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COSMOS2015 photometric redshifts probe the impact of filaments on galaxy properties
Laigle, C,Pichon, C,Arnouts, S,McCracken, H J,Dubois, Y,Devriendt, J,Slyz, A,Le Borgne, D,Benoit-Lé,vy, A,Hwang, Ho Seong,Ilbert, O,Kraljic, K,Malavasi, N,Park, Changbom,Vibert, D Oxford University Press 2018 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.474 No.4
<P>The variation of galaxy stellar masses and colour types with the distance to projected cosmic filaments are quantified using the precise photometric redshifts of the COSMOS2015 catalogue extracted from Cosmological Evolution Survey (COSMOS) field (2 deg(2)). Realistic mock catalogues are also extracted from the lightcone of the cosmological hydrodynamical simulation HORIZON-AGN. They show that the photometric redshift accuracy of the observed catalogue (sigma(z) < 0.015 at M-* > 10(10)M(circle dot) and z < 0.9) is sufficient to provide two-dimensional (2D) filaments that closely match their projected three-dimensional (3D) counterparts. Transverse stellar mass gradients are measured in projected slices of thickness 75 Mpc between 0.5 < z < 0.9, showing that the most massive galaxies are statistically closer to their neighbouring filament. At fixed stellar mass, passive galaxies are also found closer to their filament, while active star-forming galaxies statistically lie further away. The contributions of nodes and local density are removed from these gradients to highlight the specific role played by the geometry of the filaments. We find that the measured signal does persist after this removal, clearly demonstrating that proximity to a filament is not equivalent to proximity to an overdensity. These findings are in agreement with gradients measured in both 2D and 3D in the HORIZON-AGN simulation and those observed in the spectroscopic surveys VIPERS and GAMA (which both rely on the identification of 3D filaments). They are consistent with a picture in which the influence of the geometry of the large-scale environment drives anisotropic tides that impact the assembly history of galaxies, and hence their observed properties.</P>
Galaxy evolution in the metric of the cosmic web
Kraljic, K.,Arnouts, S.,Pichon, C.,Laigle, C.,de la Torre, S.,Vibert, D.,Cadiou, C.,Dubois, Y.,Treyer, M.,Schimd, C.,Codis, S.,de Lapparent, V.,Devriendt, J.,Hwang, H. S.,Le Borgne, D.,Malavasi, N.,Mi Oxford University Press 2018 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.474 No.1
Patel, Snahel,Cohen, Frederick,Dean, Brian J,De La Torre, Kelly,Deshmukh, Gauri,Estrada, Anthony A,Ghosh, Arundhati Sengupta,Gibbons, Paul,Gustafson, Amy,Huestis, Malcolm P,Le Pichon, Claire E,Lin, Ha American Chemical Society 2015 Journal of medicinal chemistry Vol.58 No.1
<P>Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLK inhibitors starting from a high-throughput screening hit. Using proposed hinge-binding interactions to infer a binding mode and specific design parameters to optimize for CNS druglike molecules, we came to focus on the di(pyridin-2-yl)amines because of their combination of desirable potency and good brain penetration following oral dosing. Our lead inhibitor GNE-3511 (26) displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that specific pharmacological inhibition of DLK may have therapeutic potential in multiple indications.</P>