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Anti-wrinkle efficacy and safety of micro-spicule containing epidermal growth factor
( Jeong Min Ha ),( Kyuboem Han ),( Jong Cheon Ha ),( Hae Eul Lee ),( Young Lee ),( Young Joon Seo ),( Chang Deok Kim ),( Jeung Hoon Lee ),( Myung Im ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Microneedle patch recently have been used to increase skin permeability improving drug delivery and for cosmetic purposes. However, such treatment may fail if skin penetration is insufficient reducing drug delivery or if compliance is reduced by discomfort.Objectives: : To evaluate the efficacy and the safety of microspicules containing epidermal growth factor (MS-EGF) used to treat periorbital wrinkles. Methods: Twenty health volunteers were enrolled in a randomized, controlled, split-face study. One periorbital area was treated daily with soluble MS-EGF and the other with EGF cream, for 4 weeks; all subjects underwent 8 weeks of follow-up. Efficacy was assessed using a wrinkle severity rating scale (WSRS), subjective satisfaction scores, digital skin image analysis, examination of skin replicas, and ultrasonic measurement of dermal depth and density. Results: Both the MS-EGF and EGF alone yielded positive effects on digital skin image analysis, skin replica examination, and ultrasound. However, the MS-EGF groupexhibited significant improvements in dermal depth and density, and on replica analysis, compared to theEGF-only group (P < 0.05). In addition, the MS-EGF group showed a significantly greater change in WSRS score compared to baseline than the EGF-alone group. Both treatments were well-tolerated; no significant side-effect was noted. Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periorbital wrinkles.
Lee, Mi-Jin,Kong, Dekun,Han, Kyuboem,Sherman, David H,Bai, Linquan,Deng, Zixin,Lin, Shuangjun,Kim, Eung-Soo Springer International 2012 Applied microbiology and biotechnology Vol.95 No.1
<P>Polyene antibiotics such as nystatin are a large family of very valuable antifungal polyketide compounds typically produced by soil actinomycetes. Previously, using a polyene cytochrome P450 hydroxylase-specific genome screening strategy, Pseudonocardia autotrophica KCTC9441 was determined to contain an approximately 125.7-kb region of contiguous DNA with a total of 23 open reading frames, which are involved in the biosynthesis and regulation of a structurally unique polyene natural product named NPP. Here, we report the complete structure of NPP, which contains an aglycone identical to nystatin and harbors a unique di-sugar moiety, mycosaminyl-(α1-4)-N-acetyl-glucosamine. A mutant generated by inactivation of a sole glycosyltransferase gene (nppDI) within the npp gene cluster can be complemented in trans either by nppDI-encoded protein or by its nystatin counterpart, NysDI, suggesting that the two sugars might be attached by two different glycosyltransferases. Compared with nystatin (which bears a single sugar moiety), the di-sugar containing NPP exhibits approximately 300-fold higher water solubility and 10-fold reduced hemolytic activity, while retaining about 50% antifungal activity against Candida albicans. These characteristics reveal NPP as a promising candidate for further development into a pharmacokinetically improved, less-cytotoxic polyene antifungal antibiotic.</P>