) has an advantage to assess adrenal dysfunction caused by adrenal cortical disorders. The aim of this study is to evaluate the clinical usefulness of NP-59 scintigraphy in each adrenral disease. Ten patients who did eleven NP-59 adrenal scintigraphies at Dong-A University Hospital from March 1990 to December 1996 were selected as the subject. Among the subject there were 5 cases of Cushing's syndrome, 2 cases of incidentaloma, 1 case of metastatic adrenal tumor, liver cirrhosis with hirsutism and hypertension respectively. Among 5 case of Cushing's syndrome, there were 2 cases of Cushing's disease, 2 cases of adrenal adenoma and 1 case of adrenal carcinoma. There are no disagreement between clinical diagnosis and scan finding in Cushing's syndrome. In 2 incidentaloma cases, even though one is interpretated as a functioning tumor, both of 2 cases could avoid unnecessary biopsy according to scintigraphy result. One case of hirsutism, clinically adrenal originated, revealed the normal scintigraphic hirsutism was extra-adrenal origin. One case of hypertension took the study to exclude the possibility of primary aldosteronism. Normal suppression scan finding revealed that primary aldosteronism did not exist in this case. In conclusion, NP-59 scintigraphy was very useful in diagnosis and differential diagnosis of Cushing's syndrome and it could avoid unnecessary biopsy in the incidental adrenal tumor.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

안동호 상류 운곡천의 이화학적 수질특성과 식물플랑크톤 군집 특성

이중복,이희무,이건주,박정원,박재충,김동걸,권기석 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

This investigation is about the characteristics of phytoplankton community and physciochemical water quality of specific 6-point the Woon-kog stream system in upsteam of the Andong Lake. DO value was showed over 8.1㎎/L at each site and COD_Mn, BOD, T-N, T-P tend to increase as they stream down and that the existence and dominance of phytoplankton was low and it was difficult to conclude the definite correlation of water quality and phytoplankton community. Finally, it seemed to be desirable that alternatives for pollutional reduction should be made and performed on the basis of the continuous monitoring of the inflow to preserve the Andong Lake.

열처리에 따른 Zircaloy-4 Tube의 부식특성에 관한 연구

이동복,최송천 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

열처리에 따른 Zircaloy-4 tube의 부식 특성을 조사하기 위하여 pilger된 시편, 수냉된 시편, 열처리된 시편에 대해, 500℃, 102 기압의 증기하에서의 부식 시험을 실시하였다. 주어진 시험조건하에서 수냉된 시편과 pilger된 시편은 좋은 nodular 부식 저항을 보였으나, 열처리된 시편은 나쁜 nodular 부식 저항을 가졌다. To investigate the effect of heat treatment on the corrosion behavior of water-quenched, heat -treated, and as-pilgered Zircaloy-4 tubes, corrosion testing was conducted at 500℃ in 102 atm of steam atmosphere. Under these given conditions, water-quenched and as-pilgered and the grains become bigger and equiaxed. Heat treated specimens exhibited improved resistance to nodular corroson, while heat- treated specimens had poor nodular corrosion resistance.

형질세포치은염에 대한 증례보고

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

After authors experienced patients with plasma cell gingivitis, who had visited Department of Periodontics of Dental Hospital of Dnakook University from 1984 to 1990, authors selected 13 cases which were very similar with plasma cell gingivitis on clinical and histopathological aspect, and then re-examined these 13 cases about following standards, sudden onset of the lesion, no favorable result on medicinal and surgical treatment, dense infiltration of plasma cell, eosinophils in the Hematoxylin-Eosin stain, mast cells in Toluidine-Blue stain. Authors concluded that 4 cases are exactly consistent with plasma cell gingivitis. Authors studied these 4 cases about clinical and histopathological feature, and reviewed the past case report and literature. The following results were elicited. 1. Clinical sign and symptom has generalized feature in oral cavity, but when the disease occurs at the lips, the lower lips shows more severe manifestation. And the disease have a predilection for female but do not have prediliection for any age. 2. The most characteristic feature of the plasma cell gingivitis is dense plasma cell infiltration in light microscope, and other characteristic microscopic features are as followings; microvesicles in the epithelial layer, proliferation of epithelium, proliferation of papillary layer in connective tissue, dilatation of capillaries and occasional infiltration of eosinophils and mast cells. 3. Plasma cell gingivitis is specific immunological reaction that plasma cells chiefly react with certain allergen but this immunological reaction is limited on few population.

방사선조사후 타액선 조직세포변화에 따른 타액분비의 감소에 관한 실험적 연구

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

After single fraction of 2, 5, 10 Gy irradiation on submandibular gland of 32 male rats, weighting 150 gm, respectively, these animal were sacrificed after 1, 7, 15 hours, 1, 3, 7, 14 days after irradiation. And excised submandibular gland were fixed in Bouin's solution for 2 hours. Paraffin sections were stained with H & E, and PAS for change of salivary gland tissue in order to get regeneration of salivary gland tissue cells and saliva secretion after irradiation. The results were following. 1. In PAS statining after 3 days of 5 Gy irradiation, decreased mucine serction of serous cells were seen, and after 7 dyas of 10 Gy irradiation, decreased mucine secretion of mucous cells were seen. Increased saliva secretion except mucous cells after 14 days was seen, but no resecretion of salivary gland tissue cells was observed in 10 Gy irradiation. 2. After 3 days of 2 Gy irradiation, 1 day of 5 Gy, and 15 yours of 10 Gy, degeneration of serous cells was seen and regeneration of these cells was seen after 14 days except 10 Gy irradiation.

스캔 설계 법칙 검사에 관한 연구

이재훈,김형국,조경연,임동욱,민형복 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.2

Since testing of digital circuit is becoming increasingly important, many methodologies have been introduced to enhance design for testability (DFT). DFT was taken into account in the automated test procedure and improved reliability of the design. Both tasks are well suited for scan rule checker. This paper presents a scan rule checker for gate level digital circuits. The scan rule checker deals with basic rule check, basic scan rule check, muxed scan rule check, clocked scan rule check and lssd. Scan design informations were represented in the configuration file and libraries were modeled for the scan rule checker. It is an efficient way for the design for testability methodology.

金代 猛安謀克地의 變貌에 대하여

李東馥 淸州大學校 1974 論文集 Vol.8 No.1

한국인 태아 췌장도 발육에 관한 면역조직화학적 연구

이원복,김동창 중앙대학교 의과대학 의과학연구소 1984 中央醫大誌 Vol.9 No.4

The pancreases of Korean human fetuses aged from 13 to 40 weeks were studied immunohistochemically to observe the development of the pancreatic islet, frequency of single endocrine cell and composition of pancreatic islet. 1. The volume fractions of endocrine tissue of the fetal pancreas were higher value(from 7 to 8%). However, the relative values of the endocrine tissues that obtained from 5 to 10 month old fetuses were constant. 2. The exocrine tissue were slowly increased during the intrauterine life. On the other hand, the connective tissue were gradually decreased in the same time. 3. At the mid-term, the number of single alpha cells were similar to that of delta cells. The number of beta cell decreased in comparison with that of non-beta cells(p<0.01). At the term, the number of single alpha, beta and delta cells were not significant. These data indicated that the epithelial cells of pancreatic duct were budding during intrauterine life. 4. At the mid-term, the pancreatic islets were composed of about 36% of alpha and beta cells respectively and 28% of delta cells. At the term the pancreatic were composed of 33% of alpha cells, 41% of beta cells and 26% of delta cells, respectively. The fetal panreatic islet showed numerous delta cells but the beta cells occupied one half of the adult islets. 5. The mantle islet was one of the typical features of fetal pancreatic islet. It was composed of the central core of beta cells and peripheral zone of alpha and delta cells interposed with a few of beta cells.