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감궁탕이 사람의 갑상선세포에서 Fas 매개성 apoptosis에 미치는 영향
남경수,손옥례,김미경,김철호,소명숙,전병훈,손윤희,Nam Kyung Soo,Son Ok Lye,Kim Mee Kyung,Kim Cheorl Ho,So Myung Suk,Jeon Byung Hun,Shon Yun Hee 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
Inflammatory cytokine, abundantly produced in Hashimoto's thyroiditis, induced Fas expression in normal thyrocytes. We determined that susceptibility to Fas-activated apoptosis could be influenced by inflammatory cytokine and investigated a potential role of Gamgung-tang (GGT, Glycyrrhizae Radix, black beans, Angelicae Radix and Cnidii Rhizoma) in the thyroid follicular cells. $IL-1\beta$ was able to induce Fas expression in normal thyrocytes. GGT inhibited $IL-1\beta-induced$ Fas expression. Thyroid follicular cells were found to undergo DNA fragmentation with the inflammatory cytokines. GGT inhibited DNA fragmentation in a dose-dependent manner. These results suggest that GGT inhibit Fas-mediated apoptosis in thyroid follicular cells, therefore, may have therapeutic potential in the treatment of autoimmune chronic thyroiditis.
불가사리 단백추출물이 Cytochrome P450 1A1과 Ornithine Decarboxylase 활성에 미치는 영향
남경수,김미경,조현정,손윤희,Nam, Kyung-Soo,Kim, Mee-Kyung,Cho, Hyun-Jung,Shon, Yun-Hee 한국해양바이오학회 2006 한국해양바이오학회지 Vol.1 No.2
The effect of protein extract from Asterina pectinifera on proliferation of human breast cancer cells and activities of cytochrome P450 1A1 and ornithine decarboxylase was tested. Protein extract from Asterina pectinifera inhibited the growth of both estrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 human breast cancer cells. Cytochrome P450 1A1 activity was significantly inhibited by the protein extract from Asterina pectinifera at concentrations of 80 (p<0.05), 120 (p<0.01) and $160{\mu}g/m{\ell}$ (p<0.01). The extract inhibited induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate, a key enzyme of polyamine biosynthesis, which is enhanced in breast tumor promotion. Therefore, Asterina pectinifera is worth further investigation with respect to breast cancer chemoprevention or therapy. 별불가사리 단백추출물을 조제하여 유방암 유발억제효과를 측정한 결과, 별불가사리 단백추출물은 estrogen-의존성의 유방암세포(MCF-7)와 estrogen-비의존성 유방암세포(MDA-MB-231)의 증식을 농도의존적으로 억제하는 효과가 있었으며, 유방암발생 발암물질 활성에 관여하는 cytochrome P450 1A1 활성도 저해하였다. 또한 유방암발생의 촉진단계에 주요한 기능을 가진 ODC 활성도 억제하였으므로 별불가사리 단백추출물은 유방암 발생을 저해할 것으로 기대된다.
별불가사리 단백추출물이 유방암예방 및 전이억제 효소계에 미치는 영향
남경수,김미경,조현정,손윤희,Nam, Kyung-Soo,Kim, Mee-Kyung,Cho, Hyun-Jung,Shon, Yun-Hee 한국해양바이오학회 2006 한국해양바이오학회지 Vol.1 No.3
별불가사리 단백추출물을 조제하여 유방암 발생 및 전이억제효과를 측정한 결과 종양세포증식에 관여하는 aromatase 활성이 농도의존적으로 억제효과가 있었으며, 침윤성 유방암에서 과발현하는 COX-2 단백질 발현을 억제하였다. 그리고 유방암이 진행될수록 활성이 증가하는 MMP-9도 농도의존적 저해율을 보였다. 그러므로 별불가사리 단백추출물은 유방암억제기전에 관련된 더 많은 연구를 통하여 유방암 예방물질로서 개발 가능성이 있는 것으로 보인다. The effect of protein extract from Asterina pectinifera on breast cancer chemopreventive (aromatase and cyclooxygenase-2) and metastatic (matrix metalloproteinase) enzymes was tested. Protein extract from A. pectinifera was capable of suppressing aromatase in a human placenta microsomal assay. Cyclooxygenase-2 (COX-2) activity was significantly inhibited by the protein extract from A. pectinifera at concentrations of 10, 20 and $40{\mu}g/m{\ell}$. The extract markedly reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated matrix metalloproteinase (MMP)-9 activity. These results suggest that A. pectinifera could be of therapeutic value in preventing human breast cancer.
남경수(Kyung Soo Nam),임희선(Heesun Lim),안병일(Byeong-il Ahn) 한국바이오경제학회 2019 바이오경제연구 Vol.2 No.2
우리나라는 GMO 표시기준을 통해 GMO 원료가 사용된 식품을 표시하도록 하는 GMO 표시제를 실시하고 있지만, 가공 단계에서 유전자변형 DNA 성분이 남아 있지 않아 검출되지 않을 경우, 표시의무를 하지 않도록 예외를 허용하고 있어 GMO 표시제도 강화(완전 표시제)에 대한 요구가 증가하고 있다. 본 연구는 이와 같은 표시제 강화가 실제로 추진될 경우 식품산업에 미치는 파급효과는 어느 정도인지를 계측하고자 하는 의도에서 비롯되었다. 시장의 균형이동에 따른 생산액 감소를 추정한 결과, GM원료가 Non-GM원료로 대체됨으로 인한 비용상승의 영향은 크지 않은 것으로 나타났다. 한편, GM식품에 대해서는 지불의향 감소와 가격하락으로 인한 영향이 더 큰 것으로 분석되었다. 과자류에 대한 분석 결과, 시나리오별 평균 생산액 감소는 3,372~4,969억 원(11.4~16.8%)인 것으로 분석되었으며, 식용유지류의 경우 시나리오별 평균 생산액 감소는 1,942~2,686억 원(12.0~16.6%) 감소하는 것으로 분석되었다. 면류의 경우, 시나리오별 평균 생산액 감소는 3,891~5,096억 원(15.5~20.3%)인 것으로 분석되었으며, 장류의 경우, 시나리오별 평균 생산액 감소는 1,720~2,238억 원(21.6~28.1%)인 것으로 분석되었다. Korea has implemented GMO labeling to the foods using GMO raw materials. However, if genetically modified DNA components are not detected in the processing stage, exceptions of labeling obligation are allowed to avoid labeling obligations. For this reason, there is an increasing demand for strengthening the GMO labeling (complete labeling). This study is based on the intention to measure the ripple effect on the food industry if labeling is strengthed in such a way. This study is analyzed on the premise that the strengthening GMO labeling would lead to the division food industry into the GM food market and the Non-GM food market. Simulation results indicate that the impact of the cost increase due to the replacement of GM raw materials with non-GM raw materials is not significant. On the other hand, GM food is found to have a greater impact due to lower willingness to pay of consumers. The average decrease in the value of production for confectionery is estimated to be 337.2 ~ 497.9 billion won, and the value of production of edible oil is estimated to be decreased by 194.2 ~ 268.6 billion won. In the case of noodles, the average decrease in the value of production is estimated to be 389.91 ~509.6 billion won (15.5-20.3%), that of miso and red pepper paste is estimated to be in the range from 172 to 222.6 billion won.
키토산올리고당이 소 미성숙난포란의 핵성숙 및 수정에 미치는 영향
남경수(Kyung Soo Nam) 한국키틴키토산학회 1999 한국키틴키토산학회지 Vol.4 No.2
N/A This study was performed to evaluate the acute oral toxicity of chitooligosaccharides in Sprague-Dawley(SD) rats. Chitosan and chitooligosaccharides were administered at dose levels of 5,000, 2,500, 1,250, 625, 312.5 and 0 mg/kg body weight. After single oral administration to both sexes of SD rats, we observed rats for 14 days. All chitooligosaccharides did not induce any toxic signs in mortalities, clinical findings, body weights and gross findings of the rats. In view of result, it was impossible to estimate LD50 values in SD rats. Therefore, it was concluded that chitooligosaccharides have no effect on acute toxicity and side effect in rats.
Electroblotting을 이용한 단일클론항체의 NH2-말단 아미노산 배열분석
남경수(Kyung Soo Nam),장현욱(Hyeun Wook Chang),정규찬(Kyu Charn Chung) 대한약학회 1990 약학회지 Vol.34 No.1
NH2-terminal amino acid sequence analysis of monoclonal antibody is very important to identify gene family and diversities of antigen-antibody recognition. When we used the PVDF (Polyviriylidene difluoride) membrane blotting method, we could easily analyze NH2-terminal sequence of monoclonal-antibody which specifically binds to phosphatidylinositol 4,5-biphosphate. PVDF membrane is an ideal solid-phase support for sequence analysis, especially when used with electroblotting method. This method is superior to continual method and will be applied to the sequence analysis of picomole quantities of proteins by gel electrophoresis.
남경수 ( Kyung Soo Nam ),이미현 ( Mi Hyun Lee ),이규식 ( Kyu Shik Lee ),신진선 ( Jin Sun Shin ),정상빈 ( Sang Bin Jeong ) 한국키틴키토산학회 2011 한국키틴키토산학회지 Vol.16 No.1
We investigated the effect of low molecular weight chitosan oligosaccharide (COS-L, Mw < 1,000) on breast cancer development and progression through the measurement of quinone reductase (QR) activity and glutathione (GSH) content and the determination of ornithine decarboxylase activity (ODC) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). In a concentration range of 0.1 to 5 mg/mL, QR activity and GSH content in MCF-7 breast cancer cells were significantly increased maximal 76.5% and 56.3% by COS-L in a dose-dependent manner, respectively. Low molecular weight chitosan oligosaccharide effectively inhibited the activity of ODC, a key enzyme in cancer promotion. These results demonstrate that COS-L may prevent the development and promotion of breast cancer through the induction of QR activity, the increase of GSH content and the inhibition of ODC activity.