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Breast Tissue Reconstruction Using Polycaprolactone Ball Scaffolds in a Partial Mastectomy Pig Model
Shim Kyu-Sik,Ryu Da Hye,조한샘,김기범,Kim Do-Hyun,Park Yong-Kyu,Heo Min,Cho Hee-Eun,윤을식,이원재,노태석,송승용,백우열 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.4
BACKGROUND: Breast cancer patients suffer from lowered quality of life (QoL) after surgery. Breast conservancy surgery (BCS) such as partial mastectomy is being practiced and studied as an alternative to solve this problem. This study confirmed breast tissue reconstruction in a pig model by fabricating a 3-dimensional (3D) printed Polycaprolactone spherical scaffold (PCL ball) to fit the tissue resected after partial mastectomy. METHODS: A 3D printed Polycaprolactone spherical scaffold with a structure that can help adipose tissue regeneration was produced using computer-aided design (CAD). A physical property test was conducted for optimization. In order to enhance biocompatibility, collagen coating was applied and a comparative study was conducted for 3 months in a partial mastectomy pig model. RESULTS: In order to identify adipose tissue and fibroglandular tissue, which mainly constitute breast tissue, the degree of adipose tissue and collagen regeneration was confirmed in a pig model after 3 months. As a result, it was confirmed that a lot of adipose tissue was regenerated in the PCL ball, whereas more collagen was regenerated in the collagen-coated Polycaprolactone spherical scaffold (PCL–COL ball). In addition, as a result of confirming the expression levels of TNF-a and IL-6, it was confirmed that PCL ball showed higher levels than PCL–COL ball. CONCLUSION: Through this study, we were able to confirm the regeneration of adipose tissue through a 3-dimensional structure in a pig model. Studies were conducted on medium and large-sized animal models for the final purpose of clinical use and reconstruction of human breast tissue, and the possibility was confirmed.
정규원(Kyu Won Chung),선희식(Hee Sik Sun),정진우(Jin Woo Jeong),심규식(Kyu Sik Shim),채현석(Hyun Suk Chae),강숙영(Sook Young Kang),한석원(Sun Won Han),박영민(Yong Min Park),주상용(Sang Yong Ju),심상인(Sang In Shim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
Chronic pancreatitis is mainly caused by chronic alcohol abuse and increases in incidence. The disease is characterized as epigastric pain radiating to back which is precipitated by alcohol inges- tion, and there may be nausea, vomiting, constipation, and mild jaundice with dark urine. The complications of chronic pancreatitis are diabetes mellitus, steatorrhea, pancreatic calcifica- tion, biliary obstruction, pseudocyst, peptic ulcer, abscess, carcinoma of pancreas, ascites and GI bleeding, etc. Since Riedel reported the case of common bile duct obstruction in chronic pancreatitis in 1892, there have been reported allmost 100 cases of common bile duct obstruction in pancreatitis. We report 2 cases of common bile duct obstruction caused by chronic pancreatitis without above complications.
신생아에 대한 가열 비 활동화한 B형 간염백신의 안전성과 면역성에 대한 임상적 관찰
전정식,이익준,심규식,정승연,정진우,최규용,조규홍,강진환,김승조,선희식,성인경,정규원,정환국,김부성 대한감염학회 1987 감염 Vol.19 No.4
A new heat-inactivated HBV vaccine has been evaluated for safety and immunogenicity in 157 newborn recipients. Three(Group 3M), one and a half(Group 1.5M), and one(Group 1M) μgm(HBsAgprotein) doses were given at 0,1 and 2 months.Three(Group 3W) and(Group 1W) μgm doses were also given at 0,1 and 2 weeks. All vaccine was administered intramuscularly in the thigh muscle. An adequate follow-up observation was possible during the period of 6 months after birth in 33, 26, 28, 34 and 36 infants in Groups 3M, 1.5M, 1M, 3W and 1W, respectively. Side effects were minor with limited local reaction at the site of adminisration. The 3W group produced seroconversion earliest and most rapidly, showing the highest rate of 60% and 70% at 1 and 2 months of age, resectively. However, at the age of 3 months, the highest seroconversion rate of 91.7% was observed in Group 1.5M, followed by 84.6% in Group 3W, 66.7% in Group 3M, 61.5% in Group 1M and 57.1% in Group 1W. At the age of 6 months, 87.5% of Group 3W, 80.8% of Group 1M, 80.4% of Group 1.5M, 83.3% of Group 3M infants showed seroconversion. However, a drop to 44.4% seroconversion was seen in Group 1W. There was no significant differences in seroconversion rates between Groups 3W, 1M, 1.5M and 3M at 6 months of age. There was also very little difference between these 4 Group regarding to the value of antibody response in terms of geometric mean titer. The vaccine was found to be safe and highly immunogenic for newborn infants. It can be concluded that 1.5M schedule is optimum for the immunization of newborn infants in immunogenicity and economy, while the 3W schedule can induce the earliest and most rapid seroconversion.
정인식,정규원,정환국,선희식,이창돈,문한림,백상홍,한석원,심규식 대한소화기내시경학회 1985 Clinical Endoscopy Vol.5 No.1
Over 26 kinds of tablets and capsules, such as Tetracycline, Quinidine and Potassium preparations were reported to cause esopbageal ulcerations, eharacterized in various size, shape and number, ind sually in mid-esophagus. Recently authors experienced 10 cases of drug-induced esophageal ulcerations due to antibiotics and antiinflammatory agents such as Tetracycline, Aspirin, etc. Four cases were men and six were women. Four cases were in third dades, three in fourth cleeades, two in fifth decades and one in sixth decades. Presenting symptoras were odynophagia(4/10), dysphagia(3/10), substernal pain(7/10) and epigastric pain(3/10). Endoscopic examination of the esophgus showed single or multiple, small and shallow ulcers on the mid-esophgeal mucosa at the level of 30cm from the ineisor in eight cases, one Iarge and deep ulcer at the level of 40cm from incisor in one patient and one amall, shallow and one large, deep ulcers at the same time. in one patient The shape of alcers were various from a round to a large horseshoe shaped one. The clinical course was mild without complications. It was suggested that drug-induced esophsgeal ulcers with antibiotics and antiinflammatory agents could be found frequently and they had benign and mild clinicalc ourse,
Metal Injection Molding 공정으로 제조된 IN 713C 합금의 고온 기계적 특성
심민철 ( Min Chul Shim ),김규식 ( Kyu Sik Kim ),조규상 ( Kyu Sang Cho ),김지식 ( Ji Sik Kim ),이기안 ( Kee Ahn Lee ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.5
We fabricated the IN 713C alloy by a metal injection molding (MIM) process and investigated the high temperature tensile properties. The microstructure of the MIMed IN 713C alloy mainly consisted of γ, γ′ and carbides. 0.98% (area fraction) of the pores was observed near the surface of the specimen, whereas 0.27% of the pores were located in the interior of the specimens. Tensile tests were conducted from room temperature to 900℃. The result of the tensile tests showed that this alloy had similar or somewhat higher strengths (YS: 734 MPa, UTS: 968 MPa, elongation: 7.16% at room temperature) from RT to 700℃ than those of cast IN 713C alloys. Above 700℃, however, strengths decreased rapidly with an increasing temperature (lower than those of cast IN 713C). The observation results of fractography revealed that the tensile fracture of the MIMed IN 713C alloy started near the surface defects and then the initial crack pro-pagated along the inter-particle region where oxides were observed regardless of deformation temperatures.
Ionic liquid-assisted carboxylation of amines by CO<sub>2</sub>: a mechanistic consideration
Shim, Yu Na,Lee, Jin Kyu,Im, Jin Kyu,Mukherjee, Deb Kumar,Nguyen, Dinh Quan,Cheong, Minserk,Kim, Hoon Sik The Royal Society of Chemistry 2011 Physical chemistry chemical physics Vol.13 No.13
<P>The catalytic roles of ionic liquids (ILs) in the syntheses of 1,3-disubstituted ureas from the carboxylation of amines by CO<SUB>2</SUB> were experimentally and theoretically investigated. The carboxylation reaction of <I>n</I>-butylamine was greatly facilitated by the presence of an IL and the catalytic activity of the IL was strongly affected by the nucleophilicity of the anion. Computational study on the mechanistic aspects of the carboxylation with methylamine with or without the presence of an IL, 1-ethyl-3-methylimidazolium chloride, implies that the activation energies of the transition states and the intermediate ionic species could be lowered significantly through the multi-interactions of the carbonyl group of CO<SUB>2</SUB> with both cations and anions of the ILs.</P> <P>Graphic Abstract</P><P>Ionic liquids like 1-ethyl-3-methylimidazolium chloride ([EMIm]Cl) can greatly facilitate the carboxylation of amines by CO<SUB>2</SUB> to 1,3-alkyl ureas through the stabilization of <I>in situ</I> generated intermediate carbamate species. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cp02482a'> </P>
Shim, Ki-Nam,Hong, Su Jin,Sung, Jae Kyu,Park, Kyung Sik,Kim, Seong-Eun,Park, Hyun-Shin,Kim, Young Sun,Lim, Seon Hee,Kim, Chung Hyeon,Park, Min Jung,Yim, Jeong Yoon,Cho, Kyung Ran,Kim, Donghee,Park, Se Lippincott WilliamsWilkins, Inc. 2009 JOURNAL OF CLINICAL GASTROENTEROLOGY Vol.43 No.7
BACKGROUND: Gastroesophageal reflux is a commonly encountered condition, but detailed data on reflux symptoms in Asian countries are lacking. GOALS: To evaluate the prevalence and to document the clinical spectrum of endoscopic reflux esophagitis (RE). STUDY: A total 25,536 subjects underwent an upper gastrointestinal endoscopic examination as part of a health check, and completed a gastroesophageal reflux questionnaire. Endoscopic findings classified according to the Los Angeles (LA) classification and the data from gastroesophageal reflux questionnaire were analyzed. RESULTS: On the basis of endoscopic findings, 2019 subjects (7.91%) were found to have RE: 5.87% in LA-A; 1.84% in LA-B; 0.18% in LA-C; and 0.02% in LA-D. Heartburn, acid regurgitation, chest pain, hoarseness, globus sensation, cough, and epigastric soreness were found to be associated with RE (P<0.05). Heartburn, acid regurgitation, and epigastric soreness were more frequent in LA-B than in LA-A (P<0.05). Epigastric soreness was most bothersome in LA-A and LA-B, and acid regurgitation was most bothersome in LA-C and LA-D (P<0.01). Heartburn, hoarseness, and globus sensation were more frequent in men with RE, and acid regurgitation was most common in women. CONCLUSIONS: The prevalence of RE was found to be 7.91% in Korea, and the profiles of reflux symptoms were found to depend on grade of RE and sex.