제올라이트 CuNaY 상에서 액상흡착평형에 관한 연구

宋連浩,權圭赫,金崧平 조선대학교 기초과학연구소 1984 自然科學硏究 Vol.7 No.1

In this work, we measured the surface excess of binary liquid mixtures of benzene and cycloexane on CuNaY Zeolite at 20, 25, 30 and 35℃. The relations between the mole fraction and the surface excess of the absorbate in the adsorbed phase were obtained from the thermodynamic analysis on the adsorption equilibrium of liquid mixtures. Excess properties in the absorbed phase were determined and which were satisfied with the themodynamic analysis. The surface excess and the mole fraction were experimentally obtained from the system of bezene-cyclohexane on CuNaY Zeolite and they were decreased with the temperature increase. Benzene was preferentially absorbed and the amount of adsorption of benzene was greater than that of cyclohexane.

황성 섬강 상류의 어류상

송호복,권오길,전상호,김휘중,조규송 江原大學校 附設 環境硏究所 1996 環境硏究 Vol.13 No.-

Fish fauna was investigated from June to November 1993 at the upper Sum river in Hoengsong. Form of stream was Aa and Aa-Bb, and pH, DO and BOD were 7.3~7.9, 8. 8~10.2mg/1 and 1.3~l. 5mg/1. The collected fishes were classified twenty nine species belonging to twenty two genera and seven family , of witch twelve species were endemic species of Korea. Dominant species was Zacco temmincki and subdominant species was Coreoleuciscus splendus. Zacco platypus, Microphgsogobio longidorsalis and Acheilognathus signifer were also numerous. Scarce species were Hemibarbus labeo, Coditis lutheri and the like. The species diversity index, dominance index and evenness index were 2.552, 0.384 and 0.758.

植生

宋鎬京,禹仁植,張圭寬 忠南大學校 環境問題硏究所 1991 環境硏究 Vol.9 No.-

전북 진안군 용담댐 주변의 植生과 土壤環境을 把握하기 위하여 1991년 10월11일에서 12일에 걸쳐 Mueller-Dombois & Ellenberg의 releve method에 의하여 12個所를 選定하였다. 植生은 10m×10m의 方形區를 設置하여 胸高直徑 3㎝ 以上의 樹種을 대상으로 매목조사를 실시하였고, 土壤은 方形區내에서 약 2㎏을 採取하였으며 分析한 結果는 다음과 같다. 교목층에 출현한 種 數는 24種이었으며, 重要値가 높은 種 順位는 리기다소나무, 일본잎갈나무, 굴참나무, 밤나무, 소나무 등의 순이었으며 관목층에 출현한 종수는 87종이고, 森林群集은 리기다소나무群集, 일본잎 갈나무群集, 굴참나무群集으로 區分되었다. 토양의 pH는 5.0- 6.3이고 全窒素는 0.12%-0.70%, 有機物含量은 1.7%-16.4%, 有效燐酸은 4-16ppm, C.E.C. 는 5.7-14.5(me/100g), K?는 0.17-0.16(me/100g), Ca??는 0.8-10.3(me/100g), Mg??는 0.5-3.5(me/100g)이다.

植生

宋鎬京,張圭寬 忠南大學校 環境問題硏究所 1992 環境硏究 Vol.10 No.-

全北 鎭安郡 龍潭댐 주변의 植物相을 把握하기 위하여 1991년 10월11-12일, 1992년 5월 29-31일, 10월 23-25일에 걸쳐 調査하였다. 本 調査 地域의 管束植物은 總 88科 202屬 277種으로 貧弱한 편이며, 主要 植物은 리기다소나무, 일본잎갈나무, 굴참나무, 졸참나무, 물오리나무, 싸리, 찔레, 맑은대쑥 등이다. 또한 出現된 管束植物의 種類는 羊齒植物이 2.5%, 裸子植物이 2.2%, 被子植物이 95.3%이다.

지속성 외래 복막투석 환자에서 염증 지표와 고해상도 B 모드 경동맥 초음파 소견의 연관성에 관한 연구

송현용,송영수,안철우,강신욱,최규헌,하성규,이현철,이호영,한대석 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

배 경 : 저알부민혈증 및 C-반응 단백(C-reactive protein, CRP)이 증가된 지속성 외래 복막투석 환자의 사망률이 높은 정확한 이유는 밝혀져 않다. 혈액투석 환자에서처럼 복막투석 환자에서 저알부민혈증 및 염증반응이 심혈관계 질환 위험인자 인지 알아보고자 하였다. 방 법: 비당뇨병성 말기 신부전, 지속성 외래 복막투석 환자 93명의 심혈관계 질환 위험인자들과 복막 투과 특성 및 알부민, CRP 등의 염증지표에 따라 고해상도 초음파를 이용한 경동맥내막-중간막 두께, 내막-중간막 면적, 플라크의 유무 등을 단면적으로 비교하였다. 결 과: 복막 투과 특성은 고투과막군 14명, 중간 고투과막군 38명, 중간 저투과막군 31명, 저투과막군 10명으로 각 군간의 경동맥 내막-중간막 두께, 플라크 유무 및 내막-중간막 면적의 차이는 없었다. 기존 관상동맥 질환 환자는 8예(8.6%)로 내막-중간막 두께는 관상동맥 질환이 없는 환자보다 증가되었고(0.79±0.21 vs 0.60±0.11 mm, p<0.05) 플라크 형성은 더 많이 보이나 통계적 유의성은 없었다(75.0 vs 63.5%, p>0.05). 혈청 알부민치와 경동맥 내막-중간막 면적은 역상관관계를 보였다(r=-0.27, p<0.05). 저알부민혈증 환자(혈청 알부민 <3.5 g/dL)는 정상 알부민혈증 환자보다 내막-중간막 두께가 증가되었고(0.67±0.15 vs 0.61±0.12 mm, p<0.05), 플라크도 유의하게 많았다(68.0 vs 55.8%, p<0.05). 혈청 CRP치와 경동맥 내막-중간막 면적은 양의 상관관계가 있었으며(r=0.21, p<0.05) CRP가 높은 환자(≥0.8 mg/dL, n=18)에서플라크가 많이 관찰되었으나(65.8 vs 50.0%, p<0.05) 경동맥 내막-중간막 두께 및 내막-중간막면적은 양군간에 차이가 없었다. 다변량 회귀 분석상 경동맥 내막-중간막 두께에 영향을 미치는 인자는 고령, 높은 CRP, 기존 심혈관계질환, 낮은 혈청 알부민 순이였다. 결 론 : 복막투석 환자에서 고해상도 초음파를 이용한 경동맥 내막-중간막 두께 측정은 심혈관계 질환 유무 예측의 비침습적 검사가 될 수 있고 저알부민혈증 및 높은 CRP과 같은 만성염증 지속상태가 복막투석 환자에서 죽상 동맥 경화증의 발생을 증가시킨다고 가정할 수 있다. Background : Continuous ambulatory peritoneal dialysis(CAPD) patients with low albumin(LA) and signs of inflammation reflected by increased C-reactive protein(CRP) level have an increased mortality, but the mechanism of this phenomenon is not clear yet. Methods : To answer whether LA and inflammation also enhance cardiovascular risk in CAPD patients, we performed cross sectional study measuring carotid artery intima-media thickness(IMT), calculated intima-media area(cIM area) and the presence of plaque by high-resolution B-mode ultrasonography in 93 non-diabetic CAPD patients. Results : Patients with coronary artery disease (CAD, n=8) had significantly increased IMT(0.79± 0.21 mm vs. 0.60±0.11 mm, p<0.05) and higher prevalence of carotid plaques(75.0% vs. 63.5%) compared to the non-CAD patients. Significant inverse correlation was observed between serum albumin (SA) level and cIM area(r=-0.27, p<0.05). Those patients with LA(SA <3.5 g/dL) had significantly increased IMT compared to non-LA patients(0.67±0.15 mm vs 0.61±0.12 mm, p<0.05). Prevalence of carotid plaques was also significantly higher in LA patients (68.0% vs. 55.8%, p<0.05). CRP level revealed a significant positive correlation with cIM area(r=0.21, p< 0.05). Patients with high CRP(≥0.8 mg/dL, n=18) had higher prevalence of carotid plaques (65.8% vs. 50.0%, p<0.05) compared to those patients with CRP <0.8 mg/dL, but IMT and cIMT area were not different. By multivariate logistic regression analysis, old age, high CRP, history of CAD and low SA were the independent risk factors affecting IMT. Conclusion : Our study strongly suggests that low albumin and chronic inflammatory state of CAPD patients could be associated with increasing atherosclerotic cardiovascular disease. (Korean J Nephrol 2002;21(2):285-294)

ATM 네트워크 관리를 위한 TMN 시스템

송명규,정호영 남서울대학교 공학연구센터 2001 공학연구 Vol.2 No.-

The main goal of this paper is to establish the overall management network structure for ATM network by adopting TMN concept. Hence, the overall management network structure for ATM network is consisted of many management elements; management layer elements and TMN's. This paper propose TMN management Unit for ATM network. And We choose the main network of overall management and ATM network based upon optical communication is also selected as TMN-DCN.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

말기 신부전 환자에서 투여 경로에 따른 유전자 재조합 인 Erythropoietin(Epokine^(�))의 효과와 안정성에 대한 연구 : 제 4상 연구 A Phase 4 Single Center Study

송현용,윤향숙,강신욱,최규헌,하성규,이호영,한대석 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

목 적 : 국내 독자적 기술로 첫 개발된 유전자 재조합 인 에리트로포에틴(Epokineⓡ)의 투여방법에 따른 유효성과 안정성을 알아보고자 하였다. 방 법 : Epokineⓡ을 주당 100-150 U/kg, 주 2회, 12주간 피하 주사하여 목표 또는 안정된 혈색소치 유지 후 무작위로 피하 및 정맥 주사군으로 나누어 12주간 혈액투석 및 복막투석 환자13명, 28명에서 유효성, 안정성을 분석하였다. 결 과 : 양군에서 혈색소치와 헤마토크릿은 Epokineⓡ 투여 2주 후부터 증가, 혈색소치가 혈액투석 환자는 투여 전 7.3 g/dL, 투여 12주 9.5 g/dL, 24주 10.6 g/dL로, 복막투석 환자는 6.8g/dL에서 12주 10.2 g/dL, 24주 10.8 g/dL로 증가하였다. 양군에서 교정 망상적혈구수(%)는투여 1주 후부터 전 기간동안 증가하였다. 혈청 내 철분, ferritin치는 양군에서 투여 2주 후부터감소, 총 철분 결합능은 투여 2주 후부터 증가하였다. 12주째 혈액투석 환자에서 많은 Epokineⓡ용량이 필요했으나(142.2±20.5 vs 117.3±33.6 U/kg/wk, p<0.001) 24주 후 양군의 용량차이는 없었다(123.6±41.5 vs 99.2±49.3 U/kg/wk, p>0.05). 혈액투석 환자에서 피하 주사가Epokineⓡ 투여용량이 더 적었으나(97.4±15.4 vs 145.4±2.9 U/kg/wk, p<0.002) 복막투석 환자는 차이가 없었다(93.0±60.2 vs 105.4±9.7 U/kg/wk, p>0.05) 연구기간 중 9명(18.8%)에서혈압강하제 추가가 필요한 혈압상승, 근육통 동반 상기도 감염 유사증상 및 두통 등의 부작용이 있었다. 대부분 자연소실 혹은 대증요법으로 치유되었고 2명이 부작용으로 탈락하였다. 결 론 : 말기 신부전 환자의 빈혈 개선에 사용하는 Epokineⓡ의 효과는 복막투석 환자에서 더 좋았으며 투여 경로는 정맥주사보다 피하주사가 높음을 알 수 있었다. Background : We evaluated the clinical efficacy and safety of recombinant human erythropoietin(Epokine^(ⓡ)). Methods : A comparative prospective study of intravenously and subcutaneously administrated Epokine^(ⓡ) conducted 13 patients performing hemodialysis and 28 patients performing continuous ambulatory peritoneal dialysis with end-stage renal disease. Epokine^(ⓡ) was given initially at a dosage of 100 unit/kg, subcutaneously, two times a week. The patients had achieved stable or more than 10 g/dL of hemoglobin level for 12 weeks and then we randomized switching intravenously or subcutaneously administrated Epokine^(ⓡ) for another 12 weeks. Results : Hemoglobin(g/dL) and hematocrit(%) increased significantly from baseline levels beginning from 2 weeks after Epokine^(ⓡ) administration. In HD patients, hemoglobin increased significantly from 7.3 to 9.5 after 12 weeks and to 10.6 after 24 weeks. In CAPD patients, hemoglobin increased significantly from 6.8 to 10.2 after 12 weeks and then 10.8 after 24 weeks(p<0.05). Corrected reticulocyte count(%) was significantly increased from baseline levels beginning from 1 week after Epokine^(ⓡ) administration and continuously increased during study period in both group. Serum ferritin and serum iron decreased significantly and total iron binding capacity increased significantly after 2 weeks. At 12 weeks, HD patients were significantly needed more dosage of Epokine^(ⓡ) than CAPD patients(142.2±20.5 vs 117.3±33.6 U/kg/wk, p<0.001), but at 24 weeks, the dosage was not different(123.6±41.5 vs 99.2±49.3 U/kg/wk, p> 0.05). In HD patients, intravenously administrated Epokine^(ⓡ) group was more dosage than subcutaneously group(97.4±15.4 vs 145.4±2.9 U/kg/wk, p< 0.002), but CAPD patients were not different by administration method(93.0±60.2 vs 105.4±9.7 U/kg/ wk, p>0.05). The 9 cases(18.8%) were suffered from headache and flu-like syndrome, but these side effects were not severe and disappeared from conventional therapy. Conclusion : Epokine^(ⓡ) administration is safe and effective in treating anemia of ESRD patients and subcutaneously administration is significantly more effective than intravenously. (Korean J Nephrol 2002;21(2):190-198)

DCCA에 의한 서어나무류 群集과 環境의 相關關係 分析

宋鎬京,張圭寬 忠南大學校環境問題硏究所 1993 環境硏究 Vol.11 No.-

서어나무류 群落의 種 造成과 立地와의 關係를 究明하기 위하여 서어나무군락 11個所, 개서어나무군락 22個所, 까치박달나무군락 7個所를 選定하고, DCCA 方法을 使用하여 分析한 結果는 다음과 같다. 1. 서어나무군락에서 重要値가 높은 種은 서어나무, 쪽동백나무, 신갈나무, 졸참나무, 대팻집나무, 당단풍, 까치박달나무, 물푸레 나무, 사람주나무 등의 순이다. 개서어나무 군락에서 重要値가 높은 種은 개서어나무, 졸참나무, 서어나무, 생강나무, 신갈나무, 고로쇠나무, 당단풍, 비목나무, 쪽동백나무 등의 순이다. 까치박달나무군락에서 重要値가 높은 種은 까치박달나무, 신갈나무, 서어나무, 쪽동백나무, 당단풍, 졸참나무 등의 순이다. 2. 主要 優占種의 種 多樣性은 서어나무군락이 가장 높고, 까치박달나무군락이 가장 낮았으며, 群落別 土壤 分析 結果를 보면 개서어나무군락이 C.E.C.를 제외한 全窒素, 有機物含量, 有效燐酸, K+, Ca++, Mg++ 等의 養料가 양호한 것으로 나타냈다. 3. 群落과 環境 要因들과의 상관관계를 보면, 개서어나무군락은 全窒素가 많은 곳에, 서어나무군락은 海拔高가 높은 곳에 주로 分布하고 있으며, 까치박달나무군락은 全窒素가 낮고 高度가 중간인 部分에 주로 分布하고 있다. On the basis of Braun-Blanquet, 40 quadrats were sampled by the releve method of Muller-Dombois & Ellenberg in natural forests of Mt. Chiri, Mt. Deokyu, Mt. Kyeryong, and Mt. Sokri. The quadrats were sampled 11 plots in Carpinus laxiflora forest, 22 plots in C. tschonoskii forest, and 7 plots in C. cordata forest. The method of DCCA were introduced to elucidate the relations of site factors and species composition in the same quadrats. The dominant tree species distributed in the region of Carpinus laxiflora communites were C. laxiflora, Styrax obassia, Quercus mongolica, and Q. serrata in descending order. The dominant tree species distributed in the region of Carpinus tschonoskii communities were C. tschonoskii, Q. serrata, C. laxiflora, and Lindera obtusiloba in descending order. The dominant tree species distributed in the region of Carpinus cordata communities were C. cordata, Q. mongolica, C. laxiflora, and S. obassia in descending order. The species diversities of major dominant species recorded the highest value in the communities of Carpinus laxiflora but the lowest value in the communities of C. cordata. The nutrient contents of total nitrogen, organic matter, available phosphorus, K+, Ca++, and Mg++ except of C.E.C. value were the highest values in the forest soils of C. tschonoskii communities. In the relations of major species communities and environmental factors, Carpinus tschonoskii communities were distributed in the good nutrition of total nitrogen, C. laxiflora communities in the high elevation area, C. cordata communities in the poor nutrition of total nitrogen and in the medium elevation area.

Streptomyces exfoliatus가 생성하는 mutanase에 의한 인공치태 억제 작용

송도원,양규호 전남대학교 치과대학 1996 전남치대논문집 Vol.8 No.1

The main component of dental plaque is the mutan containing the α-1, 3 bond. The following results were obtained by using a blue mutan to assess the factors affecting the mutan-digesting activity of Streptomyces exfoliatus isolated from soil. A clear zone was produced by mutanase-producing Streptomyces exfoliatus on the minimal essential agar containing blue mutan. Streptomyces exfoliatus digested more blue mutan in the minimal essential broth at pH 7.0 than at pH 5.5 or 8.5. Streptomyces exfoliatus digested more blue mutan at 37℃ than at 32℃ or 42℃(P<0.05). When the concentration of CaCl_2 was increased in the minimal essential broth, the digestion of blue mutan was increased(P<0.05). The optimal concentration of KCl was 10mM to digest blue mutan, but a similar amount of blue mutan was digested at the range of 0.1mM to 6.4mM of MgCl_2. When the culture supernatant of Streptomyces exfoliatus was mixed with 2X brain heart infusion broth containing 0.5% yeast extract and 10% sucrose, less artificial plaque was formed by Streptococcus mutans on the orthodontic wire(P<0.05). These results indicated that the secretion of mutanase was identified in culture supernatant of mutan-digesting Streptomyces exfoliatus, suppressing the formation of artificial plaque by Streptococcus mutans.