http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
SAMHD1 Has Differential Impact on the Efficacies of HIV Nucleoside Reverse Transcriptase Inhibitors
Huber, Andrew D.,Michailidis, Eleftherios,Schultz, Megan L.,Ong, Yee T.,Bloch, Nicolin,Puray-Chavez, Maritza N.,Leslie, Maxwell D.,Ji, Juan,Lucas, Anthony D.,Kirby, Karen A.,Landau, Nathaniel R.,Saraf American Society for Microbiology 2014 Antimicrobial Agents and Chemotherapy Vol.58 No.8
<P>Sterile alpha motif- and histidine/aspartic acid domain-containing protein 1 (SAMHD1) limits HIV-1 replication by hydrolyzing deoxynucleoside triphosphates (dNTPs) necessary for reverse transcription. Nucleoside reverse transcriptase inhibitors (NRTIs) are components of anti-HIV therapies. We report here that SAMHD1 cleaves NRTI triphosphates (TPs) at significantly lower rates than dNTPs and that SAMHD1 depletion from monocytic cells affects the susceptibility of HIV-1 infections to NRTIs in complex ways that depend not only on the relative changes in dNTP and NRTI-TP concentrations but also on the NRTI activation pathways.</P>