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Ha, E,Yim, S V,Jung, K H,Yoon, S H,Zheng, L T,Kim, M J,Hong, S J,Choe, B K,Baik, H H,Chung, J H,Kim, J W Nature Publishing Group 2006 The pharmacogenomics journal Vol.6 No.5
The use of topiramate (TPM) in the treatment of binge-eating disorder, bulimia nervosa, and antipsychotic-induced weight gain has recently increased, however, the exact molecular basis for its effects on body weight reduction and improved glucose homeostasis, is yet to be elucidated. Here we investigated the effect and signaling pathway of TPM on glucose uptake in L6 rat skeletal muscle cells, which account for >70% of glucose disposal in the body. Intriguingly, we found that TPM (10 μM) stimulated the rate of glucose uptake up to twofold increase. And TPM-stimulated glucose transport was inhibited with the overexpression of dominant-negative form of AMP-activated protein kinase (AMPK), an important mediator in glucose transport, implicating that AMPK-mediated pathway is involved. The TPM-stimulated glucose transport was blocked by SB203580, a specific inhibitor of AMPK downstream mediator, p38 mitogen-activated protein kinase (MAPK) protein. LY294002, an inhibitor of phosphatidylinositol (PI) 3-kinase, which is another crucial mediator in independent glucose transport pathway, did not inhibit TPM-stimulated glucose transport. We also found that TPM increased the phosphorylation level of AMPK and p38 MAPK, whereas no effect on the activity of PI 3-kinase of TPM, when assessed by PI 3-kinase assay, was observed. These results together suggest that TPM stimulates glucose transport, not via PI 3-kinase mediated, but via AMPK-mediated pathway in skeletal muscle cells, thereby contributing to the body weight regulation and glucose homeostasis.The Pharmacogenomics Journal (2006) 6, 327–332. doi:10.1038/sj.tpj.6500366; published online 17 January 2006
Critical Exponents for the Ferromagnetic-Paramagnetic Transition in La0.7Sr0.3Mn0.8Ti0.2O3
N. V. Khiem,L. V. Bau,P. T. Phong,L. V. Hong,N. V. Dai,D. N. H. Nam,N. X. Phuc 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
La0:7Sr0:3Mn0:8Ti0:2O3 compounds were studied by using dc magnetization measurements. The magnetic data analyzed in the paramagnetic-ferromagnetic phase transition region by using the Arrott plot method gave values of TC ~ 150:1 K for the Curie temperature and β = 0:518, = 1:0083 and δ = 2:95 for the critical exponents. The values obtained for the critical exponents are close to those predicted by the mean-feld theory. La0:7Sr0:3Mn0:8Ti0:2O3 compounds were studied by using dc magnetization measurements. The magnetic data analyzed in the paramagnetic-ferromagnetic phase transition region by using the Arrott plot method gave values of TC ~ 150:1 K for the Curie temperature and β = 0:518, = 1:0083 and δ = 2:95 for the critical exponents. The values obtained for the critical exponents are close to those predicted by the mean-feld theory.
Effects of Selective Dilution on the MagneticProperties of La0.7Sr0.3Mn1-xM'xO3 (M' = Al, Ti)
D. N. H. Nam,N. V. Dai,L. V. Hong,N. X. Phuc,L. V. Bau,P. Nordblad,R. S. Newrock 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
The magnetic lattice of mixed-valence Mn ions in La0:7Sr0:3MnO₃ is selectively diluted by partial substitution of Al or Ti for Mn. The ferromagnetic transition temperature Tc and the saturation magnetization Ms both decrease with substitution. By presenting the data in terms of selective dilution, Tc in the low-doping region is found to follow the relation Tc = Tc0(1..np), where Tc0 refers to the undiluted system and np is the dilution concentration dened as np = x=0:7 or np = x=0:3 for M0 = Al or Ti, respectively. The scaling behavior of Tc(np) can be analyzed in the framework of the molecular-field theory and the still valid when Mn is replaced by both Al and Ti. The results are discussed with respect to the contributions from ferromagnetic double exchange and other possible antiferromagnetic superexchange interactions coexisting in the material. The magnetic lattice of mixed-valence Mn ions in La0:7Sr0:3MnO₃ is selectively diluted by partial substitution of Al or Ti for Mn. The ferromagnetic transition temperature Tc and the saturation magnetization Ms both decrease with substitution. By presenting the data in terms of selective dilution, Tc in the low-doping region is found to follow the relation Tc = Tc0(1..np), where Tc0 refers to the undiluted system and np is the dilution concentration dened as np = x=0:7 or np = x=0:3 for M0 = Al or Ti, respectively. The scaling behavior of Tc(np) can be analyzed in the framework of the molecular-field theory and the still valid when Mn is replaced by both Al and Ti. The results are discussed with respect to the contributions from ferromagnetic double exchange and other possible antiferromagnetic superexchange interactions coexisting in the material.
Hong, C.,Luckey, Megan A.,Ligons, Davinna L.,Waickman, Adam T.,Park, J.Y.,Kim, Grace Y.,Keller, Hilary R.,Etzensperger, R.,Tai, X.,Lazarevic, V.,Feigenbaum, L.,Catalfamo, M.,Walsh, Scott T.R.,Park, J. Cell Press 2014 Immunity Vol.40 No.6
The common γ-chain (γc) plays a central role in signaling by IL-2 and other γc-dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of γc mRNA that results in protein expression and secretion of the γc extracellular domain. The soluble form of γc (sγc) is present in serum and directly binds to IL-2Rβ and IL-7Rα proteins on T cells to inhibit cytokine signaling and promote inflammation. sγc suppressed IL-7 signaling to impair naive T cell survival during homeostasis and exacerbated Th17-cell-mediated inflammation by inhibiting IL-2 signaling upon T cell activation. Reciprocally, the severity of Th17-cell-mediated inflammatory diseases was markedly diminished in mice lacking sγc. Thus, sγc expression is a naturally occurring immunomodulator that regulates γc cytokine signaling and controls T cell activation and differentiation.
Transition from 2-D to 1-D Transport in Superconducting YBa2Cu3O7
V. D. Lam,L. V. Hong,P. H. Khoi,J.F. Hamet,F. Boyer,이영백,J.P. Maneval 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
The resistive response of c-axis textured YBa₂Cu₃O7 bridges (100 nm thick and 10 m wide) has been studied dynamically on the nanosecond scale over a wide span of temperatures and currents. From Tc down to 75 K, dissipation is dominated by the viscosity of vortices spontaneously generated in the earth's magnetic eld. For 70 K < T < 75 K, vortex ow coexists with phase-slip centers (PSCs) characteristic of one-dimensional (1-D) transport. Eventually, below about 70 K, vortex ow is inhibited while, independently, PSCs transform into normal hot spots. All these resistive modes are identified by using a different time-varying voltage consecutive to the application of a step function of the current to the bridge.