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임경택(Kyung-Taek Rim) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.1
Objectives: Effective genetic toxicology and molecular biology research techniques and strategies that are highly correlated with the carcinogenic inhalation toxicity test and related research are required. The aim of this study was to maximize the utilization of chemical substances to prevent workers’ occupational diseases. Methods: We surveyed the literature, domestic and international references, and the status of relevant domestic and foreign professional organizations. Expert advisory opinions were reflected, and experts were consulted by participating in domestic and overseas academic conferences. Results: The current status of domestic and international genotoxic toxicity evaluation was examined through various documents from related organizations. Cell models for in vitro lung toxicology were investigated and summarized, and the human resourcesand performance results of genetic toxicity studies and pilot projects were compared and analyzed by holding an advisory meeting. We examined domestic and international genotoxicity guidelines and investigatednew test methods for the development of genotoxicity and carcinogenicity. Ultimately, we described long-term future predictions, including the implementation of our researchers’ recommendations and occupational genetic toxicology forecasts for future worker health protection. Conclusions: This research project aims to establish current genetic toxicology and molecular biology research techniques and strategies that can maximize the linkage with the carcinogenic inhalation toxicity test and research in the future. We expanded the study of genetic toxicity and establish afoundation forgenetic toxicity in accordance with research trends in Korea and abroad.
미생물복귀돌연변이(Ames)시험을 통한 탄산리튬의 변이원성 고찰
임경택 ( Kyung Taek Rim ),김수진 ( Soo Jin Kim ) 한국산업보건학회 2014 한국산업보건학회지 Vol.24 No.3
Objectives: To evaluate the mutagenicity of lithium carbonate, a bacterial reverse mutation(Ames) test was carried out using four strains of S. typhimurium(TA1535; TA1537; TA98; and TA100) and one strain of E. coli(WP2uvrA). Materials: This was carried out in a dose range from 312.5 to 5,000 μg/plate in triplicate with and without S9 activation, which is the most commonly used metabolic activation system supplemented by a post-mitochondrial fraction prepared from the livers of rodents treated with enzyme-inducing agents such as Aroclor 1254 or a combination of phenobarbitone and β-naphthoflavone. Results: No significant increases in the number of revertants were observed under the conditions examined in this study. Conclusions: Based on the above observations, it can be concluded that lithium carbonate has no mutagenic activity. Despite the results, it can have an effect by inducing acute oral toxicity, eye irritation and acute aquatic toxicity. Based on this study, we suggest that future studies should be directed toward chronic, carcinogenic testing and other related areas.
임경택 ( Kyung Taek Rim ) 한국산업위생학회 2014 한국산업보건학회지 Vol.24 No.1
Objectives: Since information on biological factors in the workplace are currently lacking, I wanted to create a handbook of these factors that would be viewable at a glance as a means to more effectively prevent occupationally-infected diseases. Proper information on biological hazards in the workplace allowing the appropriate recognition of the harmful factors is desperately needed. Methods and Results: In this study, I intended to create a high-utility handbook of biologically hazardous agents in the workplace. To ensure its effectiveness, information and references about biologically hazardous agents in the workplace were analyzed and classified and pathogen safety data sheets(PSDS) sourced from the Public Health Agency of Canada were included. I intended to make it accessible from the point of view of workers and their employers. A more effective classification system of occupational infectious diseases is presented, and biologically hazardous agents were classified according to occupations, industries, infectious diseases, and so on. The handbook consists of 60 major kinds of biologically infectious occupational factors that are expected to be generated in workplaces in Korea, and are focused on practical utility. The pathogen safety data sheets(PSDS) of 192 species were also included. To allow more effective management, domestic and foreign laws and regulations are presented. Conclusions: This case report presents general information on the history and contents of the handbook and PSDS, it will also be useful in workplaces if download from the homepage of OSHRI, KOSHA(oshri.kosha.or.kr/bridge?menuID=901).
Aluminum Oxide, Calcium Oxide, Sodium Tetraborate의 미생물복귀돌연변이시험
임경택 ( Kyung Taek Rim ),김수진 ( Soo Jin Kim ),김종규 ( Jong Gyu Kim ),김현영 ( Hyeon Yeong Kim ),양정선 ( Jeong Sun Yang ) 한국환경분석학회 2009 환경분석과 독성보건 Vol.12 No.3
We investigated the genotoxicities or mutagenicities of 3 chemicals, i.e., aluminum oxide, calcium oxide, and sodium tetraborate. We have limited toxicological data in spite of their common usage based on Ames reverse mutation test. In this study, treatment of 3 chemicals at the dose of 5,000, 2,500, 1,250, 625, and 312.5 μg/plate did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, and in Escherichia coli WP2uvrA with and without metabolic activation. These results indicate that the 3 chemicals do not have mutagenic potentials under the conditions of this study. However, further investigations were necessary because it may harmful to workers by ingestion, inhalation, skin or eye contact. And it is also desirable to prepare the local exhaust system and to wear personal protection equipments.
흡입노출에 의한 만성, 발암성시험 대상물질 및 우선순위 선정 연구
임경택 ( Kyung Taek Rim ),임철홍 ( Cheol Hong Lim ),안병준 ( Byung Joon Ahn ) 한국산업위생학회 2014 한국산업보건학회지 Vol.24 No.4
Objectives: There is requirement to select candidate materials for chronic inhalation/carcinogenicity testing, so we would like to set the priority of candidate materials. Methods and Results: We recommend the priorities for candidate materials based on the chemicals stipulated in the Occupational Safety and Health Act(OSHAct) and the Toxic Chemicals Control Act(TCCA) in Korea. Conclusions: We presented candidate chemicals consisting of solids(powders), gases and liquids(Such as organic solvents) with priorities.
산안법 관리대상물질의 변이원성 검색을 통한 GLP 유전독성 시험대상 후보물질의 선정
임경택 ( Kyung Taek Rim ),임철홍 ( Cheol Hong Lim ),안병준 ( Byung Joon Ahn ) 한국산업보건학회 (구 한국산업위생학회) 2015 한국산업보건학회지 Vol.25 No.3
Objectives: There is a requirement to select target materials for mutagenicity(Genotoxicity) testing, so we determined to set the test priorities of them by searching the related database. Methods and Results: We searched a number of databases to find information on mutagenicity tests with chemicals under the Occupational Safety and Health Act(OSH Act), such as KOSHANET, National Toxicology Program(NTP), European Chemicals Agency(ECHA), US National Library of Medicine(NLM), and Genetic Toxicology Data Bank(GENE-TOX), as well as ChemIDplus webpage, and presented the information. Also we anticipated their hazards with ACToR sites to confirm the 58 mutagenicity(Genotoxicity) tests we will perform. Conclusions: We presented target materials for mutagenicity testing with specific GLP tests consisting of reverse mutation(Ames), chromosomal aberration and micronucleus test.