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Modeling of 3-stage Electromagnetic Induction Launcher
Daehwan Kwak,Young Bae Kim,Jong Soo Kim,Chuhyun Cho,Kyung-Seung Yang,Seong-Ho Kim,Byung-Ha Lee,Sanghyuk An,Young-Hyun Lee,Seok Han Yoon,In Su Koo,Yong Gi Baik,Yun Sik Jin 한국자기학회 2015 Journal of Magnetics Vol.20 No.4
Electromagnetic Induction Launchers (EIL) have been receiving great attention due to their advantages of noncontact between the coils and a projectile. This paper describes the modeling and design of 3-stage EIL to accelerate a copper projectile of 50 kg with 290 mm diameter. Our EIL consists of three independent driving coils and pulsed power modules to generate separate driving currents. To find efficient acceleration conditions, the appropriate shape of the driving coils and the position of the projectile have been calculated by using a finite element analysis (FEA) method. The results showed that the projectile can be accelerated more effectively as the gap between the coils is smaller; a final velocity of 45 m/s was obtained. The acceleration efficiency was estimated to be 23.4% when a total electrical energy of 216 kJ was discharged.
Synteny Portal: a web-based application portal for synteny block analysis
Lee, Jongin,Hong, Woon-young,Cho, Minah,Sim, Mikang,Lee, Daehwan,Ko, Younhee,Kim, Jaebum Oxford University Press 2016 Nucleic acids research Vol.44 No.w1
<P>Recent advances in next-generation sequencing technologies and genome assembly algorithms have enabled the accumulation of a huge volume of genome sequences from various species. This has provided new opportunities for large-scale comparative genomics studies. Identifying and utilizing synteny blocks, which are genomic regions conserved among multiple species, is key to understanding genomic architecture and the evolutionary history of genomes. However, the construction and visualization of such synteny blocks from multiple species are very challenging, especially for biologists with a lack of computational skills. Here, we present Synteny Portal, a versatile web-based application portal for constructing, visualizing and browsing synteny blocks. With Synteny Portal, users can easily (i) construct synteny blocks among multiple species by using prebuilt alignments in the UCSC genome browser database, (ii) visualize and download syntenic relationships as high-quality images, (iii) browse synteny blocks with genetic information and (iv) download the details of synteny blocks to be used as input for downstream synteny-based analyses, all in an intuitive and easy-to-use web-based interface. We believe that Synteny Portal will serve as a highly valuable tool that will enable biologists to easily perform comparative genomics studies by compensating limitations of existing tools. Synteny Portal is freely available at http://bioinfo.konkuk.ac.kr/synteny_portal.</P>
Lee, Daehwan,Cho, Minah,Hong, Woon-young,Lim, Dajeong,Kim, Hyung-Chul,Cho, Yong-Min,Jeong, Jin-Young,Choi, Bong-Hwan,Ko, Younhee,Kim, Jaebum Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.9
Advances in next generation sequencing (NGS) technologies have enabled population-level studies for many animals to unravel the relationships between genotypic differences and traits of specific populations. The objective of this study was to perform evolutionary analysis of single nucleotide polymorphisms (SNP) in genes of Korean native cattle Hanwoo in comparison to SNP data from four other cattle breeds (Jersey, Simmental, Angus, and Holstein) and four related species (pig, horse, human, and mouse) obtained from public databases through NGS-based resequencing. We analyzed population structures and differentiation levels for the five cattle breeds and estimated species-specific SNPs with their origins and phylogenetic relationships among species. In addition, we identified Hanwoo-specific genes and proteins, and determined distinct changes in protein-protein interactions among five species (cattle, pig, horse, human, mouse) in the STRING network database by additionally considering indirect protein interactions. We found that the Hanwoo population was clearly different from the other four cattle populations. There were Hanwoo-specific genes related to its meat trait. Protein interaction rewiring analysis also confirmed that there were Hanwoo-specific protein-protein interactions that might have contributed to its unique meat quality.
mySyntenyPortal: an application package to construct websites for synteny block analysis
Lee, Jongin,Lee, Daehwan,Sim, Mikang,Kwon, Daehong,Kim, Juyeon,Ko, Younhee,Kim, Jaebum BioMed Central 2018 BMC bioinformatics Vol.19 No.-
<P><B>Background</B></P><P>Advances in sequencing technologies have facilitated large-scale comparative genomics based on whole genome sequencing. Constructing and investigating conserved genomic regions among multiple species (called synteny blocks) are essential in the comparative genomics. However, they require significant amounts of computational resources and time in addition to bioinformatics skills. Many web interfaces have been developed to make such tasks easier. However, these web interfaces cannot be customized for users who want to use their own set of genome sequences or definition of synteny blocks.</P><P><B>Results</B></P><P>To resolve this limitation, we present mySyntenyPortal, a stand-alone application package to construct websites for synteny block analyses by using users’ own genome data. mySyntenyPortal provides both command line and web-based interfaces to build and manage websites for large-scale comparative genomic analyses. The websites can be also easily published and accessed by other users. To demonstrate the usability of mySyntenyPortal, we present an example study for building websites to compare genomes of three mammalian species (human, mouse, and cow) and show how they can be easily utilized to identify potential genes affected by genome rearrangements.</P><P><B>Conclusions</B></P><P>mySyntenyPortal will contribute for extended comparative genomic analyses based on large-scale whole genome sequences by providing unique functionality to support the easy creation of interactive websites for synteny block analyses from user’s own genome data.</P>
Daehwan Kim,A Ram Kim,Hanjun Kim,Sunghee Lee,Byeonghak Seo,Ho Seok Suh,Chang Sun Sim,Heun Lee,Cheolin Yoo 대한직업환경의학회 2022 대한직업환경의학회지 Vol.34 No.-
Background: Occupational skin diseases are skin conditions that occur or worsen in relation to work and known to be the second most common type of occupational disease affecting individuals in the United States. In Korea, epidemiological reports related to occupational skin diseases are rare. But, no cases of occupational contact dermatitis caused by welding and grinding work have been reported previously. Case presentation: Nine male workers working in the production department for liquefied natural gas (LNG) ships in Ulsan complained of erythematous papules/patches and itching in various areas of the body after welding and grinding work. The work environment monitoring report revealed that the amount of nickel dust exceeded the time weighted average (TWA) and poor local ventilation status. Based on the symptoms and the overall results of surveys, several tests, and work environment monitoring report, the 2 workers who had positive patch-test reactions to nickel were diagnosed with nickel dust-induced allergic contact dermatitis. The other 7 workers were diagnosed that there was a high probability that they had nickel dust-induced irritant contact dermatitis. The 2 workers who had nickel dust-induced allergic contact dermatitis were recommended to switch their jobs. Conclusions: Nickel is one of the most common cause of allergic contact dermatitis. In this case, the dust was assumed to be created by welding work with a high nickel content new welding rod and subsequent grinding work, and the concentration of this dust exceeded the time weighted average. Thus, it is thought that the nickel dust may have caused contact dermatitis through continuous contact with the workers" exposed skin in a poorly ventilated space. Currently, several domestic shipbuilding companies are manufacturing LNG tankers using a new construction method. Consequently, it is highly likely that similar cases will occur in the future, which makes this case report meaningful.
이명신(Lee Myeongshin),박재형(Park Jaehyung),이보영(Lee Boyoung),현대환(Hyun Daehwan),양형모(Yang Hyungmo),정옥철(Jung Okchul),정대원(Chung Daewon) 한국항공우주연구원 2023 항공우주산업기술동향 Vol.21 No.2
정부, 상업, 군 및 민간 영역에서 우주시스템의 활용은 지속적으로 증가하면서 우주보안의 관심도 증가하고 있다. 보안의 전통적인 개념은 시스템, 데이터, 정보, 자산 등을 물리적 또는 논리적으로 내·외부 위협으로부터 보호하고 안전하게 유지하는 것이다. 따라서, 우주보안은 우주임무를 구성하는 우주시스템, 지상시스템 및 우주-지상 통신시스템을 위협으로부터 보호하고 안전하게 유지하는 것으로 정의할 수 있다. 국내에서는 우주임무운영 관련 주요 시설을 정부 주도하에 주요정보통신기반시설로 지정하여 보안관리점검을 수행하고 있다. 본 논문에서는 국외 표준기관 및 우주운영기관의 보안관리체계 플랫폼 구축 및 보안기술 구현 동향에 대하여 기술하고 있다. As the use of space systems continues to increase in government, commercial, military, and civil sectors, interest in space security is also increasing. The traditional concept of security is to physically or logically protect systems, data, information, and assets from internal and external threats and keep them safe. Therefore, space security can be defined as protecting the space system, ground system, and space-ground communication system that constitutes space missions from threats and keeping them safe. In Korea, major infrastructures related to space mission operations are designated as critical infrastructure under the leadership of the government and security management activities are being conducted. This paper describes trends in establishing security management system platforms and implementing security technologies in foreign standard organizations and space operation organizations.
Park, Daehwan,Lee, Jin Yong,Cho, Heui Kyoung,Hong, Woo Jin,Kim, Jisun,Seo, Hyemyung,Choi, Ikjang,Lee, Youngbok,Kim, Juhyeon,Min, Sun-Joon,Yoon, So-Hyun,Hwang, Jae Sung,Cho, Kwang Jin,Kim, Jin Woong American Chemical Society 2018 Biomacromolecules Vol.19 No.7
<P>We herein propose a polymeric nanovehicle system that has the ability to remarkably improve cellular uptake and transdermal delivery. Cell-penetrating peptide-patchy deformable polymeric nanovehicles were fabricated by tailored coassembly of amphiphilic poly(ethylene oxide)-<I>block</I>-poly(ε-caprolactone) (PEO-<I>b</I>-PCL), mannosylerythritol lipid (MEL), and YGRKKRRQRRR-cysteamine (TAT)-linked MEL. Using X-ray diffraction, differential scanning calorimetry, and nuclear magnetic resonance analyses, we revealed that the incorporation of MEL having an asymmetric alkyl chain configuration was responsible for the deformable phase property of the vehicles. We also discovered that the nanovehicles were mutually attracted, exhibiting a gel-like fluid characteristic due to the dipole-dipole interaction between the hydroxyl group of MEL and the methoxy group of PEO-<I>b</I>-PCL. Coassembly of TAT-linked MEL with the deformable nanovehicles significantly enhanced cellular uptake due to macropinocytosis and caveolae-/lipid raft-mediated endocytosis. Furthermore, the <I>in vivo</I> skin penetration test revealed that our TAT-patchy deformable nanovehicles remarkably improved transdermal delivery efficiency.</P> [FIG OMISSION]</BR>
김대환(Daehwan Kim),이선영(Seonyeong Lee),유승현(Senghyun Yu),박장진(jang Park),이성준(Seongjun Lee) 한국자동차공학회 2018 한국자동차공학회 지부 학술대회 논문집 Vol.2018 No.5
Most of the existing fire alarms work depending on levels of carbon monoxide when fires outbreak; but their reliability of safety must decrease because only the levels are detected as a sensing element. This study suggests an algorism to detect fire by considering the three information for high accuracy of sensing and reliability improvement: Temperature Sensor, Flame Detection Sensor, and Carbon Monoxide Level Sensor. In addition, a simulation was completed by using situational sensing data which are based on an open source code of Arduino. As the result, aimed results came out according to the software design.