Comparison of amine-functionalized mesoporous silica particles for ibuprofen delivery

Lee, Kitae,Lee, Deokkyu,Lee, Hosub,Kim, Chang-Koo,Wu, Zhijian,Lee, Kangtaek Springer-Verlag 2010 Korean Journal of Chemical Engineering Vol.27 No.4

The preanesthetic interview by anesthesiology residents: analysis of time and content

Deokkyu Kim,Sung Nyu Lee,Dong-Chan Kim,Jeongwoo Lee,고성훈,Sang-Kyi Lee,Ji-Seon Son 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.62 No.3

Background: A preanesthetic visit can increase a patient’s satisfaction. However, it is uncertain whether a preanesthetic visit by an anesthesiology resident can achieve the goal. We studied the time distribution for content of preanesthetic interviews (PI) and evaluated the patient’s satisfaction with the PI. Methods: We recorded the PI duration of 200 patients by a voice recorder. The degrees of patient satisfaction with the PI and the changes of anxiety level after the PI were quantified by a questionnaire. We analyzed the time distribution for content of the PI and the correlation between patient characteristics and PI duration or a patient’s satisfaction. Results: The total PI duration was 184 (134-286) sec (median, 25-75%), and the time distributions for content of the PI were 8 (5-10) of greeting, 45 (23-70) of history taking, 15 (10-20) of physical examination, 50 (25-98) for obtainingan informed consent, 20 (10-30) of explanation for anesthetic planning, 15 (5-28) for explanation of patient controlled analgesia, and 10 (0-4) sec for questions and answers. Age, ASA physical status, and educational level were correlated with PI duration (P < 0.001). The patient’s level of satisfaction was “very satisfied” in 39%,“satisfied” in 50%, and “moderate” in 11% of interviews. The anxiety level was “decreased” in 50%, “increased” in 8%,and “not changed” in 42% of patients. Conclusions: Although the duration of a PI given by residents was a relatively short, 89% of patients of were satisfied with the interview. The PI took a longer time to complete in patients of older age, higher ASA physical status, or lower educational levels. Background: A preanesthetic visit can increase a patient’s satisfaction. However, it is uncertain whether a preanesthetic visit by an anesthesiology resident can achieve the goal. We studied the time distribution for content of preanesthetic interviews (PI) and evaluated the patient’s satisfaction with the PI. Methods: We recorded the PI duration of 200 patients by a voice recorder. The degrees of patient satisfaction with the PI and the changes of anxiety level after the PI were quantified by a questionnaire. We analyzed the time distribution for content of the PI and the correlation between patient characteristics and PI duration or a patient’s satisfaction. Results: The total PI duration was 184 (134-286) sec (median, 25-75%), and the time distributions for content of the PI were 8 (5-10) of greeting, 45 (23-70) of history taking, 15 (10-20) of physical examination, 50 (25-98) for obtainingan informed consent, 20 (10-30) of explanation for anesthetic planning, 15 (5-28) for explanation of patient controlled analgesia, and 10 (0-4) sec for questions and answers. Age, ASA physical status, and educational level were correlated with PI duration (P < 0.001). The patient’s level of satisfaction was “very satisfied” in 39%,“satisfied” in 50%, and “moderate” in 11% of interviews. The anxiety level was “decreased” in 50%, “increased” in 8%,and “not changed” in 42% of patients. Conclusions: Although the duration of a PI given by residents was a relatively short, 89% of patients of were satisfied with the interview. The PI took a longer time to complete in patients of older age, higher ASA physical status, or lower educational levels.

Lymphangiomyomatosis discovered by massive hemoptysis during general anesthesia -A case report-

Deokkyu Kim,Sung Nyu Lee,이상귀,Jeongwoo Lee 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.62 No.4

Lymphangiomyomatosis (LAM) is a rare lung disease that is characterized by the progressive proliferation of atypical smooth muscle-like cells, which leads to severe respiratory impairment and death. Dyspnea, cough, recurrent pneumothorax, and hemoptysis are the most common clinical symptoms of LAM. We report a 29-year-old female patient with massive hemoptysis during laparoscopic gynecologic surgery under general anesthesia, who was diagnosed with pulmonary LAM.

내측후드 패턴과 보행자 머리 상해치에 대한 연구

이덕규(Deokkyu Lee),이용훈(Yonghoon Lee),주영준(Youngjun Joo) 한국자동차공학회 2013 한국자동차공학회 학술대회 및 전시회 Vol.2013 No.11

This paper describes the research on the pedestrian safety to help a better performance of head injury criteria(HIC). The importance of pedestrian protection is emphasized in a global context, efforts and challenges in manufacture and engineers. It is noted that mutual relation of a head impact energy management and specific HIC pulse generation in some kind of structural pattern of hood. Hence, this paper includes research dealing with CAE(computational aided engineering)modeling of between head and vehicle as an inelastic collision, characteristics of acceleration pulse and come up with an effective structural design. to the lower HIC value .

HyRAM+를 이용한 수소충전소 위험요소 도출

이재용(JaeYong Lee),이승종(SeungJong Lee),윤덕규(Deokkyu Youn) 한국가스학회 2022 한국가스학회 학술대회논문집 Vol.2022 No.11

Surface functionalization of SBA-15 particles for ibuprofen delivery

이강택,Dae Hyun Hwang,Deokkyu Lee,Dongcheol Choe,Sang Hoon Lee,Hosub Lee 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.4

We have synthesized SBA-15 particles and functionalized their surface with different functional groups (amine, diamine, and sulfonic acid groups) to use them as carrier materials in drug delivery. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen sorption, and zeta potential measurements were used to characterize the synthesized particles. After surface functionalization, the surface of the sulfonic acid-functionalized particles was more acidic than that of the other particles. Using ibuprofen as a model drug, we found that the release rate increased at higher pH. Furthermore, the particles with the sulfonic acid groups exhibited higher release rate than those with the amine and diamine groups. We explained the difference in the release rate using different electrostatic interaction between drug and particle surface that was caused by the surface functionalization. These results should enable design of drug carrier materials based on the SBA-15 particles with the desired release rate.

Effect of ketorolac on the prevention of emergence agitation in children after sevoflurane anesthesia

Deokkyu Kim,고성훈,A Ram Doo,임형선,Ji Seon Son,Jun-Rae Lee,한영진 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.64 No.3

Background: The purpose of this study was to evaluate the effects of ketorolac on the incidence and severity of emergence agitation in children recovering from sevoflurane anesthesia. Methods: Eighty-five children aged 3 to 7 years were randomly assigned to the control group or the ketorolac group (1 mg/kg ketorolac). The children were evaluated by the Pediatric Anesthesia Emergence Delirium Scale and a four-point agitation scale. Results: The median agitation scores did not differ significantly between the two groups. The overall incidence of emergence agitation was similar in the two groups (41% in the control group vs. 32% in the ketorolac group, P = 0.526). The number of children who received rescue drugs for treatment of emergence agitation was not significantly different between the two groups. Conclusions: The administration of 1 mg/kg of ketorolac is not effective in decreasing the incidence and severity of emergence agitation in children aged 3 to 7 years after sevoflurane anesthesia.

에세이 - 사랑방과 동굴벽화

이덕규,Lee, Deokkyu 대한건축사협회 2018 建築士 Vol.591 No.-

복강경하 신요관절제 수술 중 발생한 이산화탄소 기흉 -증례보고-

이기재 ( Kijae Lee ),김보람 ( Boram Kim ),최원영 ( Wonyoung Choi ),김덕규 ( Deokkyu Kim ) 전북대학교 의과학연구소 2015 全北醫大論文集 Vol.39 No.1

전신마취 중에는 환자가 증상을 호소할 수 없기에 새롭게 발생하는 기흉을 진단하는 것은 어렵고 이 때문에 치명적인 긴장성 기흉으로의 악화가 될 가능성이 높다. 특히, 복강경 수술에서는 기흉의 진단이 개복 수술에서보다 더 힘들다. 복강경 수술에서 수술 시야 확보를 위해 이산화탄소 가스를 이용하여 기복강을 유지해야 하는데, 이 기복강 때문에 필연적으로 기도압력이 증가하고 고이산화탄소혈증이 발생하여 기흉의 진단을 더욱 어렵게 한다. 저자들은 복강경하 신요관절제수술을 받는 두 명의 환자에서 이산화탄소 기흉이 발생하여 이에 대한 원인과 진단, 치료에 대해서 문헌 고찰과 함께 보고합니다. Pneumothorax, specifically capnothorax, during laparoscopic surgery is more difficult to diagnose compared with that of patients under open laparotomy surgery, because of normally increased airway pressure and hypercapnia due to pneumoperitoneum using carbon dioxide gas. We report two case of rapid resolution of capnothorax during laparoscopic nephroureterectomy. The cause of capnothorax is diaphragmatic injury in one patient during surgical procedure, and the entry of carbon dioxide gas into thorax cavity through the weak point of diaphragm during prolonged length of pneumoperitoneum in another patient.

Surface properties of silica nanoparticles modified with polymers for polymer nanocomposite applications

Youngchan Shin,Deokkyu Lee,이강택,안경현,김범상 한국공업화학회 2008 Journal of Industrial and Engineering Chemistry Vol.14 No.4

The surface of silica nanoparticles was modified with poly(ethylene glycol) methacrylate (PEGMA) or poly(propylene glycol) methacrylate (PPGMA) in order to improve the dispersion of nanoparticles in a polymer matrix. Nanosized silica particles were synthesized by the Sto¨ber method with tetraethyl orthosilicate (TEOS). Silica nanoparticles were treated with triethoxyvinylsilane (VTES) as a coupling agent to introduce reactive groups and the PEG or PPG were then grafted onto the particle surface via UV-photopolymerization. Various analytical methods, i.e., scanning electron microscopy (SEM), thermogravimetry (TG), zeta potential measurement, and water vapor adsorption measurement were used to comprehensively characterize the unmodified(pure) and modified silica particles. The SEM images of the pure and modified particles demonstrated that both particles have a spherical shape and a uniform size without agglomeration. The silica particles modified with polymers showed higher weight loss than unmodified silica particles because of the decomposition of the organic polymers grafted onto the particles. The surface modification of silica particles with polymers decreased the zeta potential values of the silica surface. Modified silica particles had lower water vapor adsorption due to the hydrophobic surface property resulting from the polymers grafted onto the silica surface. In addition, we have developed an electrical conductivity measurement as a novel method to analyze the surface properties of silica nanoparticles. The modified silica particles had lower electrical conductivity than that of unmodified silica particles.