http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Won Kim,Seyeon Bae,Hyemin Kim,Yejin Kim,Jiwon Choi,Sun Young Lim,Hei Jin Lee,Jihyuk Lee,Jiyea Choi,Mirim Jang,Kyoung Eun Lee,Sun G,Chung,Young-il Hwang,Jae Seung Kang,Wang Jae Lee 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.4
The L-gulono-γ-lactone oxidase gene (Gulo) encodes an essential enzyme in the synthesis of ascorbic acid from glucose. On the basis of previous findings of bone abnormalities in Gulo-/- mice under conditions of ascorbic acid insufficiency, we investigated the effect of ascorbic acid insufficiency on factors related to bone metabolism in Gulo-/- mice. Four groups of mice were raised for 4 weeks under differing conditions of ascorbic acid insufficiency, namely, wild type; ascorbic acid-sufficient Gulo-/- mice, 3-week ascorbic acid-insufficient Gulo-/- mice, and 4-week ascorbic acid-insufficient Gulo-/- mice. Four weeks of ascorbic acid insufficiency resulted in significant weight loss in Gulo-/- mice. Interestingly, average plasma osteocalcin levels were significantly decreased in Gulo-/- mice after 3 weeks of ascorbic acid insufficiency. In addition, the tibia weight in ascorbic acid-sufficient Gulo-/- mice was significantly higher than that in the other three groups. Moreover, significant decreases in trabecular bone volume near to the growth plate, as well as in trabecular bone attachment to the growth plate, were evident in 3- or 4-week ascorbic acid-insufficient Gulo-/-. In summary, ascorbic acid insufficiency in Gulo-/- mice results in severe defects in normal bone formation, which are closely related to a decrease in plasma osteocalcin levels.
( Kyoung Jin Shin ),( Jung Wook Chin ),( Dong Yup Hahn ),( Jae Hwan Lee ),( Hoo Sang Hwang ),( Dong Hwan Won ),( Jung Yeob Ham ),( Hyuk Jae Choi ),( Eun Soo Kang ),( Hi Young Kim ),( Moon Kyeong Ju ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC(50)`s 14 and 15μM. ⓒ 2012 Elsevier Inc. All rights reserve
Switching of Photonic Crystal Lasers by Graphene
Hwang, Min-Soo,Kim, Ha-Reem,Kim, Kyoung-Ho,Jeong, Kwang-Yong,Park, Jin-Sung,Choi, Jae-Hyuck,Kang, Ju-Hyung,Lee, Jung Min,Park, Won Il,Song, Jung-Hwan,Seo, Min-Kyo,Park, Hong-Gyu American Chemical Society 2017 NANO LETTERS Vol.17 No.3
<P>Unique features of graphene have motivated the development of graphene-integrated photonic devices. In particular, the electrical tunability of graphene loss enables high-speed modulation of light and tuning of cavity resonances in graphene-integrated waveguides and cavities. However, efficient control of light emission such as lasing, using graphene, remains a challenge. In this work, we demonstrate on/off switching of single- and double-cavity photonic crystal lasers by electrical gating of a monolayer graphene sheet on top of photonic crystal cavities. The optical loss of graphene was controlled by varying the gate voltage V-g, with the ion gel atop the graphene sheet. First, the fundamental properties of graphene were investigated through the transmittance measurement and numerical simulations. Next, optically pumped lasing was demonstrated for a graphene-integrated single photonic crystal cavity at V-g below-0.6 V, exhibiting a low lasing threshold of -4801 mu W, whereas lasing was not observed at V-g above -0.6 V owing to the intrinsic optical loss of graphene. Changing quality factor of the graphene-integrated photonic crystal cavity enables or disables the lasing operation. Moreover, in the double-cavity photonic crystal lasers with graphene, switching of individual cavities with separate graphene sheets was achieved, and these two lasing actions were controlled independently despite the close distance of -2.2 mu m between adjacent cavities. We believe that our simple and practical approach for switching in graphene-integrated active photonic devices will pave the way toward designing high-contrast and ultracompact photonic integrated circuits.</P>
Hwang, Ji-Hee,Lee, Ju-Hyung,Hwang, Jeong-Hwan,Chung, Kyung Min,Lee, Eun-Jung,Yoon, Yong-Joo,Moon, Mi-Kyoung,Kim, Ju-Sin,Won, Kyoung-Suk,Lee, Chang-Seop The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.6
<P>Methicillin-resistant <I>Staphylococcus aureus</I> (MRSA) is a major cause of ear infections. We attempted to evaluate the clinical usefulness of arbekacin in treating chronic suppurative otitis media (CSOM) by comparing its clinical efficacy and toxicity with those of vancomycin. Efficacy was classified according to bacterial elimination or bacteriologic failure and improved or failed clinical efficacy response. Ninety-five subjects were diagnosed with CSOM caused by MRSA. Twenty of these subjects were treated with arbekacin, and 36 with vancomycin. The bacteriological efficacy (bacterial elimination, arbekacin vs. vancomycin: 85.0% vs. 97.2%) and improved clinical efficacy (arbekacin vs. vancomycin; 90.0% vs. 97.2%) were not different between the two groups. However, the rate of complications was higher in the vancomycin group (33.3%) than in the arbekacin group (5.0%) (<I>P</I>=0.020). In addition, a total of 12 adverse reactions were observed in the vancomycin group; two for hepatotoxicity, one for nephrotoxicity, eight for leukopenia, two for skin rash, and one for drug fever. It is suggested that arbekacin be a good alternative drug to vancomycin in treatment of CSOM caused by MRSA.</P>
( Kyoung Ho Moon ),( Joon Soon Kang ),( Man Hee Won ),( Myoung Joo Park ),( Jae Hwang Choi ) 대한고관절학회 2015 Hip and Pelvis Vol.27 No.2
Purpose: This study was performed to determine the usefulness of three-dimensional computed tomography (3D-CT) in measuring periacetabular osteolysis by comparing the real volume of osteolysis in revision surgery. Materials and Methods: Twnety-three patients who had undergone revision surgery due to periacetabular osteolysis but not included septic osteolysis and implant loosening. The mean age of patients at the time of surgery was 55.2 years. And the mean time interval between the primary total hip arthroplasty and revision surgery was 13.3 years. We measured the polyethylene wear in plain radiographs using computer assisted vector wear analysis program, the volume of acetabular osteolytic lesions in high-resolution spiral CT scans using Rapidia 3D software version 2.8 algorithms before the revision surgery were performed. Intraoperative real osteolytic volume was calculated as the sum of the volumetric increments of the acetabular cup and impacted allo-cancellous bone volume. Results: Strong correlation was found between the volume of acetabular osteolytic lesions measured on 3D-CT and intraoperative real osteolytic volume which was calculated as the sum of the volumetric increments of the acetabular cup and impacted allo-cancellous bone volume. Conclusion: 3D-CT is considered a useful method for assessing and measuring the volume of periacetabular osteolysis before revision surgery.
Determinants of Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
Hwang Ji-won,Lee Sang-Chol,Kim Darae,Kim Jihoon,Kim Eun Kyoung,Chang Sung-A,Park Sung-Ji,Kim Sung Mok,Choe Yeon Hyeon,Ahn Joong Hyun,Park Seung Woo 대한의학회 2022 Journal of Korean medical science Vol.37 No.8
Background: Reduced exercise capacity reflects symptom severity and clinical outcomes in patients with hypertrophic cardiomyopathy (HCM). The present study aimed to identify factors that may affect exercise capacity in patients with HCM. Methods: In 294 patients with HCM and preserved left ventricular (LV) ejection fraction, we compared peak oxygen consumption (peak VO2) evaluated by cardiopulmonary exercise testing as a representative parameter of exercise tolerance with clinical and laboratory data, including N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), diastolic parameters on echocardiography, and the grade of myocardial fibrosis on cardiac magnetic resonance imaging (CMR). Results: Median peak VO2, was 29.0 mL/kg/min (interquartile range [IQR], 25.0–34.0). Age (estimated β = −0.140, P < 0.001), female sex (β = −5.362, P < 0.001), NT-proBNP (β = −1.256, P < 0.001), and E/e′ ratio on echocardiography (β = −0.209, P = 0.019) were significantly associated with exercise capacity. Peak VO2 was not associated with the amount of myocardial fibrosis on CMR (mean of late gadolinium enhancement 12.25 ± 9.67%LV). Conclusion: Decreased exercise capacity was associated with age, female sex, increased NTproBNP level, and E/e′ ratio on echocardiography. Hemodynamic changes and increased filling pressure on echocardiography should be monitored in this population for improved outcomes.
Ceramic-on-Ceramic Total Hip Arthroplasty: Minimum of Six-Year Follow-up Study
Won Sik Choy,김갑중,이상기,Kyoung Wan Bae,Yoon-Sub Hwang,Chang Kyu Park 대한정형외과학회 2013 Clinics in Orthopedic Surgery Vol.5 No.3
Background: This study examines the clinical and radiologic results of ceramic-on-ceramic total hip arthroplasties with regard towear, osteolysis, and fracture of the ceramic after a minimum follow-up of six years. Methods: We evaluated the results of a consecutive series of 148 primary ceramic-on-ceramic total hip arthroplasties that hadbeen performed between May 2001 and October 2005 in 142 patients. The mean age was 57.2 years (range, 23 to 81 years). Themean follow-up period was 7.8 years (range, 6.1 to 10.1 years). Preoperative diagnosis was avascular necrosis in 77 hips (52%),degenerative arthritis in 36 hips (24.3%), femur neck fracture in 18 hips (12.2%), rheumatoid arthritis in 15 hips (10.1%), and septichip sequelae in 2 hips (1.4%). Clinical results were evaluated with the Harris hip score, and the presence of postoperative groinor thigh pain. Radiologic analysis was done with special attention in terms of wear, periprosthetic osteolysis, and ceramic failures. Results: The mean Harris hip score improved from 58.3 (range, 10 to 73) to 92.5 (range, 79 to 100) on the latest follow-up evaluation. At final follow-up, groin pain was found in 4 hips (2.7%), and thigh pain was found in 6 hips (4.1%). Radiologically, all femoralstems demonstrated stable fixations without loosening. Radiolucent lines were observed around the stem in 25 hips (16.9%), andaround the cup in 4 hips (2.7%). Endosteal new bone formation was observed around the stem in 95 hips (64.2%) and around thecup in 88 hips (59.5%). No osteolysis was observed around the stem and cup. There were 2 hips (1.4%) of inclination changes ofacetabular cup, 2 hips (1.4%) of hip dislocation, 1 hip (0.7%) of ceramic head fracture, and 1 hip (0.7%) of squeaking. The Kaplan-Meier survival rate of the prostheses was 98.1% at postoperative 7.8 years. Conclusions: The ceramic-on-ceramic total hip arthroplasty produced excellent clinical results and implant survival rates with nodetectable osteolysis on a minimum six-year follow-up study. The ceramic-on-ceramic couplings could be a reasonable option ofprimary total hip arthroplasty for variable indications.
Improved FOC of IPMSM using Finite-state Model Predictive Current Control for EV
Won, Il-Kuen,Hwang, Jun-Ha,Kim, Do-Yun,Choo, Kyoung-Min,Lee, Soon-Ryung,Won, Chung-Yuen The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.5
Interior permanent magnet synchronous motor (IPMSM) is most commonly used in the automotive industry as a traction motor for electric vehicle (EV). In electric vehicle, the torque output rapidly changes according to the operation of the accelerator and the braking of the driver. The transient torques are thus generated very frequently in accordance with the variable speed control of the driver. Therefore, in this paper, a method for improving the torque response in the transient states of IPMSM is proposed. In order to complement the disadvantages of the conventional PI current controller in the field oriented control (FOC), the finite-state model predictive current control and 2D-LUT is applied to improve the torque response at the torque transient period. Simulation and experiment results are given to verify the reliability of the proposed method.