Infliximab으로 호전된 장관 증상없이 발생한 구강-안면 크론병

정보용 ( Bo Yong Jung ),이석호 ( Suck Ho Lee ),정승규 ( Seung Kyu Chung ),이창균 ( Chang Kyun Lee1 ),이태훈 ( Tae Hoon Lee ),정일권 ( Il Kwun Chung ),김선주 ( Sun Joo Kim ),조현득 ( Hyun Deuk Cho ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6

Crohn`s disease is a chronic inflammatory bowel disease that can involve the whole gastrointestinal tract. The orofacial manifestation of Crohn`s disease, which is rare, can develop irrespective of intestinal involvement. These orofacial lesions are often misdiagnosed as simple oral ulcers. Corticosteroids are the mainstay of therapy for orofacial Crohn`s disease. However, infliximab, the chimeric monoclonal antibody to tumor necrosis factor-α, is now considered as a primary treatment because of the disease`s relatively high rate of steroid resistance. We present a case of deep oral ulcer and periorbital swelling in a 65-year-old woman. She was diagnosed with intestinal Crohn`s disease 7 years ago, which was in remission after treatment with an immunosuppressive agent (azathioprine). The patient was given the diagnosed with orofacial Crohn`s disease and successfully treated with infliximab. (Korean J Gastroenterol 2012;59:437-440)

永久齒 拔齒의 原因別 統計 및 齒齡에 關한 報告

이정석 梨花女子大學校 韓國生活科學硏究院 1977 韓國生活科學硏究院 論叢 Vol.18 No.-

健全한 齒牙의 維持 保存은 齒科醫學의 窮極的 目標이다. 그러나 여러 原因으로 拔去하게 됨으로써 年齡 增加에 따라 現存 齒兒數는 減少되어가고 이에 따라 本來의 機能도 喪失되어간다. 筆者는 過去 二年間 梨花炳院 齒科에 來院한 患者 2,221名 중 永久齒를 拔去한 519名 815個齒牙를 그 原因을 ① 齒牙우식증 ② 齒周疾患 ③ 補綴上 理由 ④ 埋伏 또는 囊腫 등의 口腔外科的 理由 ⑤ 矯正治療의 目的 ⑥ 外傷으로 分類하고 拔去當時의 年齡을 調査하여 다음과 같은 結論을 얻었다. (1) 齒牙 拔去의 原因 중에서 齒牙우식증이 48.9%, 齒周疾患이 29.0%로서 全體例의 約 8割(77.9%)을 占하여 外科的 理由가 11.7%로 비교적 높았다. (2) 年齡의 增加에 따라 齒牙우식증으로 인한 拔去는 漸次 低下되고 反對로 齒周疾患으로 因한것은 顯著한 上昇 추세를 보였다. (3) 性別로 보면 男子에서는 上下握 對比가 57.5:42.5인데 女子에서는 41.0:58.9%이고 齒牙別로는 下握第三·第一大臼齒가 가장 높은 편이고 下握 中·側切齒 및 上下握 犬齒에서 가장 낮았다. (4) 齒齡은 上下握 第二大臼齒, 下握中·側切齒등이 높았고, 下握 第三·第一大臼齒 등이 낮아 拔齒의 原因과 密接한 關係가 있음이 明白히 立證되었다. This was to study 1) the cause of extraction by age and tooth types, and 2) tooth mor-tality with 2,221 out-patients who had visited to the Department of Dentistry, Ewha Womans University Hospital from January 1974 to December 1975. The following results were obtained: (1) 519 of 2,221 patients (23.3%) were extracted their one or more teeth by various causes and the average number of extracted teeth were 1.5 in male and 1.6 in female. (2) The most prevalent causes of tooth loss were due to advanced dental caries (49.0%), periodontal disease (29.1%), and impacted teeth, cyst or other oral lesions (11.85). (3) While the age increased tooth mortality due to dental caries was reduced gradual-ly from 73.1% in adolescent group to 15.8% in the 5th decade, and the number of tooth loss caused by periodontal disease was getting higher in the 4th decade (50.8%) and in the 5th decade (82.25). (4) Mean age of permanent tooth mortality in male was 37.70 and in female was 34.41. (5) The relatively high mortalities of individual teeth were revealed as follows; ??(15.7%), ??(14.9%), ??(10.6%), ??(9.8%). (6) The maxillary and mandible second molars, mandible central and lateral incis-ors retained longest, and mandible first and third molars, maxillary central incisors and third molars showed shortest in their mean age. (7) The tooth mortalities of male were longer than female, and maxillary teeth were longer than mandibular teeth.

中年期의 口腔保健管理

李正? 대한가정의학회 1984 Korean Journal of Family Medicine Vol.5 No.4

一部 女大生의 칫솔使用에 따른 齒牙磨耗症

이정석 梨花女子大學校 韓國生活科學硏究院 1971 韓國生活科學硏究院 論叢 Vol.7 No.-

An observation of wedge-shaped abrasion(so-called V-Shaped abrasion) of some Korean college gils was carried out as a step of routine dental examination.Abrasion of teeth is getting serious by improper toothbrushing.Cervical portions(neck) of the teeth- labial sites of the upper and lower canines, buccal sites of the upper and lower first and second premolars-were checked by No.6or N0.23 explorers.The abrasion was classified into two groups,i.e.,'AE'For the abrasion of enamel and or thin layer of dentin and 'AD'for the advanced cases into dentin. 1) Among the subject(N=2,222), the abrasion were checked on 616 students.The rate was 27.72%. 2) This study dealed with only the wedge-shaped abrasion.The rate would be increased if it included the all types of abrasion. 3) The rate of abrasion is raised according to the increase of age. 4) 'AD'the considerably advanced abrasion revealed 19.64% of all wedgeshaped cases.

광중합형 Glass lonomer Cement의 표면처리 방법에 따른 복합레진과의 결합력에 관한 실험적 연구

이정석,용승희 大韓齒科保存學會 1992 Restorative Dentistry & Endodontics Vol.17 No.2

수종 이원중합 레진 씨멘트의 중합률 및 세포 독성에 관한 실험적 연구

이정석,노병덕,박성호 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.1

AbstractThe degree of conversion of composite resin was known to have influence on the mechani- cal properties of composite materials such as hardness, strength, wear resisitance, dimensio- nal and color stability. Also unreacted monomer was reported to be harmful to the pulp. So the degree of conversion was a very important factor in the success of composite resin restorations.In recent, the dual cure resin cement was developed with the advocations that it could increase the curing rates in the sites where the curing ligt could not reach. Moreover many manufactors added some adhesive components in the resin cement.This study was undertaken to observe the effects of curing depth and light curing times on the degree of conversion of dual cure resin cements. CR INLAY CEMENT, DUAL CEMENT and OPTEC BOND, by the Fourier transform Infrared analysis, changing the curing depth 1mm, 2mm and 3mm, and varying the light curing time 20 seconds, 40 seconds and 80 seconds at each depth. The cytotoxicity of dual cure resin cements was tested by the in vitro MTT method using L929 cell. The results was evaluated and compared statistically.The results were obtained as follows: 1. The dual cure resin cements reavealed various degree of conversion, CR INLAY CE- MENT and DUAL CEMENT had a tendency to be more reactive to the light cure and OPTEC BOND was a more chemical one. 2. CR INLAY CEMENT and DUAL CEMENT showed the lowest degree of conversion in 2 mm depth, and in 3mm depth the degree of conversion increased, which were due to the chemical cure of dual cures, but OPTEC BOND showed decreasing degree of conversion with increasing curing depth and all experimental groups showed lower degree of conversion than CHEMICAL group which cured in dark room with no light, so the weak light?uring of dual cure resin cement prevented the chemical cure. (P<0. 05) 3. CR INLAY CEMENT and DUAL CEMENT showed increasing degree of conversion in 1 mm and 3 mm, according to the increasing cure times, but in 2 mm depth the degree of conversion decreased with increasing light?uring times and OPTEC BOND showed contrary tendency, but there was no ststistical importance in the differences among the experimental group.(P>0.05) 4. The optical density by MTT assay of extractions of CR INLAY CEMENT, DUAL CE- MENT and OPTEC BOND revealed no statitically important differences comparing with optical density of negative control.(P>0.05) 5. CR INLAY CEMENT showed a tendency of increaing cytotoxicity with days and DUAL CEMENT and OPTEC BOND showed higher cytotoxicity in 2 days than in 4 days, but there was no statistical importance in the differences. (P>0.05)

Glass lonomer cement 수복물(修復物)의 표면거칠기에 관한 실험적 연구

김광순,이승종,이정석 大韓齒科保存學會 1992 Restorative Dentistry & Endodontics Vol.17 No.1

One disadvantage of Glass Ionomer Cement Restoration is the difficulty in polishing. To find the appropriate polishing method, we polished the surface of Glass Ionomer Cement Restorations by 11 combination methods serially using disks sharde with alrge-small particles and evaluated the polishing process in terms of surface roughness, surface roughness curve, and SEM findings. In addition, a visible light curing type bonding material was applide to evaluate the possible imporvement in sruface properties. the following reusrlts were ovtainde. 1. The disk surface of Glass Ionomer Ciment was polished serially by disks with surperfine particles, but it didn't become smooth. 2. The surface of Microfilled Composite resin became smoother as using a disk with finer particles. 3. When a visible light curing type bonding material was applied in finishing process, the surface of Glass Ionomer Cement smooth as much as the applied matrix.

Argon 이온 레이저 중합에 의한 Composite resin의 물성에 관한 연구

조현경,이정석 大韓齒科保存學會 1992 Restorative Dentistry & Endodontics Vol.17 No.1

An experimentalj investigation of the physical properties of light curing composite resin P-50 was performed, in which an argon ion laser beam was irradiated. The physical and mechanical properties of laser polymerized composite resin were determined by measuring the compressive strength, diametral tensile strength, curing depth and microhardness depending upon the experimental conditions such as the laser irradiation time(10sec, 20sec, 30sec) and laser power(300mW, 500mW, 1000mW). These observations were compared with a conventional visible light curing technique. In addition, to evaluate the marginal adaptation, Class V cavity was prepared on the buocal or lingual surface of the extracted premolar and filled with P-50 light curing resin. The test samples were irradiated with both light sources so that the interface between the restoration and the tooth structure were observed under scanning electron microscope. The most of physical and mechanical properties of the laser cured resin showed a remarkable improvement than those treated with the conventional light source, while the observations with the scanning electron microscope provided no significant difference for two polymerized sources. From the results in the experiment it appears that the potential of an argon ion laser is of important value of the use in the polymerization of composite resin.

Sandwich 술식에 제V급 와동의 미세 변연누출에 미치는 영향에 대한 연구

신창승,이정석 大韓齒科保存學會 1993 Restorative Dentistry & Endodontics Vol.18 No.2

To evaluate the marginal leakage in Class V cavity, this study has been undertaken to compare the sandwich technique with the conventional method, and find out the effect of lining material, lining method, and polishing time on sandwich technique. Ninty extracted teeth were divided into eight test groups and a control group, and were prepared with a buccal Class V cavity. Four test groups were lined with Dentin Cement whereas the other four test groups were lined with Vitrabond. Half of the either group were lined 0.5mm short of the carvosurface margin and the rest were lined completely to the carvosurface margin. The four subgroups were further divided into specimens which were polished immediately and 24 hours after resin filling. The polished specimens were immersed in 37℃, 0.5% methylene blue solution for 24 hours after thermocycling at 5℃ and 55℃, 200 times and buccolingually sectioned. The sectioned specimens were examined dye penetration under light microscope. The following results were obtained, 1. At the enamel margin, the conventional method showed a lower microleakge than the sandwich technique. The difference between the control and Vitrabond group was statistically significant(P<0.05), but no difference between the control and Dentin Cement group, and between the lining materials was observed. 2. At the dentinal margin, the sandwich technique showed a significant lower amount of microleakage(P<0.05), but there was no significant difference between the lining materials. 3. Regardless of the lining material, lining method, and polishing time used, values of microleakage were significantly higher at the dential margin compared to the enamel margin(P<0.05). 4. In specimens till the cavosurface margin, microleakage at the dentinal margin was less with the light-cured base than with the chemically-cured base, but there was no siginificantly difference between the lining materials regarding the lining method and polishing time. 5. The lining material, lining method, and polishing time did not affect the amount of microleakage in the sandwich technique(P<0.05). Key word : sandwich technique, Lining material, Lining method, Polishing time

結核病棟 入院患者 喀痰에서 分離한 Nocardia屬의 同定과 藥齋 減受性에 關한 實驗

高春明,金駿杰,李正碩,李一善,李沅泳 최신의학사 1974 最新醫學 Vol.17 No.9

This study was. carried out for the identification and drug susceptibility of Nocardia species iso?lated from the sputum of pulmonary tuberculosis patients at Severance Hospital from May, 1973 to May, 1974. The results as follows: 1. Among the 138 experimental specimens, eleven of the Nocardia species were identified by the methods of direct microscopic observation and culture characteristics. 2. Of the eleven Nocardia species, 6 of the Nocardia species were identified N. asteroides, 3 of the N. brasiliensis and 2 of the strains could not identified with a ordinary methods. 3. Antimicrobial activity of experimental strains to the several antibiotics, Ampicillin, Oxacilin and Cloxacillin were excellent against to the tested groups and Streptomycin, Chloramphenical and Gantrisin were also moderated effective to the experimental group.