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Post-market surveillance assay of veterinary medicines in Korea during 2009∼2012
( Kwang Jick Lee ),( Jeong Woo Kang ),( Sung Won Park ),( Jae Jo Kim ),( Seong Joon Joh ),( Heui Jin Kim ),( Meung Ju Chae ),( Soon Ok Jee ),( Seon Jong Yun ),( Byung Jae So ) 한국예방수의학회 2013 예방수의학회지 Vol.37 No.3
As veterinary medicine industry has grown up steadily, the government quality control of veterinary medicine in market has been performed since 1964. The result of post-market surveillance assay from 2009 to 2012 was analyzed in this study. The average violation rate of all veterinary medicines, was 3.2%, 2.8%, 2.8% and 1.4% in 2009, 2010, 2011 and 2012, respectively. The total average violation rate in the category of antibiotics, other drugs except antibiotics, biologics were 1.2%, 4.4% and 0.8%, respectively. The violations due to insufficiency of major active ingredient content occupied 76.7% among the total violations. The most frequent violated in antibiotics were ampicillin and tylosin, followed by sulfonamides, penicillins etc. In case of other drugs except antibiotics, vitamin A and glucocorticoids (dexamethasone and prednisolone) were violated frequently. The overall trend of violation rates gradually decreased from 2009 to 2012, suggesting that quality of veterinary medicines has improved according to Korea Veterinary Good Manufacturing Practice (KVGMP) system settled down in 1988.
메틸렌블루 비색법을 이용한 원유중 음이온 계면활성제의 분석
이희수,이명헌,정갑수,조병훈,이광직,이승환,김정임,김문배,박종명,조준형,김옥경 한국수의공중보건학회 2001 예방수의학회지 Vol.25 No.4
A determination method for anionic surfactants residue in raw milk was established using methylene blue method. The residue in raw milk was first precipitated with acetonitril, seperated by centrifugation, concentrated by evaporation of supernatant, dissolved with distilled water, allowed to complex formation by adding the methylene blue and extracted with chloroform. The final was analysed and quantified by spectrophotometry. Based on the collaborative studies in 3 laboratories after spiking 5 to 20 ppm of standard solution, the mean of recovery rate within laboratory repeatability were 85.9%, 104.6% and 94.9%, respectively and the coefficient of variation were 9.3%, 9.8% and 6.4%. In addition, the coefficient of variation between laboratory repeatability was 16.1% which would be acceptable to the recommended guideline of CODEX. In conclusion, the present method makes feasibilities for quantified and qualified determination of anionic surfactants residue in raw milk.
HPLC를 이용한 육류중 바이피리딜리움계 제초제 잔류분석
이희수,이혜숙,조병훈,김병용,이광직,이명헌,박은정,김문배,이성모,조준형,박종명,정갑수,김옥경 한국수의공중보건학회 2001 예방수의학회지 Vol.25 No.4
A simultaneous and rapid method for determination of bipyridylium herbicides, paraquat dichloride and diquat dibromide have been developed in meat using high-performance liquid chromatography (HPLC) at UV 255/310nm. It is possible to detect effectively below maximal residue levels (MRL) set in CODEX and Korea with little amount of sample. Based on the collaborative studies in 3 laboratories, the mean of recovery within laboratory repeatability were 108.7%, 93.5% and 105.7%, respectively and the coefficient of variation were 6.9%, 9.8% and 12.1% in paraquat analysis. In case of diquat analysis, the mean of recovery were 86.3%, 87.0% and 86.3%, respectively and the coefficient of variation were 13.2%, 8.9% and 7.6%, respectively of which results would be acceptable to recommended guideline of CODEX. In addition, the coefficient of variation between laboratory repeatability were 7.9% and 9.7% in paraquat and diquat, respectively which would be also acceptable to the guideline of CODEX. In conclusion, the present method which would be equivalent to an official method of analysis makes feasible both for qualified determination in meat and for precise diagnosis of intoxification caused by paraquat and diquat, bipyridylium herbicides.
Prediction of skin penetration of Bifenthrin using in vitro micro-pig skin model
Ji-Hyun Bang(Ji-Hyun Bang),Hyun-Ok Ku(Hyun-Ok Ku),Byung-Suk Jeon(Byung-Suk Jeon),Hyobi Kim(Hyobi Kim),Kwang-Jick Lee(Kwang-Jick Lee),Yong-Sang Kim(Yong-Sang Kim),Hee Yi(Hee Yi) 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-
이상훈,김진일,박선미,이광민,박영민,정규원,배시현,방춘상,선희식,장은덕,유수은,박두호,김동빈,성용직 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.3
Hepatocellular carcinoma (HCC) is one of the most common fatal malignancies worldwide, especially in Korea. The recent advances in diagnostic techniques, such as serum tumor marker assay, ultrasonography, computerized tomography (CT), magnetic resonance imaging (MRI), and angiography, allow us to detect HCC at early stage. Even though, it remains difficult to distinguish malignant nodules from benign space-occupying lesions of liver. Distinction of HCC from benign entities such as liver abscess is important because failure of prompt diagnosis could result in a missed opportunity for curative treatment. The differential diagnosis of HCC and liver abscess, especially HCC presenting as abscess, is sometimes very difficult. We report a case of HCC with liver abscess caused by secondary infection of CBD stone and cholangitis, that mimicked the dynamic CT findings of liver abscess, in an elderly patient with chronic hepatitis C virus infection. (Korean J Hepatol 1999;5:253-258)
Lee, Seung-Jin,Park, Na-Hye,Mechesso, Abraham Fikru,Lee, Kwang-Jick,Park, Seung-Chun Elsevier Scientific Pub. Co 2017 Veterinary microbiology Vol.207 No.-
<P><B>Abstract</B></P> <P>In the present study, the molecular mechanisms of antibiotic resistance in <I>Salmonella</I> Typhimurium clinical isolates from pigs were investigated using a single-step mutation model of exposure to sub-mutant prevention concentrations (MPCs) of marbofloxacin. The minimum inhibitory concentrations (MICs) of seven antibacterial drugs were evaluated against 30 <I>S.</I> Typhimurium clinical isolates from different pigs. MPCs of marbofloxacin were also determined. The mechanism of marbofloxacin-resistance was investigated by sequencing analysis of target gene mutations and quantifying the overexpression of efflux pumps and their regulators by quantitative RT-PCR. Marbofloxacin showed the highest potency against all isolates (23.3%), including multi-drug resistant isolates. The MPC<SUB>50</SUB> (0.5μg/mL) and MPC<SUB>90</SUB> (2μg/mL) of marbofloxacin were determined, as were MPC/MIC ratios of 2.5 to 8. A <I>gyrA</I> mutation (Ser83Phe or Asp87His) was detected in isolates with an MIC>0.06μg/mL and all single-step mutants. Moreover, expression of <I>acrAB-tolC</I> and <I>marA</I>/<I>soxS</I>/<I>ramA</I> increased following a single-step mutation, but only <I>ramA</I> expression showed a positive correlation with the resistance phenotype of clinical isolates and single-step mutants (<I>p<</I> 0.05). Furthermore, the <I>acrR</I> mutation was detected in two clinical isolates and 50% of single-step mutants, regardless of whether the <I>gyrA</I> mutation was present. This is the first report of <I>acrR</I> mutations in <I>S</I>. Typhimurium isolates from pigs in Korea. Our findings suggest that a single-exposure to sub-MPCs of marbofloxacin was sufficient to reduce the susceptibility of <I>Salmonella</I> isolates. Therefore, optimized dosing based on application with the MPC concept is required to reduce the chances of marbofloxacin resistance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Multi-drug resistance was found in 36.7% of <I>Salmonella</I> Typhimurium clinical isolates from swine; only 36.4% among them were susceptible to marbofloxacin. </LI> <LI> The resistance phenotypes in isolates increased after a single-exposure to sub-MPCs of marbofloxacin. </LI> <LI> Target mutation (<I>gyrA</I>)-based and/or efflux pump (<I>acrAB</I>-<I>tolC</I>)-mediated marbofloxacin resistance in clinical isolates and single-step mutants were identified. </LI> <LI> Expression of <I>acrAB</I>-<I>tolC</I> was associated with global regulators (<I>marA</I>/<I>soxS</I>/<I>ramA</I>) and/or a local regulator (<I>acrR</I>). </LI> <LI> This is the first report on the identification of <I>S.</I> Typhimurium isolates with <I>acrR</I> mutations in Korea. </LI> </UL> </P>
Tae Haeng Cho(趙太行),Kwang Jick Lee(李光稙),Jong Myung Park(朴鍾鳴),Sun Namgoong(南宮琁),Keun Sik Park(朴根植) 한국예방수의학회 1993 예방수의학회지 Vol.17 No.1
This report was results to be analyzed for quality control to animal using antibiotics of 28, 741 lots during the periods of 1963 to 1992. Among them, 28, 574 lots are passed and 167 lots rejected through national assay. The preparation forms of animal using antibiotics of total 14, 071 lots examined for 6 years(1987-1992) were classified as feed additives 4, 781 (34.0%), injectables 3, 871 (27.5%) and soluble powders including oral suspensions 3,426(24.3%), respectively. Of the antibiotics of 14,071 lots, 1,182 lots(8.4%) were applied for raw materials, 733(5.2%) as implantations for therapy of bovine mastitis and 78 lots (0.6%) as the other antibiotics. In 1992, 2, 282 lots of animal using antibiotics were examined by regulations of national assay. Among them, mono-antimicrobial drugs were 1, 697 lots (74%) and combined antibiotics 585 lots (26%), respectively. The nomo-antibiotics and combined antibiotics were constituted with 58 kinds of chemical components. During the periods of 1985 to 1992, 18, 230 lots of antibiotics were tested by regulations of national assay. Among them, 167 lots were rejected by results of national assay. By the preparation forms, the soluble powders including the oral suspensions were highly rejected as 54 lots, and injectables, feed additives, implantations and the others were orderly rejected 49, 45, 17 and 2 lots, respectively. By reason of the rejection, 129 of 167 lots were insufficiently potency, 24 excessively humidity, 11 highly pH and 3 adequately characteristic tests, respectively.