http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Prediction of Prognosis in Glioblastoma Using Radiomics Features of Dynamic Contrast-Enhanced MRI
Pak Elena,Choi Kyu Sung,Choi Seung Hong,Park Chul-Kee,김태민,Park Sung-Hye,Lee Joo Ho,Lee Soon-Tae,Hwang Inpyeong,Yoo Roh-Eul,Kang Koung Mi,Yun Tae Jin,Kim Ji-hoon,Sohn Chul-Ho 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.9
Objective: To develop a radiomics risk score based on dynamic contrast-enhanced (DCE) MRI for prognosis prediction in patients with glioblastoma. Materials and Methods: One hundred and fifty patients (92 male [61.3%]; mean age ± standard deviation, 60.5 ± 13.5 years) with glioblastoma who underwent preoperative MRI were enrolled in the study. Six hundred and forty-two radiomic features were extracted from volume transfer constant (Ktrans), fractional volume of vascular plasma space (Vp), and fractional volume of extravascular extracellular space (Ve) maps of DCE MRI, wherein the regions of interest were based on both T1- weighted contrast-enhancing areas and non-enhancing T2 hyperintense areas. Using feature selection algorithms, salient radiomic features were selected from the 642 features. Next, a radiomics risk score was developed using a weighted combination of the selected features in the discovery set (n = 105); the risk score was validated in the validation set (n = 45) by investigating the difference in prognosis between the “radiomics risk score” groups. Finally, multivariable Cox regression analysis for progression-free survival was performed using the radiomics risk score and clinical variables as covariates. Results: 16 radiomic features obtained from non-enhancing T2 hyperintense areas were selected among the 642 features identified. The radiomics risk score was used to stratify high- and low-risk groups in both the discovery and validation sets (both p < 0.001 by the log-rank test). The radiomics risk score and presence of isocitrate dehydrogenase (IDH) mutation showed independent associations with progression-free survival in opposite directions (hazard ratio, 3.56; p = 0.004 and hazard ratio, 0.34; p = 0.022, respectively). Conclusion: We developed and validated the “radiomics risk score” from the features of DCE MRI based on non-enhancing T2 hyperintense areas for risk stratification of patients with glioblastoma. It was associated with progression-free survival independently of IDH mutation status.
Pak, Gijung,Salcedo, Dennis Espineli,Lee, Hansaem,Oh, Junsik,Maeng, Sung Kyu,Song, Kyung Guen,Hong, Seok Won,Kim, Hyun-Chul,Chandran, Kartik,Kim, Sungpyo American Chemical Society 2016 Environmental science & technology Vol.50 No.14
<P>This study mainly evaluated the effectiveness of ozonation toward the enhancement of the removal efficiencies of antibiotic-resistant bacteria (ARB), pB10 plasmid transfer, and pB10 plasmids under different pH and suspended solids (SS) and humic acid concentrations. First, chlorination was tested as a reference disinfection process. Chlorination at a very high dose concentration of Cl-2 (75 mg L-1) and a long contact time (10 min) were required to achieve approximately 90% ARB and pB10 plasmid transfer removal efficiencies. However, even these stringent conditions only resulted in a 78.8% reduction of pB10 plasmid concentrations. In case of ozonation, the estimated CT (concentration x contact time) value (at C-0 = 7 mg L-1) for achieving 4-log pB10 plasmid removal efficiency was 127.15 mg.min L-1, which was 1.04- and 1.25-fold higher than those required for ARB (122.73 mg-min L-1) and a model nonantibiotic resistant bacterial strain, E. coli K-12, (101.4 mg.min L-1), respectively. In preventing pB10 plasmid transfer, ozonation achieved better performance under conditions of higher concentrations of humic acid and lower pH. Our study results demonstrated that the applicability of CT concept in practice, conventionally used for disinfection, might not be appropriate for antibiotic resistance control in the wastewater treatment process. Further studies should be conducted in wastewater engineering on how to implement multiple barriers including disinfection to prevent ARB and ARG discharge into the environment.</P>
Cloning and Expression of Protein-arginine Methyltransferase Ⅰ
Hong, Kyeong-Man,Choi, Yong-Bock,Chang, Yoo-Jung,Kim, Han-Soo,Lee, Sang-Do,Pak, Gun-Suk,Kim, Jeong-Kyu,Rhee, Kang-Ill,Park, Hyun,Kim, Kyung-Suk,Park, Moon-Kee 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2
Purpose: PRMT I gene was cloned recently, but the biological function of these enzymes has not been clear yet. This study was designed to produce recombinant PRMT1 in Escherichia coli for the future production of monoclonal antibody. Methods: Partial human PRMT1 cDNA was amplified by PCR from human placental cDNA library. The hPRMT1 was cloned to T-vector, again to Trx fusion vector for expression. The transformed bacteria with Trx-hPRMT1 vector were induced. The induced fusion protein was purified with His-bind chromatography and was digested with recombinant enterokinase. Digested proteins were passed through His-bind column to remove TrxA protein. Results: The recombinant fusion protein, Trx-hPRMT1, was expressed in E.coli. And the pure recombinant hPRMT1 was purified from His-bind chromatography and the digestion with enterokinase. Conclusions: The purified recombinant hPRMT1 protein was adequate to use for the ^production of monoclonal antibody.
혈중 Lipoprotein ( a ) 의 농도가 인체내 혈전 생성 및 용해 인자에 미치는 영향에 관한 연구
서홍석(Hong Seog Seo),오동주(Dong Joo Oh),이은미(Eun Mi Lee),한승환(Sung Whan Han),박희남(Hui Nam Pak),임도선(Do Sun Lim),박창규(Chang Kyu Park),김영훈(Young Hoon Kim),심완주(Wan Joo Shim),노영무(Young Moo Ro),권정아(Jung Ah Kwon),이갑 대한내과학회 1996 대한내과학회지 Vol.51 No.1
Objectives: Recently, lipoprotein (a) is known as an independent genetic risk factor for cardiovascular disease. Lipoprotein (a) contains a unique structure, apolipoprotein(a), that shares a partial homology with plasminogen without haboring enzymatic activity. Several in vitro studies reported that lipoprotein(a) competes with plgsminogen for their receptors showing inhibited thrombolysis and promoted thrombosis. We investigated whether evalvuated that lipoprotein(a) has same properties in vivo by determining the homeostatic relation between lipoprotein(a) concentration and several parameters of thrombosis and thrombolysis, and whether parameters of thrombosis and thrombolysis are different in atherosclerotic vascular diseases. Methods: Lipoprotein(a), fibrinogen, plasminogen, FDP-d, antithrombin-III, prothrombin time, activated partial thromboplastin time, tissue-type plasminogen activator, alpha-2 antiplasmin, plaminogen activator inhibitor-l, platelet counts, and other lipid profiles were measured and were compared each others by venous samles in 239 cases with atherosclerotic vascular disease which consisted of 146 cases of coronary heart disease, 39 cases of non-hemorrhagic cerebral infarction, and 10 cases of arteriosclerosis obliterans and in 185 cases without atherosclerotic vascular disease., Results: There was neither significant homeostatic relationship between lipoprotein(a) levels and paramets d thrombolysis, nor between lipids levels and parameters of thrombosis and thrombolysis. Serum lipoprotein(a) levels were higher in patients with myocardial infarction than in those with non- atherosclerotic vascular disease(30.0±28.2mg vs 23.8±21.4mg/dl). Among the thrombogenic and thrombolytic parameters, only tPA and FDP-d were significantly elevated in patients with atherosclerotic vascular disease. Conclusion: The findings that lipoprotien(a) was not correlated with thrombogenic and thrombolytic profiles in vivo suggests that lipoprotein(a) is not related to thrombogenicity in Korean people, al- though lipoprotein(a) is a independent genetic risk factor for carodiovascular disease.
( Jung Hun Pak ),( Ju Sung Oh ),( Hye Jeong Kim ),( Mi Jin Kim ),( Hong Kyu Choi ),( Ho Won Jung ),( Kyung Ho Kang ),( Ji Ung Jeong ),( Young Soo Chung ) 한국육종학회 2013 Plant Breeding and Biotechnology Vol.1 No.2
A total of 34 T1 transgenic rice lines overexpressing OgPR1 from wild rice (Oryza grandiglumis) were produced in the previous study. Selection of transgenic plants using hygromycin selection medium was continuously done until T4 generation to find ten homozygous lines. These ten T4 lines were established in the Genetically Modified Organism (GMO) field of NICS (National Institute of Crop Science) in the year of 2007. Phenotypic uniformity and performance was evaluated and compared to the control Dongjin. Two lines were selected for Preliminary Yield Trial (PYT) and Replicated Yield Trial (RYT). Based on morpho-agronomic trait performance, the transgenic plants tended to head later than the control. Culm length was similar to the wild-type Dongjin but the panicle length was relatively reduced. In case of panicle number, transgenic lines showed a little increment compared to wild-type. The shape of grain was nearly the same to wild-type. Yield among lines showed a little difference but was statistically not significant. In terms of physiochemical property of the grain, the transgenic lines showed increased amylose content than the wild-type. When OgPR1-expressing transgenic rice plants were tested against rice blast disease, an enhanced resistance against the disease was observed in the transgenic plants.
Shin, Sang Hyun,Pak, Jung-Hun,Kim, Mi Jin,Kim, Hye Jeong,Oh, Ju Sung,Choi, Hong Kyu,Jung, Ho Won,Chung, Young Soo The Korean Society of Plant Pathology 2014 Plant Pathology Journal Vol.30 No.2
Wild rice, Oryza grandiglumis shows hyper-resistance response to pathogen infection. In order to identify genes necessary for defense response in plants, we have carried out a subtractive hybridization coupled with a cDNA macroarray. An acidic PATHOGENESIS-RELATED1 (PR1) gene of the wild rice is highly identical to the acidic PR1 genes of different plant species. The OgPR1a cDNA has an apparent single open reading frame with a predicted molecular mass 40,621 Da and an isoelectic point of 5.14. Both in silico analysis and a transient expression assay in onion epidermal cells revealed that the OgPR1a protein could be localized in intercellular space in plants. The OgPR1a mRNA was strongly transcribed by the exogenous treatment with ethylene and jasmonic acid as well as protein phosphatase inhibitors. Additionally, ectopic expression of the OgPR1a conferred disease resistance on Arabidopsis to the bacterial and fungal infections.