볼쯔만 머신을 이용한 인간 모션 학습 및 생성

이충연(Chung-Yeon Lee),김지섭(Ji-seob Kim),김은솔(Eun-Sol Kim),Karinne Ramírez Amaro,Michael Beetz,장병탁(Byoung-Tak Zhang) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.2B

카메라 영상 기반 모션 캡처 시스템을 이용하여 수집한 주방 공간에서의 인간 행동 데이터로부터 기본 동작들의 모션 데이터를 추출 및 전처리한 후 non-linear generative model인 cRBM을 이용하여 각 모션 데이터를 학습하였다. 초기 모션 일부를 seed로 사용하여 자동으로 생성한 새로운 모션들은 학습에서 사용된 모션들과 동일한 작업을 수행하는 결과를 나타냈다. 본 실험 결과는 일상 환경에서 인간으로부터 획득한 모션 데이터를 이용하여 생성된 가상의 모션 데이터를 통해 로봇이나 아바타의 움직임을 보다 유연하게 제어할 수 있으며 또한 인간이 유아기 때부터 주위 사람들의 행동을 따라하며 자연스럽게 자신의 행동 방법을 배우는 방식과 유사한 행동 학습 메커니즘이 로봇에게도 적용시킬 수 있음을 보인다.

Bi2InTaO7 compounds as promising photocatalysts for marine plankton removal

Leticia M. Torres-Martínez,Isaías Juárez-Ramírez,Juan S. Ramos-Garza,Francisco Vázquez-Acosta,Ricardo Gómez,ZhengYi Fu,Soo Wohn Lee 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.1

The removal of marine plankton, red (Amphidium carterae), and green (Tetraselmis suecica) tide algae, by heterogeneous photocatalysis was carried out using pyrochlore-type semiconductors. The semiconductor, Bi2InTaO7 , was prepared by the solgel method and a solid state reaction. The XRD patterns evidence formation of the pyrochlore phase in the sol-gel materials calcined at low temperatures (600-800 oC). Nanostructured sol-gel materials were observed by SEM. The sol-gel preparation allowed the formation of the pyrochlore-type compound with specific surface areas (7-13 m2g−1) higher than the solid obtained by solid state preparation (< 5 m2g−1). Band gap (Eg) values between 2.1-2.7 eV determined by UV-Vis spectroscopy were obtained. Bi2InTaO7 photocatalysts prepared by the sol-gel method were able to eliminate Tetraselmis suecica and Amphidium carterae algae totally after 50 minutes of UV-irradiation, whereas Bi2InTaO7 by solid state preparation needed more than 1 h.

Quercetin intake, MATE1 polymorphism, and metabolic syndrome in Korean population: Hallym aging study

Lee, Jung Eun,Park, Hye Won,Lee, Jae Kyung,Mok, Bo Ram,Lee, Hae-Jeung,Lee, Sung-Joon,Kim, Dong-Hyun Korean Society of Food Science and Technology 2016 Food Science and Biotechnology Vol.25 No.6

Multidrug and toxic compound extrusion transporter-1 (MATE1) is a quercetin transporter. We examined the associations of quercetin intake and polymorphism of MATE1 in relation to metabolic syndrome (MetS) in Hallym Aging Study. Quercetin intake and the measurements for MetS were assessed in 2004. Six tagging single nucleotide polymorphisms (SNPs) at MATE1 gene were genotyped in 428 Korean adults in 2012. We found a lower prevalence of MetS with quercetin intake; compared to the lowest quartile, odds ratios (ORs, 95% confidence intervals; CIs) were 0.44 (0.24-0.84) for the $3^{rd}$ quartile. Individuals with the minor allele of MATE1, rs2453589, tended to have a lower prevalence of MetS compared to those with the major allele (OR=0.69; CI=0.36-1.34). However, interactions between quercetin intake and six MATE1 polymorphisms in relation to MetS were not significant (p for interaction ${\geq}0.37$). In conclusion, intake of quercetin was associated with MetS in Korean populations.

Highly Efficient Polymer Light-Emitting Diodes Using Graphene Oxide as a Hole Transport Layer

Lee, Bo Ram,Kim, Jung-woo,Kang, Dongwoo,Lee, Dong Wook,Ko, Seo-Jin,Lee, Hyun Jung,Lee, Chang-Lyoul,Kim, Jin Young,Shin, Hyeon Suk,Song, Myoung Hoon American Chemical Society 2012 ACS NANO Vol.6 No.4

<P>We present an investigation of polymer light-emitting diodes (PLEDs) with a solution-processable graphene oxide (GO) interlayer. The GO layer with a wide band gap blocks electron transport from an emissive polymer to an ITO anode while reducing the exciton quenching between the GO and the active layer in place of poly(styrenesulfonate)-doped poly(3,4-ethylenedioxythiophene) (PEDOT:PSS). This GO interlayer maximizes hole–electron recombinations within the emissive layer, finally enhancing device performance and efficiency levels in PLEDs. It was found that the thickness of the GO layer is an important factor in device performance. PLEDs with a 4.3 nm thick GO interlayer are superior to both those with PEDOT:PSS layers as well as those with rGO, showing maximum luminance of 39 000 Cd/m<SUP>2</SUP>, maximum luminous efficiencies of 19.1 Cd/A (at 6.8 V), and maximum power efficiency as high as 11.0 lm/W (at 4.4 V). This indicates that PLEDs with a GO layer show a 220% increase in their luminous efficiency and 280% increase in their power conversion efficiency compared to PLEDs with PEDOT:PSS.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-4/nn300280q/production/images/medium/nn-2012-00280q_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn300280q'>ACS Electronic Supporting Info</A></P>

Supercritical Fluid Deposition of Conformal SrTiO[sub 3] Films with Composition Uniformity in Nanocontact Holes

Lee, J. H.,Son, J. Y.,Lee, Han-Bo-Ram,Lee, Heung-Soon,Ma, D.-J.,Lee, C.-S.,Kim, Hyungjun The Electrochemical Society 2009 Electrochemical and solid-state letters Vol.12 No.5

Low-Level Microsatellite Instability as a Potential Prognostic Factor in Sporadic Colorectal Cancer

Lee, Soo Young,Kim, Duck-Woo,Lee, Hye Seung,Ihn, Myong Hoon,Oh, Heung-Kwon,Min, Byung Soh,Kim, Woo Ram,Huh, Jung Wook,Yun, Jung-A.,Lee, Kang Young,Kim, Nam Kyu,Lee, Woo Yong,Kim, Hee Cheol,Kang, Sung- Wolters Kluwer Health 2015 Medicine Vol.94 No.50

<P><B>Abstract</B></P><P>Although microsatellite instability-high (MSI-H) colorectal cancers (CRCs) have been shown to exhibit a distinct phenotype, the clinical value of MSI-low (MSI-L) in CRC remains unclear. We designed this study to examine the clinicopathologic characteristics and oncologic implications associated with MSI-L CRCs.</P><P>We retrospectively reviewed data of CRC patients from 3 tertiary referral hospitals in Korea, who underwent surgical resection between January 2003 and December 2009 and had available MSI testing results. MSI testing was performed using the pentaplex Bethesda panel. Clinicopathologic features and oncologic outcomes were compared between MSI-L and microsatellite stable (MSS) CRCs; prognostic factors for survival were also examined.</P><P>Of the 3019 patients reviewed, 2621 (86.8%) were MSS, and 200 (6.6%) were MSI-L; the remaining 198 (6.6%) were MSI-H. MSI-L and MSS CRCs were comparable in terms of their clinicopathologic features, with the exception of proximal tumor location (MSI-L 30.0% vs MSS 22.1%, <I>P</I> = 0.024) and tumor size (MSI-L 5.2 ± 2.6 cm vs MSS 4.6 ± 2.1 cm, <I>P</I> = 0.001). No differences were detected in either 3-year disease-free survival (MSI-L 87.2% vs MSS 82.6%, <I>P</I> = 0.121) or 5-year overall survival (OS) (MSI-L 74.2% vs MSS 78.3%, <I>P</I> = 0.131) by univariable analysis. However, MSI-L was an independent prognostic factor for poor OS by Cox regression analysis (hazard ratio 1.358, 95% confidence interval 1.014–1.819, <I>P</I> = 0.040).</P><P>MSI-L may be an independent prognostic factor for OS in sporadic CRCs despite their clinicopathologic similarity to MSS. Further studies investigating the significance of MSI-L in the genesis and prognosis of CRCs are needed.</P>

Guest-Guest Interactions and Co-Occupation by Distinct Guests in the Metastable State of Clathrate Hydrates

Lee, Bo Ram,Sa, Jeong-Hoon,Hong, Sang Yeon,Lee, Ju Dong,Lee, Kun-Hong,Seo, Yongwon,Sum, Amadeu K. American Chemical Society 2019 The Journal of Physical Chemistry Part C Vol.123 No.6

<P>The current knowledge of guest-guest interactions and co-occupation in clathrate hydrates is exclusive for the same guests (H<SUB>2</SUB> or N<SUB>2</SUB>) at moderate pressure. Here, we introduce the unusual co-occupation of distinct guests in the metastable state of hydrates. With controlled hydrate fraction, particle size, and intensification of the sintering of SF<SUB>6</SUB> hydrate particles formed from water and SF<SUB>6</SUB> gas as a help gas, we observed an abnormal but unique synchronous behavior in Raman intensities of two guest molecules (SF<SUB>6</SUB> and N<SUB>2</SUB>/H<SUB>2</SUB>) in hydrates consistently and repeatedly; over time, the scattering intensity for the guests (i) increases, (ii) decreases, and (iii) finally reaches the stable level. Without a concentration change of SF<SUB>6</SUB>, this abnormal behavior must arise from the possible changes in the scattering cross section of the molecules, suggesting that N<SUB>2</SUB>/H<SUB>2</SUB> strongly interacts with SF<SUB>6</SUB> in the large cages, resulting in a possible co-occupation during the metastable transition. These observations on the metastability of gas hydrate attest the importance of the sintering effect as a barrier to prevent fast gas diffusion for reaching equilibrium, which could have significant implication in increasing overall gas storage in clathrate hydrates.</P> [FIG OMISSION]</BR>

Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model

Lee A Ram,Lee Seon-Yeong,Choi Jeong Won,Um In Gyu,Na Hyun Sik,Lee Jung Ho,Cho Mi-La 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Keloid disorder is an abnormal fibroproliferative reaction that can occur on any area of skin, and it can impair the quality of life of affected individuals. To investigate the pathogenesis and develop a treatment strategy, a preclinical animal model of keloid disorder is needed. However, keloid disorder is unique to humans, and the development of an animal model of keloid disorder is highly problematic. We developed the patient-derived keloid xenograft (PDKX), which is a humanized mouse model, and compared it to the traditional mouse xenograft model (transplantation of only keloid lesions). To establish the PDKX model, peripheral mononuclear cells (PBMCs) from ten keloid patients or five healthy control subjects were injected into NOD/SCID/IL-2Rγnull mice, and their keloid lesions were grafted onto the back after the engraftment of immune cells (transplantation of keloid lesions and KP PBMCs or HC PBMCs). Four weeks after surgery, the grafted keloid lesion was subjected to histologic evaluation. Compared to the traditional model, neotissue formed along the margin of the grafted skin, and lymphocyte infiltration and collagen synthesis were significantly elevated in the PDKX model. The neotissue sites resembled the margin areas of keloids in several respects. In detail, the levels of human Th17 cells, IL-17, HIF-1a, and chemokines were significantly elevated in the neotissue of the PDKX model. Furthermore, the weight of the keloid lesion was increased significantly in the PDKX model, which was due to the proinflammatory microenvironment of the keloid lesion. We confirmed that our patient-derived keloid xenograft (PDKX) model mimicked keloid disorder by recapitulating the in vivo microenvironment. This model will contribute to the investigation of cellular mechanisms and therapeutic treatments for keloid disorders.

Real-time detection of chlorine gas using Ni/Si shell/core nanowires

Lee, Dong-Jin,Heo, Kwang,Lee, Hyungwoo,Jin, Joon-Hyung,Chang, Hochan,Park, Minjun,Lee, Han-Bo-Ram,Kim, Hyungjun,Lee, Byung Yang Springer US 2015 NANOSCALE RESEARCH LETTERS Vol.10 No.1

<P>We demonstrate the selective adsorption of Ni/Si shell/core nanowires (Ni-Si NWs) with a Ni outer shell and a Si inner core on molecularly patterned substrates and their application to sensors for the detection of chlorine gas, a toxic halogen gas. The molecularly patterned substrates consisted of polar SiO<SUB>2</SUB> regions and nonpolar regions of self-assembled monolayers of octadecyltrichlorosilane (OTS). The NWs showed selective adsorption on the polar SiO<SUB>2</SUB> regions, avoiding assembly on the nonpolar OTS regions. Utilizing these assembled Ni-Si NWs, we demonstrate a sensor for the detection of chlorine gas. The utilization of Ni-Si NWs resulted in a much larger sensor response of approximately 23% to 5 ppm of chlorine gas compared to bare Ni NWs, due to the increased surface-to-volume ratio of the Ni-Si shell/core structure. We expect that our sensor will be utilized in the future for the real-time detection of halogen gases including chlorine with high sensitivity and fast response.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s11671-015-0729-2) contains supplementary material, which is available to authorized users.</P>

Age-associated Changes in Oxidative Stress-mediated Enzymes in the Brain of Senescence Accelerated Mice

Lee,Hyung Chul,Kim,Yong Hoon,Lee,Bo Ram,Sohn,Hyong Ok,Lee,Young Gu,Moon,Ja Young,Lee,Dong Wook 한국생명과학회 2000 한국생명과학회 학술발표회 Vol.27 No.-

SAM -P/8, a substrain of senescence-accelerated mouse (SAM), has a specific pathologic phenotypes, that is, deficits in learning and memory. It has been characterized by several age- related deficits in the brain. Age-related changes in the lipid peroxidation and activities of antioxidant enzymes were examined in the brains of senescence -prone SAM -P/8, and senescence-resistant SAM- R/1. There were no remarkable age-related changes in Cu,Zn-SOD and Mn-SOD activities of brain in both SAM-R/1 and SAM-P/8. Compared with that at 6 month-old, SAM-P/8 mice showed relatively high Cu,Zn-SOD activities at both 3 and 13 months old. Pattern of the enzyme activities in SAM -R/1 with advancing age was different with that in SAM-P/8, showing increase at 6 months of age. As in SAM-R/1, SAM -P/8 exhibited relatively little change in MDA contents with aging. This result indicates that oxidative stress in the brain of SAM-P/8 may be relatively similar to that in normal aging. The relative increase of GST activity was observed in the brain of SAM-P/8 at 13 months of age. But there was no remarkable age-related change in the brains of both SAM-R/1 and SAM-P/8. These results suggest that the levels of antioxidant status in brain may not be proper indicators for senescence.