국립공원 3개 저수지에 서식하는 생태계교란 어종의 서식양상과 먹이생물, 어류상에 미치는 영향

박승철 ( Seung-chul Park ),이광열 ( Kwang Yeol Lee ),최광식 ( Kwang-seek Choi ),한미숙 ( Mee-sook Han ),고명훈 ( Myeong-hun Ko ) 한국어류학회 2021 韓國魚類學會誌 Vol.33 No.2

본 연구는 국립공원 내 생태계교란 어종 배스와 블루길의 도입에 따른 영향을 파악하기 위해 2020년 금계지, 삼가지, 내장지에서 조사를 실시하였다. 금계지에서는 7과 11종 1,221개체가 채집되었고, 배스는 우점종 (96.3%), 블루길은 소수 (0.3%) 서식하고 있었고, 배스는 주로 밀어 (IRI, 37.2%)와 잠자리목(25.6%), 뱀잠자리목 (11.6%), 배스 (7.0%) 등을 섭식하였다. 삼가지에서는 5과 10종 854개체가 채집되었고, 배스는 우점종(60.8%)으로 주로 새우류 (33.6%)와 잠자리목 (34.4%), 밀어(21.2%), 피라미 (6.1%) 등을 섭식하였다. 내장지에서는 7과 13종 1,075개체가 채집되었고, 블루길은 우점종 (38.1%), 배스는 우세종 (9.5%)으로 나타났으며, 블루길은 주로 물벼룩류 (IRI, 77.5%)와 파리목 (9.8%), 새우류 (4.0%) 등을 섭식하였고 배스는 주로 밀어 (73.3%)와 새우류 (21.2%) 등을 섭식하였다. 금계지와 삼가지의 배스는 10여 년 전에 도입된 것으로 추정되고, 도입 이후 대부분의 어류는 개체수가 급격히 감소하였다. 내장지의 블루길은 20여 년 전에 도입된 것으로 추정되며, 도입 이후 상대풍부도가 점점 증가하여 40%대에 도달하였고, 배스는 5~6년 전에 도입되었고 도입 이후 자생 어류의 종수와 개체수가 급격히 감소하였다. 마지막으로 국립공원 내 배스와 블루길의 서식현황 및 관리방안에 대해서 논의하였다. This study was conducted to elucidate the impact of invasive species, Micropterus salmoides and Lepomis macrochirus in Geumgyeji, Samgaji and Naejangji reservoirs of National Parks, Korea in 2020. In the Geumgyeji, 1,221 individuals of 11 species in 7 families were collected including M. salmoides (relative abundance, 96.3%) and L. macrochirus (0.3%), M. salmoides fed mainly on Rhinogobius brunneus (IRI, 37.2%), Odonata (25.6%), Megaloptera (11.6%), and M. salmoides (7.0%). In the results of Samgaji showed that 854 individuals of 10 species in 5 families were collected including M. salmoides (60.8%), and M. salmoides fed mainly on Decapoda (shrimp, 33.6%), Odonata (34.4%), R. brunneus (21.2%), and Zacco platypus (6.1%). In the Naejangji showed that 1,075 individuals of 13 species belonging to 7 families were collected including L. macrochirus (38.1%) and M. salmoides (9.5%), and L. macrochirus fed mainly on Branchiopoda (77.5%), Diptera (9.8%), Decapoda (4.0%) and M. salmoides fed mainly on R. brunneus (73.3%), Decapoda (21.2%). M. salmoides of Geumgyeji and Samgaji were apparently introduced more than a 10 years ago. The fish population declined rapidly since the introduction of M. salmoides. L. macrochirus of Naejangji was introduced more than 20 years ago, which increased its relative abundance to 40%. M. salmoides was introduced five to six years ago, and the fish species and population declined rapidly since the introduction of M. salmoides. Finally, we discussed the inhabitat status and management of M. salmoides and L. macrochirus in the National Park.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

모 형광등업체에 있어서의 공기중 수은농도 및 요중 수은량 조사

박승회,김광종,장성훈,차철환 大韓産業醫學會 1989 대한직업환경의학회지 Vol.1 No.2

In order of interpret the relationship among many variables, urinary mercury and the same time mercury concentration in air were measured for 254 workers of a fluorescent lamp manufacturing factory. And monthly consumption amounts, numbers of monthly producing fluorescent lamps, numbers of inferior lamps numbers of breakage lamps, numbers of vacuum pumps and frequencies of mercury infusion were also investigated from January 1988 to March in 1989. The results were as follows; 1. On the mercury concentration in air by producing line and by working site, all of them were exceed the threshold limit value (0.05mg/㎥). 2. The highest mercury concentration in air by sampling was found at the floor of workplace (0.334mg/㎥) and next were at vacuum exhaustion prmp (0.183mg/㎥), and breathing zone of workers(0.103mg/㎥) in order. 3. The highest mean of the mercury concentration in urine by producing line was the automatic exhausting line (80.8㎍/1) and next were high speed exhausting line (72.4㎍/1), and Manual exhausting line (35.8㎍/1) in order. Distribution of workers of the mercury concentration in urine more than 200㎍/1 by working site was the highest (10%) in the vacuum exhaustion pump part and next were sealing part (6.6%), packing part (4.6%), and stem part (4.1%) in order. 4. The correlation coefficient between mercury concentration in urine and in air was the highest(0.302) and next were numbers of breakage lamps (0.223), frequencies of mercury infusion (0.223), numbers of inferior lamps (0.205) in order.

분말야금법을 이용한 TiNi기 형상기억 복합재료의 기계적특성에 관한 연구

박영철,윤두표,박민식,김광영 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.1

In this study, It is introduced that TiNi/Al-radical shape memory composite as one of new material that used shape memory alloy (SMA). It is a method to produce a better strength of composite by occuring compressive residual stress in matrix, using shape memory effect of TiNi fiber. This method os replaced of tensile residual stress happened by difference of coeffients of thermal expansion (CTE) between fiber and matrix, one of the significant faults of metal matrix composite (MMC). In this paper, shape memory composites are made by powder metallurgy. And then, an self-strengthening effect of the composites by shape memory effect above inverse transformation temperature A_f of TiNi alloy are discussed. Moreover, TiNiCo/Al composites is made by using TiNiCo alloy as fiber. And it is discussed about affection of Co in the shape memory composite. The results of the intelligent properties of TiNi/Al-radical shape memory composite, using SMA, by powder metallurgy are the tensile strength of TiNiCo wire is much higher than that of TiNi wire and the strength of TiNiCo/Al composite is generally higher than of TiNi/Al composite.

단기배양을 통한 말초혈액 CD34 양성세포의 체외증폭

박상준,김철희,배광봉,김현수,김종숙,윤환중,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Background: It is suggested that clinical practice in the areas of bone marrow transplantation and gene therapy might rely on the ex vivo expansion of hematopoietic stem/progenitor cells. However, the condition for ex vivo expansion of hematopoietic progenitor cells is not well established. The authors pursued a series of experiments to define the proper conditions for the expansion of hematopoietic cells in the short-term liquid suspension culture of mobilized peripheral blood CD34+ cells. Methods: 1.0ml cultures were initiated with 9×10^3 PB CD34+ cells, which were isolated from PB mononuclear cells (MNCs) by high-gradient cell sorting, in 12 well plates with the various combinations of hematopoietic growth factors(HGF). The following recombinant human HGFs were used: stem cell factor(SCF) 100ng/ml, granulocyte colony-stimulating factor(G-CSF) 100ng/ml, GM-CSF(granulocyte, macrophage colony-stimulating factor) 100ng/ml, interleukin-1 beta(IL-1B) 1ng/ml, interleukin-3(IL-3) 20ng/ml, interleukin-6 (IL-6) 100ng/ml. At the end of culture, colony-forming cells were evaluated by semisolid clonogenic assay. Results: 1) Using the high-gradient magnetic sorting system, CD34^+ cells were isolated with a yield of 40 3% 2) In 7 day culture of PB CD34^+ cells(9×10^3 cells), nucleated cells expanded mean 10×10^3(range, 9 to 20×10^3) with the addition of SCF alone, 35×10^3(range, 10 to 60×10^3) with SCF plus G-CSF plus GM-CSF, and 130×10^3(range, 40 to 300×10^3) with the combination of SCF, G-CSF, IL-1, IL-3, IL-6, GM-CSF. In 14 day culture, nucleated cells expanded 10×10^3 to 1,860×10^3 with combination of human hematopoietic growth factors. 3) In 10 day culture without medium change of PB CD34^+ cells, CFU-GM numbers expanded 16. 5 fold(range, 7 to 59 fold) with the addition of SCF plus G-CSF plus Il-1 plus IL-3, 31.3 fold(range, 20.5 to 101.1 fold) with the combination of SCF, G-CSF, IL-1, IL-3, GM-CSF. In 14 day culture with or without medium change of PB CD34^+ cells was inferior to 10 day culture for CFU-GM expansion. 4) There was no significant difference for CFU-GM expansion between five growth factors(SCF,G-CSF,IL-1,IL-3,GM-CSF) and six growth factors(five growth factors plus IL-6). Conclusion: The authors could confirm that short-term suspension culture of peripheral blood CD34+ cells could expand hematopoietic progenitor cells. Ten-day culture with medium change of CD34+ cells with the addition of five growth factors, i.e. SCF, G-CSF, IL-1B, IL-3, and GM-CSF, might be the most efficient in this system.

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

경주시 인왕동 교통사고 가해차량의 운전자 규명

박외철,이광진 釜慶大學校 1999 釜慶大學校 論文集 Vol.4 No.1

A Sonata II collided with two vehicles in consequence in Kyongju. There were two occupants in the car, but each of them insisted that he was not driving the car. We investigated the accident ot determine the driver through careful review of the collision report, the statements of accident and witness, photographs taken at the scene, and the expert report of the National Scientific Investigation Institute. The accident was reconstructed based on the physical principles, injuries of occupants, damages of the involved vehicles and their final stops.

전후 자본주의경제의 동향에 관한 고찰 : 전후~1980년대초를 중심으로 Centering on Post War to Beginning 1980s

박철범,김광표 朝鮮大學校 1999 經營經濟硏究 = Management and economics research Vol.22 No.2

다중 출력 MLP신경망을 이용한 한국어 음성인식에 관한 연구

鄭光宇,朴炳哲 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

In this paper, to improve the performance of the speaker-independent speech recognition system, a new reural network model and learning algorithm were proposed. Recognition algorithm for performance improvement of the recognition system had two kinds. Several experimental results were given to prove the performance of proposed algotithm on the isolated digit recognition of the speaker- independent. First, the algorithm for extraction of the feature vector was proposed. it imported, to stabilize the sequence of the feature vector to input speech, the 'Inertia Term' between neighbor frames. If, caused the reducing fluctuation components produced on the sequence of the feature vector of speech signal and tine suppressing superposition of probability distribution between feature vectors. As a result, the ability of phoneme discrimination was improved on the speaker independent speech recognition system or 3.9%. Second, the Multi-Output MLP(MO-MLP) neural network structure was proposed. It had, for reflecting the variation of the feature of the phoneme which was produced on the variable phonological environment, the structure which was assigned several output nodes to the same phoneme. So, the convergence characteristic of the neural network could be improved by the proposed structure for complex learning data and this structure could improve the ability of recognition system by generating the multi-template pattern on a neural network for 8.4%.

X선 프렉토그래피기법을 이용한 금속복합재료의 피로손상 해석에 관한 연구

김광영,박동성,박영철,윤두표,김득진 韓國非破壞檢査學會 1998 한국비파괴검사학회지 Vol.18 No.3

본 연구에서는 비파괴방법중 대단히 효과적인 방법이라 할 수 있는 X선 프렉토그래피 방법을 이용하여 파괴역학적 파라메타인 ΔK, Kmax의 정량적인 평가의 가능성에 대하여 검토하였다. 이를 위하여 Al2009-15v/o SiCw 복합재료와 SS41 불림재를 이용하여 피로균열진전시험을 실시하고 그 결과로부터 파면상의 X선 프렉토그래피 파라메타와 파면형성시의 파괴역학적 파라메타를 비교 ㆍ검토하여 X선 프렉토그래피에 의한 ΔKdhk Kmax의 평가 방법에 대하여 연구하였다. 또한, 정적하중부에 의한 소성변형률의 비파괴적 평가법에 대하여도 검토하였다. 이를 위하여 인장시험으로 소성변형을 부하한 후, X선 프렉토그래피 파라메타를 이용하여 부하된 소성변형량의 비파괴평가법에 대하여 검토하였다. 그 결과 피로파괴시의 부하된 Kmax와 피로손상 정도를 X선 프렉토그래피에 의하여 정량적으로 평가할 수 있는 방법을 제시하였다. It is attempted to verify the Quantitative relationship between fracture mechanical parameters(ΔK, Kmax)and X-ray parameters (residual stress, half-value breadth) of Al2009-15v/o SiCw composite, and normalized SS41 steel. In this study, fatigue crack propagation test were carried out X-ray diffraction was applied to fatigue fractured surface in order to investigate the change of residual stress and half-value breadth on fatigue fractured surface. And it is loaded prestrain to each tensile specimen, Al2009-15v/o SiCw composite(0.3,0.5,1,1.5,2%) and normalized SS41 steel(0.63,7.50,13.7,20%),for investigating plastic strain rate using nondestructive measurement method. X-ray diffraction was applied to the prestrained tensile specimens in order to measure the change of residual stress and half-value breadth.