Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.

강원도지방소나무의 수피두께 및 수피율

손영모 ( Yeong-mo Son ),이경학 ( Kyeong-hak Lee ),정영교 ( Young-gyo Chung ),이우균 ( Woo-kyun Lee ) 산림경영정보학회 1998 산림경영정보 Vol.1 No.2

본 연구는 강원도지방소나무에 대한 수피두께 및 수피율을 추정하기 위하여 수행되었다. 이를 위해 강원도 지방과 경북북부 지역을 대상으로 조사된 소나무 공시목을 재료로 하였다. 각 공시목에 대해 흉고직경, 수고, 수간부위별 직경 및 수피두께를 측정하였으며, 수간석해를 통해 수피 포함 간재적 및 수피제외 간재적을 추정하였다. 수간부위가 높을수록 수피두께는 감소하는 경향을 나타냈다. 수간부위별 수피두께의 변이는 낮은 수간높이에서 매우 컸고, 수간부위가 높아짐에 따라 변이는 점차 작아져 상대수간높이 0.25부터는 비슷한 변이폭을 나타내었다. 이와 같은 수피두께의 특정을 고려여 수간높이별로 수피두께를 추정할 수 있는 수피두께 추정식을 흉고직경, 수고, 수간높이, 수간높이별 직경 등을 변수로 하여 도출하였다. 추정식은 적합성, 추정계수의 통계적 신뢰성 등에 있어 타당한 것으로 나타났다. 또한, 이와 같이 유도된 수피두께추정식에 의해 추정된 수피재적을 수피포함 수간재적 및 흉고직경에 대한 비율로 나타내었다. 수피포함 간재적에 대한 수피재적비율은 재적이 0.1㎥미만일 때는 20%까지 높았으며, 간재적이 증가함에 따라 급격히 감소하여 재적 0.2㎥에서는 약 10%정도를 나타났다. 0.2㎥이상의 간재적에서는 큰 변화 없이 약 8-10% 정도의 수피율을 나타냈다. 흉고직경에 따른 수피재적율은 직경급에 따라 18-8%의 범위를 갖는 것으로 나타났다. 직경급 6cm에서는 약 18%의 수피재적율을 보이다가 직경급이 증가함에 따라 수피재적율은 급격히 감소하여 직경급 22cm에서는 약 10%정도의 수피재적율을 나타내었다. 이후로는 약 8-10%의 수피재적율을 보이고 있다. This study was carried out to estimate the bark thickness and bark percent of Pinus densiflora in Kangwon province. The sample data were surveyed in Kangwon and Kyeong-buk province. From the sample trees, dbh, height and diameter by cross section height etc were measured. As cross section height were high, the trend of bark width had decreased step by step. The variation of bark thickness by cross section height had showed high in below cross section height. As cross section height were high, the variation of bark thickness had decreased, and it had showed to similar in 0.25 of relative height or more. In consideration of bark thickness, bark thickness estimation equation was estimated with dbh , height and diameter by cross section. It had showed very significent in fitness and reliability of estimation coefficent. Bark volume by estimation equation had calculated at the rare of volume outside bark and dbh. Bark volume percent of volume outside bark had showed high to 20% level under 0.1㎥ of volume and approximately 10% in 0.2㎥ of volume. Bark percent had showed approximately 8-10% in 0.2㎥ of volume or more. Bark volume percent from dbh had showed within the range of 18 - 8% by dbh class, and it had showed approximately 18% in dbh class 6cm. With the increase of dbh class, bark volume percent had decreased Quickly and approximately 10% in 22cm of dbh class. Subsequently, bark volume percent had showed approxitely 8 - 10%.

Taxonomic Review of the Genus Eutetrapha Bates, 1884 (Coleoptera: Cerambycidae: Lamiinae) from Korea

Kyeong-Mi Kim,Jong-Kyun Park,Bong-Woo Lee 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10

The genus Eutetrapha belong to the subfamily Lamiinae of the family Cerambycidae was established in 1884 by Bates, based on a new species, Eutetrapha variicornis Bates, 1884 (= Saperda sedecimpunctata Motschulsky, 1860). Until now, the genus has been known only from Asia, and two species, Eutetrapha metallescens (Motschulsky) and Eutetrapha sedecimpunctata (Motschulsky) are presented in Korea. In this study, we report one species of the genus, Eutetrapha ocelota (Bates), for the first time from Korea with key to the Korean Eutetrapha species, short descriptions, and photographs.

Certain Autoimmune Manifestations Are Associated With Distinctive Karyotypes and Outcomes in Patients With Myelodysplastic Syndrome : A Retrospective Cohort Study

Lee, Sang Jin,Park, Jin Kyun,Lee, Eun Young,Joo, Sang Hyun,Jung, Kyeong Cheon,Lee, Eun Bong,Song, Yeong Wook,Yoon, Sung-Soo Williams & Wilkins Co 2016 Medicine Vol.95 No.13

<P><B>Abstract</B></P><P>Autoimmune manifestations (AIMs) are common in patients with myelodysplastic syndrome (MDS). This study aimed to investigate whether AIMs are associated with a specific cytogenetic abnormalities and worse survival in patients with MDS.</P><P>A total of 67 MDS patients with AIMs and 134 age- and sex-matched MDS patients without AIMs, all of whom received medical care at Seoul National University Hospital from January 2000 through July 2014, were enrolled. The clinical features, chromosomal abnormalities, and outcomes were examined. The effect of AIMs on mortality was estimated after adjusting for age, sex, and the International Prognostic Scoring System.</P><P>The mean age (±SD) at the time of MDS diagnosis was 54.5 ± 17.1 years, and 44.8% of patients were male. Neutrophilic dermatosis (ND; Sweet syndrome and pyoderma gangrenosum) was the most prevalent AIM (n = 24 36%]), followed by Behcet disease (10 [15%]), rheumatoid arthritis (9 [13%]), vasculitis (8 [12%]), myositis (3 [4%]), spondyloarthropathy (3 [4%]), and systemic lupus erythematous (2 [3%]). ND and vasculitis occurred at the time of MDS diagnosis, whereas other AIMs occurred years after MDS diagnosis. Deletion of 5q was associated with ND (<I>P</I> = 0.001), whereas trisomy 8 was associated with Behcet disease (<I>P</I> = 0.015). Strikingly, ND was associated with a 1.8-fold increase in mortality (95% CI 1.033–3.093; <I>P</I> = 0.038).</P><P>Certain AIMs in MDS patients are associated with distinctive karyotypes and worse survival. A larger study is needed to confirm whether the presence of AIMs influences disease outcome in MDS.</P>

Bone Mineral Density in Prediabetic Men

Lee, Ju Hee,Lee, Yun Hyeong,Jung, Kyoung Hye,Kim, Min Kyeong,Jang, Hye Won,Kim, Tae Kyun,Kim, Hyun Jin,Jo, Young Suk,Shong, Minho,Lee, Tae Yong,Ku, Bon Jeong Korean Diabetes Association 2010 Korean diabetes journal Vol.34 No.5

<P><B>Background</B></P><P>There are many studies regarding the effects of insulin on bone metabolism and changes in bone mineral density (BMD) in the setting of diabetes. The effect of prediabetes on BMD is not known.</P><P><B>Methods</B></P><P>A total of 802 men participated in the Korea Rural Genomic Cohort Study (in Geumsan County). According to the results of an oral glucose tolerance test, subjects were classified into normal, prediabetic, and diabetic categories. One hundred twenty-four subjects diagnosed with type 2 diabetes were excluded, leaving 678 subjects for the study inclusion. BMD was estimated with a quantitative ultrasonometer.</P><P><B>Results</B></P><P>The average BMD T scores of normal and prediabetic subjects were -1.34 ± 1.42 and -1.33 ± 1.30, respectively; there was no significant difference in the BMD T scores between these groups. The BMD T score was inversely associated with age and positively correlated with body weight, body mass index, total cholesterol, low density lipoprotein cholesterol, and HbA1c. On multiple linear regression analysis, low density lipoprotein cholesterol was the only statistically significant variable for prediabetes (β = 0.007, <I>P</I> = 0.005). On the stepwise regression analysis, age (β = -0.026, <I>P</I> < 0.001), the body mass index (β = 0.079, <I>P</I> < 0.001), and low density lipoprotein cholesterol (β = 0.004, <I>P</I> = 0.016) were significant variables for prediabetes.</P><P><B>Conclusions</B></P><P>There was no significant difference in the BMD T score between the normal and prediabetic subjects. Further studies are needed regarding the association of fracture risk and changes in BMD with the development of overt diabetes.</P>

Prevalence of Brachyspira hyodysenteriae on selected swine farms in Gyeongbuk province by PCR

( Dong Kyun Suh ),( Yun Jeong Do ),( Jong Su Ha ),( Kyeong Hyeon Lee ),( Yoo Jung Cho ),( Dong Jun Song ),( Chun Sik Lee ),( Young Chan Bae ),( Won Pil Choi ),( Keun Woo Lee ),( Jae Chan Song ) 한국동물위생학회 2001 한국동물위생학회지 (KOJVS) Vol.24 No.4

The purpose of this study is to determine the prevalence of Brachyspira hyodysenteriae from 43 swine farms with diarrhea or a history of diarrhea in Gyeongbuk province by PCR. The overall herd prevalence of B hyodysenteriae was 37.2%(16/43), and the average prevalence of B hyodysenteriae among all sampled pigs was 10.8%(50/462). Positive herds for B hyodysenteriae were distributed throughout Gyeongbuk province from 14.3~50%. Herd size had A effect on the frequency of B hyodysenteriae. The frequency of B hyodysenteriae in herds with less than 1,000 pigs was 47.4%, That of herds between 1,001 and 2,000 pigs was 41.7%. Also, the frequency of B hyodysenteriae in herds with more than 2,000 pigs was 16.7%.

제 3자 사용자 정책을 적용한 ACL 설계

이경효(Kyeong hyo Lee),오병균(Byeong-Kyun Oh),이상국(Sang Gug Lee) 한국정보과학회 2008 한국정보과학회 학술발표논문집 Vol.35 No.1

본 논문은 Web환경에서의 사용자의 권한을 검증하고 권한에 대한 이중적인 접근제어 서비스를 제공하는 역할기반의 WAC시스템의 블릭 설계서를 제안한다. WAC시스템은 User Interface Block, Access Control Block, Cipher module Block, DataBase로 구성 되며, WAC 시스템의 기능분류모델을 이용한 Block의 세부사항과 WAC시스템 기본 Bock(Access Control Bock)의 기본 기능 설계 및 사용자 접근제어 기능 설계, DES기반의 암호 Bock 기능 설계, 인터페이스 설계 대한 WAC 시스템의 전체적인 Block 설계에 대하여 기술한다.

Color Filter 수리를 위한 자외성 경화형 잉크 개발

이경균 ( Kyeong Kyun Lee ),이성구 ( Sung Koo Lee ),임은희 ( Eun Hee Lim ) 한국공업화학회 2010 응용화학 Vol.14 No.2

Base on polyester acrylate oligomer UV curable inks were prepared to repair pinhole defects in LCD color filter production. The pinhole defects in color filter are quite common during LCD production covering 1∼2% quality non-confirming fails. The pinholes sometimes refer to while-light specks when a LCD TFT is turn-on state. The formulated UV curable ink repairs those defects by filling a defective sub-pixel using inkjet printing process. Film properties such as curing time dependence, light transmittance characteristics, hardness were analyzed based on UV-cure time, UV-Vis spectroscopy and pencil hardness tester. Correlations between the formulation and inkjet printing behavior were also discussed by real-time ejection monitoring camera.

WSN에서 클러스터기반의 효율적인 pairwise key 설정 기법

이경효(Kyeong hyo Lee),조아앵(A-Aeng Cho),오병균(Byeong-Kyun Oh),이상국(Sang-Gug Lee) 한국정보과학회 2007 한국정보과학회 학술발표논문집 Vol.34 No.2D

WSN는 초기에 센서 노드들이 배치되었을 때 이웃 센서 노드들 간 보안키를 안전하고 효율적으로 설정해야하고 에너지 소비를 최소화해야하며 네트워크의 생존성을 늘리기 위해 불필요한 키 관리 동작을 지양해야한다. 네트워크 레벨의 중앙 집중적인 키 관리는 센서노드 하나에 대한 취약성 공격이 전체 네트워크의 위협으로 가용성보장이 어렵다. 따라서 본 논문에서는 네트워크를 클러스터링 하여 센서노드 노출로 인한 네트워크 전체에 주는 피해를 줄이고자 구의 형태로 클러스터링 함으로써 동일 클러스터내의 노드수의 증가에도 경로키 수를 줄일 수 있게 하여 센서 노드의 에너지 소모를 감소시켜 가용성을 보장하였다.

[ERRATUM] 차광처리가 눈개승마 유묘의 생장 및 생리적 특성에 미치는 영향

이경철(Kyeong Cheol Lee),한상균(Sang Kyun Han),권영휴(Young Hyoo Kwon),전성렬(Seong Ryeol Jeon),이창우(Chang Woo Lee),서동진(Dong Jin Seo),박완근(Wan Geun Park) 한국약용작물학회 2019 한국약용작물학회지 Vol.27 No.5