http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Acute Pulmonary Toxicity and Body Distribution of Inhaled Metallic Silver Nanoparticles
Jung-Taek Kwon,Arash Minai-Tehrani,Soon-Kyung Hwang,Ji-Eun Kim,Ji-Young Shin,Kyeong-Nam Yu,Seung-Hee Chang,Dae-Seong Kim,Yong-Taek Kwon,In-Ja Choi,Yun-Hee Cheong,Jun Sung Kim,Myung-Haing Cho 한국독성학회 2012 Toxicological Research Vol.28 No.1
The purpose of this study was to determine the acute pulmonary toxicity of metallic silver nanoparticles (MSNPs, 20.30 ㎚ in diameter). Acute pulmonary toxicity and body distribution of inhaled MSNPs in mice were evaluated using a nose-only exposure chamber (NOEC) system. Bronchoalveolar lavage (BAL) fluid analysis, Western blotting, histopathological changes, and silver burdens in various organs were determined in mice. Mice were exposed to MSNPs for 6 hrs. The mean concentration, total surface area, volume and mass concentrations in the NOEC were maintained at 1.93 × 10? particles/㎤, 1.09 × 10<SUP>10</SUP> ㎚²/㎤, 2.72 × 10<SUP>11</SUP> ㎚³/㎤, and 2854.62 ㎍/㎥, respectively. Inhalation of MSPNs caused mild pulmonary toxicity with distribution of silver in various organs but the silver burdens decreased rapidly at 24-hrs post-exposure in the lung. Furthermore, inhaled MSNPs induced activation of mitogen-activated protein kinase (MAPK) signaling in the lung. In summary, single inhaled MSNPs caused mild pulmonary toxicity, which was associated with activated MAPK signaling. Taken together, our results suggest that the inhalation toxicity of MSNPs should be carefully considered at the molecular level.
( Kyeong Taek Jung ),( Yong Gun Shul ),( Masakazu Anpo ),( Hiromi Yamashita ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.3
TS-1 zeolite film has been prepared by using nano sized TS-1 zeolite particles for the photocatalytic isomerization of cis-2-butene. TS-1 zeolite film showed optical transparent property and the thickness of film was 0.7 ㎛. UV irradiation of TS-1 zeolite film in the presence of cis-2-butene leads to the photocatalytic isomerization of cis-2-butene into trans-2-butene at the temperature of 275 K. The yield of trans-2-butene was linearly increased with UV-irradiation time.
Acute Pulmonary Toxicity and Body Distribution of Inhaled Metallic Silver Nanoparticles
Kwon, Jung-Taek,Minai-Tehrani, Arash,Hwang, Soon-Kyung,Kim, Ji-Eun,Shin, Ji-Young,Yu, Kyeong-Nam,Chang, Seung-Hee,Kim, Dae-Seong,Kwon, Yong-Taek,Choi, In-Ja,Cheong, Yun-Hee,Kim, Jun-Sung,Cho, Myung-Ha Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.1
The purpose of this study was to determine the acute pulmonary toxicity of metallic silver nanoparticles (MSNPs, 20.30 nm in diameter). Acute pulmonary toxicity and body distribution of inhaled MSNPs in mice were evaluated using a nose-only exposure chamber (NOEC) system. Bronchoalveolar lavage (BAL) fluid analysis, Western blotting, histopathological changes, and silver burdens in various organs were determined in mice. Mice were exposed to MSNPs for 6 hrs. The mean concentration, total surface area, volume and mass concentrations in the NOEC were maintained at $1.93{\times}10^7$ particles/$cm^3$, $1.09{\times}10^{10}\;nm^2/cm^3$, $2.72{\times}10^{11}\;nm^3/cm^3$, and 2854.62 ${\mu}g/m^3$, respectively. Inhalation of MSPNs caused mild pulmonary toxicity with distribution of silver in various organs but the silver burdens decreased rapidly at 24-hrs post-exposure in the lung. Furthermore, inhaled MSNPs induced activation of mitogen-activated protein kinase (MAPK) signaling in the lung. In summary, single inhaled MSNPs caused mild pulmonary toxicity, which was associated with activated MAPK signaling. Taken together, our results suggest that the inhalation toxicity of MSNPs should be carefully considered at the molecular level.
( Jung Hoon Lee ),( Tae-kyeong Lee ),( In Hye Kim ),( Jae Chul Lee ),( Moo-ho Won ),( Joon Ha Park ),( Ji Hyeon Ahn ),( Myoung Chul Shin ),( Taek Geun Ohk ),( Joong Bum Moon ),( Jun Hwi Cho ),( Chan W 대한응급의학회 2017 대한응급의학회지 Vol.28 No.5
Purpose: Post cardiac arrest (CA) syndrome is associated with a low survival rate in patients who initially have a return of spontaneous circulation (ROSC) after the CA. The aim of this study was to examine the histopathology and inflammatory response in the heart during post CA syndrome. Methods: Asphyxial CA was induced in male Sprague-Dawley rats and the survival rate of the rats was determined during the post resuscitation phase. Results: Survival of the rats decreased after CA: 66.7% at 6 hours, 36.7% at 1 day, and 6.7% at 2 days after the ROSC following CA. The rats were sacrificed at 6 hours, 12 hours, 1 day, and 2 days after the ROSC, and their heart tissues were examined. Histopathological scores increased at 12 hours post CA. Afterwards, the histopathological changes were not significant. In addition, the levels of tumor necrosis factor-α immunoreactivity increased gradually after CA. Conclusion: The survival rate of the rats 2 days post CA was very low, even though the histopathological and inflamma-tory changes in the heart were not pronounced in the early stages following the CA.
Jung Hoon Lee,Tae Nyeun Kim,Sun Taek Choi,Byung Ik Jang,Kyeong Cheol Shin,Sam Beom Lee,Young Ran Shim 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.1
Behcet`s disease (BD) is a chronic relapsing multisystem disease characterized by oral ulceration, genital ulceration and ocular lesions. Gastrointestinal involvement is rare, often difficult to treat and associated with a high mortality rate. We treated a 47-year-old Korean man with BD who had a recurrent intestinal ulcer with tumor necrosis factor α antibody (infliximab); he initially underwent right hemicolectomy due to uncontrolled intestinal bleeding. For patients with intestinal BD who fail to respond to conventional treatment, infliximab may be a safe and effective new therapeutic option.
Genotyping of apple (Malus × domestica Borkh.) using MdACS1 and MdACO1 functional markers
Jung-Woo Lee,Jeong-Hee Kim,Sun-Il Kwon,Jong-Taek Park,Kyeong-Ho Chung 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Apple is a typical climacteric fruit, whose loss of firmness during storage is associated with internal levels of ethylene. MdACS1 (1-aminocyclopropane-1-carboxylate synthase) and MdACO1 (1-aminocyclopropane-1-carboxylate oxidase) genes are characterized well as functional markers for the ethylene production of ripening apple fruit. Presence of two alleles for each gene are commonly reported in cultivated apples. MdACS1-1/1, 1-1/2 and 1-2/2 generally induce high, medium, and low ethylene production, respectively. Homozygosity of MdACO1-1 resulted in low levels of ethylene production than MdACO1-1/2 and 1-2/2. It was reported that cultivars homozygous for MdACS1-2 and MdACO1-1 had superior shelf-life with lowest ethylene production. In this study, genotypes of 42 apple cultivars including Korean-developed ones at MdACS1 and MdACO1 loci were determined. Polymorphisms were detected by PCR and were separated by electrophoresis in a 2.0% agarose gel. Of PCR products of MdACS1, the fragrament of 490 bp was corresponded to the MdACS1-1 allele and 640 bp corresponded to the MdACS1-2 allele. ACO1-1 and ACO1-2 alleles had the fragment size of 525 and 587 bp, respectively. The 42 cultivars could be grouped into three classes to each gene, MdACS1-1/1, MdACS1-1/2 and MdACS1-2/2; MdACO1-1/1, MdACO1-1/2 and MdACO1-2/2.
Jung, Jaimyun,Yoon, Jae Ik,Park, Seong-Jun,Kang, Jun-Yun,Kim, Gwang Lyeon,Song, Yi Hwa,Park, Sung Taek,Oh, Kyeong Won,Kim, Hyoung Seop Elsevier 2019 Computational materials science Vol.156 No.-
<P><B>Abstract</B></P> <P>The cornerstone of materials design is solving materials-related optimization problems to obtain microstructural or processing variables that lead to the most desirable material properties. Because the objective of materials design is to maximize their performance, the related optimization problems often require a global solution. This type of unconstrained optimization overlooks the feasibility of the solution, which is a key engineering issue. For any practical application, feasibility should be reflected in the constraints included in the optimization problems. Nevertheless, the constraints related to feasibility are considerably complex due to the high dimensionality of the design space and non-physical aspects of the constraints, such as machine specifications, material dimensions, and available initial microstructure. In this work, we propose the use of a simple support vector machine (SVM) trained with information in an existing database to model complex feasibility constraints for material optimization. We present a problem involving optimization of the initial texture of a body-centered cubic (BCC) polycrystalline material to obtain specific target textures after cold-rolling. Both unconstrained and constrained optimizations are conducted for comparison, and the results demonstrate that constrained optimizations yield viable solutions while unconstrained optimizations do not.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Method to model complex constraint is proposed. </LI> <LI> Processing path model was used to optimize initial textures. </LI> <LI> Optimal initial textures were found with the modeled constraints. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>