Improvement of systemic inflammation by the use of ustekinumab in moderate to severe psoriasis: Measured by 18FDG positron emission tomography- computed tomography

( Byung Soo Kim ),( Won Ku Lee ),( Kyoungjune Pak ),( Seong Jang Kim ),( Junhee Han ),( Jeong Min Kim ),( Gun Wook Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Ustekinumab has established a favorable benefit-risk profile for moderate to severe chronic plaque psoriasis, but little is known about its efficacy on the comorbidities especially systemic inflammation.Objectives: To evaluate the efficacy of ustekinumab for systemic and vascular inflammation of patients with moderate to severe psoriasis by by [18F]- fluorodeoxyglucose positron emission tomography-computed tomography (18FDGPET/CT). Methods: Moderate to severe psoriasis patients were evaluated with 18FDG PET/CT before ustekinumab treatment and after achieving PASI75 with ustekinumab. FDG uptake in the liver, spleen and 5 segments of aorta was evaluated by calculating the maximum standardized uptake value (SUVmax). Results: Eleven patients with psoriasis were enrolled in this study (6 males, 5 females; mean age, 41.5 years).In accordance with clinical improvement in psoriatic skin lesions, images on subsequent 18FDG PET/CT scan revealed an appreciable decrease in FDG uptake in the liver, spleen and aorta. Conclusion: This study suggests that treatment ustekinumab is effective in reducing systemic and vascular inflammation accompanied with moderate to severe psoriasis. We also show the usefulness of 18 FDG PET/CT to monitor whole-body inflammation during psoriasis treatment.

Evaluation of Bone Mineral Density Using DXA and cQCT in Postmenopausal Patients Under Thyrotropin Suppressive Therapy

Kim, Keunyoung,Kim, In-Joo,Pak, Kyoungjune,Kim, Seong-Jang,Shin, Senghyeon,Kim, Bo Hyun,Kim, Sang Soo,Lee, Byung-Joo,Jeon, Yun Kyung Issued for the Endocrine Society by the Williams & 2018 The Journal of clinical endocrinology & metabolism Vol.103 No.11

Prognostic value of volumetric parameters measured by F-18 FDG PET/CT in surgically resected non-small-cell lung cancer

Kim, Keunyoung,Kim, Seong-Jang,Kim, In-Joo,Seong Kim, Yun,Pak, Kyoungjune,Kim, Heeyoung Lippincott Williams Wilkins, Inc. 2012 Nuclear medicine communications Vol.33 No.6

OBJECTIVES: The aim of this study was to evaluate the usefulness of the tumor burden as characterized by the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by F-18 fluoro-2-deoxyglucose (F-18 FDG) PET-computed tomography (CT) in predicting recurrence-free survival (RFS) and overall survival (OS) in surgically resected non-small-cell lung cancer (NSCLC) patients. METHODS: We retrospectively reviewed 91 patients with pathologically documented stages I–IIIA NSCLC. MTV and TLG were obtained according to various thresholds of the standard uptake value (SUV) of primary tumor using preoperative F-18 FDG PET-CT. We used comparison receiver-operating characteristic curve analysis to test the statistical significance of the differences among the multiple volumetric parameters calculated by various SUV cutoff values. RFS and OS were evaluated with the Kaplan–Meier method and Cox regression analysis. RESULTS: On comparison receiver-operating characteristic curve analysis, no significant difference was found among the volumetric parameters calculated using various thresholds of SUV. Regardless of the thresholds, patients with smaller MTV and lower TLG showed longer RFS and OS. MTV and TLG measured by F-18 FDG PET-CT were found to have better predictive performance than SUVmax for recurrence and death. According to multivariate analyses, MTV2.5 was revealed as a significant prognostic factor for RFS. Tumor size over 3 cm was selected as a significant prognostic indicator of OS. CONCLUSION: Volume-based parameters of F-18 FDG PET-CT may have a role in providing prognostic information in NSCLC patients who have received surgical treatment.

Factors Associated with ¹⁸F-Fluorodeoxyglucose Uptake in T1 and T2 Invasive Ductal Carcinoma of the Breast

Kim, So Jung,Kim, Seong-Jang,Kim, In Joo,Pak, Kyoungjune,Kim, Bum Soo,Shin, Seunghyeon The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.3

Purpose The objective of this study was to investigate the relationship between diversity of $^{18}F$-fluorodeoxyglucose ($^{18}F$-FDG) uptake of primary tumor in positron emission tomography (PET) and various clinicopathologic factors in breast cancer of same pathologic T1, T2 stage. Methods A total of 258 patients with invasive ductal breast cancer were enrolled in this study. All patients underwent $^{18}F$-FDG PET-CT before surgery. Patients were divided into two groups according to tumor size based on the pathologic T stage, and maximum standardized uptake value (SUVmax) of 2.5, respectively. Results On the univariate analysis, estrogen receptor (ER), tumor size, lymphovascular invasion, p53, pathologic N status (pN) and Nottingham tumor grade (NG) were associated with high SUVmax in T1 and T2 breast cancer. On the multivariate logistic regression, tumor size and NG remained significant variables dividing high and low SUVmax. In the T1 group, ER, p53 and NG were significantly associated with high SUVmax on the univariate analysis. In this group, p53 and NG remained significant variables for dividing high and low SUVmax on the multivariate logistic regression. In the T2 group, only NG was associated with high SUVmax on the univariate analysis. Conclusions NG showed an association with $^{18}F$-FDG uptake in both T1 and T2 breast cancer independently; however, p53 in T1 breast cancer.

Hepatic FDG Uptake is not Associated with Hepatic Steatosis but with Visceral Fat Volume in Cancer Screening

Pak, Kyoungjune,Kim, Seong-Jang,Kim, In Joo,Kim, Keunyoung,Kim, Heeyoung,Kim, So Jung The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.3

Purpose We aimed to evaluate the relation between visceral fat volume and fluorodeoxyglucose (FDG) uptake of the liver measured by maximum or mean standardized uptake value. Methods We retrospectively analyzed 96 consecutive records of positron emission tomography/computed tomography (PET/CT) performed for cancer screening between May 2011 and December 2011. Subjects were divided into 2 groups according to Hounsfield unit (HU) of the liver comparing with that of the spleen. The control group (20 women, 56 men) demonstrating HU of the liver equal or greater than that of the spleen included 76 patients, while the fatty liver group (2 women, 18 men) showing HU of the liver less than that of the spleen included 20 patients. We compared FDG uptake of the liver and visceral fat volume between two groups. We evaluated correlation of hepatic FDG uptake measured by maximum or mean standardized uptake value (SUV) with visceral fat volume and attenuation. Results The fatty liver disease group showed higher aspartate aminotransferase (AST)of ($24.42{\pm}7.22$, p=0.012), alanine aminotransferase (ALT) of ($25.16{\pm}11.68$, p=0.001), body mass index (BMI) of ($24.58{\pm}3.29$, p=0.021), and visceral fat volume ($3063.53{\pm}1561.43$, p=0.011) than the control group. There were no statistically significant differences of mean standardized uptake value of the liver (liver $SUV_{mean}$) ($2.73{\pm}0.19$, p=0.723), maximum standardized uptake value of the liver (liver $SUV_{max}$) ($3.39{\pm}0.53$, p=0.8248) and liver $SUV_{mean}$/spleen $SUV_{mean}$ ($1.13{\pm}0.10$, p=0.081) between the two groups. Strong correlations were shown between liver $SUV_{mean}$ and BMI (r=0.609, p<0.001) and between liver $SUV_{mean}$ and visceral fat volume (r=0.457, p<0.001). Liver $SUV_{max}$ was also strongly correlated with BMI (r=0.622, p=0.001) and visceral fat volume (r=0.547, p<0.001). There was no significant association of mean attenuation value of the liver (liver $HU_{mean}$) with liver $SUV_{mean}$ (r=-0.003, p=0.979) or liver $SUV_{max}$ (r=-0.120, p=0.244). Conclusion Hepatic FDG uptake quantified as $SUV_{mean}$ or $SUV_{max}$ is not correlated with hepatic steatosis but with visceral fat volume in cancer screening.

Meta-analysis of meta-analyses in oncologic positron emission tomography

Pak, Kyoungjune,Shin, Seunghyeon,Kim, So Jung,Kim, Keunyoung,Seo, Youngduk,Kim, Seong-Jang,Kim, In Joo Chapman and Hall in association with the British N 2018 Nuclear medicine communications Vol.39 No.12

OBJECTIVES: As PET has become a standard of treatment in patients with cancer, publications of oncologic PET have grown sharply. We aimed to organize the data of meta-analyses of oncologic PET and assess the quality of studies. MATERIALS AND METHODS: The inclusion criteria were studies that meta-analyzed to combine the data from multiple studies of oncologic PET. We used the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) to assess the reporting quality of the included studies. RESULTS: A total of 254 meta-analyses were eligible for inclusion in the study. The peak number of publications increased up to 42 in 2014. Lung (n=39, 15.4%) is the most common site of tumor included in meta-analysis with oncologic PET. Overall, 84% of studies were categorized into diagnostic test accuracy reviews (n=214). Studies published in 2010 or later (n=213) showed higher PRISMA scores than those published in 2009 or before. CONCLUSION: A large number of meta-analyses are published in the field of oncologic PET. Meta-analyses in oncologic PET seem to be cited more often than regular research papers. The overall quality of studies is low; however, they showed improvement after PRISMA statement.

Usefulness of 18FDG positron emission tomography- computed tomography for detecting systemic inflammation in moderate to severe psoriasis

( Won Ku Lee ),( Kyoungjune Pak ),( Seong Jang Kim ),( Junhee Han ),( Jeong Min Kim ),( Gun Wook Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Byung Soo Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: There is increasing awareness that psoriasis is a systemic, immune-mediated inflammatory disease including skin and joint. Objectives: To detect and quantify systemic and vascular inflammation in patients with moderate to severe psoriasis using [18F]-fluorodeoxyglucose positron emission tomography- computed tomography (18FDG PET/CT). Furthermore, to investigate the relationship between PASI score and FDG uptake in the liver, spleen and aorta. Methods: Case series with a nested case-control study was done. Twenty seven patients with moderate to severe psoriasis and twenty five controls age and sex matched underwent 18FDG PET/CT. FDG uptakes in the liver, spleen and 5 segments of aorta were evaluated by calculating the maximum standardized uptake value (SUVmax). Results: 18FDG PET/CT of patients with moderate to severe psoriasis demonstrated increased FDG uptakes in the liver and spleen compared with the controls. There were increased FDG uptakes in the liver, spleen and all segments of aorta with psoriasis group of high PASI score compared to the group with low PASI score. Conclusion: This study shows that systemic inflammation is increased in psoriasis patients compared to the controls, and there is correlation between psoriasis severity and systemic and vascular inflammation. We also suggest that 18FDG PET/CT can be used to identify systemic and vascular inflammation in psoriasis patients.

A highly conducting graphene film with dual-side molecular n-doping.

Kim, Youngsoo,Park, Jaesung,Kang, Junmo,Yoo, Je Min,Choi, Kyoungjun,Kim, Eun Sun,Choi, Jae-Boong,Hwang, Chanyong,Novoselov, K S,Hong, Byung Hee RSC Pub 2014 Nanoscale Vol.6 No.16

<P>Doping is an efficient way to engineer the conductivity and the work function of graphene, which is, however, limited to wet-chemical doping or metal deposition particularly for n-doping, Here, we report a simple method of modulating the electrical conductivity of graphene by dual-side molecular n-doping with diethylenetriamine (DETA) on the top and amine-functionalized self-assembled monolayers (SAMs) at the bottom. The resulting charge carrier density of graphene is as high as -1.7 10(13) cm(-2), and the sheet resistance is as low as 86 39 ω sq(-1), which is believed to be the lowest sheet resistance of monolayer graphene reported so far. This facile dual-side n-doping strategy would be very useful to optimize the performance of various graphene-based electronic devices.</P>

Ultraclean Patterned Transfer of Single-Layer Graphene by Recyclable Pressure Sensitive Adhesive Films

Kim, Sang Jin,Choi, Teajun,Lee, Bora,Lee, Sunwoo,Choi, Kyoungjun,Park, Jong Bo,Yoo, Je Min,Choi, Yong Seok,Ryu, Jaechul,Kim, Philip,Hone, James,Hong, Byung Hee American Chemical Society 2015 Nano letters Vol.15 No.5

<P>We report an ultraclean, cost-effective, and easily scalable method of transferring and patterning large-area graphene using pressure sensitive adhesive films (PSAFs) at room temperature. This simple transfer is enabled by the difference in wettability and adhesion energy of graphene with respect to PSAF and a target substrate. The PSAF-transferred graphene is found to be free from residues and shows excellent charge carrier mobility as high as ∼17 700 cm<SUP>2</SUP>/V·s with less doping compared to the graphene transferred by thermal release tape (TRT) or poly(methyl methacrylate) (PMMA) as well as good uniformity over large areas. In addition, the sheet resistance of graphene transferred by recycled PSAF does not change considerably up to 4 times, which would be advantageous for more cost-effective and environmentally friendly production of large-area graphene films for practical applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-5/acs.nanolett.5b00440/production/images/medium/nl-2015-00440a_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl5b00440'>ACS Electronic Supporting Info</A></P>

Materials for Flexible, Stretchable Electronics: Graphene and 2D Materials

Kim, Sang Jin,Choi, Kyoungjun,Lee, Bora,Kim, Yuna,Hong, Byung Hee Annual Reviews 2015 Annual review of materials research Vol.45 No.-

<P>Recently, 2D materials have been intensively studied as emerging materials for future electronics, including flexible electronics, photonics, and electrochemical energy storage devices. Among representative 2D materials (such as graphene, boron nitride, and transition metal dichalcogenides) that exhibit extraordinary properties, graphene stands out in the flexible electronics field due to its combination of high electron mobility, high thermal conductivity, high specific surface area, high optical transparency, excellent mechanical flexibility, and environmental stability. This review covers the synthesis, transfer, and characterization methods of graphene and 2D materials and graphene's application to flexible devices as well as comparison with other competing materials.</P>