Surgical Workflow Manager를 통한 수술 프로세스 관리에 대한 연구

황현태(Hyun-Tae Hwang),양웅(Woong Yang),문권우(Kweon Woo Moon),이수홍(Soo-Hong Lee),박면웅(Myon Woong Park),손영태(Young Tae Sohn),김재관(Jae Kwan Kim),정다희(Dahee Chung) (사)한국CDE학회 2015 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2015 No.하계

Comparison of Corneal Deposits After LASIK and PRK in Eyes With Granular Corneal Dystrophy Type II

Kim, Tae-im,Kim, Terry,Kim, Sun Woong,Kim, Eung Kweon SLACK, Inc. 2008 Journal of refractive surgery Vol.24 No.4

<P>PURPOSE: To compare the characteristics of corneal deposits in eyes with granular corneal dystrophy type II (Avellino corneal dystrophy) after LASIK and photorefractive keratectomy (PRK). METHODS: Patients with heterozygous granular corneal dystrophy type II were examined with slit-lamp microscopy for recurrence of granular corneal dystrophy type II after uneventful LASIK and PRK surgery. One particular case involved bilateral incomplete flaps after LASIK, resulting in excimer laser ablation under the flap in one area and surface ablation in another area of both eyes. Deoxyribonucleic acid sequencing analysis in all patients confirmed the heterozygous status of granular corneal dystrophy type II. RESULTS: An abundance of coarse, white opacities consistent with granular corneal dystrophy type II were observed along the interface in all of the LASIK cases. In comparison, only a mild increase in opacities was noted in the PRK cases. In the LASIK case with bilateral incomplete flaps, abundant opacities were present in both corneas along the interface of the LASIK flap, and a minimal increase of stromal opacities was noted where no LASIK flap was present. CONCLUSIONS: Exacerbation of granular corneal dystrophy type II deposits occurred in the corneal stroma to a much greater degree after LASIK compared to surface ablation surgery.</P>

메타데이터 레지스트리 기반의 XML 스키마 생성 기법

이태웅(Tae-Woong Lee),권주흠(Ju-Hum Kweon),백두권(Doo-Kwon Baik) 한국정보과학회 2002 한국정보과학회 학술발표논문집 Vol.29 No.2Ⅰ

데이터베이스 개발에 있어서 다른 도구에 의한 다양한 스키마의 생성은 데이터베이스 간의 통합을 어렵게 만들고 있다. 이러한 이질적 문제를 해결하고자 메타데이터 레지스트리를 이용한 방안이 활발히 연구되고 있다. 메타데이터 레지스트리(Metadata Registry)는 공유와 전달 목적으로 한 메타데이터를 표준화시킨 것이다. 이는 정보 통합 측면에 대하여 로컬 스키마를 공유화된 메타데이터를 가지고 생성함으로써 글로벌 스키마로의 통합이 가능하다. 따라서 이러한 메타데이터를 기반으로 하여 공유할 수 있는 로컬 스키마의 작성 기법이 필요하다. 본 논문에서 메타데이터 레지스트리를 이용하여 XML 스키마를 생성하는 방안을 제안한다. 메타데이터를 XML 스키마로 변환하는 규칙을 제시하고 이를 기반으로 한 XML 스키마 생성 시스템을 설계하였다.

멀티데이터베이스 환경 하에서의 Deseription Logic을 이용한 의미상 질의 최적화

이태웅(Tae-Woong Lee),권주흠(Ju-Hum Kweon),백두권(Doo-Kwon Baik) 한국정보과학회 2003 한국정보과학회 학술발표논문집 Vol.30 No.1A

물류 공급 관리 시스템과 같은 정보 통합 시스템은 분산되어 있는 데이터베이스들에 대해서 정보를 통합하여 사용자에게 보여준다. 이러한 정보 통합 시스템은 전역 질의 생성하고 지역 질의로 변환하여 실행하기 전에 질의를 최적화할 필요성이 있다. 그런데, 단일데이터베이스 시스템에서의 질의 최적화 기법은 멀티데이터베이스 시스템에서 사용하기에는 부적절하다. 이는 분산된 데이터베이스 환경에서 오는 높은 연결 오버헤드, 높은 계산 시간, 데이터의 중복성 뿐만 아니라 의미 이질성 문제 때문에 기존의 최적화 방법은 사용하기가 어렵다. 이를 해결하기 위해서 의미상 질의 최적화 방법이 연구되어 왔다. 의미상 질의 최적화는 전역 질의보다 더 효과적으로 응답하고 의미상으로 동등한 질의로 변환하기 위해서 의미상 지식을 사용한다. 본 논문에서는 정보 통합 시스템에서 Description Logic(DL)을 이용하여 의미상 지식으로 사용할 지식 기반을 표현하고 이를 바탕으로 추론화된 지식을 이용하는 의미상 질의 최적화 방식을 제시한다.

The Survival of Donor-Derived Cells in a Successfully Grafted Corneal Button 10 Years after Penetrating Keratoplasty for Lattice Dystrophy

Kim, Sun Woong,Lee, Hwan Young,Kim, Tae-im,Shin, Kyoung-Jin,Yang, Woo Ick,Kim, Eung Kweon S. Karger AG 2009 Ophthalmologica Vol.223 No.6

<P><I>Aims:</I> To investigate the survival of donor-derived cells in a successfully grafted corneal button 10 years after penetrating keratoplasty for lattice dystrophy. <I>Methods:</I> In 1996, a 48-year-old male with lattice corneal dystrophy underwent penetrating keratoplasty 3 times in the right eye within a 3-month interval. Nine years and 7 months later, the patient underwent a fourth penetrating keratoplasty. After surgery, the previous graft was analyzed to determine the origin of the cells. The epithelium and endothelium were removed, and then the button was dissected into 5 stromal blocks measuring 2 × 1.8 mm. Tissues underwent forensic genotyping using 16 markers (amelogenin for sex chromosomes and 15 autosomal short tandem repeats). Patient buccal tissue DNA was used as a control. <I>Results:</I> The epithelium and buccal tissue contained identical DNA (i.e. recipient DNA). Similarly, the most peripheral stromal tissue contained only recipient DNA. In contrast, the most central stromal tissue only contained DNA of nonrecipient origin (presumably donor), while the stromal tissue between the periphery and center contained both recipient and nonrecipient DNA. <I>Conclusions:</I> The corneal stroma was infiltrated by surrounding recipient-derived keratocytes from the periphery. Therefore, more donor-derived cells had survived in the central stroma.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

ATF is improtant to late S phase-dependent regulation of DNA topoisomerase Ⅱα gene expression in HeLa cells

Son, Mee-Young,Kim, Tae-Jeong,Kweon, Kwang-In,Park, Jong-Il,Park, Chung,Lee, Young-Chul,No, Zae-Sung,Ahn, Jong-Woong,Yoon, Wan-Hee,Park, Seung-Kiel,Lim, Kyu,Hwang, Byung-Doo 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.

DNA topoisomerase IIα (Topo IIα) is regulated in late S phase-dependent manner. To identify late S phase-dependent cisacting elements of Topo IIα gene, we have investigated the synchronized HeLa cells with chloramphenicol acetyltransferase and DNase I footprinting assays. The level of Topo IIα mRNA increased after release from aphidicolin block and reached a maximum in 8 h (late S phase) in HeLa cells, and Topo II unknotting activity was also in parallel with the level of Topo IIα mRNA. The late S phase-regulatory element was found to be located in the region containing ATF-binding element between -290 and-90 bp and the region was required for a maximal stimulation during late S phase. DNase I footprinting assay showed that ATF-binding element and novel cis-acting element (Topo IIα-specific sequence) were the principal protein-binding sites and the proteins interacting with these elements were induced during late S phase. One DNA-protein complex was formed by DNA mobility shift assay when ATF-binding site was incubated with nuclear extract prepared from late S phase cells, but no protein bound in non-S phase cells. Taken together, these results suggest that ATF may be essential transacting factor for maximal expression of Topo IIα gene during late S phase in HeLa cells.

Comparison of Internal and Total Optical Aberrations for 2 Aberrometers: iTrace and OPD Scan

( Jung Bin Won ),( Sun Woong Kim ),( Eung Kweon Kim ),( Byung Jin Ha ),( Tae Im Kim ) 대한안과학회 2008 Korean Journal of Ophthalmology Vol.22 No.4

Purpose: To compare and evaluate the total and internal aberrations measured by two aberrometers: the laser ray tracing aberrometer (iTrace, Tracey Technology) and the automatic retinoscope aberrometer (OPD Scan, Nidek). Methods: A total of 54 healthy eyes were enrolled in the study. Following pupil dilation, aberrations were measured with the iTrace and OPD Scan. We compared the aberrations obtained from measurements obtained at pupillary diameters of 4 mm and 6 mm with the OPD Scan and iTrace. Aberrations of internal optics and total aberrations were compared for the two aberrometers. For each aberrometer and each eye, the averaged Zernike data were used to calculate various root-mean-square (RMS) data. These parameters, together with the refractive parameters, were then analyzed and complimented by paired t-tests. Results: At a pupil diameter of 4 mm, the number of total aberrations in the entire eye showed significant differences for the mean values of spherical aberrations (Z4,0) obtained with the OPD Scan and iTrace aberrometers (p=0.001). Aberrations of the internal optics showed significant differences in the mean values of total RMS, coma (Z3,-1), and trefoil (Z3,3) between the iTrace and OPD Scan (p<0.001, p=0.01, p<0.001) for the same pupil diameter of 4 mm. At a pupil diameter of 6 mm, the two instruments showed a similar number of total aberrations. Aberrations of the internal optics showed significant differences in the mean values of total RMS, spherical aberration (Z4,0), and coma (Z3,-1) between the two devices (p<0.001, p=0.01, p<0.001). Conclusions: The iTrace and OPD Scan showed the largest number of differences for aberrations of internal optics rather than total aberrations for both pupil diameters. These results suggest that in healthy eyes, the two aberrometers may vary in some details. The aberrometers showed more agreement at a pupil diameter of 6 mm compared to 4 mm. Korean J Ophthalmol 2008;22:210-213

ATF is improtant to late S phase-dependent regulation of DNA topoisomerase Ⅱα gene expression in Hela cells

Son, Mee-Young,Kim, Tae-Jeong,Kweon, Kwang-In,Park, Jong-Il,Park, Chung,Lee, Young-Chul,No, Zae-Sung,Ahn, Jong-Woong,Yoon, Wan-Hee,Park, Seung-Kiel,Lim, Kyu,Hwang, Byung-Doo 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

DNA topoisomerase IIα (Topo IIα) is regulated in late S phase-dependent manner. To identify late S phase-dependent cisacting elements of Topo IIα gene, we have investigated the synchronized HeLa cells with chloramphenicol acetyltransferase and DNase I footprinting assays. The level of Topo IIα mRNA increased after release from aphidicolin block and reached a maximum in 8 h (late S phase) in HeLa cells, and Topo II unknotting activity was also in parallel with the level of Topo IIα mRNA. The late S phase-regulatory element was found to be located in the region containing ATF-binding element between -290 and-90 bp and the region was required for a maximal stimulation during late S phase. DNase I footprinting assay showed that ATF-binding element and novel cis-acting element (Topo IIα-specific sequence) were the principal protein-binding sites and the proteins interacting with these elements were induced during late S phase. One DNA-protein complex was formed by DNA mobility shift assay when ATF-binding site was incubated with nuclear extract prepared from late S phase cells, but no protein bound in non-S phase cells. Taken together, these results suggest that ATF may be essential transacting factor for maximal expression of Topo IIα gene during late S phase in HeLa cells.

Characterization of Surface-Modified Poly(DL-lactide-co-glycolide) Scaffolds from Hydrophilic Monomers using Plasma-Enhanced CVD

Jung, You Jin,Lee, Kweon-Haeng,Park, Chong Won,Suh, Tae Suk,Hong, Choong Man,Hong, Seung Hwa,Ahn, Woong Shick,Chun, Heung Jae 한국공업화학회 2005 Journal of Industrial and Engineering Chemistry Vol.11 No.1

Inductively coupled plasma-assisted chemical vapor deposition (ICP-CVD) at room temperature was used to graft acrylic acid (AAc) and acrylamide (AAm) to a poly(DL-lactic-co-glycolic acid) (PLGA) scaffold surface. The surface of the grafted PLGA scaffolds was characterized by Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), electron spectroscopy for chemical analysis (ESCA), and a contact angle meter. The FTIR-ATR spectra of the surface-modified scaffolds showed the characteristic band of PAAc at 1640 cm^(-1) as well as those of PAAm at 1615 and 1660 cm^(-1), confirming that the AAc and AAm units were grafted successfully onto the surface of the PLGA scaffolds. The ESCA survey scan, as well as C₁s, O₁s, and N₁s core spectra of the modified surface, also showed that changes in the chemical composition occurred to the surfaces of the grafts. Surface tension of the scaffolds increased to 66.1 dyn/cm as a result of the grafting of the hydrophilic monomers.

Comparison of Internal and Total Optical Aberrations for 2 Aberrometers: iTrace and OPD Scan

Jung Bin Won,Sun Woong Kim,Eung Kweon Kim,Byung Jin Ha,Tae-im Kim 대한안과학회 2009 Korean Journal of Ophthalmology Vol.23 No.1

Purpose: To compare and evaluate the total and internal aberrations measured by two aberrometers: the laser ray tracing aberrometer (iTrace, Tracey Technology) and the automatic retinoscope aberrometer (OPD Scan, Nidek). Methods: A total of 54 healthy eyes were enrolled in the study. Following pupil dilation, aberrations were measured with the iTrace and OPD Scan. We compared the aberrations obtained from measurements obtained at pupillary diameters of 4 mm and 6 mm with the OPD Scan and iTrace. Aberrations of internal optics and total aberrations were compared for the two aberrometers. For each aberrometer and each eye, the averaged Zernike data were used to calculate various root-mean-square (RMS) data. These parameters, together with the refractive parameters, were then analyzed and complimented by paired t-tests. Results: At a pupil diameter of 4 mm, the number of total aberrations in the entire eye showed significant differences for the mean values of spherical aberrations (Z4,0) obtained with the OPD Scan and iTrace aberrometers (p=0.001). Aberrations of the internal optics showed significant differences in the mean values of total RMS, coma (Z3,-1), and trefoil (Z3,3) between the iTrace and OPD Scan (p<0.001, p=0.01, p<0.001) for the same pupil diameter of 4 mm. At a pupil diameter of 6 mm, the two instruments showed a similar number of total aberrations. Aberrations of the internal optics showed significant differences in the mean values of total RMS, spherical aberration (Z4,0), and coma (Z3,-1) between the two devices (p<0.001, p=0.01, p<0.001). Conclusions: The iTrace and OPD Scan showed the largest number of differences for aberrations of internal optics rather than total aberrations for both pupil diameters. These results suggest that in healthy eyes, the two aberrometers may vary in some details. The aberrometers showed more agreement at a pupil diameter of 6 mm compared to 4 mm