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Kyeongmin Kim,Se Hoon Kim,Jung-Yun Lee,Yoo-Na Kim,Seung-Tae Lee,박은향 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.4
Objective: The RAD51 assay is a recently developed functional assay for homologous recombination deficiency (HRD) that reflects real-time HRD status. We aimed to identify the applicability and predictive value of RAD51 immunohistochemical expression in pre- and post-neoadjuvant chemotherapy (NAC) samples of ovarian high-grade serous carcinoma (HGSC). Methods: We evaluated the immunohistochemical expression of RAD51/geminin/γH2AX in ovarian HGSC before and after NAC. Results: In pre-NAC tumors (n=51), 74.5% (39/51) showed at least 25% of γH2AX-positive tumor cells, suggesting endogenous DNA damage. The RAD51-high group (41.0%, 16/39) showed significantly worse progression-free survival (PFS) compared to the RAD51-low group (51.3%, 20/39) (p=0.032). In post-NAC tumors (n=50), the RAD51-high group (36.0%, 18/50) showed worse PFS (p=0.013) and tended to present worse overall survival (p=0.067) compared to the RAD51-low group (64.0%, 32/50). RAD51-high cases were more likely to progress than RAD51-low cases at both 6 months and 12 months (p=0.046 and p=0.019, respectively). Of 34 patients with matched pre- and post-NAC RAD51 results, 44% (15/34) of pre-NAC RAD51 results were changed in the post-NAC tissue, and the RAD51 high-to-high group showed the worst PFS, while the low-to-low group showed the best PFS (p=0.031). Conclusion: High RAD51 expression was significantly associated with worse PFS in HGSC, and post-NAC RAD51 status showed higher association than pre-NAC RAD51 status. Moreover, RAD51 status can be evaluated in a significant proportion of treatment-naïve HGSC samples. As RAD51 status dynamically changes, sequential follow-up of RAD51 status might reflect the biological behavior of HGSCs.
Lee, Kyeongmin,Suh, Mina,Jun, Jae Kwan,Choi, Kui Son The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.4
Purpose: The coronavirus disease 2019 (COVID-19) pandemic has significantly disrupted cancer screening services worldwide. We aimed to measure the impact of COVID-19 on gastric cancer screening rates based on age, sex, household income, and residential area. Materials and Methods: We analyzed data from the Korean National Cancer Screening Survey from 2017 to 2021 for adults aged 40-74 years. We evaluated the gastric cancer screening rate within two years in accordance with the National Cancer Screening Program protocol recommendations and that within the previous year. We compared the trends in the pre- and post-COVID-19 outbreak periods. Results: Before the COVID-19 outbreak, there was little change in the gastric cancer screening rates until 2019. After the COVID-19 outbreak, the screening rate as per recommendation decreased from 70.8% in 2019 to 68.9% in 2020 and that for one year decreased from 32.7% in 2019 to 27.2% in 2020. However, as the COVID-19 pandemic continued after 2020, both gastric cancer screening rates as per recommendations and for one year rebounded. Although a similar trend was observed for the upper endoscopy screening rate, the upper gastrointestinal series screening rate decreased from 7.8% in 2020 to 3.1% in 2021. During the pandemic, the screening rate decreased among younger adults (40-49), those residing in metropolitan regions, and those with high incomes. Conclusions: Despite a decline in gastric cancer screening rate during the COVID-19 pandemic, the rate surged in 2021. Further studies are needed to estimate the impact of cancer screening delays on future cancer-related mortalities.
Kyeongmin Lee,Wansik Cha 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.1
To predict the long-term behaviors of actinides in aqueous environments, complexation behaviors of actinides should be understood. Various organic ligands of chelating aromatic structure appearing in humic substances are known to form stable aqueous complexes. In this study, a benzene diol (or catechol) derivative, i.e., 4-nitrocatechol (nCA) is selected and its chemical equilibria including acid dissociation and complexation with U(VI) ion were examined using spectroscopic methods. In addition, the effect of ionic strength (Is) on those equilibria was evaluated by adjusting the level of NaClO4 in aqueous solutions. First, the experiments to determine the acid dissociation constant (pKa) of nCA were carried out in aqueous solutions with different ionic strengths from 0.01–2.0 M. The acid dissociation constants of nCA (pKa1) were measured to 6.73 ± 0.07, 6.69 ± 0.03, 6.38 ± 0.03, 6.09 ± 0.12, and 6.04 ± 0.07 at Is = 0.01, 0.1, 0.5, 1.0, and 2.0, respectively. These results were confirmed through the UV-Vis absorption spectral data analysis using the HypSpec program. As the pKa1 decreases as the ionic strength increases, except for Is = 2.0, these data were further analyzed with SIT (Specific ion Interaction Theory). Typically, as the solution becomes basic, a red shift is shown in the absorption spectrum. This effect can be understood from the intramolecular charge transfer (ICT) occurring in the deprotonated structures of nCA. At higher pH similar trends were also observed for measurement of pKa2. However, the determination of pKa2 is found not to be straightforward since a dimer formation equilibrium of nCA was observed as the ionic strength increased. This phenomenon will be discussed in detail with other supporting experimental results. Second of all, the complexation between the U(VI) and nCA in aqueous solutions was also examined. It was shown that nCA can easily form complexes with U(VI) ions at a wide range of pH via the deprotonation of their hydroxyl groups. U(VI)-nCA complexation will be further characterized by UV-Vis spectroscopy, IR and NMR by varying the solution ionic strength. The metal-ligand binding stoichiometry will be confirmed, for example, through the Job’s method. Finally, the acid dissociations constant and stability constants that were determined in this study will be used to provide species diagrams of aqueous U(VI)-nCA systems at a wide range of pH considering the effect of solution ionic strengths.
( Kyeongmin Han ),( Jaejoon Lee ),( Gnanendra Shanmugam ),( Sun Keun Lee ),( Junhyun Jeon ) 한국미생물·생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.7
Control of pine wilt disease, which is caused by pine wilt nematode Bursaphelenchus xylophilus, is heavily dependent on the use of chemicals such as abamectin. Although such chemicals are highly effective, demands for alternatives that are derived preferentially from natural sources, are increasing out of environmental concerns. One of the challenges to discovery of alternative control agents is lack of fast and efficient screening method that can be used in a high-throughput manner. Here we described the development of colorimetric assay for the rapid and accurate screening of candidate nematicidal compounds/biologics targeting B. xylophilus. Contrary to the conventional method, which relies on laborious visual inspection and counting of nematode population under microscope, our method utilizes a redox dye that changes its color in response to metabolic activity of nematode population in a given sample. In this work, we optimized parameters of our colorimetric assay including number of nematodes and amount of redox dye, and tested applicability of our assay for screening of chemicals and biologics. We demonstrated that our colorimetric assay can be applied to rapid and accurate quantification of nematode viability/mortality in a nematode population treated with candidate chemicals/biologics. Application of our method would facilitate high-throughput endeavors aiming at finding environment-friendly control agents for deadly disease of pine trees.
2022 개정 교육과정 문서에 제시된 교과별 저작권 관련 내용 분석
이경민(KyeongMin Lee),김자미(JaMee Kim),이원규(WonGyu Lee) 한국컴퓨터교육학회 2023 한국컴퓨터교육학회 학술발표대회논문집 Vol.27 No.2
디지털 기술의 발전으로 사회와 교육 환경의 변화가 빠르게 이루어지고 있다. 고교학점제와 AI 디지털 교과서가 도입되면서, 학교 현장에서 디지털 자료가 적극 활용될 것으로 예상되고 관련 저작권 교육을 강화할 필요성이 대두되고 있다. 따라서 본 연구는 2022 개정 교육과정에서 교과별로 저작권 관련 내용을 어떻게 다루고 있는지 키워드로 분석하는 것을 목적으로 두었다. 분석 결과 첫째, 20개 교과 중 총 11개(55%) 교과에서 저작권 관련 키워드를 포함하였고, 디지털 저작권 관련 키워드는 정보과를 비롯한 8개(40%) 교과에서 제시하였다. 둘째, 교과별 저작권 포함 범위는 ‘성취기준에 직접 포함’과 ‘이외(성취기준 해설, 성취기준 적용 시 주의사항, 교수‧학습 방법 및 평가 등)에 간접 포함’으로 구분할 수 있다. 저작권 관련 내용을 주제로 교육하기보다는 교사가 학생들의 활동과 과제를 평가할 때 타인의 저작권을 침해하지 않도록 안내하는 방식으로 간접적으로 저작권을 교육하고 있는 것이다. 셋째, 중학교 ‘정보’ 과목에서는 디지털 공간에서 살아가면서 저작권을 보호하는 방법의 사례들을 알아보는 성취기준을 제시하였다. 초등학교 실과 내 ‘디지털 사회와 인공지능’ 영역과 정보과 고등학교 과목의 성취기준에는 저작권 내용이 명시적으로 드러나 있지 않지만, 크로스커팅 방식을 통해 저작권을 성취기준에 직접 포함하지 않은 과목과 영역에서도 관련 내용을 다룰 수 있을 것이다. 현재 2022 개정 교육과정을 반영한 교과서가 나오지 않아, 본 연구에서는 교육과정 문서로만 관련 내용을 분석하였고 저작권 키워드만을 기준으로 분석하였다. 본 연구는 디지털 기술의 발전에 따라 디지털 대전환 사회에서 발생할 수 있는 저작권 이슈나 문제가 새롭게 등장하는 상황에서, 교육과정 내 저작권 교육의 개선을 위한 기초자료를 제시했다는 데 의미가 있다.
Jung Kyeongmin,Yoon Joohyun,Ahn Yeeun,Kim Soyeon,Shim Injeong,Ko Hyunwoong,Jung Sang-Hyuk,Kim Jaeyoung,Kim Hyejin,Lee Dong June,Cha Soojin,Lee Hyewon,Kim Beomsu,Cho Min Young,Cho Hyunbin,Kim Dan Say,K 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic variants associated with irritability and investigate the associated biological pathways, genes, and tissues as well as single-nucleotide polymorphism (SNP)-based heritability; 2) explore the relationships between irritability and various traits, including psychiatric disorders; and 3) identify additional and shared genetic variants for irritability and psychiatric disorders. We conducted a genome-wide association study (GWAS) using 379,506 European samples (105,975 cases and 273,531 controls) from the UK Biobank. We utilized various post-GWAS analyses, including linkage disequilibrium score regression, the bivariate causal mixture model (MiXeR), and conditional and conjunctional false discovery rate approaches. This GWAS identified 15 independent loci associated with irritability; the total SNP heritability estimate was 4.19%. Genetic correlations with psychiatric disorders were most pronounced for major depressive disorder (MDD) and bipolar II disorder (BD II). MiXeR analysis revealed polygenic overlap with schizophrenia (SCZ), bipolar I disorder (BD I), and MDD. Conditional false discovery rate analyses identified additional loci associated with SCZ (number [n] of additional SNPs = 105), BD I (n = 54), MDD (n = 107), and irritability (n = 157). Conjunctional false discovery rate analyses identified 85, 41, and 198 shared loci between irritability and SCZ, BD I, and MDD, respectively. Multiple genetic loci were associated with irritability and three main psychiatric disorders. Given that irritability is a cross-disorder trait, these findings may help to elucidate the genomics of psychiatric disorders.